JP2009537606A5 - - Google Patents
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- Publication number
- JP2009537606A5 JP2009537606A5 JP2009511518A JP2009511518A JP2009537606A5 JP 2009537606 A5 JP2009537606 A5 JP 2009537606A5 JP 2009511518 A JP2009511518 A JP 2009511518A JP 2009511518 A JP2009511518 A JP 2009511518A JP 2009537606 A5 JP2009537606 A5 JP 2009537606A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- mono
- phenyl
- amino
- carboxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 23
- -1 benzcycloalkyl Chemical group 0.000 claims description 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 6
- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 5
- 125000003118 aryl group Chemical group 0.000 claims description 5
- 125000002619 bicyclic group Chemical group 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 125000001072 heteroaryl group Chemical group 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 5
- 125000002950 monocyclic group Chemical group 0.000 claims description 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 125000004434 sulfur atom Chemical group 0.000 claims description 4
- 102000050554 Eph Family Receptors Human genes 0.000 claims description 3
- 108091008815 Eph receptors Proteins 0.000 claims description 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 3
- 125000004423 acyloxy group Chemical group 0.000 claims description 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000003373 pyrazinyl group Chemical class 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical class 0.000 claims 2
- 102100031983 Ephrin type-B receptor 4 Human genes 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- ZGBAJMQHJDFTQJ-DEOSSOPVSA-N bafetinib Chemical compound C1[C@@H](N(C)C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=NC=3)C(C)=CC=2)C=C1C(F)(F)F ZGBAJMQHJDFTQJ-DEOSSOPVSA-N 0.000 description 1
- 229950002365 bafetinib Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Chemical group 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 125000006413 ring segment Chemical group 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80318206P | 2006-05-25 | 2006-05-25 | |
| PCT/EP2007/055016 WO2007137981A1 (en) | 2006-05-25 | 2007-05-23 | Inhibitors of tyrosine kinases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013096740A Division JP2013189443A (ja) | 2006-05-25 | 2013-05-02 | チロシンキナーゼ阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009537606A JP2009537606A (ja) | 2009-10-29 |
| JP2009537606A5 true JP2009537606A5 (enExample) | 2013-01-10 |
Family
ID=38255250
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009511518A Pending JP2009537606A (ja) | 2006-05-25 | 2007-05-23 | チロシンキナーゼ阻害剤 |
| JP2013096740A Pending JP2013189443A (ja) | 2006-05-25 | 2013-05-02 | チロシンキナーゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013096740A Pending JP2013189443A (ja) | 2006-05-25 | 2013-05-02 | チロシンキナーゼ阻害剤 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US8093259B2 (enExample) |
| JP (2) | JP2009537606A (enExample) |
| WO (1) | WO2007137981A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200840581A (en) * | 2007-02-28 | 2008-10-16 | Astrazeneca Ab | Novel pyrimidine derivatives |
| TW201006823A (en) * | 2008-07-14 | 2010-02-16 | Novartis Ag | Use of pyrimidylaminobenzamide derivatives for the treatment of fibrosis |
| US20140080772A1 (en) * | 2012-09-06 | 2014-03-20 | The Board Of Regents Of The University Of Texas System | Treatments for melanoma |
| JP7057975B2 (ja) * | 2016-12-14 | 2022-04-21 | 国立大学法人信州大学 | 殺細胞効果を有するキメラ抗原受容体遺伝子改変リンパ球 |
| JP6944801B2 (ja) * | 2017-03-29 | 2021-10-06 | 株式会社Ｓｃｒｅｅｎホールディングス | ヒートローラおよびそれを備えた印刷装置 |
| CN116808044A (zh) | 2018-06-15 | 2023-09-29 | 汉达癌症医药责任有限公司 | 激酶抑制剂的盐类及其组合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516775A (en) * | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
| JP2005500025A (ja) * | 2001-05-29 | 2005-01-06 | サーナ・セラピューティクス・インコーポレイテッド | 女性生殖疾病及び状態の核酸に基づく調節 |
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| RS20160203A1 (sr) * | 2003-05-30 | 2016-10-31 | Genentech Inc | Tretman sa anti-vegf antitelima |
| KR100848067B1 (ko) * | 2003-12-25 | 2008-07-23 | 니뽄 신야쿠 가부시키가이샤 | 아미드 유도체 및 의약 |
| JP2008502738A (ja) * | 2004-06-10 | 2008-01-31 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒトの癌を処置するための、ｖｅｇｆインヒビターの使用 |
| GB0425035D0 (en) * | 2004-11-12 | 2004-12-15 | Novartis Ag | Organic compounds |
| US20080114001A1 (en) | 2005-01-28 | 2008-05-15 | Manley Paul W | Use of Pyrimidylaminobenzamides for the Treatment of Diseases that Respond to Modulation of Tie-2 Kinase Activity |
-
2007
- 2007-05-23 US US12/301,690 patent/US8093259B2/en not_active Expired - Fee Related
- 2007-05-23 JP JP2009511518A patent/JP2009537606A/ja active Pending
- 2007-05-23 WO PCT/EP2007/055016 patent/WO2007137981A1/en not_active Ceased
-
2013
- 2013-05-02 JP JP2013096740A patent/JP2013189443A/ja active Pending
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