PT1190087E - Hidroxilacao de compactina em pravastatina por micromonospora - Google Patents

Hidroxilacao de compactina em pravastatina por micromonospora

Info

Publication number
PT1190087E
PT1190087E PT00944121T PT00944121T PT1190087E PT 1190087 E PT1190087 E PT 1190087E PT 00944121 T PT00944121 T PT 00944121T PT 00944121 T PT00944121 T PT 00944121T PT 1190087 E PT1190087 E PT 1190087E
Authority
PT
Portugal
Prior art keywords
compactin
micromonospora
hydroxylate
pravastatin
compactin hydroxylate
Prior art date
Application number
PT00944121T
Other languages
English (en)
Inventor
Gabor Ambrus
Sandor Boros
Antonia Jekkel
Eva Ilkoy
Ildiko Horvath
Attila Konya
Istvan Mihaly Szabo
Zsuzsanna Nagy
Gyula Horvath
Julia Mozes
Istvan Barta
Gyorgy Somogyi
Janos Salat
Original Assignee
Ivax Drug Res Inst Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Drug Res Inst Ltd filed Critical Ivax Drug Res Inst Ltd
Publication of PT1190087E publication Critical patent/PT1190087E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29—Micromonospora
PT00944121T 1999-07-12 2000-06-29 Hidroxilacao de compactina em pravastatina por micromonospora PT1190087E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9902352A HUP9902352A1 (hu) 1999-07-12 1999-07-12 Eljárás pravasztatin mikrobiológiai előállítására

Publications (1)

Publication Number Publication Date
PT1190087E true PT1190087E (pt) 2003-10-31

Family

ID=89998701

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00944121T PT1190087E (pt) 1999-07-12 2000-06-29 Hidroxilacao de compactina em pravastatina por micromonospora

Country Status (32)

Country Link
US (2) US6905851B1 (pt)
EP (3) EP1190087B1 (pt)
JP (2) JP4531315B2 (pt)
KR (2) KR100479837B1 (pt)
CN (2) CN1590555A (pt)
AP (1) AP1405A (pt)
AT (1) ATE243262T1 (pt)
AU (2) AU773633B2 (pt)
BG (1) BG65109B1 (pt)
BR (1) BR0013156A (pt)
CA (2) CA2379015A1 (pt)
CZ (2) CZ297009B6 (pt)
DE (1) DE60003424T2 (pt)
DK (1) DK1190087T3 (pt)
ES (1) ES2200891T3 (pt)
HR (1) HRP20020028B1 (pt)
HU (1) HUP9902352A1 (pt)
IL (2) IL147583A0 (pt)
IS (1) IS2138B (pt)
MX (1) MXPA02000356A (pt)
NO (1) NO20020119L (pt)
NZ (1) NZ516563A (pt)
OA (1) OA12150A (pt)
PL (2) PL353493A1 (pt)
PT (1) PT1190087E (pt)
RU (2) RU2235780C2 (pt)
SK (2) SK285726B6 (pt)
TR (1) TR200200726T2 (pt)
UA (1) UA67854C2 (pt)
WO (2) WO2001004340A1 (pt)
YU (1) YU2002A (pt)
ZA (1) ZA200200273B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9800046A (sl) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
DE04010770T1 (de) 1999-11-30 2005-10-20 Biogal Gyogyszergyar Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe
AU779306B2 (en) 1999-12-14 2005-01-13 Teva Gyogyszergyar Reszvenytarsasag Novel forms of pravastatin sodium
JP3737801B2 (ja) * 2000-10-05 2006-01-25 テバ ジョジセルジャール レースベニュタールシャシャーグ プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウム、並びにそれを含む組成物
JP3236282B1 (ja) * 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
ATE356554T1 (de) * 2001-02-09 2007-04-15 Unilever Nv Nahrungsmittel enthaltend sojaprotein und statin
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
EP1452602A1 (en) * 2003-02-25 2004-09-01 Antibiotic Co., Method for production of pravastatin by fermentation
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
WO2005051372A2 (en) 2003-11-24 2005-06-09 Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság Method of purifying pravastatin
MX2010008654A (es) * 2008-02-06 2010-10-06 Biocon Ltd Medios de fermentacion y procedimientos para los mismos.
RU2522806C1 (ru) * 2012-11-27 2014-07-20 Федеральное государственное бюджетное учреждение науки Центр "Биоинженерия" Российской академии наук Усовершенствованный способ очистки правастатина
JP6441599B2 (ja) * 2014-07-14 2018-12-19 合同酒精株式会社 プラバスタチンの製造法
CN114031496A (zh) * 2021-11-30 2022-02-11 广东蓝宝制药有限公司 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5810572A (ja) 1981-07-07 1983-01-21 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体およびその製造法
JPS5889191A (ja) 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS59175450A (ja) * 1983-03-24 1984-10-04 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体
US5179013A (en) * 1987-02-02 1993-01-12 Sankyo Company, Limited Cytochrome P-450 enzymes
JPH06253853A (ja) * 1993-03-09 1994-09-13 Asahi Chem Ind Co Ltd マクロライド抗生物質生合成遺伝子を含有するｄｎａ
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
JPH08149986A (ja) * 1994-09-28 1996-06-11 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
JPH0889277A (ja) * 1994-09-28 1996-04-09 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
IN191580B (pt) * 1999-12-17 2003-12-06 Ranbaxy Lab Ltd

Also Published As

Publication number Publication date
EP1198448A2 (en) 2002-04-24
AP2002002404A0 (en) 2002-03-31
PL353493A1 (en) 2003-11-17
ZA200200273B (en) 2003-06-25
SK285726B6 (sk) 2007-07-06
IS6227A (is) 2002-01-11
CN1399686A (zh) 2003-02-26
AU6349200A (en) 2001-01-30
CA2373544A1 (en) 2001-01-18
WO2001003647A2 (en) 2001-01-18
EP1190087A1 (en) 2002-03-27
US6905851B1 (en) 2005-06-14
EP1198448A4 (en) 2003-05-28
AU773633B2 (en) 2004-05-27
ES2200891T3 (es) 2004-03-16
BG106302A (en) 2002-10-31
HRP20020028B1 (en) 2005-04-30
EP1327689A1 (en) 2003-07-16
NZ516563A (en) 2002-11-26
AU5835500A (en) 2001-01-30
IL147583A0 (en) 2002-08-14
US20050124051A1 (en) 2005-06-09
KR20020060150A (ko) 2002-07-16
NO20020119L (no) 2002-02-21
HUP9902352A1 (hu) 2000-09-28
KR100479837B1 (ko) 2005-03-31
UA67854C2 (en) 2004-07-15
KR20020048927A (ko) 2002-06-24
DE60003424T2 (de) 2004-05-19
IL147588A0 (en) 2002-08-14
JP4531315B2 (ja) 2010-08-25
WO2001004340A1 (en) 2001-01-18
HU9902352D0 (en) 1999-09-28
ATE243262T1 (de) 2003-07-15
BR0013156A (pt) 2002-04-02
JP2003528576A (ja) 2003-09-30
IS2138B (is) 2006-08-15
AP1405A (en) 2005-04-28
EP1190087B1 (en) 2003-06-18
WO2001003647A3 (en) 2001-06-28
CZ2002119A3 (cs) 2003-02-12
RU2004114667A (ru) 2005-10-27
CZ297009B6 (cs) 2006-08-16
RU2235780C2 (ru) 2004-09-10
NO20020119D0 (no) 2002-01-10
HRP20020028A2 (en) 2003-06-30
YU2002A (sh) 2004-12-31
JP2003504071A (ja) 2003-02-04
CA2379015A1 (en) 2001-01-18
CZ2002127A3 (cs) 2003-06-18
SK612002A3 (en) 2002-12-03
OA12150A (en) 2006-05-05
SK492002A3 (sk) 2005-03-04
DE60003424D1 (de) 2003-07-24
CN1590555A (zh) 2005-03-09
PL364872A1 (en) 2004-12-27
BG65109B1 (bg) 2007-02-28
DK1190087T3 (da) 2003-10-13
TR200200726T2 (tr) 2002-06-21
MXPA02000356A (es) 2005-06-06

Similar Documents

Publication Publication Date Title
PT1190087E (pt) Hidroxilacao de compactina em pravastatina por micromonospora
FR2815389B1 (fr) Boite de vitesses
DE60133297D1 (de) Biopsiesystem
DE50113985D1 (de) Halterung
DE59907257D1 (de) Schmutzablösevermögende Oligoester
GB0229177D0 (en) Drive system
HUP0301989A3 (en) Travel way support
GB0016939D0 (en) Sound absorbing panel
FR2807128B1 (fr) Boite de vitesses
FR2805177B1 (fr) Structure de support pour batteur
FR2814786B1 (fr) Support de train de roulement
ATA16142000A (de) Plattenaufteilsäge
FR2800816B1 (fr) Boite de vitesses
DE60041783D1 (de) Bremseinheit
DOS2000000024S (es) Diseño de botella
FR2792758B3 (fr) Mecanisme de lecteur de cd-rom
AU2002257126A8 (en) Speed sensor flange assemblies
DE60111477D1 (de) Arbeitsplattenbearbeitungssystem
ID26323A (id) Katalis untuk transesterifikasi
DE60119527D1 (de) Abgeschirmte flugzeugbremseinheit
GB0126297D0 (en) Sound absorbing panel
FR2797486B1 (fr) Boite de vitesses
ATA186599A (de) Aufschnittschneidemaschine
GB2366608B (en) Pedal support arrangements
DE69927393D1 (de) Stanzstempeleinheit