AR245705A1 - Un proceso para preparar leucotrienos-antagonistas y sus sales. - Google Patents

Un proceso para preparar leucotrienos-antagonistas y sus sales.

Info

Publication number
AR245705A1
AR245705A1 AR88310489A AR31048988A AR245705A1 AR 245705 A1 AR245705 A1 AR 245705A1 AR 88310489 A AR88310489 A AR 88310489A AR 31048988 A AR31048988 A AR 31048988A AR 245705 A1 AR245705 A1 AR 245705A1
Authority
AR
Argentina
Prior art keywords
compounds
formula
alkyl
relating
leukotriene antagonists
Prior art date
Application number
AR88310489A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of AR245705A1 publication Critical patent/AR245705A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN PROCESO PARA PREPARAR COMPUESTOS DE FENOXIALQUILALICANONAS DE FORMULA (I) Y SALES DE LOS MISMOS, ACEPTABLES FARMACEUTICAMENTE, EN LA QUE: R1 ES ALQUILO; R2 ES ALQUILO; A ES -O-, -CO-, O UN GRUPO ALQUILIDENO, R4 ES CIANO O 5-TETRAZOLILO, CADA R5 Y R6 ES HIDROGENO O ALQUILO, QUE COMPRENDE HACER REACCIONAR UN COMPUESTO DE BENZILO DE FORMULA (V) DONDE X ES HALO, CON COMPUESTOS DE FORMULA(VI), SI ES NECESARIO HACIENDO REACCIONAR LOS COMPUESTOS OBTENIDOS CON UNA AZIDA DE TRIALQUIL ESTANO PARA OBTENER LOS COMPUESTOS DE FORMULA (I) DONDE R4 ES UN GRUPO 5-TETRAZOLILO Y SI ES NECESARIO SE FORMAN LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS COMPUESTOS OBTENIDOS.
AR88310489A 1987-04-13 1988-04-06 Un proceso para preparar leucotrienos-antagonistas y sus sales. AR245705A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/038,254 US4853398A (en) 1987-04-13 1987-04-13 Leukotriene antagonists and use thereas

Publications (1)

Publication Number Publication Date
AR245705A1 true AR245705A1 (es) 1994-02-28

Family

ID=21898886

Family Applications (1)

Application Number Title Priority Date Filing Date
AR88310489A AR245705A1 (es) 1987-04-13 1988-04-06 Un proceso para preparar leucotrienos-antagonistas y sus sales.

Country Status (22)

Country Link
US (1) US4853398A (es)
EP (1) EP0288189B1 (es)
JP (1) JPS63258831A (es)
KR (1) KR880012521A (es)
CN (1) CN1012433B (es)
AR (1) AR245705A1 (es)
AT (1) ATE82273T1 (es)
AU (1) AU607203B2 (es)
CA (1) CA1329613C (es)
DE (1) DE3875782T2 (es)
DK (1) DK188488A (es)
EG (1) EG19001A (es)
ES (1) ES2045110T3 (es)
GR (1) GR3006973T3 (es)
HU (1) HU202505B (es)
IE (1) IE61883B1 (es)
IL (1) IL85989A (es)
NZ (1) NZ224143A (es)
PH (1) PH25572A (es)
PT (1) PT87181B (es)
SU (1) SU1750420A3 (es)
ZA (1) ZA882421B (es)

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US5681380A (en) 1995-06-05 1997-10-28 Kimberly-Clark Worldwide, Inc. Ink for ink jet printers
US5721287A (en) 1993-08-05 1998-02-24 Kimberly-Clark Worldwide, Inc. Method of mutating a colorant by irradiation
US6211383B1 (en) 1993-08-05 2001-04-03 Kimberly-Clark Worldwide, Inc. Nohr-McDonald elimination reaction
US5643356A (en) 1993-08-05 1997-07-01 Kimberly-Clark Corporation Ink for ink jet printers
US5645964A (en) 1993-08-05 1997-07-08 Kimberly-Clark Corporation Digital information recording media and method of using same
US5865471A (en) 1993-08-05 1999-02-02 Kimberly-Clark Worldwide, Inc. Photo-erasable data processing forms
US6017471A (en) 1993-08-05 2000-01-25 Kimberly-Clark Worldwide, Inc. Colorants and colorant modifiers
US5773182A (en) 1993-08-05 1998-06-30 Kimberly-Clark Worldwide, Inc. Method of light stabilizing a colorant
CA2120838A1 (en) 1993-08-05 1995-02-06 Ronald Sinclair Nohr Solid colored composition mutable by ultraviolet radiation
WO1997001605A1 (en) 1995-06-28 1997-01-16 Kimberly-Clark Worldwide, Inc. Novel colorants and colorant modifiers
US5685754A (en) 1994-06-30 1997-11-11 Kimberly-Clark Corporation Method of generating a reactive species and polymer coating applications therefor
US5739175A (en) 1995-06-05 1998-04-14 Kimberly-Clark Worldwide, Inc. Photoreactor composition containing an arylketoalkene wavelength-specific sensitizer
US6242057B1 (en) 1994-06-30 2001-06-05 Kimberly-Clark Worldwide, Inc. Photoreactor composition and applications therefor
US6071979A (en) 1994-06-30 2000-06-06 Kimberly-Clark Worldwide, Inc. Photoreactor composition method of generating a reactive species and applications therefor
US6008268A (en) 1994-10-21 1999-12-28 Kimberly-Clark Worldwide, Inc. Photoreactor composition, method of generating a reactive species, and applications therefor
US5849411A (en) 1995-06-05 1998-12-15 Kimberly-Clark Worldwide, Inc. Polymer film, nonwoven web and fibers containing a photoreactor composition
US5747550A (en) 1995-06-05 1998-05-05 Kimberly-Clark Worldwide, Inc. Method of generating a reactive species and polymerizing an unsaturated polymerizable material
US5786132A (en) 1995-06-05 1998-07-28 Kimberly-Clark Corporation Pre-dyes, mutable dye compositions, and methods of developing a color
US5811199A (en) 1995-06-05 1998-09-22 Kimberly-Clark Worldwide, Inc. Adhesive compositions containing a photoreactor composition
US5798015A (en) 1995-06-05 1998-08-25 Kimberly-Clark Worldwide, Inc. Method of laminating a structure with adhesive containing a photoreactor composition
PL323727A1 (en) 1995-06-05 1998-04-14 Kimberly Clark Co Novel precursors of dyes
US6099628A (en) 1996-03-29 2000-08-08 Kimberly-Clark Worldwide, Inc. Colorant stabilizers
US5782963A (en) 1996-03-29 1998-07-21 Kimberly-Clark Worldwide, Inc. Colorant stabilizers
ES2175168T3 (es) 1995-11-28 2002-11-16 Kimberly Clark Co Compuestos de colorantes estabilizados por la luz.
US5855655A (en) 1996-03-29 1999-01-05 Kimberly-Clark Worldwide, Inc. Colorant stabilizers
US5891229A (en) 1996-03-29 1999-04-06 Kimberly-Clark Worldwide, Inc. Colorant stabilizers
US6524379B2 (en) 1997-08-15 2003-02-25 Kimberly-Clark Worldwide, Inc. Colorants, colorant stabilizers, ink compositions, and improved methods of making the same
CN1090950C (zh) * 1998-03-26 2002-09-18 苏贻利 一种治疗痣的中西合成药及其制备方法
AU4818299A (en) 1998-06-03 1999-12-20 Kimberly-Clark Worldwide, Inc. Novel photoinitiators and applications therefor
SK1542000A3 (en) 1998-06-03 2001-11-06 Kimberly Clark Co Neonanoplasts produced by microemulsion technology and inks for ink jet printing
JP2002520470A (ja) 1998-07-20 2002-07-09 キンバリー クラーク ワールドワイド インコーポレイテッド 改良されたインクジェットインク組成物
CA2353685A1 (en) 1998-09-28 2000-04-06 Kimberly-Clark Worldwide, Inc. Chelates comprising chinoid groups as photoinitiators
EP1144512B1 (en) 1999-01-19 2003-04-23 Kimberly-Clark Worldwide, Inc. Novel colorants, colorant stabilizers, ink compositions, and improved methods of making the same
US6331056B1 (en) 1999-02-25 2001-12-18 Kimberly-Clark Worldwide, Inc. Printing apparatus and applications therefor
US6294698B1 (en) 1999-04-16 2001-09-25 Kimberly-Clark Worldwide, Inc. Photoinitiators and applications therefor
US6368395B1 (en) 1999-05-24 2002-04-09 Kimberly-Clark Worldwide, Inc. Subphthalocyanine colorants, ink compositions, and method of making the same
JP2008516968A (ja) * 2004-10-18 2008-05-22 メルク エンド カムパニー インコーポレーテッド ジフェニル置換アルカン類
EP1817301B1 (en) * 2004-11-22 2012-02-01 Eli Lilly And Company Potentiators of glutamate receptors
JP2010502615A (ja) * 2006-09-01 2010-01-28 メルク エンド カムパニー インコーポレーテッド ５−リポキシゲナーゼ活性化タンパク質（ｆｌａｐ）の阻害剤

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US4820722A (en) * 1987-08-14 1989-04-11 Eli Lilly And Company Disubstituted tetrazoles and their use as leukotriene antagonists

Also Published As

Publication number Publication date
US4853398A (en) 1989-08-01
NZ224143A (en) 1990-02-26
AU607203B2 (en) 1991-02-28
CA1329613C (en) 1994-05-17
PH25572A (en) 1991-08-08
HUT53358A (en) 1990-10-28
EP0288189A1 (en) 1988-10-26
AU1433388A (en) 1988-10-13
GR3006973T3 (es) 1993-06-30
PT87181B (pt) 1992-07-31
IE61883B1 (en) 1994-11-30
CN88101940A (zh) 1988-11-09
SU1750420A3 (ru) 1992-07-23
DK188488D0 (da) 1988-04-07
JPS63258831A (ja) 1988-10-26
DK188488A (da) 1988-10-14
PT87181A (pt) 1988-05-01
ES2045110T3 (es) 1994-01-16
DE3875782T2 (de) 1993-04-01
IE881061L (en) 1988-10-13
DE3875782D1 (de) 1992-12-17
KR880012521A (ko) 1988-11-28
ATE82273T1 (de) 1992-11-15
IL85989A (en) 1993-08-18
EG19001A (en) 1994-04-30
ZA882421B (en) 1989-12-27
EP0288189B1 (en) 1992-11-11
HU202505B (en) 1991-03-28
CN1012433B (zh) 1991-04-24

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