JPWO2020191252A5 - - Google Patents
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- JPWO2020191252A5 JPWO2020191252A5 JP2021556501A JP2021556501A JPWO2020191252A5 JP WO2020191252 A5 JPWO2020191252 A5 JP WO2020191252A5 JP 2021556501 A JP2021556501 A JP 2021556501A JP 2021556501 A JP2021556501 A JP 2021556501A JP WO2020191252 A5 JPWO2020191252 A5 JP WO2020191252A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- phosphorus
- sulfur
- heteroatoms
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 44
- 125000005842 heteroatom Chemical group 0.000 claims 29
- 229910052698 phosphorus Inorganic materials 0.000 claims 25
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 22
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 22
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 22
- 229910052757 nitrogen Inorganic materials 0.000 claims 22
- 229910052760 oxygen Inorganic materials 0.000 claims 22
- 239000001301 oxygen Substances 0.000 claims 22
- 229910052710 silicon Chemical group 0.000 claims 22
- 239000010703 silicon Chemical group 0.000 claims 22
- 229910052717 sulfur Inorganic materials 0.000 claims 22
- 239000011593 sulfur Chemical group 0.000 claims 22
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical group [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 21
- 239000011574 phosphorus Chemical group 0.000 claims 21
- 238000000034 method Methods 0.000 claims 16
- 125000004429 atom Chemical group 0.000 claims 13
- 108091034117 Oligonucleotide Proteins 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000001931 aliphatic group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000002619 bicyclic group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000002950 monocyclic group Chemical group 0.000 claims 6
- 125000003367 polycyclic group Chemical group 0.000 claims 6
- 238000012986 modification Methods 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 230000004048 modification Effects 0.000 claims 4
- 125000004437 phosphorous atom Chemical group 0.000 claims 4
- 125000002723 alicyclic group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 238000005486 sulfidation Methods 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 229910003849 O-Si Inorganic materials 0.000 claims 1
- 229910003872 O—Si Inorganic materials 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 239000007819 coupling partner Substances 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962821423P | 2019-03-20 | 2019-03-20 | |
| US62/821,423 | 2019-03-20 | ||
| PCT/US2020/023735 WO2020191252A1 (en) | 2019-03-20 | 2020-03-19 | Technologies useful for oligonucleotide preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022525541A JP2022525541A (ja) | 2022-05-17 |
| JPWO2020191252A5 true JPWO2020191252A5 (https=) | 2023-12-22 |
| JP2022525541A5 JP2022525541A5 (https=) | 2023-12-22 |
Family
ID=72520512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021556501A Pending JP2022525541A (ja) | 2019-03-20 | 2020-03-19 | オリゴヌクレオチド調製に有用な技術 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12590115B2 (https=) |
| EP (1) | EP3941924A4 (https=) |
| JP (1) | JP2022525541A (https=) |
| KR (1) | KR20210149750A (https=) |
| CN (1) | CN113748116A (https=) |
| AU (2) | AU2020241559A1 (https=) |
| CA (1) | CA3134036A1 (https=) |
| IL (1) | IL286487A (https=) |
| MX (1) | MX2021011351A (https=) |
| SG (1) | SG11202110045PA (https=) |
| WO (1) | WO2020191252A1 (https=) |
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| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
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| CN108135921B (zh) | 2015-07-22 | 2023-10-17 | 波涛生命科学有限公司 | 寡核苷酸组合物及其方法 |
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| EP3475424A1 (en) | 2016-06-22 | 2019-05-01 | ProQR Therapeutics II B.V. | Single-stranded rna-editing oligonucleotides |
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| TW201920672A (zh) | 2017-08-08 | 2019-06-01 | 新加坡商波濤生命科學有限公司 | 寡核苷酸組合物及其使用方法 |
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| IL277889B2 (en) | 2018-04-12 | 2025-01-01 | Wave Life Sciences Ltd | Oligonucleotide preparations and methods of using them |
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| EP4555086A1 (en) | 2022-07-15 | 2025-05-21 | ProQR Therapeutics II B.V. | Oligonucleotides for adar-mediated rna editing and use thereof |
| WO2024013360A1 (en) | 2022-07-15 | 2024-01-18 | Proqr Therapeutics Ii B.V. | Chemically modified oligonucleotides for adar-mediated rna editing |
| GB202215614D0 (en) | 2022-10-21 | 2022-12-07 | Proqr Therapeutics Ii Bv | Heteroduplex rna editing oligonucleotide complexes |
| AR131145A1 (es) | 2022-11-24 | 2025-02-19 | Proqr Therapeutics Ii Bv | Oligonucleótidos antisentido para el tratamiento de hemocromatosis hfe hereditaria |
| GB202218090D0 (en) | 2022-12-01 | 2023-01-18 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of aldehyde dehydrogenase 2 deficiency |
| CA3276262A1 (en) | 2022-12-09 | 2024-06-13 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of cardiovascular disease |
| GB202300865D0 (en) | 2023-01-20 | 2023-03-08 | Proqr Therapeutics Ii Bv | Delivery of oligonucleotides |
| EP4669753A1 (en) | 2023-02-20 | 2025-12-31 | ProQR Therapeutics II B.V. | Antisense oligonucleotides for the treatment of atherosclerotic cardiovascular disease |
| WO2024206175A1 (en) | 2023-03-24 | 2024-10-03 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurological disorders |
| GB202304363D0 (en) | 2023-03-24 | 2023-05-10 | Proqr Therapeutics Ii Bv | Chemically modified antisense oligonucleotides for use in RNA editing |
| AU2024246572A1 (en) | 2023-03-27 | 2025-10-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of liver disease |
| WO2024256620A1 (en) | 2023-06-16 | 2024-12-19 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurodegenerative disease |
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| WO2025051946A1 (en) | 2023-09-07 | 2025-03-13 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
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| WO2025104239A1 (en) | 2023-11-16 | 2025-05-22 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of classic galactosemia |
| WO2025128799A1 (en) | 2023-12-12 | 2025-06-19 | Korro Bio, Inc. | Double-stranded rna-editing oligonucleotides and uses thereof |
| WO2025132708A1 (en) | 2023-12-20 | 2025-06-26 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of huntington's disease |
| GB202404661D0 (en) | 2024-04-02 | 2024-05-15 | Proqr Therapeutics Ii Bv | Antisense oligoncleotides for the treatment of liver disease |
| WO2025224230A1 (en) | 2024-04-25 | 2025-10-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of fatty liver disease |
| GB202410081D0 (en) | 2024-07-11 | 2024-08-28 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of cardiovascular disease |
| WO2026022136A1 (en) | 2024-07-23 | 2026-01-29 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
| WO2026050243A1 (en) | 2024-08-26 | 2026-03-05 | Korro Bio, Inc. | Galnac conjugated oligonucleotides for rna editing |
| WO2026060374A2 (en) | 2024-09-16 | 2026-03-19 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurological disorders |
| WO2026068781A1 (en) | 2024-09-30 | 2026-04-02 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of liver disease |
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| CN116507724A (zh) | 2020-11-08 | 2023-07-28 | 波涛生命科学有限公司 | 寡核苷酸组合物及其方法 |
| EP4240849A4 (en) | 2020-11-08 | 2026-04-01 | Wave Life Sciences Ltd | OLIGONUCLEOTIDE COMPOSITIONS AND ASSOCIATED PROCESSES |
| JP2024536088A (ja) | 2021-09-26 | 2024-10-04 | ウェイブ ライフ サイエンシズ リミテッド | Ｍｅｃｐ２転写物を編集するための組成物及びその方法 |
| AU2022352779A1 (en) | 2021-09-26 | 2024-03-28 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof |
| CA3236136A1 (en) | 2021-10-27 | 2023-05-04 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| EP4422645A4 (en) | 2021-10-27 | 2025-12-03 | Wave Life Sciences Ltd | OLIGONUCLEOTID COMPOSITIONS AND THEIR METHODS OF USE |
| EP4476202A1 (en) | 2022-02-11 | 2024-12-18 | Wave Life Sciences Ltd. | Stereoselective technologies for chiral compounds |
| IL315089A (en) | 2022-03-02 | 2024-10-01 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods thereof for exon skipping |
| IL316178A (en) | 2022-04-15 | 2024-12-01 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods related thereto |
| CN119452084A (zh) | 2022-05-12 | 2025-02-14 | 波涛生命科学有限公司 | 寡核苷酸组合物及其方法 |
| JP2025526712A (ja) | 2022-08-11 | 2025-08-15 | ウェイブ ライフ サイエンシズ リミテッド | オリゴヌクレオチド組成物及びその方法 |
| WO2025030155A1 (en) | 2023-08-03 | 2025-02-06 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof |
| WO2025160090A1 (en) | 2024-01-22 | 2025-07-31 | Wave Life Sciences Ltd. | Technol. ogies useful for oligonucleotide preparation |
-
2020
- 2020-03-19 CN CN202080028682.0A patent/CN113748116A/zh active Pending
- 2020-03-19 JP JP2021556501A patent/JP2022525541A/ja active Pending
- 2020-03-19 EP EP20774109.1A patent/EP3941924A4/en active Pending
- 2020-03-19 SG SG11202110045PA patent/SG11202110045PA/en unknown
- 2020-03-19 US US17/439,755 patent/US12590115B2/en active Active
- 2020-03-19 WO PCT/US2020/023735 patent/WO2020191252A1/en not_active Ceased
- 2020-03-19 MX MX2021011351A patent/MX2021011351A/es unknown
- 2020-03-19 CA CA3134036A patent/CA3134036A1/en active Pending
- 2020-03-19 AU AU2020241559A patent/AU2020241559A1/en not_active Abandoned
- 2020-03-19 KR KR1020217033895A patent/KR20210149750A/ko active Pending
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