PL2499165T3 - Preparaty zawierające czynnik von willenbranda (vwf) oraz sposoby, zestawy i zastosowania z nim powiązane - Google Patents
Preparaty zawierające czynnik von willenbranda (vwf) oraz sposoby, zestawy i zastosowania z nim powiązaneInfo
- Publication number
- PL2499165T3 PL2499165T3 PL10830777T PL10830777T PL2499165T3 PL 2499165 T3 PL2499165 T3 PL 2499165T3 PL 10830777 T PL10830777 T PL 10830777T PL 10830777 T PL10830777 T PL 10830777T PL 2499165 T3 PL2499165 T3 PL 2499165T3
- Authority
- PL
- Poland
- Prior art keywords
- willenbranda
- vwf
- von
- ways
- factor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26114509P | 2009-11-13 | 2009-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2499165T3 true PL2499165T3 (pl) | 2017-04-28 |
Family
ID=43992414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10830777T PL2499165T3 (pl) | 2009-11-13 | 2010-11-12 | Preparaty zawierające czynnik von willenbranda (vwf) oraz sposoby, zestawy i zastosowania z nim powiązane |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8759293B2 (pl) |
| EP (1) | EP2499165B1 (pl) |
| JP (1) | JP5876416B2 (pl) |
| KR (1) | KR101808751B1 (pl) |
| CN (1) | CN102648212B (pl) |
| AU (1) | AU2010319425B2 (pl) |
| BR (1) | BR112012011740A2 (pl) |
| CA (1) | CA2780542C (pl) |
| CL (1) | CL2012001258A1 (pl) |
| ES (1) | ES2600879T3 (pl) |
| HU (1) | HUE029454T2 (pl) |
| IL (1) | IL219679A (pl) |
| MX (1) | MX2012005527A (pl) |
| NZ (1) | NZ600278A (pl) |
| PL (1) | PL2499165T3 (pl) |
| PT (1) | PT2499165T (pl) |
| RU (1) | RU2579977C2 (pl) |
| WO (1) | WO2011060242A2 (pl) |
| ZA (1) | ZA201203795B (pl) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6263355A (ja) * | 1985-09-13 | 1987-03-20 | Hitachi Ltd | バツテリバツクアツプramのチエツク方法 |
| WO2008151088A2 (en) | 2007-06-01 | 2008-12-11 | University Of Maryland, Baltimore | Immunoglobulin constant region fc receptor binding agents |
| US20110046060A1 (en) | 2009-08-24 | 2011-02-24 | Amunix Operating, Inc., | Coagulation factor IX compositions and methods of making and using same |
| RU2579977C2 (ru) | 2009-11-13 | 2016-04-10 | Грифольс Терапьютикс Инк. | СОДЕРЖАЩИЕ ФАКТОР ФОН ВИЛЛЕБРАНДА (vWF) ПРЕПАРАТЫ И СПОСОБЫ, НАБОРЫ И ПРИМЕНЕНИЯ, СВЯЗАННЫЕ С НИМИ |
| EP2598533B1 (en) | 2010-07-28 | 2019-02-20 | Gliknik Inc. | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions |
| WO2013098676A1 (en) | 2011-12-30 | 2013-07-04 | Grifols, S.A. | Method for purifying factor viii |
| HUE041595T2 (hu) | 2012-01-12 | 2019-05-28 | Bioverativ Therapeutics Inc | A VIII-as faktorral szembeni immunogenitás csökkentése a VIII-as faktorterápiát kapó egyéneknél |
| HRP20191920T1 (hr) * | 2012-01-12 | 2020-01-10 | Bioverativ Therapeutics Inc. | Kimerni polipeptidi faktora viii i njihova uporaba |
| CN119192402A (zh) | 2012-02-15 | 2024-12-27 | 比奥贝拉蒂治疗公司 | 因子viii组合物及其制备和使用方法 |
| WO2013123457A1 (en) | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
| JP2015515482A (ja) * | 2012-04-24 | 2015-05-28 | ノヴォ ノルディスク アー/エス | 血友病の治療に適する化合物 |
| PL2882450T3 (pl) * | 2012-07-11 | 2020-06-29 | Bioverativ Therapeutics Inc. | Kompleks czynnika viii z xten i białkiem czynnika von willebranda oraz jego zastosowania |
| KR20150058236A (ko) | 2012-08-20 | 2015-05-28 | 글리크닉 인코포레이티드 | 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자 |
| EP3859004A1 (en) * | 2012-10-24 | 2021-08-04 | Platelet Targeted Therapeutics LLC | Platelet targeted treatment |
| GB201304973D0 (en) * | 2013-03-19 | 2013-05-01 | Profactor Pharma Ltd | Recombinant protein |
| ES2657291T3 (es) | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
| EP3008084A2 (en) * | 2013-06-12 | 2016-04-20 | Novo Nordisk A/S | Compounds suitable for treatment of haemophilia |
| AU2014302100B2 (en) * | 2013-06-28 | 2020-02-13 | Bioverativ Therapeutics Inc. | Thrombin cleavable linker with XTEN and its uses thereof |
| US20160229903A1 (en) * | 2013-06-28 | 2016-08-11 | Biogen Ma Inc. | Thrombin cleavable linker |
| US10947269B2 (en) | 2013-08-08 | 2021-03-16 | Bioverativ Therapeutics Inc. | Purification of chimeric FVIII molecules |
| WO2015023891A2 (en) | 2013-08-14 | 2015-02-19 | Biogen Idec Ma Inc. | Factor viii-xten fusions and uses thereof |
| FI4176894T3 (fi) * | 2014-01-10 | 2024-05-29 | Bioverativ Therapeutics Inc | Kimeerisiä tekijä viii -proteiineja ja niiden käyttötarkoituksia |
| US10626164B2 (en) | 2014-07-25 | 2020-04-21 | Csl Limited | Purification of VWF |
| US9701933B2 (en) * | 2014-09-19 | 2017-07-11 | Sarfaraz K. Niazi | Harvesting and purification or perfusion yielder (HAPPY) device |
| CN107406493B (zh) * | 2015-03-06 | 2021-08-13 | 康诺贝林伦瑙有限公司 | 具有改善的半衰期的经修饰的血管性血友病因子 |
| RU2017145002A (ru) | 2015-05-22 | 2019-06-24 | Цсл Беринг Ленгнау Аг | Способы получения модифицированного фактора фон виллебранда |
| JP6573989B2 (ja) | 2015-05-22 | 2019-09-11 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 血友病を処置するための切断型フォン・ヴィルブランド因子ポリペプチド |
| AU2016297862C1 (en) | 2015-07-24 | 2022-12-15 | Gliknik Inc. | Fusion proteins of human protein fragments to create orderly multimerized immunoglobulin Fc compositions with enhanced complement binding |
| CA2994547A1 (en) | 2015-08-03 | 2017-02-09 | Bioverativ Therapeutics Inc. | Factor ix fusion proteins and methods of making and using same |
| JP6851381B6 (ja) | 2016-01-07 | 2021-04-21 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 変異切断型フォンウィルブランド因子 |
| CN108779165B (zh) | 2016-01-07 | 2022-12-02 | 康诺贝林伦瑙有限公司 | 突变的冯·维勒布兰德因子 |
| US11034775B2 (en) | 2016-06-07 | 2021-06-15 | Gliknik Inc. | Cysteine-optimized stradomers |
| KR102175878B1 (ko) | 2016-06-24 | 2020-11-06 | 재단법인 목암생명과학연구소 | Fviii 및 vwf 인자를 포함하는 키메라 단백질 및 그 용도 |
| ES2908008T3 (es) | 2016-11-11 | 2022-04-27 | CSL Behring Lengnau AG | Polipéptidos truncados del Factor de von Willebrand para su administración extravascular en el tratamiento o profilaxis de un trastorno de la coagulación sanguínea |
| EP3538133B1 (en) | 2016-11-11 | 2021-02-17 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for treating hemophilia |
| BR112019011198A2 (pt) | 2016-12-02 | 2019-12-17 | Bioverativ Therapeutics Inc | métodos de indução de tolerância imune a fatores de coagulação |
| US12161696B2 (en) | 2016-12-02 | 2024-12-10 | Bioverativ Therapeutics Inc. | Methods of treating hemophilic arthropathy using chimeric clotting factors |
| PE20191354A1 (es) | 2016-12-09 | 2019-10-01 | Gliknik Inc | Optimizacion de fabricacion de gl-2045, un stradomer multimerizante |
| KR20190093186A (ko) | 2016-12-09 | 2019-08-08 | 글리크닉 인코포레이티드 | 다가 Fc 화합물에 의해 염증성 장애를 치료하는 방법 |
| CN111132693A (zh) | 2017-04-20 | 2020-05-08 | 芝加哥大学 | 用与免疫治疗抗体连接的ecm亲和肽治疗癌症的方法和组合物 |
| GB201707139D0 (en) * | 2017-05-04 | 2017-06-21 | Imp Innovations Ltd | Polypeptides |
| KR20200018690A (ko) | 2017-06-22 | 2020-02-19 | 체에스엘 베링 렝나우 아게 | 절단된 vwf에 의한 fviii 면역원성의 조절 |
| FI3648787T3 (fi) * | 2017-07-07 | 2025-01-20 | Takeda Pharmaceuticals Co | Elektiiviseen leikkaustoimenpiteeseen osallistuvien vaikeaa von willebrandin tautia sairastavien potilaiden hoito antamalla rekombinanttia vwf:ää |
| CA3081106A1 (en) * | 2017-11-01 | 2019-05-09 | Queen's University At Kingston | Von willebrand factor proteins for treating bleeding disorders |
| WO2019173289A1 (en) | 2018-03-05 | 2019-09-12 | The University Of Chicago | Methods and compositions for treating cancer with ecm-affinity peptides linked to cytokines |
| TW202015723A (zh) | 2018-05-18 | 2020-05-01 | 美商百歐維拉提夫治療公司 | 治療a型血友病的方法 |
| US10654911B1 (en) * | 2019-04-02 | 2020-05-19 | Beijing Neoletix Biological Technology Co., Ltd. | Vector co-expressing truncated von Willebrand factor and factor VIII |
| AU2020300820A1 (en) | 2019-07-04 | 2022-03-03 | CSL Behring Lengnau AG | A truncated von willebrand factor (vWF) for increasing the in vitro stability of coagulation factor VIII |
| WO2021094344A1 (en) | 2019-11-11 | 2021-05-20 | CSL Behring Lengnau AG | Polypeptides for inducing tolerance to factor viii |
| JPWO2024106355A1 (pl) * | 2022-11-14 | 2024-05-23 | ||
| CN116333081B (zh) * | 2022-12-27 | 2025-09-19 | 大连海洋大学 | 长牡蛎CgVg功能域DUF1943和VWD重组蛋白及应用 |
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2010
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- 2010-11-12 AU AU2010319425A patent/AU2010319425B2/en active Active
- 2010-11-12 MX MX2012005527A patent/MX2012005527A/es active IP Right Grant
- 2010-11-12 BR BR112012011740A patent/BR112012011740A2/pt not_active Application Discontinuation
- 2010-11-12 PT PT108307778T patent/PT2499165T/pt unknown
- 2010-11-12 US US13/509,309 patent/US8759293B2/en active Active
- 2010-11-12 PL PL10830777T patent/PL2499165T3/pl unknown
- 2010-11-12 CA CA2780542A patent/CA2780542C/en active Active
- 2010-11-12 HU HUE10830777A patent/HUE029454T2/en unknown
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- 2010-11-12 JP JP2012539007A patent/JP5876416B2/ja active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| CL2012001258A1 (es) | 2012-09-14 |
| US20120289468A1 (en) | 2012-11-15 |
| US8759293B2 (en) | 2014-06-24 |
| ES2600879T3 (es) | 2017-02-13 |
| NZ600278A (en) | 2014-04-30 |
| IL219679A0 (en) | 2012-07-31 |
| KR101808751B1 (ko) | 2017-12-13 |
| AU2010319425B2 (en) | 2015-07-02 |
| WO2011060242A3 (en) | 2011-10-13 |
| AU2010319425A1 (en) | 2012-06-14 |
| JP5876416B2 (ja) | 2016-03-02 |
| RU2012122402A (ru) | 2013-12-20 |
| JP2013510581A (ja) | 2013-03-28 |
| CN102648212B (zh) | 2014-12-03 |
| PT2499165T (pt) | 2016-10-28 |
| CA2780542C (en) | 2020-03-24 |
| IL219679A (en) | 2016-11-30 |
| RU2579977C2 (ru) | 2016-04-10 |
| HUE029454T2 (en) | 2017-03-28 |
| EP2499165A2 (en) | 2012-09-19 |
| CA2780542A1 (en) | 2011-05-19 |
| EP2499165A4 (en) | 2013-09-11 |
| EP2499165B1 (en) | 2016-09-14 |
| MX2012005527A (es) | 2012-08-08 |
| HK1170244A1 (zh) | 2013-02-22 |
| BR112012011740A2 (pt) | 2018-03-27 |
| CN102648212A (zh) | 2012-08-22 |
| WO2011060242A2 (en) | 2011-05-19 |
| KR20120113214A (ko) | 2012-10-12 |
| ZA201203795B (en) | 2014-10-29 |
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