DE69839529D1 - Expressionsvektoren und zellinien zur expression von vaskulärem wachstumsfaktor d, sowie verfahren zur behandlung von melanomen - Google Patents
Expressionsvektoren und zellinien zur expression von vaskulärem wachstumsfaktor d, sowie verfahren zur behandlung von melanomenInfo
- Publication number
- DE69839529D1 DE69839529D1 DE69839529T DE69839529T DE69839529D1 DE 69839529 D1 DE69839529 D1 DE 69839529D1 DE 69839529 T DE69839529 T DE 69839529T DE 69839529 T DE69839529 T DE 69839529T DE 69839529 D1 DE69839529 D1 DE 69839529D1
- Authority
- DE
- Germany
- Prior art keywords
- growth factor
- cell lines
- expression vectors
- vascular growth
- treating melanoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013604 expression vector Substances 0.000 title 1
- 239000003102 growth factor Substances 0.000 title 1
- 201000001441 melanoma Diseases 0.000 title 1
- 230000006444 vascular growth Effects 0.000 title 1
- 102000009519 Vascular Endothelial Growth Factor D Human genes 0.000 abstract 1
- 108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 230000035168 lymphangiogenesis Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPP1131A AUPP113197A0 (en) | 1997-12-24 | 1997-12-24 | Growth factor |
US8739298P | 1998-05-29 | 1998-05-29 | |
PCT/US1998/027373 WO1999033485A1 (en) | 1997-12-24 | 1998-12-23 | Expression vectors and cell lines expressing vascular endothelial growth factor d, and method of treating melanomas |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69839529D1 true DE69839529D1 (de) | 2008-07-03 |
Family
ID=25645688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69839529T Expired - Lifetime DE69839529D1 (de) | 1997-12-24 | 1998-12-23 | Expressionsvektoren und zellinien zur expression von vaskulärem wachstumsfaktor d, sowie verfahren zur behandlung von melanomen |
Country Status (10)
Country | Link |
---|---|
US (4) | US7947472B2 (de) |
EP (1) | EP1054687B8 (de) |
JP (2) | JP2003517265A (de) |
KR (1) | KR100628697B1 (de) |
CN (1) | CN1345247A (de) |
AT (1) | ATE395928T1 (de) |
CA (1) | CA2315977A1 (de) |
DE (1) | DE69839529D1 (de) |
NZ (1) | NZ505011A (de) |
WO (1) | WO1999033485A1 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6824777B1 (en) | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
EP0956339B1 (de) | 1996-08-23 | 2005-10-12 | Ludwig Institute For Cancer Research | Rekombinanter vaskulärer endothelzellen wachstumsfaktor d (vegf-d) |
US7125714B2 (en) | 1997-02-05 | 2006-10-24 | Licentia Ltd. | Progenitor cell materials and methods |
EP1054687B8 (de) | 1997-12-24 | 2008-07-16 | Vegenics Limited | Expressionsvektoren und zellinien zur expression von vaskulärem wachstumsfaktor d, sowie verfahren zur behandlung von melanomen |
DE69942981D1 (de) | 1998-10-09 | 2011-01-05 | Vegenics Ltd | Flt4 (vegfr-3) als ziel für tumornachweis (imaging) und antitumortherapie |
DK1140175T3 (da) * | 1998-12-21 | 2006-08-14 | Ludwig Inst Cancer Res | Antistoffer mod trunkeret VEGF-D og anvendelser deraf |
WO2001051075A1 (en) * | 2000-01-11 | 2001-07-19 | Epstein Stephen E | Enhancing lymph channel development and treatment of lymphatic obstructive disease |
JP4981229B2 (ja) * | 2000-02-25 | 2012-07-18 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | ハイブリッド血管内皮成長因子DNAsおよびタンパク質に関与する物質および方法 |
US20020102260A1 (en) * | 2000-03-02 | 2002-08-01 | Marc Achen | Methods for treating neoplastic disease characterized by vascular endothelial growth factor D expression, for screening for neoplastic disease or metastatic risk, and for maintaining vascularization of tissue |
EP1519193B1 (de) * | 2000-03-02 | 2011-11-09 | Vegenics Pty Ltd | Verfahren zum Auffinden von Tumoren welche den vaskulären endothelialen Wachstumsfaktor D exprimieren |
ES2234818T3 (es) * | 2000-03-02 | 2005-07-01 | Ludwig Institute For Cancer Research | Procedimiento para tratar canceres que expresan el factor de crecimiento endotelial d. |
AU2006201128B2 (en) * | 2000-03-02 | 2009-05-28 | Vegenics Limited | Methods for treating, screening for, and detecting cancers expressing vascular endothelial growth factor D |
AU6456501A (en) * | 2000-05-03 | 2001-11-12 | Ludwig Inst Cancer Res | A method for activating only the vascular endothelial growth factor receptor-3 and uses thereof |
WO2002029087A2 (en) * | 2000-10-02 | 2002-04-11 | St. Elizabeth's Medical Center Of Boston, Inc. | Use of lymphangiogenic agents to treat lymphatic disorders |
US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
US7026462B2 (en) | 2000-12-07 | 2006-04-11 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
US7611711B2 (en) | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
CN1494552A (zh) * | 2001-01-19 | 2004-05-05 | ·��ά��֢�о�Ժ | Flt4(VEGFR-3)作为靶用于肿瘤成像和抗肿瘤治疗 |
AR027161A1 (es) * | 2001-05-15 | 2003-03-19 | Bio Sidus S A | Metodo para inducir la proliferacion neovascular y regeneracion tisular |
AU2002322461B2 (en) * | 2001-07-12 | 2007-12-06 | Vegenics Limited | Lymphatic endothelial cells materials and methods |
US20030113324A1 (en) * | 2001-10-01 | 2003-06-19 | Kari Alitalo | Neuropilin/VEGF-C/VEGFR-3 materials and methods |
US20040214766A1 (en) * | 2001-10-01 | 2004-10-28 | Kari Alitalo | VEGF-C or VEGF-D materials and methods for treatment of neuropathologies |
AUPS051002A0 (en) * | 2002-02-14 | 2002-03-07 | Riancorp Pty Ltd | Low level laser therapy method and means |
ITRM20020119A1 (it) * | 2002-03-05 | 2003-09-05 | Geymonat Spa | Composizioni contenenti plgf ad uso farmaceutico e cosmetico. |
US20030228283A1 (en) * | 2002-05-03 | 2003-12-11 | Ludwig Institute For Cancer Research | Preventing secondary lymphedema with VEGF-D DNA |
CN1327000C (zh) * | 2002-09-06 | 2007-07-18 | 中国人民解放军军事医学科学院基础医学研究所 | 靶向黑色素瘤的可复制性腺病毒穿梭载体及腺病毒 |
CN101928344B (zh) | 2002-10-17 | 2014-08-13 | 根马布股份公司 | 抗cd20的人单克隆抗体 |
US20040248796A1 (en) * | 2003-02-04 | 2004-12-09 | Kari Alitalo | VEGF-B and PDGF modulation of stem cells |
WO2005016963A2 (en) * | 2003-06-12 | 2005-02-24 | Ludwig Institute For Cancer Research | Heparin binding veger-3 ligands |
US20050043235A1 (en) * | 2003-06-12 | 2005-02-24 | Kari Alitalo | Use of VEGF-C or VEGF-D in reconstructive surgery |
JP5848861B2 (ja) | 2004-04-20 | 2016-01-27 | ジェンマブ エー/エスGenmab A/S | Cd20に対するヒトモノクローナル抗体 |
EP2314614B1 (de) | 2005-02-28 | 2015-11-25 | Sangamo BioSciences, Inc. | Anti-angiogene Verfahren und Zusammensetzungen |
EP1919944B1 (de) * | 2005-08-15 | 2011-03-23 | Vegenics Pty Ltd | Modifizierte vegf und pdgf mit verbesserten angiogenen eigenschaften |
WO2008096268A2 (en) * | 2007-02-07 | 2008-08-14 | Vegenics Limited | Autologous lymph node transfer in combination with vegf-c or vegf-d growth factor therapy to treat secondary lymphedema and to improve reconstructive surgery |
US20110305703A1 (en) * | 2008-12-08 | 2011-12-15 | Vegenics Pty Limited | Isolated vegf-c and vegf-d peptides and uses thereof |
WO2012088563A1 (en) * | 2010-11-24 | 2012-07-05 | Vegenics Pty Limited | Vegfr-2-specific forms of vegf-d and vegf-c and uses thereof |
RS60026B1 (sr) | 2013-02-18 | 2020-04-30 | Vegenics Pty Ltd | Molekuli koji vezuju ligande i njihove upotrebe |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4851341A (en) * | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
US5179426A (en) * | 1987-08-04 | 1993-01-12 | Seiko Epson Corporation | Josephson device |
US5179007A (en) * | 1989-07-07 | 1993-01-12 | The Texas A & M University System | Method and vector for the purification of foreign proteins |
US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
US6107046A (en) | 1992-10-09 | 2000-08-22 | Orion Corporation | Antibodies to Flt4, a receptor tyrosine kinase and uses thereof |
US6824777B1 (en) | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
AU696764B2 (en) * | 1994-03-08 | 1998-09-17 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
AU7142996A (en) * | 1995-09-29 | 1997-04-28 | Universita' Degli Studi Di Siena | Regulated genes and uses thereof |
US5792850A (en) * | 1996-05-23 | 1998-08-11 | Zymogenetics, Inc. | Hematopoietic cytokine receptor |
EP0935001B2 (de) | 1996-07-15 | 2011-08-10 | Chugai Seiyaku Kabushiki Kaisha | Neuartige vegf-ähnliche faktoren |
EP0956339B1 (de) * | 1996-08-23 | 2005-10-12 | Ludwig Institute For Cancer Research | Rekombinanter vaskulärer endothelzellen wachstumsfaktor d (vegf-d) |
AU5439998A (en) | 1996-12-06 | 1998-06-29 | Zymogenetics Inc. | Vascular endothelial growth factor |
EP1054687B8 (de) | 1997-12-24 | 2008-07-16 | Vegenics Limited | Expressionsvektoren und zellinien zur expression von vaskulärem wachstumsfaktor d, sowie verfahren zur behandlung von melanomen |
US20050043235A1 (en) * | 2003-06-12 | 2005-02-24 | Kari Alitalo | Use of VEGF-C or VEGF-D in reconstructive surgery |
US6889580B1 (en) | 2004-04-19 | 2005-05-10 | A.A.G. Industrial Co., Ltd. | Socket for adapting itself to open ends of wrenches of different sizes |
-
1998
- 1998-12-23 EP EP98966053A patent/EP1054687B8/de not_active Expired - Lifetime
- 1998-12-23 US US09/219,345 patent/US7947472B2/en not_active Expired - Fee Related
- 1998-12-23 WO PCT/US1998/027373 patent/WO1999033485A1/en active IP Right Grant
- 1998-12-23 CN CN98812705A patent/CN1345247A/zh active Pending
- 1998-12-23 KR KR1020007007045A patent/KR100628697B1/ko not_active IP Right Cessation
- 1998-12-23 DE DE69839529T patent/DE69839529D1/de not_active Expired - Lifetime
- 1998-12-23 CA CA002315977A patent/CA2315977A1/en not_active Abandoned
- 1998-12-23 AT AT98966053T patent/ATE395928T1/de not_active IP Right Cessation
- 1998-12-23 JP JP2000526237A patent/JP2003517265A/ja active Pending
- 1998-12-23 NZ NZ505011A patent/NZ505011A/xx unknown
-
2009
- 2009-02-27 JP JP2009046292A patent/JP2009159972A/ja active Pending
- 2009-10-12 US US12/577,496 patent/US20110059890A1/en not_active Abandoned
-
2010
- 2010-11-05 US US12/940,615 patent/US20110269146A1/en not_active Abandoned
-
2012
- 2012-04-17 US US13/449,163 patent/US8461109B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20110269146A1 (en) | 2011-11-03 |
WO1999033485A1 (en) | 1999-07-08 |
KR20010033537A (ko) | 2001-04-25 |
EP1054687B1 (de) | 2008-05-21 |
JP2003517265A (ja) | 2003-05-27 |
ATE395928T1 (de) | 2008-06-15 |
KR100628697B1 (ko) | 2006-09-28 |
US20120270781A1 (en) | 2012-10-25 |
US20110059890A1 (en) | 2011-03-10 |
US20020127222A1 (en) | 2002-09-12 |
EP1054687B8 (de) | 2008-07-16 |
EP1054687A1 (de) | 2000-11-29 |
NZ505011A (en) | 2004-12-24 |
EP1054687A4 (de) | 2004-06-09 |
CN1345247A (zh) | 2002-04-17 |
US7947472B2 (en) | 2011-05-24 |
CA2315977A1 (en) | 1999-07-08 |
JP2009159972A (ja) | 2009-07-23 |
US8461109B2 (en) | 2013-06-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: VEGENICS LTD., TOORAK, VICTORIA, AU |
|
8364 | No opposition during term of opposition |