MX2020012397A - Metodos de tratamiento de la hemofilia a. - Google Patents

Metodos de tratamiento de la hemofilia a.

Info

Publication number
MX2020012397A
MX2020012397A MX2020012397A MX2020012397A MX2020012397A MX 2020012397 A MX2020012397 A MX 2020012397A MX 2020012397 A MX2020012397 A MX 2020012397A MX 2020012397 A MX2020012397 A MX 2020012397A MX 2020012397 A MX2020012397 A MX 2020012397A
Authority
MX
Mexico
Prior art keywords
vwf
treating hemophilia
methods
domain
subject
Prior art date
Application number
MX2020012397A
Other languages
English (en)
Inventor
Dan Rudin
Alison Innes
Suresh Katragadda
Kara Rice
Chhabra Ekta Seth
Nancy Wong
Original Assignee
Bioverativ Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioverativ Therapeutics Inc filed Critical Bioverativ Therapeutics Inc
Publication of MX2020012397A publication Critical patent/MX2020012397A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente descripción proporciona un método de tratamiento de la hemofilia A en un sujeto humano que lo necesite, que comprende administrar al sujeto un polipéptido quimérico que comprende (i) una proteína del factor VIII (FVIII) y (ii) un fragmento del factor de von Willebrand (VWF) que comprende un dominio D' del VWF y un dominio D3 del VWF en un intervalo de dosificación.
MX2020012397A 2018-05-18 2019-05-17 Metodos de tratamiento de la hemofilia a. MX2020012397A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862673670P 2018-05-18 2018-05-18
US201862712880P 2018-07-31 2018-07-31
US201862773785P 2018-11-30 2018-11-30
US201962801576P 2019-02-05 2019-02-05
PCT/US2019/032956 WO2019222682A1 (en) 2018-05-18 2019-05-17 Methods of treating hemophilia a

Publications (1)

Publication Number Publication Date
MX2020012397A true MX2020012397A (es) 2021-04-12

Family

ID=67002363

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020012397A MX2020012397A (es) 2018-05-18 2019-05-17 Metodos de tratamiento de la hemofilia a.

Country Status (13)

Country Link
EP (1) EP3793588A1 (es)
JP (2) JP2021523878A (es)
KR (1) KR20210020030A (es)
CN (1) CN112512555A (es)
AU (1) AU2019270184A1 (es)
BR (1) BR112020022164A2 (es)
CA (1) CA3099049A1 (es)
CO (1) CO2020014566A2 (es)
MA (1) MA52630A (es)
MX (1) MX2020012397A (es)
SG (1) SG11202010767SA (es)
TW (1) TW202015723A (es)
WO (1) WO2019222682A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021257899A1 (en) * 2020-06-19 2021-12-23 Bioverativ Therapeutics Inc. Methods for treating hemophilia a and population pharmacokinetics tools for determining treatments and uses thereof
EP4358938A1 (en) * 2021-06-23 2024-05-01 Bioverativ Therapeutics Inc. Formulations of factor viii chimeric proteins and uses thereof
TW202334244A (zh) * 2021-10-15 2023-09-01 美商百歐維拉提夫治療公司 因子ｖｉｉｉ嵌合蛋白的配製品及其用途
WO2023172893A2 (en) * 2022-03-08 2023-09-14 Bioverativ Therapeutics Inc. Methods of treating hemophilia a

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BR112017002781A2 (pt) 2014-08-13 2017-12-19 Sabatino Denise cassete de expressão aprimorado para acondicionamento e expressão de variantes do fator viii para o tratamento de distúrbios de hemostasia
WO2016142288A1 (en) 2015-03-06 2016-09-15 Csl Behring Recombinant Facility Ag Modified von willebrand factor having improved half-life
SG11201708755WA (en) 2015-05-22 2017-12-28 Csl Behring Recombinant Facility Ag Truncated von willebrand factor polypeptides for treating hemophilia
CN108779165B (zh) 2016-01-07 2022-12-02 康诺贝林伦瑙有限公司 突变的冯·维勒布兰德因子
AU2017204955B2 (en) 2016-01-07 2021-04-01 CSL Behring Lengnau AG Mutated truncated von Willebrand Factor
EP3476937A4 (en) 2016-06-24 2019-12-04 Mogam Institute for Biomedical Research CHIMERIC PROTEIN WITH FVIII AND VWF FACTORS AND USE THEREOF
KR20190073576A (ko) 2016-11-11 2019-06-26 체에스엘 베링 렝나우 아게 혈액 응고 장애의 치료 또는 예방에서 혈관외 투여를 위한 절단된 폰 빌레브란트 인자 폴리펩타이드
CN110520149A (zh) 2016-12-02 2019-11-29 比奥维拉迪维治疗股份有限公司 诱导对凝血因子的免疫耐受性的方法

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AU2019270184A1 (en) 2020-11-26
CA3099049A1 (en) 2019-11-21
SG11202010767SA (en) 2020-11-27
US20190375822A1 (en) 2019-12-12
BR112020022164A2 (pt) 2021-02-02
TW202015723A (zh) 2020-05-01
CO2020014566A2 (es) 2020-12-10
JP2023101713A (ja) 2023-07-21
CN112512555A (zh) 2021-03-16
WO2019222682A1 (en) 2019-11-21
JP2021523878A (ja) 2021-09-09
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