CZ297009B6 - Zpusob hydroxylace kompaktinu na pravastatin za pouzití mikromonospor - Google Patents
Zpusob hydroxylace kompaktinu na pravastatin za pouzití mikromonospor Download PDFInfo
- Publication number
- CZ297009B6 CZ297009B6 CZ20020119A CZ2002119A CZ297009B6 CZ 297009 B6 CZ297009 B6 CZ 297009B6 CZ 20020119 A CZ20020119 A CZ 20020119A CZ 2002119 A CZ2002119 A CZ 2002119A CZ 297009 B6 CZ297009 B6 CZ 297009B6
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- Czechia
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- strain
- compound
- micromonospora
- formula
- pravastatin
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Classifications
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/29—Micromonospora
Landscapes
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9902352A HUP9902352A1 (hu) | 1999-07-12 | 1999-07-12 | Eljárás pravasztatin mikrobiológiai előállítására |
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| CZ2002119A3 CZ2002119A3 (cs) | 2003-02-12 |
| CZ297009B6 true CZ297009B6 (cs) | 2006-08-16 |
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| CZ20020119A CZ297009B6 (cs) | 1999-07-12 | 2000-06-29 | Zpusob hydroxylace kompaktinu na pravastatin za pouzití mikromonospor |
| CZ2002127A CZ2002127A3 (cs) | 1999-07-12 | 2000-07-11 | Mikrobiální způsob výroby pravastatinu |
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| CZ2002127A CZ2002127A3 (cs) | 1999-07-12 | 2000-07-11 | Mikrobiální způsob výroby pravastatinu |
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Families Citing this family (19)
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|---|---|---|---|---|
| SI9800046A (sl) | 1998-02-18 | 1999-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti |
| HUP9902352A1 (hu) * | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
| ES2273737T3 (es) | 1999-11-30 | 2007-05-16 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Procedimiento para la recuperacion de compuestos de estatina de un caldo de fermentacion. |
| IL150187A0 (en) | 1999-12-14 | 2002-12-01 | Biogal Pharmaceutical Co Ltd | Novel forms of pravastatin sodium |
| HRP20030347A2 (en) * | 2000-10-05 | 2005-04-30 | Teva Gy�gyszergy�r R�szv�nyt�rsas�g | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same |
| JP3236282B1 (ja) * | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
| WO2002064809A2 (en) * | 2001-02-09 | 2002-08-22 | Unilever N.V. | Process for the preparation of one or more statins by fermentation |
| JP2003026634A (ja) * | 2001-07-17 | 2003-01-29 | Mercian Corp | プラバスタチンナトリウム塩の製造方法 |
| US6716615B2 (en) | 2002-02-27 | 2004-04-06 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase |
| JP3422791B2 (ja) | 2002-08-06 | 2003-06-30 | 三共株式会社 | プラバスタチンの単離・精製方法 |
| EP1452602A1 (en) * | 2003-02-25 | 2004-09-01 | Antibiotic Co., | Method for production of pravastatin by fermentation |
| CN1244688C (zh) * | 2003-07-09 | 2006-03-08 | 上海天伟生物制药有限公司 | 生产普伐他汀钠的微生物和方法 |
| EP2033636A1 (en) | 2003-11-24 | 2009-03-11 | TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method of purifying pravastatin |
| RU2595380C2 (ru) * | 2008-02-06 | 2016-08-27 | Байокон Лимитид | Ферментационная среда для получения правастатина и способ получения правастатина |
| RU2522806C1 (ru) * | 2012-11-27 | 2014-07-20 | Федеральное государственное бюджетное учреждение науки Центр "Биоинженерия" Российской академии наук | Усовершенствованный способ очистки правастатина |
| JP6441599B2 (ja) * | 2014-07-14 | 2018-12-19 | 合同酒精株式会社 | プラバスタチンの製造法 |
| CN114031496B (zh) * | 2021-11-30 | 2024-09-27 | 广东蓝宝制药有限公司 | 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法 |
| CN114133331A (zh) * | 2021-12-10 | 2022-03-04 | 广东蓝宝制药有限公司 | 一种回收获得高纯度普伐他汀酯的方法 |
| CN119330849A (zh) * | 2022-12-25 | 2025-01-21 | 塔里木大学 | 一种化合物abagg及其用途 |
Citations (2)
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|---|---|---|---|---|
| US5179013A (en) * | 1987-02-02 | 1993-01-12 | Sankyo Company, Limited | Cytochrome P-450 enzymes |
| WO1996040863A1 (en) * | 1995-06-07 | 1996-12-19 | Massachusetts Institute Of Technology | Conversion of compactin to pravastatin by actinomadura |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DK149080C (da) | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| JPS5810572A (ja) | 1981-07-07 | 1983-01-21 | Sankyo Co Ltd | Ｍｌ−２３６ｂ誘導体およびその製造法 |
| JPS5889191A (ja) * | 1981-11-20 | 1983-05-27 | Sankyo Co Ltd | ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法 |
| JPS59175450A (ja) * | 1983-03-24 | 1984-10-04 | Sankyo Co Ltd | Ｍｌ−２３６ｂ誘導体 |
| NZ250609A (en) * | 1992-12-28 | 1995-07-26 | Sankyo Co | Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments |
| IL108432A (en) * | 1993-01-29 | 1997-09-30 | Sankyo Co | DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| JPH06253853A (ja) * | 1993-03-09 | 1994-09-13 | Asahi Chem Ind Co Ltd | マクロライド抗生物質生合成遺伝子を含有するｄｎａ |
| US6043064A (en) * | 1993-10-22 | 2000-03-28 | Bristol-Myers Squibb Company | Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof |
| JPH0889277A (ja) * | 1994-09-28 | 1996-04-09 | Taisho Pharmaceut Co Ltd | １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法 |
| JPH08149986A (ja) * | 1994-09-28 | 1996-06-11 | Taisho Pharmaceut Co Ltd | １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法 |
| SI20072A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
| US6682913B1 (en) * | 1999-02-03 | 2004-01-27 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
| HUP9902352A1 (hu) * | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
| IN191580B (enExample) * | 1999-12-17 | 2003-12-06 | Ranbaxy Lab Ltd |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5179013A (en) * | 1987-02-02 | 1993-01-12 | Sankyo Company, Limited | Cytochrome P-450 enzymes |
| WO1996040863A1 (en) * | 1995-06-07 | 1996-12-19 | Massachusetts Institute Of Technology | Conversion of compactin to pravastatin by actinomadura |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20080629 |