JP7563782B2 - ミトコンドリア抽出物の腎障害関連疾患を治療及び/又は予防する用途 - Google Patents

ミトコンドリア抽出物の腎障害関連疾患を治療及び/又は予防する用途 Download PDF

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JP7563782B2
JP7563782B2 JP2022556517A JP2022556517A JP7563782B2 JP 7563782 B2 JP7563782 B2 JP 7563782B2 JP 2022556517 A JP2022556517 A JP 2022556517A JP 2022556517 A JP2022556517 A JP 2022556517A JP 7563782 B2 JP7563782 B2 JP 7563782B2
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renal
cells
mitochondrial
epithelial cells
renal epithelial
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JP2023518083A (ja
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鄭漢中
許智凱
曾恵卿
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Taiwan Mitochondrion Application Technology Co Ltd
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JP2022556517A 2020-03-20 2021-03-19 ミトコンドリア抽出物の腎障害関連疾患を治療及び/又は予防する用途 Active JP7563782B2 (ja)

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JP2024112807A JP7736347B2 (ja) 2020-03-20 2024-07-12 ミトコンドリア抽出物の腎障害関連疾患を治療及び/又は予防する用途

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US202062992546P 2020-03-20 2020-03-20
US62/992,546 2020-03-20
PCT/CN2021/081686 WO2021185341A1 (zh) 2020-03-20 2021-03-19 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途

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JP2024112807A Active JP7736347B2 (ja) 2020-03-20 2024-07-12 ミトコンドリア抽出物の腎障害関連疾患を治療及び/又は予防する用途

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US (6) US20230042445A1 (https=)
EP (2) EP4122474A4 (https=)
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CN (16) CN118557602A (https=)
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Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI789724B (zh) * 2020-03-20 2023-01-11 台灣粒線體應用技術股份有限公司 粒線體用於治療及/或預防肌腱受損或其相關疾病之用途
US20250186498A1 (en) * 2022-05-16 2025-06-12 Taiwan Mitochondrion Applied Technology Co., Ltd. Composition for hearing loss mitigation and use thereof
CN116478920B (zh) * 2023-05-05 2025-03-25 重庆理工大学 一种离体线粒体的体外储存方法
CN117180312A (zh) * 2023-10-09 2023-12-08 上海市第六人民医院 iMSCs线粒体在制备治疗骨缺损的药物中的应用
CN117883479A (zh) * 2023-11-02 2024-04-16 上海市第六人民医院 人源线粒体在制备治疗跟腱损伤的药物中的应用
WO2025126112A1 (en) * 2023-12-12 2025-06-19 Cells For Cells S.A. Composition enriched in mitochondria isolated from umbilical cord mesenchymal stem cells, useful in osteoarthritis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019507729A (ja) 2016-01-15 2019-03-22 ザ チルドレンズ メディカル センター コーポレーション ミトコンドリアおよび組み合わされたミトコンドリア剤の治療的使用

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0202298B1 (en) * 1984-11-29 1992-07-15 Regents Of The University Of Minnesota Wound healing agents
US6100068A (en) * 1997-01-21 2000-08-08 Paik-Inje Memorial Institute For Biomedical Science Method of protein production using mitochondrial translation system
US5834418A (en) * 1996-03-20 1998-11-10 Theratechnologies, Inc. Process for the preparation of platelet growth factors extract
US7005274B1 (en) * 1999-09-15 2006-02-28 Migenix Corp. Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass
BRPI0507349A (pt) * 2004-02-02 2007-04-17 Nestec Sa genes associados á osteoartrite canina e processos e composições relacionados
TW200817019A (en) * 2006-07-10 2008-04-16 Univ Columbia De novo formation and regeneration of vascularized tissue from tissue progenitor cells and vascular progenitor cells
WO2009002811A2 (en) * 2007-06-22 2008-12-31 Children's Medical Center Corporation Therapeutic platelet compositions and methods
US8734854B2 (en) * 2009-07-09 2014-05-27 Orogen Biosciences Inc. Process for removing growth factors from platelets
US20130022666A1 (en) * 2011-07-20 2013-01-24 Anna Brzezinska Methods and compositions for transfer of mitochondria into mammalian cells
EP2741757B1 (en) * 2011-09-11 2018-05-16 Minovia Therapeutics Ltd. Compositions of functional mitochondria and uses thereof
EP2591812A1 (en) * 2011-11-14 2013-05-15 University of Twente, Institute for Biomedical Technology and Technical Medicine (MIRA) A dextran-based tissuelette containing platelet-rich plasma lysate for cartilage repair
US20140024677A1 (en) * 2012-04-09 2014-01-23 Musc Foundation For Research Development Methods for inducing mitochondrial biogenesis
US10702556B2 (en) * 2012-05-16 2020-07-07 Minovia Therpautices Ltd. Compositions and methods for inducing angiogenesis
AU2013326861A1 (en) * 2012-10-04 2015-04-23 Genesys Research Institute Platelet compositions and uses thereof
CN105163750B (zh) * 2013-02-07 2022-07-15 李震义 长效人重组可溶性肿瘤坏死因子α受体在制备预防和治疗慢性肝病重症肝损伤药物中的用途
US20140271589A1 (en) * 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
ES2883580T3 (es) * 2013-03-21 2021-12-09 Collplant Ltd Composiciones que comprenden colágeno y PRP para la regeneración de tejidos y su método de producción
US20150064715A1 (en) * 2013-08-28 2015-03-05 Musc Foundation For Research Development Urinary biomarkers of renal and mitochondrial dysfunction
TW201509425A (zh) * 2013-09-13 2015-03-16 Taichung Hospital Ministry Of Health And Welfare 以血液製備修復傷口用醫藥組合物之方法
TWI672147B (zh) * 2014-09-10 2019-09-21 台灣粒線體應用技術股份有限公司 以外源性粒線體爲有效成份之組合物、其用途及修復細胞之方法
JP6441472B2 (ja) * 2014-09-30 2018-12-19 台灣粒線體應用技術股▲扮▼有限公司Taiwan Mitochondrion Applied Technology Co.,Ltd. 活性成分として外因性ミトコンドリアを含む組成物、ならびにその使用およびそのための細胞修復法
CN105520891B (zh) * 2014-09-30 2019-05-21 台湾粒线体应用技术股份有限公司 以外源性线粒体为有效成份的组合物、其用途及修复细胞的方法
CN107249600A (zh) * 2014-12-31 2017-10-13 台湾粒线体应用技术股份有限公司 新颖医药组合物及其用于治疗肺损伤的用途
WO2016114781A1 (en) * 2015-01-15 2016-07-21 Boss William K Jr Repair and rejuvenation of tissues using platelet-rich plasma
CN104546915B (zh) * 2015-02-16 2018-12-11 天晴干细胞股份有限公司 一种治疗骨性关节炎的组合物的制备方法
IL299482B2 (en) * 2015-02-26 2025-02-01 Minovia Therapeutics Ltd Mammalian cells are enriched with active mitochondria
CA2987271A1 (en) * 2015-05-22 2016-12-01 President And Fellows Of Harvard College Methods, systems, and compositions for determining blood clot formation, and uses thereof
CN105030647B (zh) * 2015-09-14 2018-04-24 广州赛莱拉干细胞科技股份有限公司 一种减少皱纹的制剂及其制备方法
US20180303970A1 (en) * 2015-11-02 2018-10-25 VeriGraft AB Compositions and methods for healing wounds
US11903974B2 (en) * 2015-11-30 2024-02-20 Flagship Pioneering Innovations V, Inc. Methods and compositions relating to chondrisomes from cultured cells
CN105477018A (zh) * 2015-12-07 2016-04-13 深圳爱生再生医学科技有限公司 修复皮肤溃疡的干细胞制剂及其制备方法
US20170224764A1 (en) * 2016-02-10 2017-08-10 Cornell University Therapeutic targeting of mitochondria to prevent osteoarthritis
TWI637748B (zh) * 2016-07-12 2018-10-11 中山醫學大學 蓮蓬萃取物用於治療及/或預防腎臟病變之用途
CN106190963A (zh) * 2016-07-13 2016-12-07 浙江大学 一种采用线粒体移植促进损伤神经元存活的方法
EP3549589A4 (en) * 2016-11-30 2020-07-15 Paean Biotechnology Inc. PHARMACEUTICAL COMPOSITION CONTAINING MITOCHONDRIA
CN106822183B (zh) * 2016-12-26 2020-04-14 中山光禾医疗科技有限公司 一种光敏富血小板血浆凝胶及其制备方法和用途
US20200023005A1 (en) * 2017-03-26 2020-01-23 Minovia Therapeutics Ltd. Mitochondrial compositions and methods for treatment of skin and hair
US20200268940A1 (en) * 2017-05-15 2020-08-27 Richard J. Miron Liquid platelet-rich fibrin as a carrier system for biomaterials and biomolecules
EP3630134B8 (en) * 2017-06-01 2022-01-19 The United States of America as represented by The Secretary Department of Health and Human Services Formation of stable cartilage
US20190008896A1 (en) * 2017-07-07 2019-01-10 Richard Postrel Methods and Systems for the Prevention, Treatment and Management of Disease and Effects of Aging Via Cell-to-Cell Restoration Therapy Using Subcellular Transactions
CN107625969A (zh) * 2017-10-18 2018-01-26 南京市儿童医院 MiR‑214拮抗剂在制备用于减轻蛋白尿引起的肾小管损伤相关病症的药物中的用途
WO2019083201A2 (ko) * 2017-10-24 2019-05-02 주식회사 엑소코바이오 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 신장 기능 개선 용도
KR20190052266A (ko) * 2017-11-08 2019-05-16 원광대학교산학협력단 우르솔산을 유효성분으로 포함하는 신장 기능의 개선 또는 치료용 조성물
KR102275822B1 (ko) * 2018-02-02 2021-07-12 주식회사 파이안바이오테크놀로지 분리된 미토콘드리아를 포함하는 류마티스 관절염 예방 또는 치료용 약학 조성물
CN112154210A (zh) * 2018-03-13 2020-12-29 利兰斯坦福初级大学董事会 用于逆转细胞老化的瞬时细胞重编程
WO2019183042A1 (en) * 2018-03-20 2019-09-26 Unity Biotechnology, Inc. Autologous mitochondrial extraction and expansion
US12329781B2 (en) * 2018-07-22 2025-06-17 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of renal diseases
CN112601532A (zh) * 2018-07-22 2021-04-02 米诺维亚疗法有限公司 使用富集有功能性线粒体的干细胞的线粒体增强疗法
US12268714B2 (en) * 2018-09-14 2025-04-08 Luca Science Inc. Transplantation of mitochondria into lymphoid organ and composition therefor
KR102128003B1 (ko) * 2018-10-31 2020-06-29 차의과학대학교 산학협력단 분리된 미토콘드리아를 포함하는 건병증 예방 또는 치료용 약학 조성물
CN110055216A (zh) * 2019-05-09 2019-07-26 张秀明 一种改善间质干细胞生物学功能的方法
CN110638833A (zh) * 2019-11-15 2020-01-03 西安圣德生物科技有限公司 促进毛发生长的组合物及其使用方法
CN110812480B (zh) * 2019-11-28 2021-04-02 中国科学院昆明动物研究所 一种抗菌肽和线粒体dna复合物及其多克隆抗体和应用
TWI789724B (zh) * 2020-03-20 2023-01-11 台灣粒線體應用技術股份有限公司 粒線體用於治療及/或預防肌腱受損或其相關疾病之用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019507729A (ja) 2016-01-15 2019-03-22 ザ チルドレンズ メディカル センター コーポレーション ミトコンドリアおよび組み合わされたミトコンドリア剤の治療的使用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Hanieh JABBARI et al.,"Mitochondrial transplantation ameliorates ischemia/reperfusion-induced kidney injury in rat",Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,2020年04月28日,Vol. 1866, No. 8,Article No. 165809,DOI: 10.1016/j.bbadis.2020.165809
Ilias P. DOULAMIS et al.,"Mitochondrial transplantation by intra-arterial injection for acute kidney injury",American Journal of Physiology-Renal Physiology,2020年07月,Vol. 319, No. 3,p.F403-F413,DOI: 10.1152/ajprenal.00255.2020
Ki Wung CHUNG et al.,"Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis",Cell Metabolism,2019年10月,Vol. 30, No. 4,p.784-799.e5,DOI: 10.1016/j.cmet.2019.08.003

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