KR100353303B1 - 항균활성을갖는고리형헥사펩티드 - Google Patents

항균활성을갖는고리형헥사펩티드 Download PDF

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Publication number
KR100353303B1
KR100353303B1 KR1019970702213A KR19970702213A KR100353303B1 KR 100353303 B1 KR100353303 B1 KR 100353303B1 KR 1019970702213 A KR1019970702213 A KR 1019970702213A KR 19970702213 A KR19970702213 A KR 19970702213A KR 100353303 B1 KR100353303 B1 KR 100353303B1
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KR
South Korea
Prior art keywords
alkoxy
phenyl
alkyl
substituted
alkanoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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KR1019970702213A
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English (en)
Korean (ko)
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KR970707150A (ko
Inventor
히데노리 오키
마사키 도미시마
아키라 야마다
히사시 다카스기
Original Assignee
후지사와 야꾸힝 고교 가부시키가이샤
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26305774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100353303(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB9420425A external-priority patent/GB9420425D0/en
Priority claimed from GBGB9508745.8A external-priority patent/GB9508745D0/en
Application filed by 후지사와 야꾸힝 고교 가부시키가이샤 filed Critical 후지사와 야꾸힝 고교 가부시키가이샤
Publication of KR970707150A publication Critical patent/KR970707150A/ko
Application granted granted Critical
Publication of KR100353303B1 publication Critical patent/KR100353303B1/ko
Assigned to 아스텔라스세이야쿠 가부시키가이샤 reassignment 아스텔라스세이야쿠 가부시키가이샤 권리의 전부이전등록 Assignors: 후지사와 야꾸힝 고교 가부시키가이샤
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1019970702213A 1994-10-07 1995-09-29 항균활성을갖는고리형헥사펩티드 Expired - Lifetime KR100353303B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9420425A GB9420425D0 (en) 1994-10-07 1994-10-07 New compound
GBGB9508745.8A GB9508745D0 (en) 1995-04-28 1995-04-28 New compound
GB9508745.8 1995-04-28
GB9420425.2 1995-04-28

Publications (2)

Publication Number Publication Date
KR970707150A KR970707150A (ko) 1997-12-01
KR100353303B1 true KR100353303B1 (ko) 2003-01-15

Family

ID=26305774

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970702213A Expired - Lifetime KR100353303B1 (ko) 1994-10-07 1995-09-29 항균활성을갖는고리형헥사펩티드

Country Status (26)

Country Link
US (2) US6107458A (https=)
EP (1) EP0788511B1 (https=)
JP (2) JP2897427B2 (https=)
KR (1) KR100353303B1 (https=)
CN (1) CN1203089C (https=)
AR (1) AR041770A1 (https=)
AT (1) ATE229541T1 (https=)
AU (1) AU696949B2 (https=)
BR (2) BR9504791B1 (https=)
CA (1) CA2202058C (https=)
DE (2) DE69529172T2 (https=)
DK (1) DK0788511T3 (https=)
ES (1) ES2187575T3 (https=)
FI (1) FI119988B (https=)
FR (1) FR08C0028I2 (https=)
HU (1) HU228151B1 (https=)
IL (1) IL115484A (https=)
LU (1) LU91452I2 (https=)
MX (1) MX9702531A (https=)
NL (1) NL300352I2 (https=)
NO (2) NO328483B1 (https=)
OA (1) OA10475A (https=)
PT (1) PT788511E (https=)
RU (1) RU2165423C2 (https=)
TR (1) TR199501229A2 (https=)
WO (1) WO1996011210A1 (https=)

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US5696084A (en) * 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
AUPO371596A0 (en) * 1996-11-19 1996-12-12 Fujisawa Pharmaceutical Co., Ltd. New compound
AUPO381496A0 (en) * 1996-11-25 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. New compound
EP0994101A4 (en) * 1997-06-18 2002-05-02 Fujisawa Pharmaceutical Co NEW PREPARATION PROCESS
JP3561917B2 (ja) * 1998-02-09 2004-09-08 藤沢薬品工業株式会社 新規化合物
AU756792B2 (en) * 1998-02-09 2003-01-23 Fujisawa Pharmaceutical Co., Ltd. New compound
US7084279B1 (en) * 1999-02-11 2006-08-01 Emisphere Technologies Inc. Oxadiazole compounds and compositions for delivering active agents
ES2251976T3 (es) * 1999-02-11 2006-05-16 Emisphere Technologies, Inc. Compuestos y composiciones de oxadiazol para aportar agentes activos.
AUPP999799A0 (en) * 1999-04-27 1999-05-20 Fujisawa Pharmaceutical Co., Ltd. New compound
AUPQ066399A0 (en) 1999-05-31 1999-06-24 Fujisawa Pharmaceutical Co., Ltd. Antifungal combination use
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
DE60040989D1 (de) * 1999-07-27 2009-01-15 Aventis Pharma Gmbh Cyclohexapeptide, deren herstellung und verwendung in pharmazeutische zusammensetzungen
AUPQ462399A0 (en) * 1999-12-13 2000-01-13 Fujisawa Pharmaceutical Co., Ltd. New use
TWI250992B (en) 2000-02-21 2006-03-11 Astellas Pharma Inc Polypeptide compounds for the prophylactic and/or therapeutic treatment of infectious diseases caused by pathogenic microorganisms
ES2191516B1 (es) * 2000-07-28 2005-01-01 Consejo Superior De Investigaciones Cientificas Antibioticos antifungicos de naturaleza peptidica inhibidores de la germinacion y el crecimiento de hongos fitopatogenos.
AUPQ938700A0 (en) * 2000-08-14 2000-09-07 Fujisawa Pharmaceutical Co., Ltd. Antifungal combination use
WO2002060446A1 (fr) 2001-01-29 2002-08-08 Shionogi & Co., Ltd. Preparation medicamenteuse contenant du 5-methyle-1-phenyle-2-(1h)-pyridone en tant que principe actif
JP2005053782A (ja) * 2001-08-31 2005-03-03 Fujisawa Pharmaceut Co Ltd 環状リポペプチド化合物の新規結晶
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
JP4784093B2 (ja) * 2002-08-08 2011-09-28 アステラス製薬株式会社 イソオキサゾリル安息香酸の製造法
AU2003903205A0 (en) * 2003-06-23 2003-07-10 Fujisawa Pharmaceutical Co., Ltd. New compound
DE602004010915T2 (de) 2003-07-22 2008-12-11 Theravance, Inc., South San Francisco Verwendung eines antimykotischen echinocandin-mittels in kombination mit einem antibakteriellen glycopeptid-mittel
CN1845751A (zh) * 2003-09-05 2006-10-11 默克公司 固定相和利用该固定相的纯化方法
ATE547404T1 (de) * 2003-09-22 2012-03-15 Msd Kk Piperidinderivate
US7476673B2 (en) * 2003-12-30 2009-01-13 Allergan, Inc. Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors
WO2005113523A1 (en) * 2004-05-20 2005-12-01 Foldrx Pharmaceuticals, Inc. 2-((hetero) aryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
CN101084211A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为治疗剂的用途
MX2007003318A (es) 2004-09-20 2007-05-18 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
BRPI0515482A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seus usos como agentes terapêuticos
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
MX2007003332A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
BRPI0515500A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados piridazina para inibição de estearoil-coa-desaturase
AU2005286647A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
EP2402323A3 (en) * 2004-10-13 2012-05-30 PTC Therapeutics, Inc. Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases
CA2618646A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
JP5222561B2 (ja) * 2005-10-07 2013-06-26 キッセイ薬品工業株式会社 含窒素芳香族複素環化合物およびそれを含有する医薬組成物
CN101516387B (zh) * 2006-07-26 2014-06-04 桑多斯股份公司 卡泊芬净制剂
US8853392B2 (en) 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
AU2008286879B2 (en) 2007-08-13 2013-08-22 Monsanto Technology Llc Compositions and methods for controlling nematodes
CN101861330A (zh) * 2007-10-29 2010-10-13 安斯泰来制药有限公司 多肽化合物
US8034806B2 (en) 2007-11-02 2011-10-11 Vanderbilt University Bicyclic mGluR5 positive allosteric modulators and methods of making and using same
CN102076670B (zh) * 2008-06-24 2013-05-22 Irm责任有限公司 调节g蛋白偶联受体的化合物和方法
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
BR112013023531A2 (pt) 2011-04-04 2016-12-06 Xellia Pharmaceuticals Aps processo de um único vaso para a fabricação de micafungina ou de um sal desta
BR112013026420A2 (pt) 2011-04-20 2020-11-03 Xellia Pharmaceuticals Aps método de produção de um sal de micafungina farmaceuticamente aceitável
CN102775476B (zh) * 2011-05-12 2015-01-07 上海天伟生物制药有限公司 一种米卡芬净钠盐的制备方法
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CN102627689B (zh) * 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
CN102659930B (zh) 2012-03-30 2014-04-23 上海天伟生物制药有限公司 一种高纯度环肽类物质的晶体及其制备方法和用途
JP7109189B2 (ja) * 2014-05-29 2022-07-29 シャンハイ テックウェル バイオファーマシューティカル カンパニー リミテッド シクロペプチド系化合物の組成物およびその製造方法と使用
JP6491325B2 (ja) * 2014-05-29 2019-03-27 シャンハイ テックウェル バイオファーマシューティカル カンパニー リミテッドＳｈａｎｇｈａｉ Ｔｅｃｈｗｅｌｌ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．，Ｌｔｄ シクロペプチド系化合物の溶媒和物およびその製造方法と使用
WO2016056023A2 (en) * 2014-10-07 2016-04-14 Alaparthi Lakshmi Prasad Intermediates and processes to prepare micafungin
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WO2020013116A1 (ja) * 2018-07-10 2020-01-16 京都薬品工業株式会社 Ｐｔｐ－１ｂ阻害剤およびその用途
CN110734408A (zh) * 2019-10-22 2020-01-31 重庆康乐制药有限公司 一种米卡芬净类衍生物侧链中间体的制备方法
CN115785226B (zh) * 2021-09-09 2026-02-24 上海天伟生物制药有限公司 一种棘白菌素药物杂质及其制备、纯化方法和应用

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0462531A2 (en) * 1990-06-18 1991-12-27 Fujisawa Pharmaceutical Co., Ltd. Cyclic polypeptide with antibiotic activity, process for its preparation and pure culture of a Coelomycetes strain

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SU1574603A1 (ru) * 1988-08-11 1990-06-30 Ивановский Химико-Технологический Институт Способ получени мезо-тетраарилоктаметилпорфиринов
NZ247149A (en) * 1992-03-19 1996-10-28 Lilly Co Eli Cyclic peptide antifungal agents and compositions thereof

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0462531A2 (en) * 1990-06-18 1991-12-27 Fujisawa Pharmaceutical Co., Ltd. Cyclic polypeptide with antibiotic activity, process for its preparation and pure culture of a Coelomycetes strain

Also Published As

Publication number Publication date
FR08C0028I2 (https=) 2009-11-20
FR08C0028I1 (https=) 2008-08-15
AU696949B2 (en) 1998-09-24
CA2202058C (en) 2007-11-06
PT788511E (pt) 2003-04-30
NO971544L (no) 1997-06-04
RU2165423C2 (ru) 2001-04-20
BR9504791A (pt) 1996-10-22
FI119988B (fi) 2009-05-29
BRPI9504791B8 (pt) 2019-12-31
ATE229541T1 (de) 2002-12-15
US6107458A (en) 2000-08-22
DE69529172T2 (de) 2003-04-17
HU228151B1 (en) 2012-12-28
EP0788511A1 (en) 1997-08-13
KR970707150A (ko) 1997-12-01
AR041770A1 (es) 2005-06-01
JPH10324695A (ja) 1998-12-08
BR9504791B1 (pt) 2010-10-05
DE122008000025I2 (de) 2011-02-17
NO328483B1 (no) 2010-03-01
HUT77736A (hu) 1998-07-28
MX9702531A (es) 1997-06-28
OA10475A (en) 2002-04-08
WO1996011210A1 (en) 1996-04-18
AU3578095A (en) 1996-05-02
CN1203089C (zh) 2005-05-25
IL115484A (en) 2000-07-16
JP2897427B2 (ja) 1999-05-31
LU91452I2 (fr) 2008-08-04
JP3518665B2 (ja) 2004-04-12
NL300352I2 (nl) 2008-11-03
ES2187575T3 (es) 2003-06-16
CA2202058A1 (en) 1996-04-18
NO2010016I2 (no) 2011-10-17
FI971397L (fi) 1997-05-27
US6265536B1 (en) 2001-07-24
CN1168675A (zh) 1997-12-24
IL115484A0 (en) 1996-01-19
NO971544D0 (no) 1997-04-04
TR199501229A2 (tr) 1996-07-21
DK0788511T3 (da) 2003-03-31
DE122008000025I1 (de) 2008-08-21
NL300352I1 (nl) 2008-08-01
NO2010016I1 (no) 2010-08-16
DE69529172D1 (de) 2003-01-23
HK1004136A1 (en) 1998-11-20
EP0788511B1 (en) 2002-12-11
FI971397A0 (fi) 1997-04-04
JPH10507174A (ja) 1998-07-14

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