CN1399686A - 利用小单孢菌将密实菌素羟基化为普伐他汀 - Google Patents

利用小单孢菌将密实菌素羟基化为普伐他汀 Download PDF

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Publication number
CN1399686A
CN1399686A CN00811127A CN00811127A CN1399686A CN 1399686 A CN1399686 A CN 1399686A CN 00811127 A CN00811127 A CN 00811127A CN 00811127 A CN00811127 A CN 00811127A CN 1399686 A CN1399686 A CN 1399686A
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CN
China
Prior art keywords
compound
micromonospora
pravastatin
formula
idr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00811127A
Other languages
English (en)
Chinese (zh)
Inventor
A·杰克尔
G·阿姆布鲁斯
E·伊尔克伊
I·霍瓦斯
A·孔亚
I·M·斯扎博
Z·纳吉
G·霍瓦斯
J·默泽斯
I·巴塔
G·索莫格伊
J·萨拉特
S·伯罗斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ivax LLC
Original Assignee
Ivax LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax LLC filed Critical Ivax LLC
Publication of CN1399686A publication Critical patent/CN1399686A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29—Micromonospora

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN00811127A 1999-07-12 2000-06-29 利用小单孢菌将密实菌素羟基化为普伐他汀 Pending CN1399686A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9902352A HUP9902352A1 (hu) 1999-07-12 1999-07-12 Eljárás pravasztatin mikrobiológiai előállítására
HUP9902352 1999-07-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2004100493556A Division CN1590555A (zh) 1999-07-12 2000-06-29 利用小单孢菌将密实菌素羟基化为普伐他汀

Publications (1)

Publication Number Publication Date
CN1399686A true CN1399686A (zh) 2003-02-26

Family

ID=89998701

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2004100493556A Pending CN1590555A (zh) 1999-07-12 2000-06-29 利用小单孢菌将密实菌素羟基化为普伐他汀
CN00811127A Pending CN1399686A (zh) 1999-07-12 2000-06-29 利用小单孢菌将密实菌素羟基化为普伐他汀

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNA2004100493556A Pending CN1590555A (zh) 1999-07-12 2000-06-29 利用小单孢菌将密实菌素羟基化为普伐他汀

Country Status (32)

Country Link
US (2) US6905851B1 (enExample)
EP (3) EP1190087B1 (enExample)
JP (2) JP4531315B2 (enExample)
KR (2) KR100479837B1 (enExample)
CN (2) CN1590555A (enExample)
AP (1) AP1405A (enExample)
AT (1) ATE243262T1 (enExample)
AU (2) AU773633B2 (enExample)
BG (1) BG65109B1 (enExample)
BR (1) BR0013156A (enExample)
CA (2) CA2379015A1 (enExample)
CZ (2) CZ297009B6 (enExample)
DE (1) DE60003424T2 (enExample)
DK (1) DK1190087T3 (enExample)
ES (1) ES2200891T3 (enExample)
HR (1) HRP20020028B1 (enExample)
HU (1) HUP9902352A1 (enExample)
IL (2) IL147583A0 (enExample)
IS (1) IS2138B (enExample)
MX (1) MXPA02000356A (enExample)
NO (1) NO20020119L (enExample)
NZ (1) NZ516563A (enExample)
OA (1) OA12150A (enExample)
PL (2) PL353493A1 (enExample)
PT (1) PT1190087E (enExample)
RU (2) RU2235780C2 (enExample)
SK (2) SK285726B6 (enExample)
TR (1) TR200200726T2 (enExample)
UA (1) UA67854C2 (enExample)
WO (2) WO2001004340A1 (enExample)
YU (1) YU2002A (enExample)
ZA (1) ZA200200273B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005005618A1 (en) * 2003-07-09 2005-01-20 Shanghai Techwell Biopharmaceutical Co., Ltd. The microorganism and the process for preparation of pravastatin

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9800046A (sl) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
AU1804601A (en) 1999-11-30 2001-06-12 Biogal Gyogyszergyar Rt Process for recovering statin compounds from a fermentation broth
KR20020062340A (ko) 1999-12-14 2002-07-25 비오갈 기오기스제르갸르 알티. 신규 형태의 프라바스타틴 나트륨
HRP20030347A2 (en) * 2000-10-05 2005-04-30 Teva Gy�gyszergy�r R�szv�nyt�rsas�g Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP3236282B1 (ja) * 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
CN100456962C (zh) * 2001-02-09 2009-02-04 荷兰联合利华有限公司 含大豆蛋白和抑制素的食物制品
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
EP1452602A1 (en) * 2003-02-25 2004-09-01 Antibiotic Co., Method for production of pravastatin by fermentation
TWI319707B (en) 2003-11-24 2010-01-21 Method of purifying pravastatin
US8927256B2 (en) * 2008-02-06 2015-01-06 Biocon Limited Fermentation medias and processes thereof
RU2522806C1 (ru) * 2012-11-27 2014-07-20 Федеральное государственное бюджетное учреждение науки Центр "Биоинженерия" Российской академии наук Усовершенствованный способ очистки правастатина
JP6441599B2 (ja) * 2014-07-14 2018-12-19 合同酒精株式会社 プラバスタチンの製造法
CN114031496B (zh) * 2021-11-30 2024-09-27 广东蓝宝制药有限公司 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法
CN116694497B (zh) * 2022-12-25 2024-10-18 塔里木大学 一株转化甘油和甘氨酸的放线菌

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5810572A (ja) 1981-07-07 1983-01-21 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体およびその製造法
JPS5889191A (ja) * 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS59175450A (ja) * 1983-03-24 1984-10-04 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体
US5179013A (en) * 1987-02-02 1993-01-12 Sankyo Company, Limited Cytochrome P-450 enzymes
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
IL108432A (en) * 1993-01-29 1997-09-30 Sankyo Co DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JPH06253853A (ja) * 1993-03-09 1994-09-13 Asahi Chem Ind Co Ltd マクロライド抗生物質生合成遺伝子を含有するｄｎａ
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
JPH0889277A (ja) * 1994-09-28 1996-04-09 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
JPH08149986A (ja) * 1994-09-28 1996-06-11 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
IN191580B (enExample) * 1999-12-17 2003-12-06 Ranbaxy Lab Ltd

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005005618A1 (en) * 2003-07-09 2005-01-20 Shanghai Techwell Biopharmaceutical Co., Ltd. The microorganism and the process for preparation of pravastatin

Also Published As

Publication number Publication date
WO2001003647A2 (en) 2001-01-18
TR200200726T2 (tr) 2002-06-21
CZ2002119A3 (cs) 2003-02-12
HRP20020028B1 (en) 2005-04-30
PL364872A1 (en) 2004-12-27
BR0013156A (pt) 2002-04-02
BG65109B1 (bg) 2007-02-28
NO20020119D0 (no) 2002-01-10
EP1198448A4 (en) 2003-05-28
AU773633B2 (en) 2004-05-27
KR100479837B1 (ko) 2005-03-31
CA2373544A1 (en) 2001-01-18
MXPA02000356A (es) 2005-06-06
PT1190087E (pt) 2003-10-31
KR20020048927A (ko) 2002-06-24
CN1590555A (zh) 2005-03-09
DE60003424D1 (de) 2003-07-24
JP2003504071A (ja) 2003-02-04
JP4531315B2 (ja) 2010-08-25
SK612002A3 (en) 2002-12-03
HU9902352D0 (en) 1999-09-28
AP2002002404A0 (en) 2002-03-31
WO2001004340A1 (en) 2001-01-18
KR20020060150A (ko) 2002-07-16
EP1190087A1 (en) 2002-03-27
AU6349200A (en) 2001-01-30
IS2138B (is) 2006-08-15
NO20020119L (no) 2002-02-21
YU2002A (sh) 2004-12-31
JP2003528576A (ja) 2003-09-30
WO2001003647A3 (en) 2001-06-28
HUP9902352A1 (hu) 2000-09-28
AP1405A (en) 2005-04-28
RU2235780C2 (ru) 2004-09-10
CZ297009B6 (cs) 2006-08-16
UA67854C2 (en) 2004-07-15
ATE243262T1 (de) 2003-07-15
DK1190087T3 (da) 2003-10-13
NZ516563A (en) 2002-11-26
IL147588A0 (en) 2002-08-14
EP1190087B1 (en) 2003-06-18
CZ2002127A3 (cs) 2003-06-18
ZA200200273B (en) 2003-06-25
DE60003424T2 (de) 2004-05-19
OA12150A (en) 2006-05-05
SK492002A3 (sk) 2005-03-04
US20050124051A1 (en) 2005-06-09
CA2379015A1 (en) 2001-01-18
SK285726B6 (sk) 2007-07-06
ES2200891T3 (es) 2004-03-16
US6905851B1 (en) 2005-06-14
EP1198448A2 (en) 2002-04-24
HRP20020028A2 (en) 2003-06-30
IL147583A0 (en) 2002-08-14
BG106302A (en) 2002-10-31
PL353493A1 (en) 2003-11-17
RU2004114667A (ru) 2005-10-27
AU5835500A (en) 2001-01-30
IS6227A (is) 2002-01-11
EP1327689A1 (en) 2003-07-16

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CI01 Publication of corrected invention patent application

Correction item: Inventor

Correct: I * M * Si Zaqi|Z * Naji|C * Somoguei|J. Sarat

False: Missing 6,7,11,12 inventor

Number: 9

Volume: 19

CI02 Correction of invention patent application

Correction item: Inventor

Correct: I * M * Si Zaqi|Z * Naji|C * Somoguei|J. Sarat

False: Missing 6,7,11,12 inventor

Number: 9

Page: The title page

Volume: 19

COR Change of bibliographic data

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