CN115135328A - 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途 - Google Patents

线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途 Download PDF

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CN115135328A
CN115135328A CN202180014670.7A CN202180014670A CN115135328A CN 115135328 A CN115135328 A CN 115135328A CN 202180014670 A CN202180014670 A CN 202180014670A CN 115135328 A CN115135328 A CN 115135328A
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kidney
renal
mitochondria
cells
injury
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CN115135328B (zh
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郑汉中
许智凯
曾惠卿
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National Chung Hsing University
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Abstract

一种线粒体萃取物用于治疗或预防肾脏损伤相关疾病的用途，该线粒体萃取物能够有效改善肾脏损伤相关疾病，并预防肾脏损伤相关疾病的恶化。

Description

PCT国内申请，说明书已公开。

Claims (9)

  1. PCT国内申请，权利要求书已公开。
CN202180014670.7A 2020-03-20 2021-03-19 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途 Active CN115135328B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202311570784.7A CN117357559A (zh) 2020-03-20 2021-03-19 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途
CN202311621466.9A CN117379458A (zh) 2020-03-20 2021-03-19 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062992546P 2020-03-20 2020-03-20
US62/992,546 2020-03-20
PCT/CN2021/081686 WO2021185341A1 (zh) 2020-03-20 2021-03-19 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途

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CN202311621466.9A Division CN117379458A (zh) 2020-03-20 2021-03-19 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途
CN202311570784.7A Division CN117357559A (zh) 2020-03-20 2021-03-19 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途

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CN115135328A true CN115135328A (zh) 2022-09-30
CN115135328B CN115135328B (zh) 2024-01-02

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CN202180022924.XA Pending CN115335065A (zh) 2020-03-20 2021-03-19 细胞培养组合物及其用途
CN202180014670.7A Active CN115135328B (zh) 2020-03-20 2021-03-19 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途
CN202311570784.7A Pending CN117357559A (zh) 2020-03-20 2021-03-19 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途
CN202180014777.1A Active CN115103683B (zh) 2020-03-20 2021-03-19 线粒体用于治疗及/或预防肌腱受损或其相关疾病的用途
CN202311621466.9A Pending CN117379458A (zh) 2020-03-20 2021-03-19 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途
CN202180022422.7A Active CN115297872B (zh) 2020-03-20 2021-03-22 含有线粒体的组合物及其修复软骨损伤或改善退化性关节炎的用途
CN202180022370.3A Pending CN115315248A (zh) 2020-03-20 2021-03-22 促进毛发再生的组合物、富线粒体血浆、其制造方法及其用途

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CN202180022924.XA Pending CN115335065A (zh) 2020-03-20 2021-03-19 细胞培养组合物及其用途

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CN202311570784.7A Pending CN117357559A (zh) 2020-03-20 2021-03-19 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途
CN202180014777.1A Active CN115103683B (zh) 2020-03-20 2021-03-19 线粒体用于治疗及/或预防肌腱受损或其相关疾病的用途
CN202311621466.9A Pending CN117379458A (zh) 2020-03-20 2021-03-19 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途
CN202180022422.7A Active CN115297872B (zh) 2020-03-20 2021-03-22 含有线粒体的组合物及其修复软骨损伤或改善退化性关节炎的用途
CN202180022370.3A Pending CN115315248A (zh) 2020-03-20 2021-03-22 促进毛发再生的组合物、富线粒体血浆、其制造方法及其用途

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US (6) US20230165899A1 (zh)
EP (2) EP4122474A4 (zh)
JP (1) JP2023518083A (zh)
CN (7) CN115335065A (zh)
TW (9) TWI787761B (zh)
WO (6) WO2021185340A1 (zh)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140024677A1 (en) * 2012-04-09 2014-01-23 Musc Foundation For Research Development Methods for inducing mitochondrial biogenesis
WO2014121481A1 (zh) * 2013-02-07 2014-08-14 李震义 长效人重组可溶性肿瘤坏死因子α受体在制备预防和治疗慢性肝病重症肝损伤药物中的用途
US20150064715A1 (en) * 2013-08-28 2015-03-05 Musc Foundation For Research Development Urinary biomarkers of renal and mitochondrial dysfunction
CN107595942A (zh) * 2016-07-12 2018-01-19 陈璟贤 莲蓬萃取物用于制造治疗及/或预防肾脏疾病的组合物的用途
CN107625969A (zh) * 2017-10-18 2018-01-26 南京市儿童医院 MiR‑214拮抗剂在制备用于减轻蛋白尿引起的肾小管损伤相关病症的药物中的用途
WO2019083201A2 (ko) * 2017-10-24 2019-05-02 주식회사 엑소코바이오 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 신장 기능 개선 용도
KR20190052266A (ko) * 2017-11-08 2019-05-16 원광대학교산학협력단 우르솔산을 유효성분으로 포함하는 신장 기능의 개선 또는 치료용 조성물
WO2020021534A1 (en) * 2018-07-22 2020-01-30 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of renal diseases

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7005274B1 (en) * 1999-09-15 2006-02-28 Migenix Corp. Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass
EP1711635A1 (en) * 2004-02-02 2006-10-18 Nestec S.A. Genes associated with canine osteoarthritis and related methods and compositions
WO2013035101A1 (en) * 2011-09-11 2013-03-14 Minovia Therapeutics Ltd. Compositions of functional mitochondria and uses thereof
EP2591812A1 (en) * 2011-11-14 2013-05-15 University of Twente, Institute for Biomedical Technology and Technical Medicine (MIRA) A dextran-based tissuelette containing platelet-rich plasma lysate for cartilage repair
WO2013171752A1 (en) * 2012-05-16 2013-11-21 Minovia Therapeutics Ltd. Compositions and methods for inducing angiogenesis
TWI672147B (zh) * 2014-09-10 2019-09-21 台灣粒線體應用技術股份有限公司 以外源性粒線體爲有效成份之組合物、其用途及修復細胞之方法
CN105520891B (zh) * 2014-09-30 2019-05-21 台湾粒线体应用技术股份有限公司 以外源性线粒体为有效成份的组合物、其用途及修复细胞的方法
JP6355220B2 (ja) * 2014-12-31 2018-07-11 台灣粒線體應用技術股▲扮▼有限公司Ｔａｉｗａｎ Ｍｉｔｏｃｈｏｎｄｒｉｏｎ Ａｐｐｌｉｅｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．，Ｌｔｄ． 肺損傷を治療するための新規な医薬組成物及びその使用
CN104546915B (zh) * 2015-02-16 2018-12-11 天晴干细胞股份有限公司 一种治疗骨性关节炎的组合物的制备方法
IL299482A (en) * 2015-02-26 2023-02-01 Minovia Therapeutics Ltd Mammalian cells are enriched in active mitochondria
CN105030647B (zh) * 2015-09-14 2018-04-24 广州赛莱拉干细胞科技股份有限公司 一种减少皱纹的制剂及其制备方法
JP7185527B2 (ja) * 2016-01-15 2022-12-07 ザ チルドレンズ メディカル センター コーポレーション ミトコンドリアおよび組み合わされたミトコンドリア剤の治療的使用
US20170224764A1 (en) * 2016-02-10 2017-08-10 Cornell University Therapeutic targeting of mitochondria to prevent osteoarthritis
CN106190963A (zh) * 2016-07-13 2016-12-07 浙江大学 一种采用线粒体移植促进损伤神经元存活的方法
WO2018101708A1 (ko) * 2016-11-30 2018-06-07 차의과학대학교 산학협력단 미토콘드리아를 포함하는 약학 조성물
CN106822183B (zh) * 2016-12-26 2020-04-14 中山光禾医疗科技有限公司 一种光敏富血小板血浆凝胶及其制备方法和用途
EP3600351A4 (en) * 2017-03-26 2020-11-25 Minovia Therapeutics Ltd. MITOCHONDRIAL COMPOSITIONS AND PROCESSES FOR THE TREATMENT OF THE SKIN AND HAIR
EP3630134B8 (en) * 2017-06-01 2022-01-19 The United States of America as represented by The Secretary Department of Health and Human Services Formation of stable cartilage
KR102275822B1 (ko) * 2018-02-02 2021-07-12 주식회사 파이안바이오테크놀로지 분리된 미토콘드리아를 포함하는 류마티스 관절염 예방 또는 치료용 약학 조성물
AU2019235861A1 (en) * 2018-03-13 2020-10-01 The Board Of Trustees Of The Leland Stanford Junior University Transient cellular reprogramming for reversal of cell aging
WO2019183042A1 (en) * 2018-03-20 2019-09-26 Unity Biotechnology, Inc. Autologous mitochondrial extraction and expansion
KR20210035829A (ko) * 2018-07-22 2021-04-01 미노비아 테라퓨틱스 리미티드 기능성 미토콘드리아가 풍부화된 줄기 세포를 사용한 미토콘드리아 증강 요법
KR102128003B1 (ko) * 2018-10-31 2020-06-29 차의과학대학교 산학협력단 분리된 미토콘드리아를 포함하는 건병증 예방 또는 치료용 약학 조성물
CN110055216A (zh) * 2019-05-09 2019-07-26 张秀明 一种改善间质干细胞生物学功能的方法
CN110638833A (zh) * 2019-11-15 2020-01-03 西安圣德生物科技有限公司 促进毛发生长的组合物及其使用方法
CN110812480B (zh) * 2019-11-28 2021-04-02 中国科学院昆明动物研究所 一种抗菌肽和线粒体dna复合物及其多克隆抗体和应用

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140024677A1 (en) * 2012-04-09 2014-01-23 Musc Foundation For Research Development Methods for inducing mitochondrial biogenesis
WO2014121481A1 (zh) * 2013-02-07 2014-08-14 李震义 长效人重组可溶性肿瘤坏死因子α受体在制备预防和治疗慢性肝病重症肝损伤药物中的用途
US20150064715A1 (en) * 2013-08-28 2015-03-05 Musc Foundation For Research Development Urinary biomarkers of renal and mitochondrial dysfunction
CN107595942A (zh) * 2016-07-12 2018-01-19 陈璟贤 莲蓬萃取物用于制造治疗及/或预防肾脏疾病的组合物的用途
CN107625969A (zh) * 2017-10-18 2018-01-26 南京市儿童医院 MiR‑214拮抗剂在制备用于减轻蛋白尿引起的肾小管损伤相关病症的药物中的用途
WO2019083201A2 (ko) * 2017-10-24 2019-05-02 주식회사 엑소코바이오 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 신장 기능 개선 용도
KR20190052266A (ko) * 2017-11-08 2019-05-16 원광대학교산학협력단 우르솔산을 유효성분으로 포함하는 신장 기능의 개선 또는 치료용 조성물
WO2020021534A1 (en) * 2018-07-22 2020-01-30 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of renal diseases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
余宗超;尹良红;刘娜;: "从线粒体动力学角度探索肾脏病治疗新策略", no. 04, pages 205 - 209 *
刘杰: "线粒体质量控制与急性肾损伤", pages 1032 - 1034 *
张炯;王佳;王芳;李贵森;: "辣椒素减轻肾缺血再灌注损伤的线粒体相关机制", 中国动脉硬化杂志, no. 06 *
詹明;张国阳;杨军;余晶波;: "糖尿病肾病患者线粒体结构变化对肾小管病理损伤的影响分析", 现代实用医学, no. 05 *

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