JPWO2020232256A5 - - Google Patents
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- JPWO2020232256A5 JPWO2020232256A5 JP2021567815A JP2021567815A JPWO2020232256A5 JP WO2020232256 A5 JPWO2020232256 A5 JP WO2020232256A5 JP 2021567815 A JP2021567815 A JP 2021567815A JP 2021567815 A JP2021567815 A JP 2021567815A JP WO2020232256 A5 JPWO2020232256 A5 JP WO2020232256A5
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- cancer
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- alkyl
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- pharmaceutically acceptable
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- 125000000217 alkyl group Chemical group 0.000 claims description 62
- 150000001875 compounds Chemical class 0.000 claims description 56
- 150000003839 salts Chemical class 0.000 claims description 52
- 229910052739 hydrogen Inorganic materials 0.000 claims description 40
- 229910052799 carbon Inorganic materials 0.000 claims description 30
- 125000004043 oxo group Chemical group O=* 0.000 claims description 24
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 18
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 18
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 18
- 125000000623 heterocyclic group Chemical group 0.000 claims description 16
- 125000001424 substituent group Chemical group 0.000 claims description 15
- 125000003545 alkoxy group Chemical group 0.000 claims description 14
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 229910052801 chlorine Inorganic materials 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 229910052731 fluorine Inorganic materials 0.000 claims description 12
- 229910052736 halogen Inorganic materials 0.000 claims description 12
- 150000002367 halogens Chemical class 0.000 claims description 12
- 125000003003 spiro group Chemical group 0.000 claims description 12
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 claims description 10
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962848114P | 2019-05-15 | 2019-05-15 | |
| US62/848,114 | 2019-05-15 | ||
| PCT/US2020/032904 WO2020232256A1 (en) | 2019-05-15 | 2020-05-14 | Triaryl compounds for treatment of pd-l1 diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022531970A JP2022531970A (ja) | 2022-07-12 |
| JPWO2020232256A5 true JPWO2020232256A5 (enExample) | 2023-05-19 |
| JP7656547B2 JP7656547B2 (ja) | 2025-04-03 |
Family
ID=73289294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021567815A Active JP7656547B2 (ja) | 2019-05-15 | 2020-05-14 | Ｐｄ－ｌ１疾患治療用のトリアリール化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11266643B2 (enExample) |
| EP (1) | EP3968996A4 (enExample) |
| JP (1) | JP7656547B2 (enExample) |
| KR (1) | KR20220009420A (enExample) |
| CN (1) | CN114340633A (enExample) |
| AU (2) | AU2020276277B2 (enExample) |
| BR (1) | BR112021022659A2 (enExample) |
| CA (1) | CA3139526A1 (enExample) |
| IL (1) | IL287843B2 (enExample) |
| MA (1) | MA55974A (enExample) |
| MX (1) | MX2021013819A (enExample) |
| SG (1) | SG11202112310TA (enExample) |
| WO (1) | WO2020232256A1 (enExample) |
| ZA (1) | ZA202108626B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3474845B1 (en) | 2016-06-27 | 2024-03-20 | ChemoCentryx, Inc. | Immunomodulator compounds |
| IL272258B (en) | 2017-07-28 | 2022-08-01 | Chemocentryx Inc | Immunomodulator compounds |
| EP3664793B1 (en) | 2017-08-08 | 2022-06-29 | ChemoCentryx, Inc. | Macrocyclic immunomodulators |
| US10568874B2 (en) | 2018-02-22 | 2020-02-25 | Chemocentryx, Inc. | Indane-amines as PD-L1 antagonists |
| MA55974A (fr) * | 2019-05-15 | 2022-03-23 | Chemocentryx Inc | Composés triaryles pour le traitement de maladies pd-l1 |
| CA3139242A1 (en) * | 2019-06-20 | 2020-12-24 | Viengkham Malathong | Compounds for treatment of pd-l1 diseases |
| CA3145303A1 (en) | 2019-07-10 | 2021-01-14 | Chemocentryx, Inc. | Indanes as pd-l1 inhibitors |
| EP4045037A4 (en) | 2019-10-16 | 2023-11-15 | ChemoCentryx, Inc. | HETEROARYL-BIPHENYL AMINE FOR THE TREATMENT OF PD-L1 DISEASE |
| EP4045036A4 (en) | 2019-10-16 | 2023-11-15 | ChemoCentryx, Inc. | Heteroaryl-biphenyl amides for the treatment of pd-l1 diseases |
| CN112812113B (zh) * | 2019-11-15 | 2022-09-20 | 杭州和正医药有限公司 | 免疫调节化合物、组合物及其应用 |
| JP2023509155A (ja) * | 2020-01-03 | 2023-03-07 | 上▲海▼翰森生物医▲薬▼科技有限公司 | ビフェニル系誘導体阻害剤、その調製方法及び使用 |
| BR112022026397A2 (pt) * | 2020-06-23 | 2023-03-14 | Chemocentryx Inc | Métodos para tratar câncer usando derivados de amida de heteroaril-bifenila |
| WO2022152316A1 (zh) * | 2021-01-18 | 2022-07-21 | 南京明德新药研发有限公司 | 联苯衍生物及其应用 |
| US12018015B2 (en) | 2021-06-18 | 2024-06-25 | Aligos Therapeutics, Inc. | Methods and compositions for targeting PD-L1 |
| TW202337455A (zh) | 2021-12-09 | 2023-10-01 | 美商迪賽孚爾製藥有限公司 | Ｒａｆ激酶抑制劑及其使用方法 |
| WO2023114365A1 (en) * | 2021-12-16 | 2023-06-22 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
| CN115010658B (zh) * | 2022-05-11 | 2023-06-27 | 南方医科大学 | 一种化合物及其制备方法与应用 |
| WO2024018403A1 (en) * | 2022-07-21 | 2024-01-25 | Arbutus Biopharma Corporation | Substituted imidazoamide compounds, and methods using same |
| WO2024134466A1 (en) * | 2022-12-21 | 2024-06-27 | Arbutus Biopharma Corporation | Substituted arylamine compounds, substituted heteroarylamine compounds, and methods using same |
| US20240277706A1 (en) * | 2023-01-20 | 2024-08-22 | Aligos Therapeutics, Inc. | Methods and compostitions for targeting pd-l1 |
| WO2025015063A1 (en) * | 2023-07-13 | 2025-01-16 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
| CN116903489B (zh) * | 2023-07-14 | 2025-09-02 | 北京汉典制药有限公司 | 三联苯类化合物、其制备方法及其应用 |
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| GB9604926D0 (en) | 1996-03-08 | 1996-05-08 | Sandoz Ltd | Organic compounds |
| EP2301923B1 (en) | 2006-03-31 | 2016-06-08 | Novartis AG | Pyridine derivatives as dgat inhibitors |
| DE602006009764D1 (de) * | 2006-04-21 | 2009-11-26 | Cellzome Ltd | Terphenylderivate zur Alzheimerbehandlung |
| WO2008008059A1 (en) | 2006-07-12 | 2008-01-17 | Locus Pharmaceuticals, Inc. | Anti-cancer agents ans uses thereof |
| EA029901B1 (ru) | 2013-09-04 | 2018-05-31 | Бристол-Майерс Сквибб Компани | Соединения для применения в качестве иммуномодуляторов |
| CU24345B1 (es) | 2013-09-06 | 2018-05-08 | Aurigene Discovery Tech Ltd | Derivados de 1,3,4-oxadiazol y 1,3,4-tiadiazol como inmunomoduladores |
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