JPS5724384A - Manufacture of spiro-quaternary ammonium halides and n-(2-pyrimidinyl)piperazinyl alkylazaspiroalkane dione - Google Patents

Manufacture of spiro-quaternary ammonium halides and n-(2-pyrimidinyl)piperazinyl alkylazaspiroalkane dione

Info

Publication number
JPS5724384A
JPS5724384A JP7944381A JP7944381A JPS5724384A JP S5724384 A JPS5724384 A JP S5724384A JP 7944381 A JP7944381 A JP 7944381A JP 7944381 A JP7944381 A JP 7944381A JP S5724384 A JPS5724384 A JP S5724384A
Authority
JP
Japan
Prior art keywords
alkylazaspiroalkane
dione
piperazinyl
spiro
pyrimidinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7944381A
Other languages
English (en)
Other versions
JPS634828B2 (ja
Inventor
Shii Shiimusu Jiyatsuku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22729338&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS5724384(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of JPS5724384A publication Critical patent/JPS5724384A/ja
Publication of JPS634828B2 publication Critical patent/JPS634828B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP7944381A 1980-10-16 1981-05-27 Manufacture of spiro-quaternary ammonium halides and n-(2-pyrimidinyl)piperazinyl alkylazaspiroalkane dione Granted JPS5724384A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/197,416 US4351939A (en) 1980-10-16 1980-10-16 Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process

Publications (2)

Publication Number Publication Date
JPS5724384A true JPS5724384A (en) 1982-02-08
JPS634828B2 JPS634828B2 (ja) 1988-02-01

Family

ID=22729338

Family Applications (2)

Application Number Title Priority Date Filing Date
JP7944381A Granted JPS5724384A (en) 1980-10-16 1981-05-27 Manufacture of spiro-quaternary ammonium halides and n-(2-pyrimidinyl)piperazinyl alkylazaspiroalkane dione
JP60282152A Granted JPS61178983A (ja) 1980-10-16 1985-12-17 スピロ−第４級アンモニウムハロゲン化物類およびその製法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP60282152A Granted JPS61178983A (ja) 1980-10-16 1985-12-17 スピロ−第４級アンモニウムハロゲン化物類およびその製法

Country Status (33)

Country Link
US (1) US4351939A (ja)
JP (2) JPS5724384A (ja)
KR (2) KR890000465B1 (ja)
AT (1) AT382153B (ja)
AU (1) AU524822B2 (ja)
BE (1) BE890509A (ja)
CA (1) CA1175832A (ja)
CH (1) CH647778A5 (ja)
CY (1) CY1325A (ja)
DE (1) DE3141256C2 (ja)
DK (1) DK148481C (ja)
ES (2) ES501994A0 (ja)
FI (1) FI75159C (ja)
FR (1) FR2492383A1 (ja)
GB (1) GB2085436B (ja)
GR (1) GR74687B (ja)
HK (1) HK35386A (ja)
HU (2) HU187999B (ja)
IE (1) IE51646B1 (ja)
IL (1) IL64047A (ja)
IT (1) IT1143244B (ja)
KE (1) KE3596A (ja)
LU (1) LU83657A1 (ja)
MY (1) MY8600475A (ja)
NL (2) NL179055C (ja)
NZ (1) NZ196974A (ja)
OA (1) OA06920A (ja)
PT (1) PT73824B (ja)
SE (2) SE439167B (ja)
SG (1) SG97885G (ja)
SU (1) SU1342420A3 (ja)
YU (2) YU42565B (ja)
ZA (1) ZA812759B (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5945380U (ja) * 1982-09-20 1984-03-26 いすゞ自動車株式会社 車両用帯状体の固定装置
CN1044474C (zh) * 1994-05-05 1999-08-04 布里斯托尔-米尔斯·斯奎布公司 大规模合成氮哌酮的改进方法
JP2009506121A (ja) * 2005-08-30 2009-02-12 ハネウェル・インターナショナル・インコーポレーテッド スピロ四級アンモニウム系の合成方法
JP2009539889A (ja) * 2006-06-16 2009-11-19 北京大学 スピロシクロピペラジン類の第四級アンモニウム塩化合物、その製造方法および使用
JP2013525265A (ja) * 2010-04-26 2013-06-20 大日本住友製薬株式会社 リン酸塩を用いる第四級アンモニウム塩の製造法
JP2013525264A (ja) * 2010-04-26 2013-06-20 大日本住友製薬株式会社 第四級アンモニウム塩の製造法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387221B (de) * 1980-09-08 1988-12-27 Bristol Myers Co Verfahren zur herstellung des neuen
US4507303A (en) * 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US5066783A (en) * 1986-05-20 1991-11-19 Cohen Eric A Antiviral peptides and means for treating herpes infections
US4810789A (en) * 1987-08-28 1989-03-07 Bristol-Myers Company Process for buspirone hydrochloride polymorphic crystalline form conversion
US5015646A (en) * 1987-08-28 1991-05-14 Bristol-Myers Squibb Co. Pharmaceutically useful polymorphic modification of buspirone
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .
US5521313A (en) * 1994-05-05 1996-05-28 Bristol-Myers Squibb Company Process for preparing certain azapirones
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
AR038368A1 (es) * 2002-02-01 2005-01-12 Novartis Ag Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
CN101362751B (zh) * 2007-08-10 2011-05-11 成都科瑞德医药投资有限责任公司 枸橼酸坦度螺酮及其制备方法、制剂和质量控制方法
IT201900000657A1 (it) 2019-01-16 2020-07-16 Procos Spa Processo per la sintesi di gepirone

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB948730A (en) * 1959-04-08 1964-02-05 Wellcome Found Substituted cyclopropanes and related compounds
US3968216A (en) * 1969-10-29 1976-07-06 Smith Kline & French Laboratories Limited Method of inhibiting histamine activity with guanidine compounds
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5945380U (ja) * 1982-09-20 1984-03-26 いすゞ自動車株式会社 車両用帯状体の固定装置
JPS6333028Y2 (ja) * 1982-09-20 1988-09-02
CN1044474C (zh) * 1994-05-05 1999-08-04 布里斯托尔-米尔斯·斯奎布公司 大规模合成氮哌酮的改进方法
JP2009506121A (ja) * 2005-08-30 2009-02-12 ハネウェル・インターナショナル・インコーポレーテッド スピロ四級アンモニウム系の合成方法
JP2009539889A (ja) * 2006-06-16 2009-11-19 北京大学 スピロシクロピペラジン類の第四級アンモニウム塩化合物、その製造方法および使用
US9133195B2 (en) 2006-06-16 2015-09-15 Peking University Quaternary ammonium salt compounds of spirocyclopiperazines, preparation methods and uses thereof
JP2013525265A (ja) * 2010-04-26 2013-06-20 大日本住友製薬株式会社 リン酸塩を用いる第四級アンモニウム塩の製造法
JP2013525264A (ja) * 2010-04-26 2013-06-20 大日本住友製薬株式会社 第四級アンモニウム塩の製造法

Also Published As

Publication number Publication date
IL64047A0 (en) 1982-01-31
ZA812759B (en) 1982-05-26
ES8206516A1 (es) 1982-08-16
JPS634828B2 (ja) 1988-02-01
NZ196974A (en) 1983-05-31
FR2492383B1 (ja) 1985-01-25
KE3596A (en) 1986-02-07
LU83657A1 (fr) 1982-04-14
SE8600174D0 (sv) 1986-01-15
DK148481B (da) 1985-07-15
CA1175832A (en) 1984-10-09
SG97885G (en) 1986-07-25
YU43316B (en) 1989-06-30
HU185967B (en) 1985-04-28
GR74687B (ja) 1984-07-03
DK148481C (da) 1985-12-16
IE51646B1 (en) 1987-01-21
IL64047A (en) 1984-12-31
GB2085436A (en) 1982-04-28
FR2492383A1 (fr) 1982-04-23
DE3141256C2 (de) 1986-06-05
SE447257B (sv) 1986-11-03
FI813178L (fi) 1982-04-17
SE8600174L (sv) 1986-01-15
US4351939A (en) 1982-09-28
KR870000321B1 (en) 1987-02-27
MY8600475A (en) 1986-12-31
ES8304967A1 (es) 1983-03-16
ES501994A0 (es) 1982-08-16
FI75159C (fi) 1988-05-09
PT73824B (en) 1983-10-31
AU7029281A (en) 1982-04-22
SE8106060L (sv) 1982-04-17
YU110381A (en) 1983-12-31
OA06920A (fr) 1983-05-31
NL179055C (nl) 1986-07-01
BE890509A (fr) 1982-03-25
SU1342420A3 (ru) 1987-09-30
CH647778A5 (de) 1985-02-15
YU42565B (en) 1988-10-31
CY1325A (en) 1986-06-27
KR890000465B1 (ko) 1989-03-18
GB2085436B (en) 1984-01-18
JPS6153353B2 (ja) 1986-11-17
KR830007659A (ko) 1983-11-04
ES511079A0 (es) 1983-03-16
DK433781A (da) 1982-04-17
DE3141256A1 (de) 1982-08-19
PT73824A (en) 1981-11-01
SE439167B (sv) 1985-06-03
AU524822B2 (en) 1982-10-07
NL8501430A (nl) 1985-09-02
HK35386A (en) 1986-05-30
IE812420L (en) 1982-04-16
IT1143244B (it) 1986-10-22
NL179055B (nl) 1986-02-03
AT382153B (de) 1987-01-26
YU136083A (en) 1986-02-28
JPS61178983A (ja) 1986-08-11
ATA444681A (de) 1986-06-15
FI75159B (fi) 1988-01-29
HU187999B (en) 1986-03-28
IT8149476A0 (it) 1981-10-13
NL8104660A (nl) 1982-05-17

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