KR830007659A - 스피로-쿼터너리 암모늄 헬라이드 및 n-(2-피리미디닐)피페라지닐알킬아자스피로알칸디온 제조방법 - Google Patents

스피로-쿼터너리 암모늄 헬라이드 및 n-(2-피리미디닐)피페라지닐알킬아자스피로알칸디온 제조방법 Download PDF

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Publication number
KR830007659A
KR830007659A KR1019810003924A KR810003924A KR830007659A KR 830007659 A KR830007659 A KR 830007659A KR 1019810003924 A KR1019810003924 A KR 1019810003924A KR 810003924 A KR810003924 A KR 810003924A KR 830007659 A KR830007659 A KR 830007659A
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South Korea
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formula
pyrimidinyl
spiro
quaternary ammonium
compound
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KR1019810003924A
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English (en)
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KR870000321B1 (en
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시·심스 잭
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도미낙 엠·메자펠
브리스톨-마이어스 컴페니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

스피로-쿼터너리 암모늄 헬라이드 및 N-(2-피리미디닐) 피페라지닐알킬아자스피로 알칸디온 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기 구조식(Ⅱ)의 1-(2-피리미디닐) 피페라진을 하기 구조식(Ⅲ)의 디할로알칸으로 강염기의 존재하에 처리하여서 하기 구조식(I)의 스피로-쿼터너리 할라이드를 제조하는 방법 :
    X-CH2CH2(CH2)nCH2-X'
    윗식에서 n=1 혹 2, X와 X'=염소, 브롬 혹은 요오드.
  2. 구조식(Ⅲ)의 화합물이 1,4-디브로모부탄인 청구범위 1에 따르는 방법.
  3. 구조식(Ⅲ)의 화합물이 1,4-디클로로부탄인 청구범위 1에 따르는 방법.
  4. 하기 구조식(I)의 스피로-쿼터너리 암모늄 할라이드와 하기 구조식(V)의 스피로-치환된 글루타르아미드를 강염기하에 농축시켜서 하기 구조식(Ⅳ)의 N-(2-피리미디닐)-피페라지닐알킬아자스피로알칸디온의 제조방법 :
    윗식에서 n=1 혹은 2, t=4 혹은 5, X=염소, 브롬 혹은 요오드임.
  5. 구조식(I)의 화합물이 8-(2-피리미디닐)-8-아자-5-아조니아스피로[4,5]데칸 브로마이드인 청구범위 4에 따르는 방법.
  6. 구조식(I)의 화합물이 8-(2-피리미디닐)-8-아자-5-아조니아스피로[4,5]데칸 브로마이드인 청구범위 4에 따르는 방법.
  7. 하기 구조식(Va)의 스피로-글루타르아미드와 하기 구조식(Ia)의 스피로-쿼터너리 암모늄 헬라이드를 액체반응미디엄에서 강염기의 존재하에 농축시켜서 하기 구조식(Ⅳa)의 8-[4-[4-(2-피리미디닐)-1-피레라지닐]부틸]-8-아자스피로[4,5]데칸-7,9-디온의 제조방법 :
    ※참고사항:최초출원 내용에 의하여 공개하는 것임.
KR8103924A 1980-10-16 1981-10-16 Process for preparing spiro-quaternary ammonium halide and n-(2-pyrimidinyl) piperazinyl alkylazaspiro alkamidione KR870000321B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US197416 1980-10-16
US06/197,416 US4351939A (en) 1980-10-16 1980-10-16 Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process

Publications (2)

Publication Number Publication Date
KR830007659A true KR830007659A (ko) 1983-11-04
KR870000321B1 KR870000321B1 (en) 1987-02-27

Family

ID=22729338

Family Applications (2)

Application Number Title Priority Date Filing Date
KR8103924A KR870000321B1 (en) 1980-10-16 1981-10-16 Process for preparing spiro-quaternary ammonium halide and n-(2-pyrimidinyl) piperazinyl alkylazaspiro alkamidione
KR1019810003924D KR890000465B1 (ko) 1980-10-16 1981-10-16 스피로-쿼터너리 암모늄 할라이드 및 n-(2-피리미디닐)피페라지닐 알킬아자스피로알칸디온의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019810003924D KR890000465B1 (ko) 1980-10-16 1981-10-16 스피로-쿼터너리 암모늄 할라이드 및 n-(2-피리미디닐)피페라지닐 알킬아자스피로알칸디온의 제조방법

Country Status (33)

Country Link
US (1) US4351939A (ko)
JP (2) JPS5724384A (ko)
KR (2) KR870000321B1 (ko)
AT (1) AT382153B (ko)
AU (1) AU524822B2 (ko)
BE (1) BE890509A (ko)
CA (1) CA1175832A (ko)
CH (1) CH647778A5 (ko)
CY (1) CY1325A (ko)
DE (1) DE3141256C2 (ko)
DK (1) DK148481C (ko)
ES (2) ES8206516A1 (ko)
FI (1) FI75159C (ko)
FR (1) FR2492383A1 (ko)
GB (1) GB2085436B (ko)
GR (1) GR74687B (ko)
HK (1) HK35386A (ko)
HU (2) HU185967B (ko)
IE (1) IE51646B1 (ko)
IL (1) IL64047A (ko)
IT (1) IT1143244B (ko)
KE (1) KE3596A (ko)
LU (1) LU83657A1 (ko)
MY (1) MY8600475A (ko)
NL (2) NL179055C (ko)
NZ (1) NZ196974A (ko)
OA (1) OA06920A (ko)
PT (1) PT73824B (ko)
SE (2) SE439167B (ko)
SG (1) SG97885G (ko)
SU (1) SU1342420A3 (ko)
YU (2) YU42565B (ko)
ZA (1) ZA812759B (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387221B (de) * 1980-09-08 1988-12-27 Bristol Myers Co Verfahren zur herstellung des neuen
US4507303A (en) * 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
JPS5945380U (ja) * 1982-09-20 1984-03-26 いすゞ自動車株式会社 車両用帯状体の固定装置
US5066783A (en) * 1986-05-20 1991-11-19 Cohen Eric A Antiviral peptides and means for treating herpes infections
US4810789A (en) * 1987-08-28 1989-03-07 Bristol-Myers Company Process for buspirone hydrochloride polymorphic crystalline form conversion
US5015646A (en) * 1987-08-28 1991-05-14 Bristol-Myers Squibb Co. Pharmaceutically useful polymorphic modification of buspirone
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .
US5521313A (en) * 1994-05-05 1996-05-28 Bristol-Myers Squibb Company Process for preparing certain azapirones
CA2146593A1 (en) * 1994-05-05 1995-11-06 Jack Melton Large-scale process for azapirone synthesis
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
TW200302728A (en) * 2002-02-01 2003-08-16 Novartis Ag Substituted amines as IgE inhibitors
DE602006021437D1 (de) * 2005-08-30 2011-06-01 Honeywell Int Inc Verfahren zur synthese von quaternären ammonium-spirosystemen
CN101089000B (zh) * 2006-06-16 2011-01-05 北京大学 螺环哌嗪季铵盐类化合物及其制备方法和应用
CN101362751B (zh) * 2007-08-10 2011-05-11 成都科瑞德医药投资有限责任公司 枸橼酸坦度螺酮及其制备方法、制剂和质量控制方法
WO2011136384A1 (en) * 2010-04-26 2011-11-03 Dainippon Sumitomo Pharma Co., Ltd. A process of a quaternary ammonium salt using phosphate
EP2563790B1 (en) * 2010-04-26 2016-09-14 Sumitomo Dainippon Pharma Co., Ltd. A process of a quaternary ammonium salt
IT201900000657A1 (it) 2019-01-16 2020-07-16 Procos Spa Processo per la sintesi di gepirone

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB948730A (en) * 1959-04-08 1964-02-05 Wellcome Found Substituted cyclopropanes and related compounds
US3968216A (en) * 1969-10-29 1976-07-06 Smith Kline & French Laboratories Limited Method of inhibiting histamine activity with guanidine compounds
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation

Also Published As

Publication number Publication date
ZA812759B (en) 1982-05-26
ATA444681A (de) 1986-06-15
IT1143244B (it) 1986-10-22
KE3596A (en) 1986-02-07
HU187999B (en) 1986-03-28
IT8149476A0 (it) 1981-10-13
MY8600475A (en) 1986-12-31
IE812420L (en) 1982-04-16
NL8104660A (nl) 1982-05-17
GR74687B (ko) 1984-07-03
DE3141256A1 (de) 1982-08-19
IL64047A (en) 1984-12-31
SU1342420A3 (ru) 1987-09-30
PT73824A (en) 1981-11-01
SE439167B (sv) 1985-06-03
DE3141256C2 (de) 1986-06-05
JPS6153353B2 (ko) 1986-11-17
JPS5724384A (en) 1982-02-08
FI75159C (fi) 1988-05-09
ES501994A0 (es) 1982-08-16
CY1325A (en) 1986-06-27
NZ196974A (en) 1983-05-31
DK148481C (da) 1985-12-16
YU136083A (en) 1986-02-28
SE8600174L (sv) 1986-01-15
NL179055C (nl) 1986-07-01
NL179055B (nl) 1986-02-03
KR870000321B1 (en) 1987-02-27
HK35386A (en) 1986-05-30
YU110381A (en) 1983-12-31
YU43316B (en) 1989-06-30
AT382153B (de) 1987-01-26
OA06920A (fr) 1983-05-31
JPS61178983A (ja) 1986-08-11
BE890509A (fr) 1982-03-25
CH647778A5 (de) 1985-02-15
IE51646B1 (en) 1987-01-21
KR890000465B1 (ko) 1989-03-18
SE447257B (sv) 1986-11-03
ES8304967A1 (es) 1983-03-16
SE8106060L (sv) 1982-04-17
GB2085436A (en) 1982-04-28
LU83657A1 (fr) 1982-04-14
HU185967B (en) 1985-04-28
FI75159B (fi) 1988-01-29
US4351939A (en) 1982-09-28
FR2492383B1 (ko) 1985-01-25
JPS634828B2 (ko) 1988-02-01
AU524822B2 (en) 1982-10-07
SG97885G (en) 1986-07-25
CA1175832A (en) 1984-10-09
FR2492383A1 (fr) 1982-04-23
ES8206516A1 (es) 1982-08-16
AU7029281A (en) 1982-04-22
IL64047A0 (en) 1982-01-31
NL8501430A (nl) 1985-09-02
FI813178L (fi) 1982-04-17
SE8600174D0 (sv) 1986-01-15
PT73824B (en) 1983-10-31
YU42565B (en) 1988-10-31
DK148481B (da) 1985-07-15
GB2085436B (en) 1984-01-18
DK433781A (da) 1982-04-17
ES511079A0 (es) 1983-03-16

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