|
US836805A
(en)
|
1904-05-10 |
1906-11-27 |
Alva Battie Dozier |
Telephone or switchboard plug.
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US3992518A
(en)
|
1974-10-24 |
1976-11-16 |
G. D. Searle & Co. |
Method for making a microsealed delivery device
|
|
GB1478759A
(en)
|
1974-11-18 |
1977-07-06 |
Alza Corp |
Process for forming outlet passageways in pills using a laser
|
|
US4284444A
(en)
|
1977-08-01 |
1981-08-18 |
Herculite Protective Fabrics Corporation |
Activated polymer materials and process for making same
|
|
US4704362A
(en)
|
1977-11-08 |
1987-11-03 |
Genentech, Inc. |
Recombinant cloning vehicle microbial polypeptide expression
|
|
US4200098A
(en)
|
1978-10-23 |
1980-04-29 |
Alza Corporation |
Osmotic system with distribution zone for dispensing beneficial agent
|
|
US4235881A
(en)
|
1978-12-04 |
1980-11-25 |
Cort Joseph H |
Method for producing high potency factor VIII
|
|
US4200984A
(en)
|
1979-03-12 |
1980-05-06 |
Fink Ray D |
Detachable tool combining bracket and method
|
|
US4342832A
(en)
|
1979-07-05 |
1982-08-03 |
Genentech, Inc. |
Method of constructing a replicable cloning vehicle having quasi-synthetic genes
|
|
US4215051A
(en)
|
1979-08-29 |
1980-07-29 |
Standard Oil Company (Indiana) |
Formation, purification and recovery of phthalic anhydride
|
|
ZA811368B
(en)
|
1980-03-24 |
1982-04-28 |
Genentech Inc |
Bacterial polypedtide expression employing tryptophan promoter-operator
|
|
US4398908A
(en)
|
1980-11-28 |
1983-08-16 |
Siposs George G |
Insulin delivery system
|
|
US4456591A
(en)
|
1981-06-25 |
1984-06-26 |
Baxter Travenol Laboratories, Inc. |
Therapeutic method for activating factor VII
|
|
US4435173A
(en)
|
1982-03-05 |
1984-03-06 |
Delta Medical Industries |
Variable rate syringe pump for insulin delivery
|
|
US4542025A
(en)
|
1982-07-29 |
1985-09-17 |
The Stolle Research And Development Corporation |
Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
|
|
US4599311A
(en)
|
1982-08-13 |
1986-07-08 |
Kawasaki Glenn H |
Glycolytic promotersfor regulated protein expression: protease inhibitor
|
|
US4713339A
(en)
|
1983-01-19 |
1987-12-15 |
Genentech, Inc. |
Polycistronic expression vector construction
|
|
US4870008A
(en)
|
1983-08-12 |
1989-09-26 |
Chiron Corporation |
Secretory expression in eukaryotes
|
|
US4757006A
(en)
|
1983-10-28 |
1988-07-12 |
Genetics Institute, Inc. |
Human factor VIII:C gene and recombinant methods for production
|
|
US7138505B1
(en)
|
1984-01-12 |
2006-11-21 |
Novartis Vaccines And Diagnostics, Inc. |
Factor VIII:C nucleic acid molecules
|
|
US5004804A
(en)
|
1984-01-12 |
1991-04-02 |
Nordisk Gentofte |
Method and composition for preparation of factor VIIIC
|
|
DE3572982D1
(en)
|
1984-03-06 |
1989-10-19 |
Takeda Chemical Industries Ltd |
Chemically modified lymphokine and production thereof
|
|
US5916588A
(en)
|
1984-04-12 |
1999-06-29 |
The Liposome Company, Inc. |
Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
|
|
US5231112A
(en)
|
1984-04-12 |
1993-07-27 |
The Liposome Company, Inc. |
Compositions containing tris salt of cholesterol hemisuccinate and antifungal
|
|
US4965199A
(en)
|
1984-04-20 |
1990-10-23 |
Genentech, Inc. |
Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
|
|
US4931373A
(en)
|
1984-05-25 |
1990-06-05 |
Zymogenetics, Inc. |
Stable DNA constructs for expression of α-1 antitrypsin
|
|
JPS61502760A
(ja)
|
1984-07-24 |
1986-11-27 |
キイ・フア−マシユ−テイカルズ・インコ−ポレイテツド |
粘着性経皮投与層
|
|
US4766073A
(en)
|
1985-02-25 |
1988-08-23 |
Zymogenetics Inc. |
Expression of biologically active PDGF analogs in eucaryotic cells
|
|
US4885249A
(en)
|
1984-12-05 |
1989-12-05 |
Allelix, Inc. |
Aspergillus niger transformation system
|
|
US4970300A
(en)
|
1985-02-01 |
1990-11-13 |
New York University |
Modified factor VIII
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4965188A
(en)
|
1986-08-22 |
1990-10-23 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
|
|
US5981216A
(en)
|
1985-04-01 |
1999-11-09 |
Alusuisse Holdings A.G. |
Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
|
|
CA1341174C
(en)
|
1985-04-12 |
2001-01-30 |
John J. Toole Jr. |
Procoagulant proteins derived from factor viii: c
|
|
GR860984B
(en)
|
1985-04-17 |
1986-08-18 |
Zymogenetics Inc |
Expression of factor vii and ix activities in mammalian cells
|
|
ATE74164T1
(de)
|
1985-04-22 |
1992-04-15 |
Genetics Inst |
Herstellung mit hoher leistung des aktivfaktors ix.
|
|
US4684479A
(en)
|
1985-08-14 |
1987-08-04 |
Arrigo Joseph S D |
Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
|
|
KR910006424B1
(ko)
|
1985-08-21 |
1991-08-24 |
인코텍스 비.브이 |
편성브리프(brief) 제조방법
|
|
US4882279A
(en)
|
1985-10-25 |
1989-11-21 |
Phillips Petroleum Company |
Site selective genomic modification of yeast of the genus pichia
|
|
US5250421A
(en)
|
1986-01-03 |
1993-10-05 |
Genetics Institute, Inc. |
Method for producing factor VIII:C-type proteins
|
|
US5198349A
(en)
|
1986-01-03 |
1993-03-30 |
Genetics Institute, Inc. |
Method for producing factor VIII:C and analogs
|
|
DE3785102T2
(de)
|
1986-01-03 |
1993-07-22 |
Genetics Inst |
Verfahren zur herstellung von faktor-viii:c-typ-proteinen.
|
|
US4935349A
(en)
|
1986-01-17 |
1990-06-19 |
Zymogenetics, Inc. |
Expression of higher eucaryotic genes in aspergillus
|
|
US5595886A
(en)
|
1986-01-27 |
1997-01-21 |
Chiron Corporation |
Protein complexes having Factor VIII:C activity and production thereof
|
|
US4800159A
(en)
|
1986-02-07 |
1989-01-24 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences
|
|
DK122686D0
(da)
|
1986-03-17 |
1986-03-17 |
Novo Industri As |
Fremstilling af proteiner
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US5422260A
(en)
|
1986-05-29 |
1995-06-06 |
Genetics Institute, Inc. -Legal Affairs |
Human factor VIII:c muteins
|
|
US6759057B1
(en)
|
1986-06-12 |
2004-07-06 |
The Liposome Company, Inc. |
Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
|
|
US5543502A
(en)
|
1986-06-24 |
1996-08-06 |
Novo Nordisk A/S |
Process for producing a coagulation active complex of factor VIII fragments
|
|
IE60901B1
(en)
|
1986-08-21 |
1994-08-24 |
Vestar Inc |
Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
|
|
US4933185A
(en)
|
1986-09-24 |
1990-06-12 |
Massachusetts Institute Of Technology |
System for controlled release of biologically active compounds
|
|
US6024983A
(en)
|
1986-10-24 |
2000-02-15 |
Southern Research Institute |
Composition for delivering bioactive agents for immune response and its preparation
|
|
US4912040A
(en)
|
1986-11-14 |
1990-03-27 |
Genetics Institute, Inc. |
Eucaryotic expression system
|
|
US6406713B1
(en)
|
1987-03-05 |
2002-06-18 |
The Liposome Company, Inc. |
Methods of preparing low-toxicity drug-lipid complexes
|
|
US4775207A
(en)
|
1987-03-17 |
1988-10-04 |
Bell Communications Research, Inc. |
Electro-optical switch
|
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・２・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
|
CA1331157C
(en)
|
1987-04-06 |
1994-08-02 |
Randal J. Kaufman |
Method for producing factor viii:c-type proteins
|
|
US6060447A
(en)
|
1987-05-19 |
2000-05-09 |
Chiron Corporation |
Protein complexes having Factor VIII:C activity and production thereof
|
|
IE69026B1
(en)
|
1987-06-12 |
1996-08-07 |
Immuno Ag |
Novel proteins with factor VIII activity process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
|
|
US6346513B1
(en)
|
1987-06-12 |
2002-02-12 |
Baxter Trading Gmbh |
Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
|
|
DE3720246A1
(de)
|
1987-06-19 |
1988-12-29 |
Behringwerke Ag |
Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
|
|
US4897268A
(en)
|
1987-08-03 |
1990-01-30 |
Southern Research Institute |
Drug delivery system and method of making the same
|
|
US4976696A
(en)
|
1987-08-10 |
1990-12-11 |
Becton, Dickinson And Company |
Syringe pump and the like for delivering medication
|
|
FR2619314B1
(fr)
|
1987-08-11 |
1990-06-15 |
Transgene Sa |
Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
|
|
US4861800A
(en)
|
1987-08-18 |
1989-08-29 |
Buyske Donald A |
Method for administering the drug deprenyl so as to minimize the danger of side effects
|
|
US4994371A
(en)
|
1987-08-28 |
1991-02-19 |
Davie Earl W |
DNA preparation of Christmas factor and use of DNA sequences
|
|
AU598958B2
(en)
|
1987-11-12 |
1990-07-05 |
Vestar, Inc. |
Improved amphotericin b liposome preparation
|
|
US5270176A
(en)
|
1987-11-20 |
1993-12-14 |
Hoechst Aktiengesellschaft |
Method for the selective cleavage of fusion proteins with lysostaphin
|
|
GB8807504D0
(en)
|
1988-03-29 |
1988-05-05 |
Sandoz Ltd |
Improvements in/relating to organic compounds
|
|
US5037743A
(en)
|
1988-08-05 |
1991-08-06 |
Zymogenetics, Inc. |
BAR1 secretion signal
|
|
JP2717808B2
(ja)
|
1988-08-10 |
1998-02-25 |
テルモ株式会社 |
シリンジポンプ
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5534617A
(en)
|
1988-10-28 |
1996-07-09 |
Genentech, Inc. |
Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
|
|
US6780613B1
(en)
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
|
US5004803A
(en)
|
1988-11-14 |
1991-04-02 |
Genetics Institute, Inc. |
Production of procoagulant proteins
|
|
CA2006596C
(en)
|
1988-12-22 |
2000-09-05 |
Rika Ishikawa |
Chemically-modified g-csf
|
|
ATE148171T1
(de)
|
1989-02-21 |
1997-02-15 |
Univ Washington |
Modifizierte formen von fortpflanzungshormonen
|
|
US5017378A
(en)
|
1989-05-01 |
1991-05-21 |
The University Of Virginia Alumni Patents Foundation |
Intraorgan injection of biologically active compounds contained in slow-release microcapsules or microspheres
|
|
WO1990013361A1
(en)
|
1989-05-04 |
1990-11-15 |
Southern Research Institute |
Improved encapsulation process and products therefrom
|
|
US5599907A
(en)
|
1989-05-10 |
1997-02-04 |
Somatogen, Inc. |
Production and use of multimeric hemoglobins
|
|
US5298022A
(en)
|
1989-05-29 |
1994-03-29 |
Amplifon Spa |
Wearable artificial pancreas
|
|
FR2647677B1
(fr)
|
1989-05-31 |
1991-09-27 |
Roussel Uclaf |
Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines
|
|
US7413537B2
(en)
|
1989-09-01 |
2008-08-19 |
Dyax Corp. |
Directed evolution of disulfide-bonded micro-proteins
|
|
SE465222C5
(sv)
|
1989-12-15 |
1998-02-10 |
Pharmacia & Upjohn Ab |
Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
|
|
US5492534A
(en)
|
1990-04-02 |
1996-02-20 |
Pharmetrix Corporation |
Controlled release portable pump
|
|
US5318540A
(en)
|
1990-04-02 |
1994-06-07 |
Pharmetrix Corporation |
Controlled release infusion device
|
|
US6552170B1
(en)
|
1990-04-06 |
2003-04-22 |
Amgen Inc. |
PEGylation reagents and compounds formed therewith
|
|
US5176502A
(en)
|
1990-04-25 |
1993-01-05 |
Becton, Dickinson And Company |
Syringe pump and the like for delivering medication
|
|
US6517859B1
(en)
|
1990-05-16 |
2003-02-11 |
Southern Research Institute |
Microcapsules for administration of neuroactive agents
|
|
US5215680A
(en)
|
1990-07-10 |
1993-06-01 |
Cavitation-Control Technology, Inc. |
Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
|
|
US5583107A
(en)
|
1990-09-04 |
1996-12-10 |
Cor Therapeutics, Inc. |
Agents affecting thrombosis and hemostasis
|
|
AU662508B2
(en)
|
1990-12-13 |
1995-09-07 |
Pharmacia & Upjohn Company |
Fusion polypeptides
|
|
US5206161A
(en)
|
1991-02-01 |
1993-04-27 |
Genentech, Inc. |
Human plasma carboxypeptidase B
|
|
US20060122376A1
(en)
|
1991-02-07 |
2006-06-08 |
Chiron Corporation |
Protein complexes having factor VIII:C activity and production thereof
|
|
US5833982A
(en)
|
1991-02-28 |
1998-11-10 |
Zymogenetics, Inc. |
Modified factor VII
|
|
SG47099A1
(en)
|
1991-03-15 |
1998-03-20 |
Amgen Boulder Inc |
Pegylation of polypeptides
|
|
US5846951A
(en)
|
1991-06-06 |
1998-12-08 |
The School Of Pharmacy, University Of London |
Pharmaceutical compositions
|
|
IE922437A1
(en)
|
1991-07-25 |
1993-01-27 |
Idec Pharma Corp |
Recombinant antibodies for human therapy
|
|
CA2078721A1
(en)
|
1991-09-24 |
1993-03-25 |
Hiroshi Yonemura |
Process for preparing human coagulation factor viii protein complex
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
US6376463B1
(en)
|
1992-04-07 |
2002-04-23 |
Emory University |
Modified factor VIII
|
|
US5364771A
(en)
|
1992-04-07 |
1994-11-15 |
Emory University |
Hybrid human/porcine factor VIII
|
|
US5859204A
(en)
|
1992-04-07 |
1999-01-12 |
Emory University |
Modified factor VIII
|
|
US6037452A
(en)
|
1992-04-10 |
2000-03-14 |
Alpha Therapeutic Corporation |
Poly(alkylene oxide)-Factor VIII or Factor IX conjugate
|
|
CA2124690C
(en)
|
1992-10-02 |
2007-09-11 |
Thomas Osterberg |
Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer
|
|
CA2149326C
(en)
|
1992-11-13 |
2007-04-17 |
Mitchell E. Reff |
Fully impaired consensus kozak sequences for mammalian expression
|
|
US5563045A
(en)
|
1992-11-13 |
1996-10-08 |
Genetics Institute, Inc. |
Chimeric procoagulant proteins
|
|
US5573776A
(en)
|
1992-12-02 |
1996-11-12 |
Alza Corporation |
Oral osmotic device with hydrogel driving member
|
|
US6090925A
(en)
|
1993-03-09 |
2000-07-18 |
Epic Therapeutics, Inc. |
Macromolecular microparticles and methods of production and use
|
|
US5554730A
(en)
|
1993-03-09 |
1996-09-10 |
Middlesex Sciences, Inc. |
Method and kit for making a polysaccharide-protein conjugate
|
|
US5981719A
(en)
|
1993-03-09 |
1999-11-09 |
Epic Therapeutics, Inc. |
Macromolecular microparticles and methods of production and use
|
|
ES2113094T3
(es)
|
1993-03-09 |
1998-04-16 |
Epic Therapeutics Inc |
Las microparticulas macromoleculares y metodos de obtencion.
|
|
SE504074C2
(sv)
|
1993-07-05 |
1996-11-04 |
Pharmacia Ab |
Proteinberedning för subkutan, intramuskulär eller intradermal administrering
|
|
US5576291A
(en)
|
1993-09-13 |
1996-11-19 |
Baxter International Inc. |
Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US20020042079A1
(en)
|
1994-02-01 |
2002-04-11 |
Sanford M. Simon |
Methods and agents for measuring and controlling multidrug resistance
|
|
US5660848A
(en)
|
1994-11-02 |
1997-08-26 |
The Population Council, Center For Biomedical Research |
Subdermally implantable device
|
|
GB9422383D0
(en)
|
1994-11-05 |
1995-01-04 |
Wellcome Found |
Antibodies
|
|
SE503424C2
(sv)
|
1994-11-14 |
1996-06-10 |
Pharmacia Ab |
Process för rening av rekombinant koagulationsfaktor VIII
|
|
US6818439B1
(en)
|
1994-12-30 |
2004-11-16 |
Chiron Corporation |
Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders
|
|
US6485726B1
(en)
|
1995-01-17 |
2002-11-26 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
US6030613A
(en)
|
1995-01-17 |
2000-02-29 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
US6086875A
(en)
|
1995-01-17 |
2000-07-11 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of immunogens
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
US7846455B2
(en)
|
1996-07-15 |
2010-12-07 |
The United States Of America As Represented By The Department Of Health And Human Services |
Attenuated chimeric respiratory syncytial virus
|
|
SE9503380D0
(sv)
|
1995-09-29 |
1995-09-29 |
Pharmacia Ab |
Protein derivatives
|
|
GB9526733D0
(en)
|
1995-12-30 |
1996-02-28 |
Delta Biotechnology Ltd |
Fusion proteins
|
|
SI0932399T1
(sl)
|
1996-03-12 |
2006-10-31 |
Pg Txl Co Lp |
Vodotopna paklitakselna predzdravila
|
|
US6441025B2
(en)
|
1996-03-12 |
2002-08-27 |
Pg-Txl Company, L.P. |
Water soluble paclitaxel derivatives
|
|
US8183344B2
(en)
|
1996-04-24 |
2012-05-22 |
University Of Michigan |
Inactivation resistant factor VIII
|
|
US6458563B1
(en)
|
1996-06-26 |
2002-10-01 |
Emory University |
Modified factor VIII
|
|
US7560107B2
(en)
|
1996-06-26 |
2009-07-14 |
Emory University |
Modified factor VIII
|
|
AU3968897A
(en)
|
1996-08-02 |
1998-02-25 |
Bristol-Myers Squibb Company |
A method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
|
DE69725747T2
(de)
|
1996-08-23 |
2004-07-29 |
Sequus Pharmaceuticals, Inc., Menlo Park |
Liposome enthaltend cisplatin
|
|
US6056973A
(en)
|
1996-10-11 |
2000-05-02 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method of preparation
|
|
EP0932390A1
(en)
|
1996-10-11 |
1999-08-04 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method
|
|
ES2321769T3
(es)
|
1996-10-15 |
2009-06-10 |
Transave, Inc. |
Liposomas de n-acil fosfatidiletanolamina para el transporte de medicamentos.
|
|
US6361796B1
(en)
|
1996-10-25 |
2002-03-26 |
Shire Laboratories, Inc. |
Soluble form osmotic dose delivery system
|
|
AU721653B2
(en)
|
1996-10-25 |
2000-07-13 |
Supernus Pharmaceuticals, Inc. |
Soluble form osmotic dose delivery system
|
|
WO1998022577A1
(en)
|
1996-11-15 |
1998-05-28 |
Maria Grazia Masucci |
Fusion proteins having increased half-lives
|
|
EP0842657A1
(en)
|
1996-11-19 |
1998-05-20 |
OctoPlus B.V. |
Microspheres for controlled release and processes to prepare these microspheres
|
|
US6395302B1
(en)
|
1996-11-19 |
2002-05-28 |
Octoplus B.V. |
Method for the preparation of microspheres which contain colloidal systems
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
US20020019036A1
(en)
|
1996-12-13 |
2002-02-14 |
Hans-Peter Schwarz |
Von willebrand factor derivatives and methods of isolating proteins that bind to von willebrand factor
|
|
US6294170B1
(en)
|
1997-08-08 |
2001-09-25 |
Amgen Inc. |
Composition and method for treating inflammatory diseases
|
|
AT405516B
(de)
|
1997-02-27 |
1999-09-27 |
Immuno Ag |
Faktor x-analoge mit modifizierter proteasespaltstelle
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
CA2225189C
(en)
|
1997-03-06 |
2010-05-25 |
Queen's University At Kingston |
Canine factor viii gene, protein and methods of use
|
|
WO1998041645A1
(en)
|
1997-03-14 |
1998-09-24 |
Idec Pharmaceuticals Corporation |
Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
|
|
DE69833755T2
(de)
|
1997-05-21 |
2006-12-28 |
Biovation Ltd. |
Verfahren zur herstellung von nicht-immunogenen proteinen
|
|
US7786070B2
(en)
|
1997-09-10 |
2010-08-31 |
Novo Nordisk Healthcare A/G |
Subcutaneous administration of coagulation factor VII
|
|
US6310183B1
(en)
|
1997-09-10 |
2001-10-30 |
Novo Nordisk A/S |
Coagulation factor VIIa composition
|
|
DE19747261A1
(de)
|
1997-10-25 |
1999-04-29 |
Bayer Ag |
Osmotisches Arzneimittelfreisetzungssystem
|
|
GB9722131D0
(en)
|
1997-10-20 |
1997-12-17 |
Medical Res Council |
Method
|
|
DE69838526T2
(de)
|
1998-02-05 |
2008-07-03 |
Biosense Webster, Inc., Diamond Bar |
Gerät zum Freisetzen eines Medikaments im Herzen
|
|
EP1054973A1
(en)
|
1998-02-11 |
2000-11-29 |
Maxygen, Inc. |
Antigen library immunization
|
|
US20050260605A1
(en)
|
1998-02-11 |
2005-11-24 |
Maxygen, Inc. |
Targeting of genetic vaccine vectors
|
|
DK1068241T3
(da)
|
1998-04-02 |
2008-02-04 |
Genentech Inc |
Antistofvarianter og fragmenter deraf
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6242195B1
(en)
|
1998-04-02 |
2001-06-05 |
Genentech, Inc. |
Methods for determining binding of an analyte to a receptor
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
US6406632B1
(en)
|
1998-04-03 |
2002-06-18 |
Symyx Technologies, Inc. |
Rapid characterization of polymers
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
US7090976B2
(en)
|
1999-11-10 |
2006-08-15 |
Rigel Pharmaceuticals, Inc. |
Methods and compositions comprising Renilla GFP
|
|
GB9815157D0
(en)
|
1998-07-13 |
1998-09-09 |
Metron Designs Ltd |
High resolution pulse width setting from relatively low frequency clocks
|
|
JP2002522063A
(ja)
|
1998-08-17 |
2002-07-23 |
アブジェニックス インコーポレイテッド |
増加した血清半減期を有する改変された分子の生成
|
|
US6927044B2
(en)
|
1998-09-25 |
2005-08-09 |
Regeneron Pharmaceuticals, Inc. |
IL-1 receptor based cytokine traps
|
|
DK1129186T4
(da)
|
1998-11-10 |
2017-02-06 |
Stichting Sanquin Bloedvoorziening |
Et faktor VIII-polypeptid med faktor VIII:C-aktivitet
|
|
EP1006183A1
(en)
|
1998-12-03 |
2000-06-07 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Recombinant soluble Fc receptors
|
|
US6329186B1
(en)
|
1998-12-07 |
2001-12-11 |
Novozymes A/S |
Glucoamylases with N-terminal extensions
|
|
US6358703B1
(en)
|
1998-12-10 |
2002-03-19 |
Bayer Corporation |
Expression system for factor VIII
|
|
US6713086B2
(en)
|
1998-12-18 |
2004-03-30 |
Abbott Laboratories |
Controlled release formulation of divalproex sodium
|
|
KR101155191B1
(ko)
|
1999-01-15 |
2012-06-13 |
제넨테크, 인크. |
효과기 기능이 변화된 폴리펩티드 변이체
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
AU766410B2
(en)
|
1999-03-03 |
2003-10-16 |
Optinose As |
Nasal delivery device
|
|
US6183770B1
(en)
|
1999-04-15 |
2001-02-06 |
Acutek International |
Carrier patch for the delivery of agents to the skin
|
|
US7666400B2
(en)
|
2005-04-06 |
2010-02-23 |
Ibc Pharmaceuticals, Inc. |
PEGylation by the dock and lock (DNL) technique
|
|
US6743211B1
(en)
|
1999-11-23 |
2004-06-01 |
Georgia Tech Research Corporation |
Devices and methods for enhanced microneedle penetration of biological barriers
|
|
US7829085B2
(en)
|
1999-07-14 |
2010-11-09 |
Life Sciences Research Partners Vzw |
Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII
|
|
JP2003526625A
(ja)
|
1999-07-23 |
2003-09-09 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
血小板の活性化の調節
|
|
CA2380633A1
(en)
|
1999-08-06 |
2001-02-15 |
Genentech, Inc. |
Peptide antagonists of factor viia
|
|
US6458387B1
(en)
|
1999-10-18 |
2002-10-01 |
Epic Therapeutics, Inc. |
Sustained release microspheres
|
|
US20030109428A1
(en)
|
1999-12-01 |
2003-06-12 |
John Bertin |
Novel molecules of the card-related protein family and uses thereof
|
|
US20050287153A1
(en)
|
2002-06-28 |
2005-12-29 |
Genentech, Inc. |
Serum albumin binding peptides for tumor targeting
|
|
US6352721B1
(en)
|
2000-01-14 |
2002-03-05 |
Osmotica Corp. |
Combined diffusion/osmotic pumping drug delivery system
|
|
WO2001058935A2
(en)
|
2000-02-11 |
2001-08-16 |
Maxygen Aps |
FACTOR VII OR VIIa-LIKE MOLECULES
|
|
WO2001058957A2
(en)
|
2000-02-11 |
2001-08-16 |
Lexigen Pharmaceuticals Corp. |
Enhancing the circulating half-life of antibody-based fusion proteins
|
|
CA2405557C
(en)
|
2000-04-12 |
2013-09-24 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
JP2001326635A
(ja)
|
2000-05-16 |
2001-11-22 |
Matsushita Electric Ind Co Ltd |
インターネットの課金システム
|
|
ES2256234T3
(es)
|
2000-05-16 |
2006-07-16 |
Lipoxen Technologies Limited |
Derivatizacion de proteinas en solucion acuosa.
|
|
AU2001284982A1
(en)
|
2000-08-15 |
2002-02-25 |
Board Of Trustees Of The University Of Illinois |
Method of forming microparticles
|
|
US7176288B2
(en)
|
2000-09-13 |
2007-02-13 |
Novo Nordisk Healthcare A/G |
Human coagulation factor VII variants
|
|
EP1319016A4
(en)
|
2000-09-19 |
2006-05-10 |
Univ Emory |
MODIFIED FACTOR VIII
|
|
DE10053224A1
(de)
|
2000-10-26 |
2002-05-08 |
Univ Goettingen Georg August |
Verfahren zur Exposition von Peptiden und Polypeptiden auf der Zelloberfläche von Bakterien
|
|
US20030228309A1
(en)
|
2000-11-08 |
2003-12-11 |
Theodora Salcedo |
Antibodies that immunospecifically bind to TRAIL receptors
|
|
AU2002226028A1
(en)
|
2000-11-14 |
2002-05-27 |
Board Of Regents, Unversity Of Texas Systems |
Mutant human factor ix with an increased resistance to inhibition by heparin
|
|
GB0029407D0
(en)
|
2000-12-01 |
2001-01-17 |
Affitech As |
Product
|
|
DE60143544D1
(de)
|
2000-12-12 |
2011-01-05 |
Medimmune Llc |
Moleküle mit längeren halbwertszeiten, zusammensetzungen und deren verwendung
|
|
US20030104591A1
(en)
|
2000-12-14 |
2003-06-05 |
Murray Christopher J. |
Methods and compositions for grafting functional loops into a protein
|
|
US20030049689A1
(en)
|
2000-12-14 |
2003-03-13 |
Cynthia Edwards |
Multifunctional polypeptides
|
|
EP1354042A2
(en)
|
2000-12-29 |
2003-10-22 |
Curagen Corporation |
Proteins and nucleic acids encoding same
|
|
IN190699B
(da)
|
2001-02-02 |
2003-08-16 |
Sun Pharmaceutical Ind Ltd |
|
|
IL156842A0
(en)
|
2001-02-05 |
2004-02-08 |
Novo Nordisk Healthcare Ag |
Combined use of factor vii polypeptides and factor ix polypeptides
|
|
US6888319B2
(en)
|
2001-03-01 |
2005-05-03 |
Palomar Medical Technologies, Inc. |
Flashlamp drive circuit
|
|
US7211395B2
(en)
|
2001-03-09 |
2007-05-01 |
Dyax Corp. |
Serum albumin binding moieties
|
|
PE20020908A1
(es)
|
2001-03-21 |
2002-10-26 |
Cell Therapeutics Inc |
Produccion recombinante de polimeros polianionicos y uso de de los mismos
|
|
US6992174B2
(en)
|
2001-03-30 |
2006-01-31 |
Emd Lexigen Research Center Corp. |
Reducing the immunogenicity of fusion proteins
|
|
US20040106794A1
(en)
|
2001-04-16 |
2004-06-03 |
Schering Corporation |
3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
|
|
US20050048512A1
(en)
|
2001-04-26 |
2005-03-03 |
Avidia Research Institute |
Combinatorial libraries of monomer domains
|
|
WO2002087621A1
(en)
|
2001-04-30 |
2002-11-07 |
Shire Laboratories Inc. |
Pharmaceutical composition including ace/nep inhibitors and bioavailability enhancers
|
|
TW503179B
(en)
|
2001-05-07 |
2002-09-21 |
Benq Corp |
Ink jetting device having bubble valve and the method thereof
|
|
US6838093B2
(en)
|
2001-06-01 |
2005-01-04 |
Shire Laboratories, Inc. |
System for osmotic delivery of pharmaceutically active agents
|
|
CA2450125A1
(en)
|
2001-06-15 |
2002-12-27 |
Andre C. Schuh |
Gene therapy for hemophilia a
|
|
KR100407467B1
(ko)
|
2001-07-12 |
2003-11-28 |
최수봉 |
리모컨 방식의 인슐린 자동주사기
|
|
AU2002322394A1
(en)
|
2001-07-30 |
2003-02-17 |
Eli Lilly And Company |
Method for treating diabetes and obesity
|
|
EP1427820A2
(en)
|
2001-09-04 |
2004-06-16 |
MERCK PATENT GmbH |
Modified factor ix
|
|
JP2003110596A
(ja)
|
2001-09-28 |
2003-04-11 |
Hitachi Ltd |
データ通信サービス提供方法
|
|
US7125843B2
(en)
|
2001-10-19 |
2006-10-24 |
Neose Technologies, Inc. |
Glycoconjugates including more than one peptide
|
|
CN101724075B
(zh)
|
2001-10-10 |
2014-04-30 |
诺和诺德公司 |
肽的重构和糖缀合
|
|
US6960657B2
(en)
|
2001-11-02 |
2005-11-01 |
Novo Nordisk Healthcare A/G |
Human coagulation factor VII polypeptides
|
|
CN100463962C
(zh)
|
2001-12-07 |
2009-02-25 |
图尔金株式会社 |
嵌合蛋白质的表型筛选
|
|
EP2261250B1
(en)
|
2001-12-21 |
2015-07-01 |
Human Genome Sciences, Inc. |
GCSF-Albumin fusion proteins
|
|
KR101271635B1
(ko)
|
2001-12-21 |
2013-06-12 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
알부민 융합 단백질
|
|
US20080167238A1
(en)
|
2001-12-21 |
2008-07-10 |
Human Genome Sciences, Inc. |
Albumin Fusion Proteins
|
|
US20080194481A1
(en)
|
2001-12-21 |
2008-08-14 |
Human Genome Sciences, Inc. |
Albumin Fusion Proteins
|
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
|
KR20040088572A
(ko)
|
2002-03-01 |
2004-10-16 |
이뮤노메딕스, 인코오포레이티드 |
제거율 증강을 위한 양특이성 항체 점 돌연변이들
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
EP1487992A4
(en)
|
2002-03-15 |
2007-10-31 |
Brigham & Womens Hospital |
CENTRAL AIRWAY DELIVERY FOR SYSTEMIC DRUG DELIVERY
|
|
DK1499719T3
(da)
|
2002-04-30 |
2011-02-28 |
Bayer Healthcare Llc |
Faktor VII- eller VIIa-polypeptidvarianter
|
|
US6945952B2
(en)
|
2002-06-25 |
2005-09-20 |
Theraject, Inc. |
Solid solution perforator for drug delivery and other applications
|
|
US7294513B2
(en)
|
2002-07-24 |
2007-11-13 |
Wyatt Technology Corporation |
Method and apparatus for characterizing solutions of small particles
|
|
US7314709B2
(en)
|
2002-08-06 |
2008-01-01 |
Vanderbilt University |
Compositions and methods for detecting and quantifying COX-2 activity by lipoamino acid metabolism
|
|
US7425620B2
(en)
|
2002-08-14 |
2008-09-16 |
Scott Koenig |
FcγRIIB-specific antibodies and methods of use thereof
|
|
WO2004027901A2
(en)
|
2002-09-17 |
2004-04-01 |
Diffusion Science, Inc. |
Electrochemical generation, storage and reaction of hydrogen and oxygen using gas permeable catalyst-coated hollow microspheres
|
|
US6911323B2
(en)
|
2002-09-25 |
2005-06-28 |
Novo Nordisk Healthcare A/G |
Human coagulation factor VII polypeptides
|
|
EP2364996B1
(en)
|
2002-09-27 |
2016-11-09 |
Xencor Inc. |
Optimized FC variants and methods for their generation
|
|
SI1562972T1
(sl)
|
2002-10-15 |
2010-12-31 |
Facet Biotech Corp |
ALTERACIJA FcRn VEZANIH AFINITET ALI SERUMSKIH RAZPOLOVNIH DOB ANTITELESC Z MUTAGENEZO
|
|
GB2395337B
(en)
|
2002-11-14 |
2005-12-28 |
Gary Michael Wilson |
Warning Unit
|
|
ES2897506T3
(es)
|
2003-01-09 |
2022-03-01 |
Macrogenics Inc |
Identificación y modificación de anticuerpos con regiones Fc variantes y métodos de utilización de los mismos
|
|
US7041635B2
(en)
|
2003-01-28 |
2006-05-09 |
In2Gen Co., Ltd. |
Factor VIII polypeptide
|
|
EP1444986A1
(en)
|
2003-02-07 |
2004-08-11 |
Aventis Behring GmbH |
Pharmaceutical preparation for the improved treatment of blood-clotting disorders
|
|
CN102139114A
(zh)
|
2003-02-26 |
2011-08-03 |
尼克塔治疗公司 |
聚合物-因子viii部分缀合物
|
|
WO2004076484A1
(en)
|
2003-02-27 |
2004-09-10 |
National Research Council Of Canada |
Peptide inhibitors of thrombin as potent anticoagulants
|
|
WO2004076522A1
(ja)
|
2003-02-28 |
2004-09-10 |
Kuraray Co., Ltd. |
硬化性樹脂組成物
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
|
US20050176108A1
(en)
|
2003-03-13 |
2005-08-11 |
Young-Min Kim |
Physiologically active polypeptide conjugate having prolonged in vivo half-life
|
|
ATE497783T1
(de)
|
2003-05-06 |
2011-02-15 |
Syntonix Pharmaceuticals Inc |
Gerinnungsfaktor vii-fc chimäre proteine zur behandlung von hämostatischen krankheiten
|
|
US7132398B2
(en)
|
2003-05-06 |
2006-11-07 |
Dendreon Corporation |
Method of treatment of hemorrhagic disease using a factor VIIa/tissue factor inhibitor
|
|
US7348004B2
(en)
|
2003-05-06 |
2008-03-25 |
Syntonix Pharmaceuticals, Inc. |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
US20070161087A1
(en)
|
2003-05-29 |
2007-07-12 |
Wolfgang Glaesner |
Glp-1 fusion proteins
|
|
US7498024B2
(en)
|
2003-06-03 |
2009-03-03 |
Cell Genesys, Inc. |
Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site
|
|
ES2527102T3
(es)
|
2003-06-19 |
2015-01-20 |
Genentech, Inc. |
Composiciones y métodos para el tratamiento de trastornos relacionados con la coagulación
|
|
EP1654290B1
(en)
|
2003-08-12 |
2019-03-13 |
Lipoxen Technologies Limited |
Sialic acid derivatives for protein derivatisation and conjugation
|
|
JP4934796B2
(ja)
|
2003-08-14 |
2012-05-16 |
トロンボジェニクス・ナムローゼ・フエンノートシャップ |
可変抗体
|
|
US7550263B2
(en)
|
2003-09-05 |
2009-06-23 |
Gtc Biotherapeutics, Inc. |
Method for the production of fusion proteins in transgenic mammal milk
|
|
US20050152979A1
(en)
|
2003-09-05 |
2005-07-14 |
Cell Therapeutics, Inc. |
Hydrophobic drug compositions containing reconstitution enhancer
|
|
CN101870729A
(zh)
|
2003-09-09 |
2010-10-27 |
诺和诺德医疗保健公司 |
凝固因子ⅶ多肽
|
|
BRPI0414539B8
(pt)
|
2003-09-19 |
2021-05-25 |
Novo Nordisk As |
composto, composição farmacêutica, e, uso de um composto
|
|
GB0324368D0
(en)
|
2003-10-17 |
2003-11-19 |
Univ Cambridge Tech |
Polypeptides including modified constant regions
|
|
EP1682106A4
(en)
|
2003-10-30 |
2008-06-11 |
Univ Emory |
MODIFIED FVIII FACTOR WITH REDUCED IMMUNOGENICITY THROUGH MUTAGENESIS OF A2 AND C2 EPITOPES
|
|
US7211559B2
(en)
|
2003-10-31 |
2007-05-01 |
University Of Maryland, Baltimore |
Factor VIII compositions and methods
|
|
WO2005047327A2
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
|
WO2005051289A2
(en)
|
2003-11-18 |
2005-06-09 |
Iconic Therapeutics, Inc. |
Homogeneous preparations of chimeric proteins
|
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
WO2005077981A2
(en)
|
2003-12-22 |
2005-08-25 |
Xencor, Inc. |
Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES
|
|
WO2005070963A1
(en)
|
2004-01-12 |
2005-08-04 |
Applied Molecular Evolution, Inc |
Fc region variants
|
|
US20060026719A1
(en)
|
2004-01-14 |
2006-02-02 |
Kieliszewski Marcia J |
Methods of producing peptides/proteins in plants and peptides/proteins produced thereby
|
|
EP1729795B1
(en)
|
2004-02-09 |
2016-02-03 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US8076288B2
(en)
|
2004-02-11 |
2011-12-13 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides having glucose lowering activity
|
|
US7276585B2
(en)
|
2004-03-24 |
2007-10-02 |
Xencor, Inc. |
Immunoglobulin variants outside the Fc region
|
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
KR100624013B1
(ko)
|
2004-06-25 |
2006-09-19 |
주식회사 녹십자홀딩스 |
동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제
|
|
US20080233100A1
(en)
|
2004-06-30 |
2008-09-25 |
Yiyou Chen |
Targeted enzymes
|
|
WO2006085967A2
(en)
|
2004-07-09 |
2006-08-17 |
Xencor, Inc. |
OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
|
|
SI2471813T1
(sl)
|
2004-07-15 |
2015-03-31 |
Xencor, Inc. |
Optimirane Fc variante
|
|
EP1778839B1
(en)
|
2004-08-13 |
2008-07-09 |
Roche Diagniostics GMBH |
C-terminal modification of polypeptides
|
|
US7566701B2
(en)
|
2004-09-07 |
2009-07-28 |
Archemix Corp. |
Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
|
|
CA2580796C
(en)
|
2004-09-24 |
2013-03-26 |
Amgen Inc. |
Modified fc molecules having peptides inserted in internal loop regions
|
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
|
PT2371856T
(pt)
|
2004-11-12 |
2022-08-12 |
Bayer Healthcare Llc |
Modificação de fviii direcionada a sítio
|
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
WO2006127040A2
(en)
|
2004-11-16 |
2006-11-30 |
Avidia Research Institute |
Protein scaffolds and uses therof
|
|
EP1835938B1
(en)
|
2004-12-27 |
2013-08-07 |
Baxter International Inc. |
Polymer-von willebrand factor-conjugates
|
|
EP1841787A2
(en)
|
2005-01-25 |
2007-10-10 |
Cell Therapeutics, Inc. |
Conjugates of biologically active proteins having a modified in vivo half-life
|
|
US8263545B2
(en)
|
2005-02-11 |
2012-09-11 |
Amylin Pharmaceuticals, Inc. |
GIP analog and hybrid polypeptides with selectable properties
|
|
WO2006103298A2
(en)
|
2005-04-01 |
2006-10-05 |
Novo Nordisk Health Care Ag |
Blood coagulation fviii analogues
|
|
GB0516091D0
(en)
|
2005-08-04 |
2005-09-14 |
Haemostatix Ltd |
Therapeutic agent
|
|
EP1924596A4
(en)
|
2005-08-12 |
2009-07-29 |
Human Genome Sciences Inc |
ALBUM INFUSION PROTEINS
|
|
US20090011992A1
(en)
|
2005-09-21 |
2009-01-08 |
Novo Nordisk Healthcare A/G |
Human Coagulation Factor VII Polypeptides
|
|
JP2009509535A
(ja)
|
2005-09-27 |
2009-03-12 |
アムニクス， インコーポレイテッド |
タンパク様薬剤およびその使用
|
|
US7846445B2
(en)
|
2005-09-27 |
2010-12-07 |
Amunix Operating, Inc. |
Methods for production of unstructured recombinant polymers and uses thereof
|
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
|
US20090099031A1
(en)
|
2005-09-27 |
2009-04-16 |
Stemmer Willem P |
Genetic package and uses thereof
|
|
US20130172274A1
(en)
|
2005-12-20 |
2013-07-04 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
EP1971355B1
(en)
|
2005-12-20 |
2020-03-11 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
US8048848B2
(en)
|
2006-02-03 |
2011-11-01 |
Prolor Biotech Ltd. |
Long-acting interferons and derivatives thereof and methods thereof
|
|
EP1816201A1
(en)
|
2006-02-06 |
2007-08-08 |
CSL Behring GmbH |
Modified coagulation factor VIIa with extended half-life
|
|
FR2897868B1
(fr)
|
2006-02-24 |
2012-08-31 |
Lab Francais Du Fractionnement |
Anticorps anti-idiotypiques neutralisant l'activite inhibitrice d'un anticorps inhibiteur dirige contre le domaine c1 du facteur viii.
|
|
EP1996937A4
(en)
|
2006-03-06 |
2009-04-08 |
Amunix Inc |
GENETIC PACKS AND USES THEREOF
|
|
CA2643182C
(en)
|
2006-03-13 |
2014-09-02 |
Tir Technology Lp |
Adaptive control apparatus and method for a solid-state lighting system
|
|
US7645860B2
(en)
|
2006-03-31 |
2010-01-12 |
Baxter Healthcare S.A. |
Factor VIII polymer conjugates
|
|
US7683158B2
(en)
|
2006-03-31 |
2010-03-23 |
Baxter International Inc. |
Pegylated factor VIII
|
|
US9283260B2
(en)
|
2006-04-21 |
2016-03-15 |
Amgen Inc. |
Lyophilized therapeutic peptibody formulations
|
|
WO2007130535A2
(en)
|
2006-05-04 |
2007-11-15 |
Molecular Innovations |
Novel protein fusion/tag technology
|
|
WO2007144173A1
(en)
|
2006-06-14 |
2007-12-21 |
Csl Behring Gmbh |
Proteolytically cleavable fusion protein comprising a blood coagulation factor
|
|
US7939632B2
(en)
|
2006-06-14 |
2011-05-10 |
Csl Behring Gmbh |
Proteolytically cleavable fusion proteins with high molar specific activity
|
|
EP1867660A1
(en)
|
2006-06-14 |
2007-12-19 |
CSL Behring GmbH |
Proteolytically cleavable fusion protein comprising a blood coagulation factor
|
|
EP2423306A1
(en)
|
2006-06-19 |
2012-02-29 |
Catalyst Biosciences, Inc. |
Modified coagulation factor IX polypeptides and use thereof for treatment
|
|
US20080242607A1
(en)
|
2006-07-21 |
2008-10-02 |
Neose Technologies, Inc. |
Glycosylation of peptides via o-linked glycosylation sequences
|
|
US7812121B2
(en)
|
2006-08-31 |
2010-10-12 |
Baker Audrey E |
GLP-2 mimetibodies, polypeptides, compositions, methods and uses
|
|
EP2068905A4
(en)
|
2006-09-14 |
2009-12-30 |
Human Genome Sciences Inc |
ALBUM INFUSION PROTEINS
|
|
US20100075375A1
(en)
|
2006-10-03 |
2010-03-25 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates
|
|
JP5457185B2
(ja)
|
2006-10-04 |
2014-04-02 |
ノヴォ ノルディスク アー／エス |
グリセロール連結のｐｅｇ化された糖および糖ペプチド
|
|
WO2008049711A1
(en)
|
2006-10-27 |
2008-05-02 |
Novo Nordisk A/S |
Peptide extended insulins
|
|
CN101190945A
(zh)
|
2006-11-29 |
2008-06-04 |
中国人民解放军军事医学科学院放射与辐射医学研究所 |
特异性抗凝血物质的制备及其应用
|
|
EP1935430A1
(en)
|
2006-12-22 |
2008-06-25 |
CSL Behring GmbH |
Modified coagulation factors with prolonged in vivo half-life
|
|
CA2673459C
(en)
|
2006-12-22 |
2016-09-13 |
Stefan Schulte |
Modified coagulation factors with prolonged in vivo half-life
|
|
NZ577728A
(en)
|
2006-12-27 |
2012-01-12 |
Baxter Int |
Von willebrand factor- and factor viii-polymer conjugates having a releasable linkage
|
|
EP2099475B1
(en)
|
2007-01-03 |
2016-08-24 |
Novo Nordisk Health Care AG |
Subcutaneous administration of coagulation factor viia-related polypeptides
|
|
US7700734B2
(en)
|
2007-01-09 |
2010-04-20 |
Shu-Wha Lin |
Recombinant human factor IX and use thereof
|
|
EP2108045B1
(en)
|
2007-02-01 |
2013-12-11 |
Baxter International Inc. |
Improved fix-mutant proteins for hemophilia b treatment
|
|
WO2008127702A2
(en)
|
2007-04-13 |
2008-10-23 |
Catalyst Biosciences, Inc. |
Modified factor vii polypetides and uses thereof
|
|
EP2517714A1
(en)
|
2007-04-26 |
2012-10-31 |
Inspiration Biopharmaceuticals, Inc. |
Recombinant vitamin K dependent proteins with high sialic acid content and methods of preparing same
|
|
WO2008151258A2
(en)
|
2007-06-04 |
2008-12-11 |
Neose Technologies, Inc. |
O-linked glycosylation using n-acetylglucosaminyl transferases
|
|
JP2010529155A
(ja)
|
2007-06-13 |
2010-08-26 |
ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー |
出血性疾患の治療及び予防的処置における血管外投与のためのｖｗｆ安定化ｆｖｉｉｉ製剤及びｆｖｉｉｉなしのｖｗｆ製剤の使用
|
|
DK2369005T3
(da)
|
2007-06-21 |
2013-06-24 |
Univ Muenchen Tech |
Biologisk aktive proteiner med forøget stabilitet in vivo og/eller in vitro
|
|
AU2008287340A1
(en)
|
2007-08-15 |
2009-02-19 |
Amunix, Inc. |
Compositions and methods for modifying properties of biologically active polypeptides
|
|
CN104004739A
(zh)
|
2007-10-15 |
2014-08-27 |
北卡罗来纳-查佩尔山大学 |
半衰期延长的人因子ix变体
|
|
CA2703948A1
(en)
|
2007-11-01 |
2009-05-07 |
University Of Rochester |
Recombinant factor viii having increased stability
|
|
US8173597B2
(en)
|
2007-11-09 |
2012-05-08 |
Baxter International Inc. |
Modified recombinant factor VIII and von Willebrand factor and methods of use
|
|
EP3936116A1
(en)
|
2007-12-28 |
2022-01-12 |
Takeda Pharmaceutical Company Limited |
Rrecombinant vwf containing formulations
|
|
KR100981092B1
(ko)
|
2008-02-29 |
2010-09-08 |
고려대학교 산학협력단 |
제8 혈액응고 인자와 폰 빌리 블란트 인자 변이체의 재조합발현 벡터 시스템
|
|
JP5444629B2
(ja)
|
2008-04-03 |
2014-03-19 |
富士通株式会社 |
照度センサ用光案内機構及び携帯電話機
|
|
BRPI0910702A2
(pt)
|
2008-04-16 |
2016-07-05 |
Bayer Healthcare Llc |
polipeptídeos de fator ix modificados e usos dos mesmos
|
|
CN102065887A
(zh)
|
2008-04-16 |
2011-05-18 |
拜耳医药保健有限公司 |
因子ix的定点修饰
|
|
AR071478A1
(es)
|
2008-04-17 |
2010-06-23 |
Baxter Healthcare Sa |
Peptidos de bajo peso molecular con actividad procoagulante para el tratamiento de pacientes con deficiencia de factor v (fv), fvii, fviii, fx y/o fxi
|
|
CN102105582A
(zh)
|
2008-04-21 |
2011-06-22 |
诺沃-诺迪斯克有限公司 |
高糖基化人凝血因子ix
|
|
RU2010149797A
(ru)
|
2008-05-06 |
2012-06-20 |
Октафарма АГ (CH) |
Комплекс
|
|
MX2010013219A
(es)
|
2008-06-04 |
2011-04-11 |
Bayer Healthcare Llc |
Muteínas de fviii para el tratamiento de la enfermedad de von willebrand.
|
|
CA2728012C
(en)
|
2008-06-24 |
2017-10-31 |
Csl Behring Gmbh |
Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life
|
|
US20110112022A1
(en)
|
2008-06-25 |
2011-05-12 |
Bayer Healthcare Llc |
Factor VIII Muteins with Reduced Immonugenicity
|
|
CA3092223C
(en)
|
2008-07-21 |
2023-01-03 |
Apogenix Ag |
Tnfsf single chain molecules
|
|
CA2740793A1
(en)
|
2008-11-03 |
2010-06-03 |
Haiyan Jiang |
Method for the treatment of hemophilia
|
|
EP2368124A4
(en)
|
2008-11-24 |
2012-09-19 |
Bayer Healthcare Llc |
METHOD FOR DETERMINING THE ACTIVITY OF A PEGYLATED BLOOD GENERATION FACTOR IN A SILICON-BASED ACTIVATED PART THROMBOPLASTINE TIME ASSAY
|
|
US8703717B2
(en)
|
2009-02-03 |
2014-04-22 |
Amunix Operating Inc. |
Growth hormone polypeptides and methods of making and using same
|
|
US8680050B2
(en)
|
2009-02-03 |
2014-03-25 |
Amunix Operating Inc. |
Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
|
|
CN102348715B
(zh)
|
2009-02-03 |
2017-12-08 |
阿穆尼克斯运营公司 |
延伸重组多肽和包含该延伸重组多肽的组合物
|
|
CL2011001856A1
(es)
|
2009-02-03 |
2012-03-09 |
Amunix Operating Inc |
Polipeptido recombinante extendido aislado (xten) que mejora las propiedades de una proteina biologicamente activa fusionada a el; proteina de fusion aislada que comprende xten ligado a una proteina biologicamente activa; composicion que comprende dicha proteina de fusion; y uso para preparar medicamentos para tratar enfermedades.
|
|
US20120142593A1
(en)
|
2009-03-24 |
2012-06-07 |
Bayer Healthcare Llc |
Factor VIII Variants and Methods of Use
|
|
DE202010018378U1
(de)
|
2009-04-10 |
2016-04-07 |
Tufts Medical Center, Inc. |
PAR-1-Aktivierung durch Metalloproteinase-1 (MMP-1)
|
|
GB0908515D0
(en)
|
2009-05-18 |
2009-06-24 |
Apitope Technology Bristol Ltd |
Peptide
|
|
CN106916229A
(zh)
|
2009-06-08 |
2017-07-04 |
阿穆尼克斯运营公司 |
生长激素多肽及其制备和使用方法
|
|
NZ596778A
(en)
|
2009-06-08 |
2013-11-29 |
Amunix Operating Inc |
Glucose-regulating polypeptides and methods of making and using same
|
|
AU2010284977A1
(en)
|
2009-08-20 |
2012-03-29 |
Csl Behring Gmbh |
Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders
|
|
AU2010290077C1
(en)
|
2009-08-24 |
2015-12-03 |
Bioverativ Therapeutics Inc. |
Coagulation factor IX compositions and methods of making and using same
|
|
WO2011028344A2
(en)
|
2009-08-25 |
2011-03-10 |
Amunix Operating Inc. |
Interleukin-1 receptor antagonist compositions and methods of making and using same
|
|
JP5544219B2
(ja)
|
2009-09-24 |
2014-07-09 |
富士フイルム株式会社 |
内視鏡システム
|
|
ES2717902T5
(es)
|
2009-10-02 |
2022-11-29 |
Childrens Hospital Philadelphia |
Composiciones y procedimientos para mejorar la función del factor VIII de coagulación
|
|
TWI423962B
(zh)
|
2009-10-07 |
2014-01-21 |
Lg Life Sciences Ltd |
有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物
|
|
PL2499165T3
(pl)
|
2009-11-13 |
2017-04-28 |
Grifols Therapeutics Inc. |
Preparaty zawierające czynnik von willenbranda (vwf) oraz sposoby, zestawy i zastosowania z nim powiązane
|
|
LT2501234T
(lt)
|
2009-11-20 |
2017-12-11 |
Tonix Pharma Holdings Limited |
Būdai ir kompozicijos, skirti simptomų, susijusių su potrauminiu streso sutrikimu, gydymui naudojant ciklobenzapriną
|
|
AU2010325787B2
(en)
|
2009-12-06 |
2016-05-12 |
Bioverativ Therapeutics Inc. |
Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof
|
|
US20110312881A1
(en)
|
2009-12-21 |
2011-12-22 |
Amunix, Inc. |
Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases
|
|
EP2977055A1
(en)
|
2010-02-16 |
2016-01-27 |
Novo Nordisk A/S |
Factor viii fusion protein
|
|
CN102770449B
(zh)
|
2010-02-16 |
2016-02-24 |
诺沃—诺迪斯克有限公司 |
具有降低的vwf结合的因子viii分子
|
|
US8466059B2
(en)
|
2010-03-30 |
2013-06-18 |
Taiwan Semiconductor Manufacturing Company, Ltd. |
Multi-layer interconnect structure for stacked dies
|
|
EP3372617B1
(en)
|
2010-04-02 |
2024-07-24 |
Amunix Pharmaceuticals, Inc. |
Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
|
|
WO2011123830A2
(en)
|
2010-04-02 |
2011-10-06 |
Amunix Operating Inc. |
Alpha 1-antitrypsin compositions and methods of making and using same
|
|
TWI510487B
(zh)
|
2010-04-21 |
2015-12-01 |
Plexxikon Inc |
用於激酶調節的化合物和方法及其適應症
|
|
EP2730663B1
(en)
|
2010-04-21 |
2023-03-22 |
Erik Berntorp |
Genetic factors associated with inhibitor development in hemophilia A
|
|
ES2813650T3
(es)
|
2010-05-20 |
2021-03-24 |
Allergan Inc |
Toxinas clostridiales degradables
|
|
EP3508573A1
(en)
|
2010-07-09 |
2019-07-10 |
Bioverativ Therapeutics Inc. |
Systems for factor viii processing and methods thereof
|
|
NZ605400A
(en)
|
2010-07-09 |
2015-05-29 |
Biogen Idec Hemophilia Inc |
Chimeric clotting factors
|
|
NZ605348A
(en)
|
2010-07-09 |
2015-01-30 |
Biogen Idec Hemophilia Inc |
Factor ix polypeptides and methods of use thereof
|
|
US20130183280A1
(en)
|
2010-07-15 |
2013-07-18 |
Novo Nordisk A/S |
Stabilized factor viii variants
|
|
US20130017997A1
(en)
|
2010-08-19 |
2013-01-17 |
Amunix Operating Inc. |
Factor VIII Compositions and Methods of Making and Using Same
|
|
SI2717898T1
(sl)
|
2011-06-10 |
2019-07-31 |
Bioverativ Therapeutics Inc. |
Spojine prokoagulantov in metode za njihovo uporabo
|
|
EP3513804B1
(en)
|
2011-07-08 |
2022-03-23 |
Bioverativ Therapeutics Inc. |
Factor viii chimeric and hybrid polypeptides, and methods of use thereof
|
|
CN103917554B
(zh)
|
2011-10-18 |
2017-03-08 |
杰特有限公司 |
用于改善重构后纯化的因子viii的稳定性的方法
|
|
KR102018405B1
(ko)
|
2011-12-21 |
2019-09-04 |
어드밴스드 테크놀러지 머티리얼즈, 인코포레이티드 |
라이너에 기초한 운송 및 공급 시스템들
|
|
US8920268B2
(en)
|
2012-01-11 |
2014-12-30 |
Aldila Golf Corp. |
Small diameter crossbow bolt
|
|
WO2013106787A1
(en)
|
2012-01-12 |
2013-07-18 |
Biogen Idec Ma Inc. |
Chimeric factor viii polypeptides and uses thereof
|
|
SI2802668T1
(sl)
|
2012-01-12 |
2019-01-31 |
Bioverativ Therapeutics Inc. |
Zmanjšanje imunogeničnosti proti faktorju VIII pri posameznikih, ki se zdravijo zaradi faktorja VIII
|
|
RS63870B1
(sr)
|
2012-02-15 |
2023-01-31 |
Bioverativ Therapeutics Inc |
Sastavi faktora viii i postupci za pravljenje i upotrebu istih
|
|
WO2013120939A1
(en)
|
2012-02-15 |
2013-08-22 |
Csl Behring Gmbh |
Von willebrand factor variants having improved factor viii binding affinity
|
|
NZ628014A
(en)
|
2012-02-15 |
2016-09-30 |
Biogen Ma Inc |
Recombinant factor viii proteins
|
|
JP2015515482A
(ja)
|
2012-04-24 |
2015-05-28 |
ノヴォ ノルディスク アー／エス |
血友病の治療に適する化合物
|
|
CN104411323A
(zh)
|
2012-04-24 |
2015-03-11 |
诺和诺德A/S（股份有限公司） |
适用于治疗血友病的药物组合物
|
|
WO2013189827A2
(en)
|
2012-06-22 |
2013-12-27 |
Asml Netherlands B.V. |
Radiation source and lithographic apparatus.
|
|
KR102403545B1
(ko)
|
2012-07-11 |
2022-05-30 |
바이오버라티브 테라퓨틱스 인크. |
Xten 및 폰 빌레브란트 인자 단백질과의 viii 인자 복합체 및 이의 용도
|
|
CN104619677B
(zh)
|
2012-07-18 |
2016-10-26 |
西北大学 |
形成乙烯的方法
|
|
WO2014070953A1
(en)
|
2012-10-30 |
2014-05-08 |
Biogen Idec Ma Inc. |
Methods of Using FVIII Polypeptide
|
|
WO2014100913A1
(en)
|
2012-12-24 |
2014-07-03 |
Beijing Anxinhuaide Biotech. Co., Ltd |
Improving the half life of a therapeutic polypeptide by fusing with a trimeric scaffold protein via a spacer
|
|
SG11201505926VA
(en)
|
2013-03-15 |
2015-09-29 |
Biogen Ma Inc |
Factor ix polypeptide formulations
|
|
ES2926798T3
(es)
|
2013-03-15 |
2022-10-28 |
Bioverativ Therapeutics Inc |
Formulaciones de polipéptido de factor VIII
|
|
ES2657291T3
(es)
|
2013-04-22 |
2018-03-02 |
Csl Ltd. |
Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro
|
|
TW201536811A
(zh)
|
2013-05-31 |
2015-10-01 |
Biogen Idec Inc |
嵌合ｆｖｉｉ－ｘｔｅｎ分子及其用途
|
|
EP3008084A2
(en)
|
2013-06-12 |
2016-04-20 |
Novo Nordisk A/S |
Compounds suitable for treatment of haemophilia
|
|
WO2014210448A1
(en)
|
2013-06-27 |
2014-12-31 |
The Board Of Regents Of The University Of Texas System |
Compositions and methods relating to myomaker-induced muscle cell fusion
|
|
SG10201913738YA
(en)
|
2013-06-28 |
2020-03-30 |
Bioverativ Therapeutics Inc |
Thrombin cleavable linker with xten and its uses thereof
|
|
US20160229903A1
(en)
|
2013-06-28 |
2016-08-11 |
Biogen Ma Inc. |
Thrombin cleavable linker
|
|
WO2015021423A2
(en)
|
2013-08-08 |
2015-02-12 |
Biogen Idec Ma Inc. |
Purification of chimeric fviii molecules
|
|
EP3033097B1
(en)
|
2013-08-14 |
2021-03-10 |
Bioverativ Therapeutics Inc. |
Factor viii-xten fusions and uses thereof
|
|
EP4332839A3
(en)
|
2013-12-06 |
2024-06-05 |
Bioverativ Therapeutics Inc. |
Population pharmacokinetics tools and uses thereof
|
|
CN117106095A
(zh)
|
2014-01-10 |
2023-11-24 |
比奥贝拉蒂治疗公司 |
因子viii嵌合蛋白及其用途
|
|
EP3152230B1
(en)
|
2014-06-06 |
2019-08-07 |
Octapharma AG |
Preparation comprising factor viii and von willebrand factor peptides
|
|
US10253088B2
(en)
|
2014-07-02 |
2019-04-09 |
CSL Behring Lengnau AG |
Modified von Willebrand Factor
|
|
WO2016012595A1
(en)
|
2014-07-25 |
2016-01-28 |
Csl Behring Gmbh |
Improved factor viii preparations suitable for therapeutic use and processes to obtain these
|
|
SG11201701033QA
(en)
|
2014-08-13 |
2017-03-30 |
Philadelphia Children Hospital |
An improved expression cassette for packaging and expression of variant factor viii for the treatment of hemostasis disorders
|
|
DK3265483T3
(da)
|
2015-03-06 |
2020-03-02 |
CSL Behring Lengnau AG |
Modificeret von Willebrand-faktor med forbedret halveringstid
|
|
US9958572B2
(en)
|
2015-03-31 |
2018-05-01 |
Halliburton Energy Services, Inc. |
Synthetic test beds for fracturing optimization and methods of manufacture and use thereof
|
|
ES2774011T3
(es)
|
2015-05-22 |
2020-07-16 |
CSL Behring Lengnau AG |
Polipéptidos del factor de von Willebrand truncado para tratar la hemofilia
|
|
TWI741992B
(zh)
|
2015-08-03 |
2021-10-11 |
美商百歐維拉提夫治療公司 |
因子ｉｘ融合蛋白以及其製備及使用方法
|
|
US10144942B2
(en)
|
2015-10-14 |
2018-12-04 |
Translate Bio, Inc. |
Modification of RNA-related enzymes for enhanced production
|
|
EP3400002B1
(en)
|
2016-01-07 |
2022-02-02 |
CSL Behring Lengnau AG |
Mutated truncated von willebrand factor
|
|
BR112018013822A2
(pt)
|
2016-01-07 |
2018-12-11 |
Csl Behring Recombinant Facility Ag |
?polipeptídeo modificado, complexo, composição farmacêutica, métodos para tratamento de um distúrbio hemorrágico, para produção de um polipeptídeo e para aumento da meia-vida do fator viii, uso de um polipeptídeo modificado, polinucleotídeo, plasmídeo ou vetor, e, célula hospedeira?
|
|
US11046749B2
(en)
|
2016-06-24 |
2021-06-29 |
Mogam Institute For Biomedical Research |
Chimera protein comprising FVIII and vWF factors, and use thereof
|
|
TW201828974A
(zh)
|
2016-11-11 |
2018-08-16 |
瑞士商Ｃｓｌ貝林重組技能公司 |
用於血管外施予以治療或預防凝血疾病之截短型類血友病因子（ｖｏｎ Ｗｉｌｌｅｂｒａｎｄ ｆａｃｔｏｒ）多肽類
|
|
EP3548066A1
(en)
|
2016-12-02 |
2019-10-09 |
Bioverativ Therapeutics Inc. |
Methods of treating hemophilic arthropathy using chimeric clotting factors
|
|
CN110520149A
(zh)
|
2016-12-02 |
2019-11-29 |
比奥维拉迪维治疗股份有限公司 |
诱导对凝血因子的免疫耐受性的方法
|
|
JP2021523878A
(ja)
|
2018-05-18 |
2021-09-09 |
バイオベラティブ セラピューティクス インコーポレイテッド |
血友病ａを処置する方法
|
|
JP7050015B2
(ja)
|
2019-01-17 |
2022-04-07 |
古河電池株式会社 |
鉛蓄電池
|
|
WO2021257899A1
(en)
|
2020-06-19 |
2021-12-23 |
Bioverativ Therapeutics Inc. |
Methods for treating hemophilia a and population pharmacokinetics tools for determining treatments and uses thereof
|
|
WO2022129303A1
(en)
|
2020-12-18 |
2022-06-23 |
UCB Biopharma SRL |
Dihydroisoquinolinyl derivatives
|