DE69523074D1 - Verfahren zur behandlung von implantierbaren biologischen geweben zur verringerung von verkalkung - Google Patents
Verfahren zur behandlung von implantierbaren biologischen geweben zur verringerung von verkalkungInfo
- Publication number
- DE69523074D1 DE69523074D1 DE69523074T DE69523074T DE69523074D1 DE 69523074 D1 DE69523074 D1 DE 69523074D1 DE 69523074 T DE69523074 T DE 69523074T DE 69523074 T DE69523074 T DE 69523074T DE 69523074 D1 DE69523074 D1 DE 69523074D1
- Authority
- DE
- Germany
- Prior art keywords
- biological tissues
- implantable biological
- reduce calcification
- treating implantable
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/02—Treatment of implants to prevent calcification or mineralisation in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/915—Method or apparatus for preparing biological material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28235894A | 1994-07-29 | 1994-07-29 | |
PCT/US1995/010001 WO1996004028A1 (en) | 1994-07-29 | 1995-07-25 | Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69523074D1 true DE69523074D1 (de) | 2001-11-08 |
DE69523074T2 DE69523074T2 (de) | 2002-06-06 |
Family
ID=23081148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69523074T Expired - Lifetime DE69523074T2 (de) | 1994-07-29 | 1995-07-25 | Verfahren zur behandlung von implantierbaren biologischen geweben zur verringerung von verkalkung |
Country Status (6)
Country | Link |
---|---|
US (2) | US6561970B1 (de) |
EP (1) | EP0804255B1 (de) |
JP (1) | JP3797673B2 (de) |
CA (1) | CA2196165C (de) |
DE (1) | DE69523074T2 (de) |
WO (1) | WO1996004028A1 (de) |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE40570E1 (en) | 1994-07-29 | 2008-11-11 | Edwards Lifesciences Corporation | Apparatuses and methods for treating biological tissue to mitigate calcification |
US5931969A (en) * | 1994-07-29 | 1999-08-03 | Baxter International Inc. | Methods and apparatuses for treating biological tissue to mitigate calcification |
EP0804255B1 (de) | 1994-07-29 | 2001-10-04 | Edwards Lifesciences Corporation | Verfahren zur behandlung von implantierbaren biologischen geweben zur verringerung von verkalkung |
US7001328B1 (en) * | 1994-11-15 | 2006-02-21 | Kenton W. Gregory | Method for using tropoelastin and for producing tropoelastin biomaterials |
US5782931A (en) * | 1996-07-30 | 1998-07-21 | Baxter International Inc. | Methods for mitigating calcification and improving durability in glutaraldehyde-fixed bioprostheses and articles manufactured by such methods |
EP1378257B1 (de) * | 1996-08-23 | 2008-05-14 | Cook Biotech, Inc. | Transplantationsprothese auf Kollagenbasis |
US8716227B2 (en) * | 1996-08-23 | 2014-05-06 | Cook Biotech Incorporated | Graft prosthesis, materials and methods |
US6666892B2 (en) * | 1996-08-23 | 2003-12-23 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
US6214054B1 (en) * | 1998-09-21 | 2001-04-10 | Edwards Lifesciences Corporation | Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby |
US8882850B2 (en) * | 1998-12-01 | 2014-11-11 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
US6440164B1 (en) * | 1999-10-21 | 2002-08-27 | Scimed Life Systems, Inc. | Implantable prosthetic valve |
US6602286B1 (en) * | 2000-10-26 | 2003-08-05 | Ernst Peter Strecker | Implantable valve system |
US7377938B2 (en) * | 2001-07-19 | 2008-05-27 | The Cleveland Clinic Foundation | Prosthetic cardiac value and method for making same |
US20030022146A1 (en) * | 2001-07-26 | 2003-01-30 | Cunanan Crystal M. | Oxidized bioprosthetic materials |
US6878168B2 (en) | 2002-01-03 | 2005-04-12 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
US7007698B2 (en) * | 2002-04-03 | 2006-03-07 | Boston Scientific Corporation | Body lumen closure |
US6752828B2 (en) * | 2002-04-03 | 2004-06-22 | Scimed Life Systems, Inc. | Artificial valve |
US8349348B2 (en) * | 2002-08-06 | 2013-01-08 | Matrix Medical, Llc | Biocompatible phase invertible proteinaceous compositions and methods for making and using the same |
US9101536B2 (en) * | 2002-08-06 | 2015-08-11 | Matrix Medical Llc | Biocompatible phase invertable proteinaceous compositions and methods for making and using the same |
EP3915529A1 (de) * | 2002-08-06 | 2021-12-01 | BAXTER INTERNATIONAL INC. (a Delaware corporation) | Biokompatible phasenumkehrbare proteinhaltige zusammensetzungen und verfahren zur herstellung und verwendung davon |
US10098981B2 (en) | 2002-08-06 | 2018-10-16 | Baxter International Inc. | Biocompatible phase invertable proteinaceous compositions and methods for making and using the same |
WO2004037128A1 (en) * | 2002-10-24 | 2004-05-06 | Boston Scientific Limited | Venous valve apparatus and method |
US7189259B2 (en) * | 2002-11-26 | 2007-03-13 | Clemson University | Tissue material and process for bioprosthesis |
US20040153145A1 (en) * | 2002-11-26 | 2004-08-05 | Clemson University | Fixation method for bioprostheses |
US6945957B2 (en) * | 2002-12-30 | 2005-09-20 | Scimed Life Systems, Inc. | Valve treatment catheter and methods |
US7474722B1 (en) * | 2003-03-21 | 2009-01-06 | D2Audio Corporation | Systems and methods for sample rate conversion using multiple rate estimate counters |
US7330999B2 (en) * | 2003-04-23 | 2008-02-12 | Dot Hill Systems Corporation | Network storage appliance with integrated redundant servers and storage controllers |
US7129210B2 (en) * | 2003-07-23 | 2006-10-31 | Covalent Medical, Inc. | Tissue adhesive sealant |
US7854761B2 (en) * | 2003-12-19 | 2010-12-21 | Boston Scientific Scimed, Inc. | Methods for venous valve replacement with a catheter |
US8128681B2 (en) | 2003-12-19 | 2012-03-06 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US7566343B2 (en) | 2004-09-02 | 2009-07-28 | Boston Scientific Scimed, Inc. | Cardiac valve, system, and method |
US20060173490A1 (en) | 2005-02-01 | 2006-08-03 | Boston Scientific Scimed, Inc. | Filter system and method |
US7854755B2 (en) * | 2005-02-01 | 2010-12-21 | Boston Scientific Scimed, Inc. | Vascular catheter, system, and method |
US7878966B2 (en) * | 2005-02-04 | 2011-02-01 | Boston Scientific Scimed, Inc. | Ventricular assist and support device |
US7780722B2 (en) * | 2005-02-07 | 2010-08-24 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US7670368B2 (en) * | 2005-02-07 | 2010-03-02 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US20060195183A1 (en) * | 2005-02-18 | 2006-08-31 | The Cleveland Clinic Foundation | Apparatus and methods for replacing a cardiac valve |
US7867274B2 (en) * | 2005-02-23 | 2011-01-11 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
US7579381B2 (en) * | 2005-03-25 | 2009-08-25 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
US7722666B2 (en) | 2005-04-15 | 2010-05-25 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
WO2006113906A1 (en) * | 2005-04-20 | 2006-10-26 | The Cleveland Clinic Foundation | Apparatus and method for replacing a cardiac valve |
US8012198B2 (en) | 2005-06-10 | 2011-09-06 | Boston Scientific Scimed, Inc. | Venous valve, system, and method |
US7569071B2 (en) * | 2005-09-21 | 2009-08-04 | Boston Scientific Scimed, Inc. | Venous valve, system, and method with sinus pocket |
US7658706B2 (en) * | 2005-12-05 | 2010-02-09 | Rti Biologics, Inc. | Vascular graft sterilization and decellularization |
US7799038B2 (en) * | 2006-01-20 | 2010-09-21 | Boston Scientific Scimed, Inc. | Translumenal apparatus, system, and method |
WO2008002767A1 (en) * | 2006-06-29 | 2008-01-03 | Mayo Foundation For Medical Education And Research | Genetically modified heart valve xenografts |
CN103933612B (zh) * | 2006-10-27 | 2016-06-22 | 爱德华兹生命科学公司 | 用于外科植入的生物组织 |
US8142805B1 (en) | 2006-11-06 | 2012-03-27 | Clemson University Research Foundation | Implantable devices including fixed tissues |
WO2008091493A1 (en) | 2007-01-08 | 2008-07-31 | California Institute Of Technology | In-situ formation of a valve |
WO2008089365A2 (en) * | 2007-01-19 | 2008-07-24 | The Cleveland Clinic Foundation | Method for implanting a cardiovascular valve |
US7967853B2 (en) | 2007-02-05 | 2011-06-28 | Boston Scientific Scimed, Inc. | Percutaneous valve, system and method |
EP2117468A1 (de) * | 2007-02-05 | 2009-11-18 | Boston Scientific Limited | Systeme und verfahren zur herzklappenfreisetzung |
US9101691B2 (en) | 2007-06-11 | 2015-08-11 | Edwards Lifesciences Corporation | Methods for pre-stressing and capping bioprosthetic tissue |
WO2008154532A1 (en) * | 2007-06-11 | 2008-12-18 | California Pacific Medical Center | Method and kit for dynamic gene expression monitoring |
US8828079B2 (en) * | 2007-07-26 | 2014-09-09 | Boston Scientific Scimed, Inc. | Circulatory valve, system and method |
US7892276B2 (en) | 2007-12-21 | 2011-02-22 | Boston Scientific Scimed, Inc. | Valve with delayed leaflet deployment |
US8357387B2 (en) | 2007-12-21 | 2013-01-22 | Edwards Lifesciences Corporation | Capping bioprosthetic tissue to reduce calcification |
US20090171456A1 (en) * | 2007-12-28 | 2009-07-02 | Kveen Graig L | Percutaneous heart valve, system, and method |
US9119714B2 (en) * | 2008-10-29 | 2015-09-01 | The Regents Of The University Of Colorado, A Body Corporate | Shape memory polymer prosthetic medical device |
US20100261662A1 (en) * | 2009-04-09 | 2010-10-14 | Endologix, Inc. | Utilization of mural thrombus for local drug delivery into vascular tissue |
WO2010127041A1 (en) * | 2009-04-29 | 2010-11-04 | The Cleveland Clinic Foundation | Apparatus and method for replacing a diseased cardiac valve |
WO2011002996A2 (en) * | 2009-07-02 | 2011-01-06 | The Cleveland Clinic Foundation | Apparatus and method for replacing a diseased cardiac valve |
FR2951549B1 (fr) | 2009-10-15 | 2013-08-23 | Olivier Schussler | Procede d'obtention de bioprotheses medicales implantables |
US9211361B2 (en) * | 2010-03-15 | 2015-12-15 | Kemal Schankereli | Thin collagen tissue for medical device applications |
BR122014006918B1 (pt) | 2010-03-23 | 2020-09-29 | Edwards Lifesciences Corporation. | Método para preparar material de membrana de tecido bioprotético |
WO2011139488A2 (en) | 2010-05-06 | 2011-11-10 | Mayo Foundation For Medical Education And Research | Methods and materials for reducing cardiac xenograft rejection |
US8906601B2 (en) | 2010-06-17 | 2014-12-09 | Edwardss Lifesciences Corporation | Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates |
CA2794135C (en) | 2010-06-17 | 2018-01-02 | Edwards Lifesciences Corporation | Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates |
US9351829B2 (en) | 2010-11-17 | 2016-05-31 | Edwards Lifesciences Corporation | Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability |
US9358107B2 (en) | 2011-06-30 | 2016-06-07 | Edwards Lifesciences Corporation | Systems, dies, and methods for processing pericardial tissue |
US9668859B2 (en) | 2011-08-05 | 2017-06-06 | California Institute Of Technology | Percutaneous heart valve delivery systems |
CN102499993B (zh) * | 2011-11-01 | 2014-01-15 | 上海微创医疗器械(集团)有限公司 | 一种边缘刚性化人工生物瓣膜的制备方法 |
US10238771B2 (en) | 2012-11-08 | 2019-03-26 | Edwards Lifesciences Corporation | Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system |
WO2014144247A1 (en) | 2013-03-15 | 2014-09-18 | Arash Kheradvar | Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves |
US9615922B2 (en) | 2013-09-30 | 2017-04-11 | Edwards Lifesciences Corporation | Method and apparatus for preparing a contoured biological tissue |
US10959839B2 (en) | 2013-10-08 | 2021-03-30 | Edwards Lifesciences Corporation | Method for directing cellular migration patterns on a biological tissue |
US10631968B2 (en) | 2017-03-06 | 2020-04-28 | Edwards Lifesciences Corporation | Humidity-management packaging systems and methods |
WO2018222434A1 (en) | 2017-05-31 | 2018-12-06 | Edwards Lifesciences Corporation | Collagen fibers and articles formed therefrom |
WO2019147585A1 (en) | 2018-01-23 | 2019-08-01 | Edwards Lifesciences Corporation | Method for pre-stretching implantable biocompatible materials, and materials and devices produced thereby |
US11103619B2 (en) | 2018-08-30 | 2021-08-31 | Efstathios-Andreas AGATHOS | Anticalcification treatment for impantable biological tissues using calcitonin |
WO2020092205A1 (en) | 2018-11-01 | 2020-05-07 | Edwards Lifesciences Corporation | Transcatheter pulmonic regenerative valve |
EP3920849A1 (de) | 2019-02-04 | 2021-12-15 | Medtronic, Inc. | Ballonexpandierbarer rahmen zur transkatheterimplantation einer herzklappenprothese |
US11771554B2 (en) | 2019-05-17 | 2023-10-03 | Medtronic, Inc. | Supra annular tapered balloon expandable stent for transcatheter implantation of a cardiac valve prosthesis |
CR20220339A (es) | 2019-12-12 | 2022-11-09 | Edwards Lifesciences Corp | Anillo de anuloplastia híbrido |
CN111588909A (zh) * | 2020-02-24 | 2020-08-28 | 科凯(南通)生命科学有限公司 | 一种生物医用材料防钙化的方法 |
US12011349B2 (en) | 2020-03-04 | 2024-06-18 | Medtronic, Inc. | Balloon expandable stent with lengthened commissure posts for transcatheter implantation of a cardiac valve prosthesis |
US12083009B2 (en) | 2020-04-15 | 2024-09-10 | Vitae LLC | Method of processing collagen-based tissue for bioprosthetic devices |
CN115350332A (zh) * | 2022-09-01 | 2022-11-18 | 晨兴(南通)医疗器械有限公司 | 抗钙化生物瓣膜材料的制备方法及抗钙化生物瓣膜材料 |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2393580A (en) | 1942-03-31 | 1946-01-22 | Edwin C Weiskopf | Method of preparing tissue |
DE1063330B (de) | 1955-11-01 | 1959-08-13 | Dr Med Norman Rosenberg | Stoffe fuer Fremdtransplantationen |
US3093439A (en) | 1961-07-05 | 1963-06-11 | Johnson & Johnson | Process for preparing tanned collagenous material with dialdehyde starch |
US3961097A (en) | 1971-10-28 | 1976-06-01 | Gravlee Jr Joseph F | Method of preparing tissue for microscopic examination |
US4050893A (en) | 1974-07-22 | 1977-09-27 | Hancock Laboratories, Inc. | Arrangement for preparing natural tissue for implantation |
IL47062A (en) | 1975-04-10 | 1979-07-25 | Yeda Res & Dev | Process for diminishing antigenicity of tissues to be usedas transplants by treatment with glutaraldehyde |
US4082507A (en) | 1976-05-10 | 1978-04-04 | Sawyer Philip Nicholas | Prosthesis and method for making the same |
US4239492A (en) | 1979-06-14 | 1980-12-16 | Beisang Arthur A | Method of preparing vascular grafts of human and other umbilical cord origins for tissue ingrowth |
US4378224A (en) * | 1980-09-19 | 1983-03-29 | Nimni Marcel E | Coating for bioprosthetic device and method of making same |
DE3042860A1 (de) | 1980-11-13 | 1982-06-09 | Heyl & Co Chemisch-Pharmazeutische Fabrik, 1000 Berlin | Kollagenpraeparate, verfahren zu ihrer herstellung und ihre verwendung in der human- und veterinaermedizin |
IN157379B (de) | 1981-04-30 | 1986-03-15 | Extracorporeal Med Spec | |
US4323358A (en) | 1981-04-30 | 1982-04-06 | Vascor, Inc. | Method for inhibiting mineralization of natural tissue during implantation |
US4350492A (en) | 1981-08-24 | 1982-09-21 | Vascor, Inc. | Method for preparing tissue heart valve |
FR2523810B1 (fr) | 1982-03-23 | 1988-11-25 | Carpentier Alain | Tissu biologique greffable et procede pour sa preparation |
US4481009A (en) * | 1982-05-13 | 1984-11-06 | American Hospital Supply Corporation | Polymer incorporation into implantable biological tissue to inhibit calcification |
US4402697A (en) * | 1982-08-25 | 1983-09-06 | Extracorporeal Medical Specialties, Inc. | Method for inhibiting mineralization of natural tissue during implantation |
US4405327A (en) | 1982-08-25 | 1983-09-20 | Extracorporeal Medical Specialties, Inc. | Method for inhibiting mineralization of natural tissue during implantation |
JPS60500014A (ja) * | 1982-11-12 | 1985-01-10 | バツクスター トラベノル ラボラトリーズ インコーポレーテツド | 移殖できる生物学的組織の化学滅菌 |
US5215541A (en) * | 1982-11-12 | 1993-06-01 | Baxter International Inc. | Surfactant treatment of implantable biological tissue to inhibit calcification |
WO1984001879A1 (en) | 1982-11-12 | 1984-05-24 | American Hospital Supply Corp | Surfactant treatment of implantable biological tissue to inhibit calcification |
US4885005A (en) | 1982-11-12 | 1989-12-05 | Baxter International Inc. | Surfactant treatment of implantable biological tissue to inhibit calcification |
US4713446A (en) * | 1985-09-06 | 1987-12-15 | Minnesota Mining And Manufacturing Company | Viscoelastic collagen solution for ophthalmic use and method of preparation |
US4729139A (en) * | 1985-11-05 | 1988-03-08 | Baxter Travenol | Selective incorporation of a polymer into implantable biological tissue to inhibit calcification |
US4770665A (en) * | 1985-11-05 | 1988-09-13 | American Hospital Supply Corporation | Elastomeric polymer incorporation into implantable biological tissue to inhibit calcification |
US4786287A (en) | 1986-10-10 | 1988-11-22 | Baxter Travenol Laboratories | Process for decreasing residual aldehyde levels in implantable bioprosthetic tissue |
US4798611A (en) * | 1986-10-14 | 1989-01-17 | Hancock Jaffe Laboratories | Enhancement of xenogeneic tissue |
US4800603A (en) * | 1987-01-30 | 1989-01-31 | Jaffe Norman R | Tissue fixation with vapor |
US4994237A (en) * | 1987-10-02 | 1991-02-19 | The Beth Israel Hospital Association | Microwave preservation of bioprostheses |
EP0364517B1 (de) | 1988-02-03 | 1994-04-06 | Biomedical Design, Inc. | Verhütung der kalzifizierung einer prothese |
US4976733A (en) | 1988-02-03 | 1990-12-11 | Biomedical Design, Inc. | Prevention of prosthesis calcification |
US5746775A (en) | 1988-04-01 | 1998-05-05 | The Board Of Regent6S Of The University Of Michigan | Method of making calcification-resistant bioprosthetic tissue |
EP0362438A1 (de) | 1988-06-21 | 1990-04-11 | Mathilde Elisabeth Boon | Mikrowellenbehandlung von xenogenen Knorpeltransplantaten |
SU1651890A1 (ru) * | 1988-06-22 | 1991-05-30 | Институт сердечно-сосудистой хирургии им.А.Н.Бакулева | Способ обработки биопротезов клапанов сердца |
US5264214A (en) * | 1988-11-21 | 1993-11-23 | Collagen Corporation | Composition for bone repair |
US5171273A (en) * | 1989-01-13 | 1992-12-15 | University Of Medicine And Dentistry Of New Jersey | Synthetic collagen orthopaedic structures such as grafts, tendons and other structures |
US5002566A (en) | 1989-02-17 | 1991-03-26 | Baxter International Inc. | Calcification mitigation of bioprosthetic implants |
US5068086A (en) | 1990-06-12 | 1991-11-26 | Raytheon Company | Method and apparatus for batch fixating tissue specimens |
US5104405A (en) | 1991-02-21 | 1992-04-14 | The University Of Southern California | Process for improving the biostability of tissue implant devices and bioprosthetic implants so produced |
US5476516A (en) * | 1992-03-13 | 1995-12-19 | Albert Einstein College Of Medicine Of Yeshiva University | Anticalcification treatment for aldehyde-tanned biological tissue |
US5283256A (en) * | 1992-07-22 | 1994-02-01 | Merck & Co., Inc. | Cholesterol-lowering agents |
US5437287A (en) * | 1992-08-17 | 1995-08-01 | Carbomedics, Inc. | Sterilization of tissue implants using iodine |
US5447536A (en) * | 1994-02-17 | 1995-09-05 | Biomedical Design, Inc. | Method for fixation of biological tissue |
JPH09510108A (ja) | 1994-03-14 | 1997-10-14 | クリオライフ,インコーポレイティド | 移植用処理組織及び調製方法 |
US5595571A (en) | 1994-04-18 | 1997-01-21 | Hancock Jaffe Laboratories | Biological material pre-fixation treatment |
US5931969A (en) * | 1994-07-29 | 1999-08-03 | Baxter International Inc. | Methods and apparatuses for treating biological tissue to mitigate calcification |
EP0804255B1 (de) | 1994-07-29 | 2001-10-04 | Edwards Lifesciences Corporation | Verfahren zur behandlung von implantierbaren biologischen geweben zur verringerung von verkalkung |
US5674298A (en) * | 1994-10-21 | 1997-10-07 | The Board Of Regents Of The University Of Michigan | Calcification-resistant bioprosthetic tissue and methods of making same |
US5782931A (en) * | 1996-07-30 | 1998-07-21 | Baxter International Inc. | Methods for mitigating calcification and improving durability in glutaraldehyde-fixed bioprostheses and articles manufactured by such methods |
AU735988B2 (en) * | 1997-02-10 | 2001-07-26 | Biomedical Design, Inc. | Method of sterilization |
US5891196A (en) * | 1997-04-16 | 1999-04-06 | Baxter International Inc. | Method for actively binding heparin to crosslinked biological tissues |
US6008292A (en) * | 1997-12-02 | 1999-12-28 | Baxter International Inc. | Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials |
BE1012763A3 (nl) | 1999-06-25 | 2001-03-06 | Wiele Michel Van De Nv | Poolgaren selectiesysteem voor grijperaxminsterweefmachines. |
-
1995
- 1995-07-25 EP EP95931511A patent/EP0804255B1/de not_active Expired - Lifetime
- 1995-07-25 CA CA002196165A patent/CA2196165C/en not_active Expired - Lifetime
- 1995-07-25 JP JP50681296A patent/JP3797673B2/ja not_active Expired - Lifetime
- 1995-07-25 WO PCT/US1995/010001 patent/WO1996004028A1/en active IP Right Grant
- 1995-07-25 DE DE69523074T patent/DE69523074T2/de not_active Expired - Lifetime
-
1996
- 1996-12-12 US US08/764,821 patent/US6561970B1/en not_active Expired - Lifetime
-
2003
- 2003-02-05 US US10/359,479 patent/US7029434B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1996004028A1 (en) | 1996-02-15 |
US6561970B1 (en) | 2003-05-13 |
JP3797673B2 (ja) | 2006-07-19 |
EP0804255A1 (de) | 1997-11-05 |
US7029434B2 (en) | 2006-04-18 |
DE69523074T2 (de) | 2002-06-06 |
CA2196165A1 (en) | 1996-02-15 |
EP0804255B1 (de) | 2001-10-04 |
CA2196165C (en) | 2004-06-08 |
US20040030405A1 (en) | 2004-02-12 |
JPH10507102A (ja) | 1998-07-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69523074D1 (de) | Verfahren zur behandlung von implantierbaren biologischen geweben zur verringerung von verkalkung | |
DE69609868D1 (de) | Neue steroidester zur behandlung von hauterkrankungen | |
DE69806970D1 (de) | Verfahren zur behandlung von hartgeweben | |
DE69925266D1 (de) | Verfahren und gerät zur behandlung von herzarhythmie | |
DE69829336D1 (de) | Vorrichtung und Verfahren zur Behandlung von Körpergewebe | |
DE69726289D1 (de) | Verfahren und zusammensetzung zur behandlung von substraten bezüglich benetzbarkeit | |
DE69821913D1 (de) | Verfahren zur behandlung der hautpigmentierung | |
DE60042611D1 (de) | Verfahren zur behandlung von gefässerkrankungen, dxid auszeichnen | |
DE69434672D1 (de) | Verfahren zur behandlung von hühnereiern | |
DE69421912D1 (de) | Methode zur behandlung von wasser | |
ATA76995A (de) | Stabiles präparat zur behandlung von blutgerinnungsstörungen | |
ATA46794A (de) | Einrichtung zur behandlung von hautzonen | |
DE60029033D1 (de) | Verfahren zur Behandlung von Tissuepapier | |
DE69714828D1 (de) | Verfahren zur Behandlung von Abfallstoffen | |
DE69115921D1 (de) | Verfahren zur behandlung und verwendung von abfallstoffen | |
DE69427774D1 (de) | Kontinuierliches verfahren zur behandlung von nahrungsmitteln | |
ATE257189T1 (de) | Verfahren zur behandlung von cellulosischen formkörpern | |
DE59707519D1 (de) | Verwendung von 1-hydroxy-2-pyridonen zur behandlung von hautinfektionen | |
DE59209268D1 (de) | Verfahren zur thermochemisch-thermischen behandlung von einsatzstählen | |
DE69626311D1 (de) | Zusammensetzung zur behandlung von wäsche sowie verfahren hierfür | |
DE69328615D1 (de) | Verfahren zur behandlung von viehhaltungsgülle | |
DE69621447D1 (de) | Verwendung von nitroflavonoide zur behandlung von angstzuständen | |
DE69936994D1 (de) | Verfahren zur behandlung von okularen neovaskularen erkrankungen | |
ATE281841T1 (de) | Verfahren zur herstellung von mikania extrakten enthaltend mikanolide und dihydromikanolide und verwendung in der behandlung proliferativer erkrankungen | |
DE59102745D1 (de) | Verfahren une einrichtung zur behandlung von saatgut. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |