|
US4034075A
(en)
|
1972-07-03 |
1977-07-05 |
Allen & Hanburys Limited |
Quinaldic acid derivatives
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
PT98990A
(pt)
|
1990-09-19 |
1992-08-31 |
American Home Prod |
Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
|
|
US5120842A
(en)
|
1991-04-01 |
1992-06-09 |
American Home Products Corporation |
Silyl ethers of rapamycin
|
|
US5100883A
(en)
|
1991-04-08 |
1992-03-31 |
American Home Products Corporation |
Fluorinated esters of rapamycin
|
|
US5118678A
(en)
|
1991-04-17 |
1992-06-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5118677A
(en)
|
1991-05-20 |
1992-06-02 |
American Home Products Corporation |
Amide esters of rapamycin
|
|
US5151413A
(en)
|
1991-11-06 |
1992-09-29 |
American Home Products Corporation |
Rapamycin acetals as immunosuppressant and antifungal agents
|
|
GB9125660D0
(en)
|
1991-12-03 |
1992-01-29 |
Smithkline Beecham Plc |
Novel compound
|
|
ZA935112B
(en)
|
1992-07-17 |
1994-02-08 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
|
ZA935111B
(en)
|
1992-07-17 |
1994-02-04 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
|
US5256790A
(en)
|
1992-08-13 |
1993-10-26 |
American Home Products Corporation |
27-hydroxyrapamycin and derivatives thereof
|
|
GB9221220D0
(en)
|
1992-10-09 |
1992-11-25 |
Sandoz Ag |
Organic componds
|
|
US5258389A
(en)
|
1992-11-09 |
1993-11-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
|
|
DK0669929T3
(da)
|
1992-11-13 |
2007-01-29 |
Immunex Corp |
Elk-ligand, et cytokin
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
US5516658A
(en)
|
1993-08-20 |
1996-05-14 |
Immunex Corporation |
DNA encoding cytokines that bind the cell surface receptor hek
|
|
WO1995014023A1
(en)
|
1993-11-19 |
1995-05-26 |
Abbott Laboratories |
Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
|
|
SG64372A1
(en)
|
1993-12-17 |
1999-04-27 |
Novartis Ag |
Rapamycin derivatives
|
|
WO1995028484A1
(en)
|
1994-04-15 |
1995-10-26 |
Amgen Inc. |
Hek5, hek7, hek8, hek11, new eph-like receptor protein tyrosine kinases
|
|
US6303769B1
(en)
|
1994-07-08 |
2001-10-16 |
Immunex Corporation |
Lerk-5 dna
|
|
US5919905A
(en)
|
1994-10-05 |
1999-07-06 |
Immunex Corporation |
Cytokine designated LERK-6
|
|
US6057124A
(en)
|
1995-01-27 |
2000-05-02 |
Amgen Inc. |
Nucleic acids encoding ligands for HEK4 receptors
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
PT821671E
(pt)
|
1995-04-20 |
2001-04-30 |
Pfizer |
Derivados do acido arilsulfonil hidroxamico como inibidores de mmp e tnf
|
|
WO1996041807A1
(en)
|
1995-06-09 |
1996-12-27 |
Novartis Ag |
Rapamycin derivatives
|
|
DE69624081T2
(de)
|
1995-12-20 |
2003-06-12 |
Hoffmann La Roche |
Matrix-metalloprotease Inhibitoren
|
|
AU735648B2
(en)
|
1996-07-12 |
2001-07-12 |
Ariad Pharmaceuticals, Inc. |
Materials and method for treating or preventing pathogenic fungal infection
|
|
TR199900066T2
(xx)
|
1996-07-18 |
1999-04-21 |
Pfizer Inc. |
Matriks metalloproteazlar�n fosfinat bazl� inhibit�rleri
|
|
TR199900387T2
(xx)
|
1996-08-23 |
1999-04-21 |
Pfizer Inc. |
Arils�lfonilamino hidroksamik asit t�revleri.
|
|
CA2277100C
(en)
|
1997-01-06 |
2005-11-22 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
EA002594B1
(ru)
|
1997-02-03 |
2002-06-27 |
Пфайзер Продактс Инк. |
Производные арилсульфониламиногидроксамовой кислоты
|
|
AU5493598A
(en)
|
1997-02-07 |
1998-08-26 |
Pfizer Inc. |
N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
|
|
CN1247531A
(zh)
|
1997-02-11 |
2000-03-15 |
辉瑞大药厂 |
芳基磺酰基异羟肟酸衍生物
|
|
US6150395A
(en)
|
1997-05-30 |
2000-11-21 |
The Regents Of The University Of California |
Indole-3-carbinol (I3C) derivatives and methods
|
|
PT1003720E
(pt)
|
1997-08-08 |
2004-07-30 |
Pfizer Prod Inc |
Derivados de acido ariloxiarilsulfonilamino hidroxamico
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
PT1004578E
(pt)
|
1998-11-05 |
2004-06-30 |
Pfizer Prod Inc |
Derivados hidroxamida do acido 5-oxo-pirrolidino-2-carboxilico
|
|
GB9912961D0
(en)
|
1999-06-03 |
1999-08-04 |
Pfizer Ltd |
Metalloprotease inhibitors
|
|
US6521424B2
(en)
|
1999-06-07 |
2003-02-18 |
Immunex Corporation |
Recombinant expression of Tek antagonists
|
|
ATE324444T1
(de)
|
1999-06-07 |
2006-05-15 |
Immunex Corp |
Tek-antagonisten
|
|
AU783158B2
(en)
|
1999-08-24 |
2005-09-29 |
Ariad Pharmaceuticals, Inc. |
28-epirapalogs
|
|
US6727225B2
(en)
|
1999-12-20 |
2004-04-27 |
Immunex Corporation |
TWEAK receptor
|
|
ATE358718T1
(de)
|
2000-02-25 |
2007-04-15 |
Immunex Corp |
Integrin antagonisten
|
|
US6861424B2
(en)
|
2001-06-06 |
2005-03-01 |
Schering Aktiengesellschaft |
Platelet adenosine diphosphate receptor antagonists
|
|
WO2005005434A1
(en)
|
2003-07-08 |
2005-01-20 |
Novartis Ag |
Use of rapamycin and rapamycin derivatives for the treatment of bone loss
|
|
WO2005016252A2
(en)
|
2003-07-11 |
2005-02-24 |
Ariad Gene Therapeutics, Inc. |
Phosphorus-containing macrocycles
|
|
AR045134A1
(es)
|
2003-07-29 |
2005-10-19 |
Smithkline Beecham Plc |
Compuesto de 1h - imidazo [4,5-c] piridin-ilo, composicion farmaceutica que lo comprende, proceso para prepararla, su uso para preparar dicha composicion farmaceutica, combinacion farmaceutica, uso de la combinacion farmaceutica para la preparacion de un medicamento, procedimientos para preparar dic
|
|
WO2005016883A2
(en)
|
2003-08-14 |
2005-02-24 |
Icos Corporation |
Acrylamide derivatives as vla-1 integrin antagonists and uses thereof
|
|
ES2341351T3
(es)
|
2004-08-26 |
2010-06-18 |
Pfizer, Inc. |
Compuestos de aminoheteroarilo enantiomericamente puros como inhibidores de proteina cinasas.
|
|
US7666901B2
(en)
|
2004-10-13 |
2010-02-23 |
Wyeth |
Analogs of 17-hydroxywortmannin as PI3K inhibitors
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
CA2622870A1
(en)
|
2005-09-20 |
2007-03-29 |
Pfizer Products Inc. |
Dosage forms and methods of treatment using a tyrosine kinase inhibitor
|
|
US8247397B2
(en)
|
2007-09-12 |
2012-08-21 |
Genentech, Inc. |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
JP5348725B2
(ja)
|
2007-10-25 |
2013-11-20 |
ジェネンテック， インコーポレイテッド |
チエノピリミジン化合物の製造方法
|
|
US8278313B2
(en)
|
2008-03-11 |
2012-10-02 |
Abbott Laboratories |
Macrocyclic spiro pyrimidine derivatives
|
|
EP2445346A4
(en)
|
2009-06-24 |
2012-12-05 |
Genentech Inc |
OXOHETEROCYCLIC FUSIONED PYRIMIDINE COMPOUNDS AND COMPOSITIONS AND METHOD FOR THEIR USE
|
|
HUE027509T2
(en)
|
2011-04-06 |
2016-10-28 |
Taiho Pharmaceutical Co Ltd |
New imidazo-oxazine compounds or salts thereof
|
|
AR090037A1
(es)
|
2011-11-15 |
2014-10-15 |
Xention Ltd |
Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
|
|
HUE039713T2
(hu)
|
2012-06-08 |
2019-02-28 |
Sensorion |
H4 receptor inhibitorok tinnitus kezelésére
|
|
AU2014249233A1
(en)
|
2013-03-13 |
2015-09-24 |
The Regents Of The University Of Michigan |
Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof
|
|
UY35464A
(es)
|
2013-03-15 |
2014-10-31 |
Araxes Pharma Llc |
Inhibidores covalentes de kras g12c.
|
|
WO2014152588A1
(en)
|
2013-03-15 |
2014-09-25 |
Araxes Pharma Llc |
Covalent inhibitors of kras g12c
|
|
WO2014143659A1
(en)
|
2013-03-15 |
2014-09-18 |
Araxes Pharma Llc |
Irreversible covalent inhibitors of the gtpase k-ras g12c
|
|
US9947335B2
(en)
|
2013-04-05 |
2018-04-17 |
Dolby Laboratories Licensing Corporation |
Companding apparatus and method to reduce quantization noise using advanced spectral extension
|
|
SI3043784T1
(sl)
|
2013-09-09 |
2019-08-30 |
Peloton Therapeutics, Inc. |
Aril etri in njihova uporaba
|
|
JO3805B1
(ar)
|
2013-10-10 |
2021-01-31 |
Araxes Pharma Llc |
مثبطات كراس جي12سي
|
|
UA119971C2
(uk)
|
2013-10-10 |
2019-09-10 |
Араксіс Фарма Ллк |
Інгібітори g12c kras
|
|
CN106029648A
(zh)
|
2013-12-19 |
2016-10-12 |
拜耳制药股份公司 |
作为肾上腺素能受体α2C拮抗剂的取代的联哌啶基衍生物
|
|
AR102094A1
(es)
|
2014-09-25 |
2017-02-01 |
Araxes Pharma Llc |
Inhibidores de proteínas kras con una mutación g12c
|
|
WO2016049565A1
(en)
|
2014-09-25 |
2016-03-31 |
Araxes Pharma Llc |
Compositions and methods for inhibition of ras
|
|
US10011600B2
(en)
|
2014-09-25 |
2018-07-03 |
Araxes Pharma Llc |
Methods and compositions for inhibition of Ras
|
|
EA201792214A1
(ru)
|
2015-04-10 |
2018-01-31 |
Араксис Фарма Ллк |
Соединения замещенного хиназолина
|
|
US10428064B2
(en)
|
2015-04-15 |
2019-10-01 |
Araxes Pharma Llc |
Fused-tricyclic inhibitors of KRAS and methods of use thereof
|
|
EP3325447A1
(en)
|
2015-07-22 |
2018-05-30 |
Araxes Pharma LLC |
Substituted quinazoline compounds and their use as inhibitors of g12c mutant kras, hras and/or nras proteins
|
|
US10144724B2
(en)
|
2015-07-22 |
2018-12-04 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use thereof
|
|
US10882847B2
(en)
|
2015-09-28 |
2021-01-05 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
WO2017058915A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058807A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058768A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
EP3356339A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058805A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
EP3356353A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017070256A2
(en)
|
2015-10-19 |
2017-04-27 |
Araxes Pharma Llc |
Method for screening inhibitors of ras
|
|
SG10201912959QA
(en)
|
2015-10-21 |
2020-02-27 |
Otsuka Pharma Co Ltd |
Benzolactam compounds as protein kinase inhibitors
|
|
KR20180081596A
(ko)
|
2015-11-16 |
2018-07-16 |
아락세스 파마 엘엘씨 |
치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법
|
|
WO2017100546A1
(en)
|
2015-12-09 |
2017-06-15 |
Araxes Pharma Llc |
Methods for preparation of quinazoline derivatives
|
|
US10822312B2
(en)
|
2016-03-30 |
2020-11-03 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use
|
|
SG11201810171SA
(en)
|
2016-05-18 |
2018-12-28 |
Mirati Therapeutics Inc |
Kras g12c inhibitors
|
|
US10703741B2
(en)
|
2016-07-27 |
2020-07-07 |
Padlock Therapeutics, Inc. |
Covalent inhibitors of PAD4
|
|
US10280172B2
(en)
|
2016-09-29 |
2019-05-07 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
US10377743B2
(en)
|
2016-10-07 |
2019-08-13 |
Araxes Pharma Llc |
Inhibitors of RAS and methods of use thereof
|
|
EP4001269A1
(en)
*
|
2016-12-22 |
2022-05-25 |
Amgen Inc. |
Benzoisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer
|
|
WO2018140512A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
|
|
WO2018140599A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
Benzothiophene and benzothiazole compounds and methods of use thereof
|
|
WO2018140514A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
|
|
CN110382482A
(zh)
|
2017-01-26 |
2019-10-25 |
亚瑞克西斯制药公司 |
稠合的杂-杂二环化合物及其使用方法
|
|
US11279689B2
(en)
|
2017-01-26 |
2022-03-22 |
Araxes Pharma Llc |
1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
|
|
JP2020505395A
(ja)
|
2017-01-26 |
2020-02-20 |
アラクセス ファーマ エルエルシー |
縮合ｎ−複素環式化合物およびその使用方法
|
|
JOP20190186A1
(ar)
|
2017-02-02 |
2019-08-01 |
Astellas Pharma Inc |
مركب كينازولين
|
|
CN110603258A
(zh)
|
2017-05-11 |
2019-12-20 |
阿斯利康(瑞典)有限公司 |
抑制g12c突变型ras蛋白的杂芳基化合物
|
|
JOP20190272A1
(ar)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
مثبطات kras g12c وطرق لاستخدامها
|
|
TW201906832A
(zh)
|
2017-05-25 |
2019-02-16 |
美商亞瑞克西斯製藥公司 |
用於癌症治療之化合物及其使用方法
|
|
MX2019013954A
(es)
|
2017-05-25 |
2020-08-31 |
Araxes Pharma Llc |
Inhibidores covalentes de kras.
|
|
WO2018218069A1
(en)
|
2017-05-25 |
2018-11-29 |
Araxes Pharma Llc |
Quinazoline derivatives as modulators of mutant kras, hras or nras
|
|
CN107556289A
(zh)
|
2017-06-22 |
2018-01-09 |
天津国际生物医药联合研究院 |
一种氯苯‑吡啶类化合物及其应用
|
|
SG11202001499WA
(en)
|
2017-09-08 |
2020-03-30 |
Amgen Inc |
Inhibitors of kras g12c and methods of using the same
|
|
AU2018336171B2
(en)
|
2017-09-22 |
2023-01-05 |
Jubilant Epipad LLC |
Heterocyclic compounds as PAD inhibitors
|
|
GB201715342D0
(en)
|
2017-09-22 |
2017-11-08 |
Univ Nottingham |
Compounds
|
|
CA3076476A1
(en)
|
2017-10-18 |
2019-04-25 |
Jubilant Epipad LLC |
Imidazo-pyridine compounds as pad inhibitors
|
|
US10647715B2
(en)
|
2017-11-15 |
2020-05-12 |
Mirati Therapeutics, Inc. |
KRas G12C inhibitors
|
|
ES2944547T3
(es)
|
2017-11-15 |
2023-06-22 |
Mirati Therapeutics Inc |
Inhibidores de KRas G12C
|
|
WO2019099703A1
(en)
|
2017-11-16 |
2019-05-23 |
Sidecar Therapeutics, Inc. |
Apoptosis signal-regulating kinase 1 (ask 1) inhibitor compounds
|
|
TW201938561A
(zh)
|
2017-12-08 |
2019-10-01 |
瑞典商阿斯特捷利康公司 |
化學化合物
|
|
TW201942116A
(zh)
|
2018-02-09 |
2019-11-01 |
美商輝瑞股份有限公司 |
作為抗癌劑之四氫喹唑啉衍生物
|
|
EP3759111A1
(en)
|
2018-03-02 |
2021-01-06 |
Otsuka Pharmaceutical Co., Ltd. |
Pharmaceutical compounds
|
|
EP3774769A1
(en)
|
2018-03-28 |
2021-02-17 |
Bayer Pharma Aktiengesellschaft |
4-(3-amino-6-fluoro-1h-indazol-5-yl)-1,2,6-trimethyl-1,4-dihydropyridine-3,5-dic arbonitrile compounds for treating hyperproliferative disorders
|
|
EP3807276A2
(en)
|
2018-06-12 |
2021-04-21 |
Amgen Inc. |
Kras g12c inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer
|
|
TW202019921A
(zh)
|
2018-07-24 |
2020-06-01 |
日商大鵬藥品工業股份有限公司 |
用於抑制shp2活性之雜雙環化合物
|
|
AU2019320945C1
(en)
|
2018-08-16 |
2021-09-30 |
F. Hoffmann-La Roche Ag |
Fused ring compounds
|
|
TW202033518A
(zh)
|
2018-10-15 |
2020-09-16 |
美商美國禮來大藥廠 |
Kras g12c 抑制劑
|
|
EP3871673B1
(en)
|
2018-10-26 |
2024-01-03 |
Taiho Pharmaceutical Co., Ltd. |
Novel indazole compound or salt thereof
|
|
CN118084870A
(zh)
|
2018-11-09 |
2024-05-28 |
豪夫迈·罗氏有限公司 |
稠环化合物
|
|
EP3883565A1
(en)
|
2018-11-19 |
2021-09-29 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
KR20210097715A
(ko)
|
2018-11-29 |
2021-08-09 |
아락세스 파마 엘엘씨 |
암 치료용 화합물 및 이의 사용 방법
|
|
EP3908283A4
(en)
|
2019-01-10 |
2022-10-12 |
Mirati Therapeutics, Inc. |
KRAS G12C INHIBITORS
|
|
EP3919483A4
(en)
|
2019-01-29 |
2022-02-09 |
Brightgene Bio-medical Technology Co., Ltd. |
HETEROCYCLIC BENZOPYRIDONE COMPOUND AND USE THEREOF
|
|
WO2020177629A1
(zh)
|
2019-03-01 |
2020-09-10 |
劲方医药科技(上海)有限公司 |
螺环取代的嘧啶并环类化合物，其制法与医药上的用途
|
|
MX2021010674A
(es)
|
2019-03-05 |
2021-09-28 |
Astrazeneca Ab |
Compuestos triciclicos condensados utiles como agentes anticancerigenos.
|
|
US20220251109A1
(en)
|
2019-04-28 |
2022-08-11 |
Genfleet Therapeutics (Shanghai) Inc. |
Oxaazaquinazoline-7(8h)-ketone compound, preparation method therefor and pharmaceutical application thereof
|
|
SG11202112790SA
(en)
|
2019-05-20 |
2021-12-30 |
California Inst Of Techn |
Kras g12c inhibitors and uses thereof
|
|
WO2020234103A1
(en)
|
2019-05-21 |
2020-11-26 |
Bayer Aktiengesellschaft |
Identification and use of kras inhibitors
|
|
CN112585129B
(zh)
|
2019-05-21 |
2022-03-01 |
益方生物科技(上海)股份有限公司 |
杂环化合物，其制备方法和用途
|
|
TW202110837A
(zh)
|
2019-05-24 |
2021-03-16 |
大陸商江蘇恆瑞醫藥股份有限公司 |
氫化吡啶并嘧啶類衍生物、其製備方法及其在醫藥上的應用
|
|
JP2022534765A
(ja)
|
2019-05-29 |
2022-08-03 |
上▲海▼翰森生物医▲薬▼科技有限公司 |
窒素含有複素環系誘導物レギュレーター、その製造方法及び使用
|
|
CN113396147B
(zh)
|
2019-05-31 |
2024-06-18 |
上海翰森生物医药科技有限公司 |
芳香杂环类衍生物调节剂、其制备方法和应用
|
|
JP2022539341A
(ja)
|
2019-06-24 |
2022-09-08 |
クヮントン ニューオップ バイオファーマシューティカルズ カンパニー， リミテッド |
Ｋｒａｓ ｇ１２ｃの阻害剤としての複素環式化合物
|
|
US20220372036A1
(en)
|
2019-06-25 |
2022-11-24 |
Medshine Discovery Inc. |
Seven-membered heterocyclic derivative acting as kras g12c mutant protein inhibitor
|
|
CN110256421A
(zh)
|
2019-06-26 |
2019-09-20 |
微境生物医药科技(上海)有限公司 |
Kras-g12c抑制剂
|
|
CN114040914A
(zh)
|
2019-07-01 |
2022-02-11 |
江苏恒瑞医药股份有限公司 |
喹唑啉酮类衍生物、其制备方法及其在医药上的应用
|
|
EP4011886A4
(en)
|
2019-08-02 |
2023-07-26 |
Shanghai Jemincare Pharmaceuticals Co., Ltd. |
TETRACYCLIC COMPOUND, METHOD OF PRODUCTION THEREOF AND USE THEREOF
|
|
CN112341457A
(zh)
|
2019-08-07 |
2021-02-09 |
北京加科思新药研发有限公司 |
Kras突变蛋白抑制剂
|
|
CN114174298B
(zh)
|
2019-08-14 |
2023-08-01 |
正大天晴药业集团南京顺欣制药有限公司 |
哒嗪酮并嘧啶类衍生物及其医药用途
|
|
CN112390797A
(zh)
|
2019-08-15 |
2021-02-23 |
微境生物医药科技(上海)有限公司 |
新型螺环类K-Ras G12C抑制剂
|
|
CN114222743A
(zh)
|
2019-08-16 |
2022-03-22 |
劲方医药科技(上海)有限公司 |
氧代六元环并嘧啶类化合物，其制法与医药上的用途
|
|
WO2021037018A1
(zh)
|
2019-08-26 |
2021-03-04 |
南京创济生物医药有限公司 |
二氢或四氢喹唑啉类化合物及其中间体、制备方法和应用
|
|
WO2021043322A1
(zh)
|
2019-09-06 |
2021-03-11 |
正大天晴药业集团南京顺欣制药有限公司 |
氮杂环庚烷并嘧啶类衍生物及其医药用途
|
|
CN116947885A
(zh)
|
2019-09-20 |
2023-10-27 |
上海济煜医药科技有限公司 |
稠合吡啶酮类化合物及其制备方法和应用
|
|
TW202115062A
(zh)
|
2019-09-25 |
2021-04-16 |
大陸商北京加科思新藥研發有限公司 |
Kras突變蛋白抑制劑
|
|
US20220389021A1
(en)
|
2019-09-29 |
2022-12-08 |
Beigene, Ltd. |
Inhibitors of kras g12c
|
|
WO2021063346A1
(zh)
|
2019-09-30 |
2021-04-08 |
上海迪诺医药科技有限公司 |
Kras g12c抑制剂及其应用
|
|
CN112694475A
(zh)
|
2019-10-23 |
2021-04-23 |
苏州泽璟生物制药股份有限公司 |
环烷基类和杂环烷基类抑制剂及其制备方法和应用
|
|
EP4048671A1
(en)
|
2019-10-24 |
2022-08-31 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer
|
|
JP2023502891A
(ja)
|
2019-10-30 |
2023-01-26 |
▲勁▼方医▲薬▼科技（上海）有限公司 |
置換された複素環－環系化合物、その調製方法及び医薬への応用
|
|
WO2021084765A1
(en)
|
2019-10-31 |
2021-05-06 |
Taiho Pharmaceutical Co., Ltd |
4-aminobut-2-enamide derivatives and salts thereof
|
|
CN113286794B
(zh)
|
2019-11-04 |
2024-03-12 |
北京加科思新药研发有限公司 |
Kras突变蛋白抑制剂
|
|
WO2021093758A1
(zh)
|
2019-11-15 |
2021-05-20 |
四川海思科制药有限公司 |
一种嘧啶并环衍生物及其在医药上的应用
|
|
CN112824410A
(zh)
|
2019-11-21 |
2021-05-21 |
苏州泽璟生物制药股份有限公司 |
氮杂七元环类抑制剂及其制备方法和应用
|
|
EP4067343A4
(en)
|
2019-11-29 |
2024-01-03 |
Taiho Pharmaceutical Co Ltd |
NOVEL PHENOLIC COMPOUND OR SALT THEREOF
|
|
WO2021104431A1
(zh)
|
2019-11-29 |
2021-06-03 |
苏州信诺维医药科技股份有限公司 |
Kras g12c抑制剂化合物及其用途
|
|
JP7480298B2
(ja)
|
2019-12-02 |
2024-05-09 |
シャンハイ インリー ファーマシューティカル カンパニー リミテッド |
酸素含有複素環化合物、その製造方法及び使用
|
|
WO2021113595A1
(en)
|
2019-12-06 |
2021-06-10 |
Beta Pharma, Inc. |
Phosphorus derivatives as kras inhibitors
|
|
PT3886991T
(pt)
|
2019-12-11 |
2022-10-17 |
Lilly Co Eli |
Inibidores de kras g12c
|
|
WO2021120045A1
(en)
|
2019-12-18 |
2021-06-24 |
InventisBio Co., Ltd. |
Heterocyclic compounds, preparation methods and uses thereof
|
|
MX2022007527A
(es)
|
2019-12-19 |
2022-07-19 |
Jacobio Pharmaceuticals Co Ltd |
Inhibidores de proteinas kras mutantes.
|
|
CN114761408B
(zh)
|
2019-12-19 |
2023-09-15 |
贝达药业股份有限公司 |
Kras g12c抑制剂及其在医药上的应用
|
|
WO2021127404A1
(en)
|
2019-12-20 |
2021-06-24 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
WO2021120890A1
(en)
|
2019-12-20 |
2021-06-24 |
Novartis Ag |
Pyrazolyl derivatives useful as anti-cancer agents
|
|
CN113045565A
(zh)
|
2019-12-27 |
2021-06-29 |
微境生物医药科技(上海)有限公司 |
新型K-Ras G12C抑制剂
|
|
CN115003668A
(zh)
|
2020-01-21 |
2022-09-02 |
南京明德新药研发有限公司 |
作为kras抑制剂的大环类化合物
|
|
WO2021219072A1
(zh)
|
2020-04-30 |
2021-11-04 |
上海科州药物研发有限公司 |
作为kras抑制剂的杂环化合物的制备及其应用方法
|
|
WO2022066646A1
(en)
|
2020-09-22 |
2022-03-31 |
Mirati Therapeutics, Inc. |
Kras g12d inhibitors
|
|
US11999753B2
(en)
|
2020-12-16 |
2024-06-04 |
Mirati Therapeutics, Inc. |
Tetrahydropyridopyrimidine pan-KRas inhibitors
|