DE69827001D1 - Gewebedezellularization - Google Patents

Gewebedezellularization

Info

Publication number
DE69827001D1
DE69827001D1 DE1998627001 DE69827001T DE69827001D1 DE 69827001 D1 DE69827001 D1 DE 69827001D1 DE 1998627001 DE1998627001 DE 1998627001 DE 69827001 T DE69827001 T DE 69827001T DE 69827001 D1 DE69827001 D1 DE 69827001D1
Authority
DE
Germany
Prior art keywords
gewebedezellularization
acellular
mineralization
immunoreactivity
ligaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE1998627001
Other languages
English (en)
Other versions
DE69827001T2 (de
Inventor
Steven Goldstein
S Black
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Artivion Inc
Original Assignee
Cryolife Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cryolife Inc filed Critical Cryolife Inc
Publication of DE69827001D1 publication Critical patent/DE69827001D1/de
Application granted granted Critical
Publication of DE69827001T2 publication Critical patent/DE69827001T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3695—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2415—Manufacturing methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/02—Treatment of implants to prevent calcification or mineralisation in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material
    • Y10S623/916—Blood vessel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material
    • Y10S623/918—Heart
DE69827001T 1997-04-11 1998-04-10 Gewebedezellularization Expired - Lifetime DE69827001T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83885297A 1997-04-11 1997-04-11
US838852 1997-04-11
PCT/US1998/007072 WO1998046165A1 (en) 1997-04-11 1998-04-10 Tissue decellularization

Publications (2)

Publication Number Publication Date
DE69827001D1 true DE69827001D1 (de) 2004-11-18
DE69827001T2 DE69827001T2 (de) 2005-09-08

Family

ID=25278218

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69827001T Expired - Lifetime DE69827001T2 (de) 1997-04-11 1998-04-10 Gewebedezellularization

Country Status (11)

Country Link
US (2) US20010000804A1 (de)
EP (1) EP0987998B1 (de)
JP (1) JP2001520542A (de)
AT (1) ATE279163T1 (de)
AU (1) AU746318B2 (de)
CA (1) CA2286655C (de)
DE (1) DE69827001T2 (de)
DK (1) DK0987998T3 (de)
ES (1) ES2231980T3 (de)
PT (1) PT987998E (de)
WO (1) WO1998046165A1 (de)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999022781A2 (en) 1997-10-31 1999-05-14 Children's Medical Center Corporation Bladder reconstruction
US6630001B2 (en) * 1998-06-24 2003-10-07 International Heart Institute Of Montana Foundation Compliant dehyrated tissue for implantation and process of making the same
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US6214054B1 (en) * 1998-09-21 2001-04-10 Edwards Lifesciences Corporation Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6479064B1 (en) * 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
US6866686B2 (en) * 2000-01-28 2005-03-15 Cryolife, Inc. Tissue graft
DE10010074B4 (de) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
DE10010073B4 (de) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerung für implantierbare Herzklappenprothesen
EP1278559B1 (de) * 2000-04-28 2008-03-26 Baylor College Of Medicine Dezellularisierte gefässprothesen
AU2001284968B2 (en) * 2000-08-16 2006-12-21 Duke University Decellularized tissue engineered constructs and tissues
FR2828263B1 (fr) 2001-08-03 2007-05-11 Philipp Bonhoeffer Dispositif d'implantation d'un implant et procede d'implantation du dispositif
US6878168B2 (en) 2002-01-03 2005-04-12 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
US8308797B2 (en) 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
US7402319B2 (en) 2002-09-27 2008-07-22 Board Of Regents, The University Of Texas System Cell-free tissue replacement for tissue engineering
US7129035B2 (en) * 2002-12-11 2006-10-31 Cryolife, Inc. Method of preserving tissue
US20040176855A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
JP2007526017A (ja) 2003-06-25 2007-09-13 エイセル インコーポレイテッド 組織修復用に調整されたマトリクス組成物
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
AU2006227711A1 (en) * 2005-03-16 2006-09-28 Musculoskeletal Transplant Foundation Soft tissue processing
US20100112543A1 (en) * 2005-03-16 2010-05-06 Manh-Dan Ngo Processing soft tissue, methods and compositions related thereto
JP2009505752A (ja) 2005-08-26 2009-02-12 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 臓器および組織の脱細胞化および再細胞化
DE102005051849B4 (de) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Vorrichtung zur Implantation und Befestigung von Herzklappenprothesen
DE102005052628B4 (de) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US20070162119A1 (en) * 2006-01-07 2007-07-12 Medical College Of Georgia Research Institute, Inc. Tympanic membrane prosthesis and a tool for manufacturing the prosthesis
EP2077718B2 (de) * 2006-10-27 2022-03-09 Edwards Lifesciences Corporation Biologisches gewebe für chirurgische implantation
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
JP5220101B2 (ja) 2007-05-15 2013-06-26 イエナバルブ テクノロジー インク 自己拡張型の心臓弁ステントを挿入するためにカテーテル先端、カテーテルシステムおよび医療挿入システムを操作するためのハンドル
AU2008260187A1 (en) 2007-05-29 2008-12-11 Christopher B. Reid Methods for production and uses of multipotent cell populations
CA2688265C (en) 2007-06-08 2021-02-16 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
US9101691B2 (en) * 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
US8465540B2 (en) 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
BR112012021347A2 (pt) 2008-02-26 2019-09-24 Jenavalve Tecnology Inc stent para posicionamento e ancoragem de uma prótese valvular em um local de implantação no coração de um paciente
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
US9168130B2 (en) 2008-02-26 2015-10-27 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8317858B2 (en) 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8398704B2 (en) 2008-02-26 2013-03-19 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9044305B2 (en) * 2008-04-03 2015-06-02 Cook Medical Technologies Llc Self cleaning devices, systems and methods of use
EP2113261B1 (de) 2008-04-29 2013-11-06 Proxy Biomedical Limited Gewebereparaturimplantat
WO2010033860A1 (en) * 2008-09-18 2010-03-25 The Curators Of The University Of Missouri Bionanocomposite for tissue regeneration and soft tissue repair
WO2010057013A1 (en) 2008-11-14 2010-05-20 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
WO2010057015A1 (en) 2008-11-14 2010-05-20 Wake Forest University Health Sciences Kidney structures and methods of forming the same
US9150318B1 (en) 2009-01-02 2015-10-06 Lifecell Corporation Method for sterilizing an acellular tissue matrix
WO2010105021A2 (en) * 2009-03-11 2010-09-16 Cryolife, Inc. Bioburden-reducing antibiotic composition and method of use
US20100292779A1 (en) 2009-05-15 2010-11-18 Helmut Straubinger Device for compressing a stent and a system as well as a method for loading a stent into a medical delivery system
US8652500B2 (en) 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
FR2951549B1 (fr) 2009-10-15 2013-08-23 Olivier Schussler Procede d'obtention de bioprotheses medicales implantables
EP2538988B1 (de) 2010-02-26 2019-01-30 DeCell Technologies Inc. Verfahren zur gewebe-entzellularisierung
WO2011109450A2 (en) 2010-03-01 2011-09-09 Colibri Heart Valve Llc Percutaneously deliverable heart valve and methods associated therewith
CN102811681B (zh) 2010-03-23 2016-10-12 爱德华兹生命科学公司 调节片状生物假体组织的方法
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
US11278406B2 (en) 2010-05-20 2022-03-22 Jenavalve Technology, Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
AU2011257298B2 (en) 2010-05-25 2014-07-31 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US8906601B2 (en) 2010-06-17 2014-12-09 Edwardss Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
CA2806544C (en) 2010-06-28 2016-08-23 Colibri Heart Valve Llc Method and apparatus for the endoluminal delivery of intravascular devices
US8377143B2 (en) 2010-07-06 2013-02-19 Cryolife, Inc. Tissue implants for implantation and methods for preparing the same
US8475827B2 (en) 2010-07-06 2013-07-02 Cryolife, Inc. Tissue implants for implantation and methods for preparing the same
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
ES2562707T3 (es) 2010-09-01 2016-03-07 Regents Of The University Of Minnesota Métodos de recelularización de un tejido u órgano para una mejor capacidad de trasplante
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
SG10201601962WA (en) 2010-12-14 2016-04-28 Colibri Heart Valve Llc Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
CA2835862A1 (en) * 2011-05-27 2012-12-06 Cormatrix Cardiovascular, Inc. Extracellular matrix material valve conduit and methods of making thereof
CA2852369A1 (en) 2011-10-21 2013-04-25 Jenavalve Technology Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
CN102350008A (zh) 2011-10-25 2012-02-15 微创医疗器械(上海)有限公司 一种处理动物源性胶原纤维材料的方法
EP2811939B8 (de) * 2012-02-10 2017-11-15 CVDevices, LLC Produkt aus biologischem gewebe für stents und herstellungsverfahren
US9670457B2 (en) 2012-05-08 2017-06-06 Stem Cell Reserve Lp Stem cells and matrix from cord tissue
WO2013171007A1 (en) 2012-05-16 2013-11-21 Jenavalve Technology Gmbh Catheter delivery system for introducing an expandable heart valve prosthesis and medical device for the treatment of a heart valve defect
GB201215725D0 (en) * 2012-09-04 2012-10-17 Univ Leeds Composite connective tissue and bone implants
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
EP2953580A2 (de) 2013-02-11 2015-12-16 Cook Medical Technologies LLC Expandierbarer stützrahmen und medizinische vorrichtung
KR102577616B1 (ko) 2013-03-15 2023-09-11 미로매트릭스 메디칼 인크. 섬 세포 재세포화를 위한 관류 탈세포화된 간의 용도
US9795638B1 (en) * 2013-03-16 2017-10-24 BioDlogics, LLC Cardiothoracic construct and methods of use
EP4098226A1 (de) 2013-08-30 2022-12-07 JenaValve Technology, Inc. Endoprothese mit einem radial zusammenklappbaren rahmen und einer klappenprothese
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
US10959839B2 (en) 2013-10-08 2021-03-30 Edwards Lifesciences Corporation Method for directing cellular migration patterns on a biological tissue
AU2014341866B2 (en) 2013-11-04 2018-07-05 Lifecell Corporation Methods of removing alpha-galactose
WO2015134618A1 (en) 2014-03-04 2015-09-11 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Method and apparatus for decellularization of tissue
EP3288495B1 (de) 2015-05-01 2019-09-25 JenaValve Technology, Inc. Vorrichtung mit reduzierter herzschrittmacherrate bei herzklappenersatz
EP3454795B1 (de) 2016-05-13 2023-01-11 JenaValve Technology, Inc. Herzklappenprotheseneinführungssystem zur einführung einer herzklappenprothese mit einführerhülse und ladesystem
US11278643B2 (en) 2016-09-06 2022-03-22 Mayo Foundation For Medical Education And Research Use of resected liver serum for whole liver-engineering
WO2018102826A1 (en) * 2016-12-02 2018-06-07 Vascudyne, Llc Engineered tissue prosthesis
WO2018138658A1 (en) 2017-01-27 2018-08-02 Jenavalve Technology, Inc. Heart valve mimicry
WO2019051476A1 (en) 2017-09-11 2019-03-14 Incubar, LLC SEALING DEVICE FOR USE AS A VASCULAR DUCT IMPLANT FOR REDUCING ENDOFUCTION
CN109260517B (zh) * 2018-09-19 2020-10-30 杭州启明医疗器械股份有限公司 一种可预装干燥生物心脏瓣膜及其制备方法
EP3852683A1 (de) 2018-11-01 2021-07-28 Edwards Lifesciences Corporation Pulmonales regeneratives transkatheterventil

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8618374D0 (en) * 1986-07-28 1986-09-03 Hsc Res Dev Corp Biological vascular prostheses
KR100365573B1 (ko) * 1994-03-14 2004-08-25 크라이어라이프, 인크. 이식용처리조직및이의제조방법
US5595571A (en) * 1994-04-18 1997-01-21 Hancock Jaffe Laboratories Biological material pre-fixation treatment
WO1996032905A1 (en) * 1995-04-19 1996-10-24 St. Jude Medical, Inc. Matrix substrate for a viable body tissue-derived prosthesis and method for making the same

Also Published As

Publication number Publication date
EP0987998A4 (de) 2002-05-22
CA2286655A1 (en) 1998-10-22
ATE279163T1 (de) 2004-10-15
AU746318B2 (en) 2002-04-18
ES2231980T3 (es) 2005-05-16
US20030228692A1 (en) 2003-12-11
DK0987998T3 (da) 2005-01-17
JP2001520542A (ja) 2001-10-30
US20010000804A1 (en) 2001-05-03
EP0987998B1 (de) 2004-10-13
CA2286655C (en) 2009-02-24
PT987998E (pt) 2005-02-28
WO1998046165A1 (en) 1998-10-22
US7318998B2 (en) 2008-01-15
DE69827001T2 (de) 2005-09-08
EP0987998A1 (de) 2000-03-29
AU7105898A (en) 1998-11-11

Similar Documents

Publication Publication Date Title
DE69827001D1 (de) Gewebedezellularization
IS1724B (is) Aðferð við meðhöndlun á ígræðlingi úr málmi fyrirskurðaðgerð
DE60137430D1 (de) Gewebeimplant zur wiederherstellung von knorpelgewebe
ES8506455A1 (es) Un metodo de inhibicion de la mineralizacion del tejido natural
ES8600062A1 (es) Un metodo para inhibir la mineralizacion de un tejido natural
TR199902033T2 (xx) Diyabet i�in s�lfonilura-glitazon sinerjik kombinasyonlar�.
EE9700225A (et) Meetod diabetes mellituse raviks, kasutades KKF
ATE539701T1 (de) Zusammengesetzte schlinge zur behandlung von inkontinenz
ATE279181T1 (de) Verwendung von 5ht-6 antagonisten zur behandlung adhd
ATE222488T1 (de) Verwendung von anti-vegf-mitteln zur behandlung der endometriose
FI962350A (fi) BPM-12, BMP-13 sekä niiden jännettä indusoivat koostumukset
ATE395928T1 (de) Expressionsvektoren und zellinien zur expression von vaskulärem wachstumsfaktor d, sowie verfahren zur behandlung von melanomen
TR199701669A1 (xx) Deri preparasyonu i�in bile�imler.
DE3788231T2 (de) Kosmetisches mittel und zusammensetzung zur behandlung der haut.
PT1109571E (pt) Metodos de tratamento da hipertensao e composicoes para utilizacao nesses metodos
ATE226058T1 (de) Verwendung von lysin zur behandlung des haarausfalls
ATE234614T1 (de) Verwendung von selegilin zur behandlung von gehörverlust bei säugetieren
ATE251462T1 (de) Verfahren zur behandlung von narbengewebe
ATE306278T1 (de) Behandlung von knochenleiden mit adrenomedullin
EA199900006A1 (ru) Препарат и способ для лечения застоной сердечной недостаточности
DE59805246D1 (de) Tissue-faktor zur beeinflussung von gefässbildung
MX9504896A (es) Pericardio bovino tratado con glutaraldehido, como bioprotesis de pared toracoabdominal, tejido pulmonar y bronquial.
UA34378A (uk) Спосіб лікування перелому надколінника

Legal Events

Date Code Title Description
8364 No opposition during term of opposition