JPH0613514B2 - インドール化合物、その製造方法および該化合物を含有する血圧降下および徐脈作用を有する心臓循環疾患の治療剤 - Google Patents
インドール化合物、その製造方法および該化合物を含有する血圧降下および徐脈作用を有する心臓循環疾患の治療剤Info
- Publication number
- JPH0613514B2 JPH0613514B2 JP1053974A JP5397489A JPH0613514B2 JP H0613514 B2 JPH0613514 B2 JP H0613514B2 JP 1053974 A JP1053974 A JP 1053974A JP 5397489 A JP5397489 A JP 5397489A JP H0613514 B2 JPH0613514 B2 JP H0613514B2
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- Japan
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- group
- compound
- general formula
- formula
- hydrogen atom
- Prior art date
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- Expired - Lifetime
Links
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- 239000003755 preservative agent Substances 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- 238000011158 quantitative evaluation Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 210000005245 right atrium Anatomy 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000009154 spontaneous behavior Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000001975 sympathomimetic effect Effects 0.000 description 1
- 229940064707 sympathomimetics Drugs 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3807533.4 | 1988-03-08 | ||
| DE3807533A DE3807533A1 (de) | 1988-03-08 | 1988-03-08 | Pyridocycloheptindol-verbindungen, verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01272583A JPH01272583A (ja) | 1989-10-31 |
| JPH0613514B2 true JPH0613514B2 (ja) | 1994-02-23 |
Family
ID=6349134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1053974A Expired - Lifetime JPH0613514B2 (ja) | 1988-03-08 | 1989-03-08 | インドール化合物、その製造方法および該化合物を含有する血圧降下および徐脈作用を有する心臓循環疾患の治療剤 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5159080A (en, 2012) |
| JP (1) | JPH0613514B2 (en, 2012) |
| KR (1) | KR910004449B1 (en, 2012) |
| CN (1) | CN1024551C (en, 2012) |
| AT (1) | AT395243B (en, 2012) |
| AU (1) | AU610701B2 (en, 2012) |
| BE (1) | BE1002923A4 (en, 2012) |
| CH (1) | CH677792A5 (en, 2012) |
| CZ (1) | CZ143789A3 (en, 2012) |
| DD (1) | DD283622A5 (en, 2012) |
| DE (1) | DE3807533A1 (en, 2012) |
| DK (1) | DK110089A (en, 2012) |
| FI (1) | FI92066C (en, 2012) |
| FR (1) | FR2628426A1 (en, 2012) |
| GB (1) | GB2216889B (en, 2012) |
| GR (1) | GR1000311B (en, 2012) |
| HU (1) | HU205355B (en, 2012) |
| IE (1) | IE61683B1 (en, 2012) |
| IL (1) | IL89476A (en, 2012) |
| IT (1) | IT1228569B (en, 2012) |
| LU (1) | LU87463A1 (en, 2012) |
| NL (1) | NL8900552A (en, 2012) |
| NO (1) | NO890978L (en, 2012) |
| NZ (1) | NZ228246A (en, 2012) |
| PL (1) | PL159893B1 (en, 2012) |
| PT (1) | PT89941B (en, 2012) |
| SE (1) | SE500580C2 (en, 2012) |
| SU (1) | SU1650012A3 (en, 2012) |
| YU (1) | YU48489A (en, 2012) |
| ZA (1) | ZA891721B (en, 2012) |
-
1988
- 1988-03-08 DE DE3807533A patent/DE3807533A1/de active Granted
-
1989
- 1989-03-01 LU LU87463A patent/LU87463A1/fr unknown
- 1989-03-02 GB GB8904792A patent/GB2216889B/en not_active Expired - Fee Related
- 1989-03-02 AT AT0047389A patent/AT395243B/de not_active IP Right Cessation
- 1989-03-02 CH CH807/89A patent/CH677792A5/de not_active IP Right Cessation
- 1989-03-02 SE SE8900725A patent/SE500580C2/sv unknown
- 1989-03-03 IL IL8947689A patent/IL89476A/en unknown
- 1989-03-03 IT IT8919648A patent/IT1228569B/it active
- 1989-03-03 IE IE70089A patent/IE61683B1/en not_active IP Right Cessation
- 1989-03-07 FR FR8902978A patent/FR2628426A1/fr active Granted
- 1989-03-07 DD DD89326336A patent/DD283622A5/de not_active IP Right Cessation
- 1989-03-07 DK DK110089A patent/DK110089A/da not_active Application Discontinuation
- 1989-03-07 YU YU00484/89A patent/YU48489A/xx unknown
- 1989-03-07 NZ NZ228246A patent/NZ228246A/en unknown
- 1989-03-07 SU SU894613697A patent/SU1650012A3/ru active
- 1989-03-07 NL NL8900552A patent/NL8900552A/nl not_active Application Discontinuation
- 1989-03-07 AU AU31095/89A patent/AU610701B2/en not_active Ceased
- 1989-03-07 ZA ZA891721A patent/ZA891721B/xx unknown
- 1989-03-07 NO NO89890978A patent/NO890978L/no unknown
- 1989-03-07 CZ CS891437A patent/CZ143789A3/cs unknown
- 1989-03-07 KR KR1019890002754A patent/KR910004449B1/ko not_active Expired
- 1989-03-07 CN CN89102030A patent/CN1024551C/zh not_active Expired - Fee Related
- 1989-03-07 GR GR890100145A patent/GR1000311B/el unknown
- 1989-03-07 HU HU891112A patent/HU205355B/hu not_active IP Right Cessation
- 1989-03-08 FI FI891086A patent/FI92066C/fi not_active IP Right Cessation
- 1989-03-08 JP JP1053974A patent/JPH0613514B2/ja not_active Expired - Lifetime
- 1989-03-08 BE BE8900249A patent/BE1002923A4/fr not_active IP Right Cessation
- 1989-03-08 PT PT89941A patent/PT89941B/pt not_active IP Right Cessation
- 1989-03-08 PL PL1989278135A patent/PL159893B1/pl unknown
-
1990
- 1990-12-18 US US07/629,188 patent/US5159080A/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| TETRAHEDRON=1975 * |
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