JP2023518083A - ミトコンドリア抽出物の腎障害関連疾患を治療及び/又は予防する用途 - Google Patents
ミトコンドリア抽出物の腎障害関連疾患を治療及び/又は予防する用途 Download PDFInfo
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- JP2023518083A JP2023518083A JP2022556517A JP2022556517A JP2023518083A JP 2023518083 A JP2023518083 A JP 2023518083A JP 2022556517 A JP2022556517 A JP 2022556517A JP 2022556517 A JP2022556517 A JP 2022556517A JP 2023518083 A JP2023518083 A JP 2023518083A
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Abstract
Description
Claims (9)
- ミトコンドリアの腎障害関連疾患を予防又は/及び治療する組成物を調製する用途。
- 前記腎障害関連疾患は腎線維化である、請求項1に記載の用途。
- 前記腎障害関連疾患は腎臓の炎症である、請求項1に記載の用途。
- 前記腎障害関連疾患はミトコンドリア損傷の症状を有する、請求項1に記載の用途。
- 前記腎障害関連疾患は慢性腎臓病である、請求項1に記載の用途。
- 前記腎障害関連疾患は尿細管損傷である、請求項1に記載の用途。
- 前記尿細管損傷の症状は損傷面積が25%より大きい、請求項6に記載の用途。
- 前記組成物中の前記ミトコンドリアの分量は5μg以上である、請求項1に記載の用途。
- 前記組成物中の前記ミトコンドリアの分量は40μg以上である、請求項1に記載の用途。
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TWI789723B (zh) * | 2020-03-20 | 2023-01-11 | 台灣粒線體應用技術股份有限公司 | 粒線體用於治療或/及預防腎臟損傷相關疾病之用途 |
WO2023221987A1 (zh) * | 2022-05-16 | 2023-11-23 | 台湾粒线体应用技术股份有限公司 | 用于减缓口腔损伤的组合物、其用途及其制备方法 |
CN116478920A (zh) * | 2023-05-05 | 2023-07-25 | 重庆理工大学 | 一种离体线粒体的体外储存方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019507729A (ja) * | 2016-01-15 | 2019-03-22 | ザ チルドレンズ メディカル センター コーポレーション | ミトコンドリアおよび組み合わされたミトコンドリア剤の治療的使用 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7005274B1 (en) * | 1999-09-15 | 2006-02-28 | Migenix Corp. | Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass |
AU2005210503B2 (en) * | 2004-02-02 | 2010-02-25 | Nestec S.A. | Genes associated with canine osteoarthritis and related methods and compositions |
WO2009002811A2 (en) * | 2007-06-22 | 2008-12-31 | Children's Medical Center Corporation | Therapeutic platelet compositions and methods |
US8734854B2 (en) * | 2009-07-09 | 2014-05-27 | Orogen Biosciences Inc. | Process for removing growth factors from platelets |
US20130022666A1 (en) * | 2011-07-20 | 2013-01-24 | Anna Brzezinska | Methods and compositions for transfer of mitochondria into mammalian cells |
WO2013035101A1 (en) * | 2011-09-11 | 2013-03-14 | Minovia Therapeutics Ltd. | Compositions of functional mitochondria and uses thereof |
EP2591812A1 (en) * | 2011-11-14 | 2013-05-15 | University of Twente, Institute for Biomedical Technology and Technical Medicine (MIRA) | A dextran-based tissuelette containing platelet-rich plasma lysate for cartilage repair |
US20140024677A1 (en) * | 2012-04-09 | 2014-01-23 | Musc Foundation For Research Development | Methods for inducing mitochondrial biogenesis |
WO2013171752A1 (en) * | 2012-05-16 | 2013-11-21 | Minovia Therapeutics Ltd. | Compositions and methods for inducing angiogenesis |
CN105163750B (zh) * | 2013-02-07 | 2022-07-15 | 李震义 | 长效人重组可溶性肿瘤坏死因子α受体在制备预防和治疗慢性肝病重症肝损伤药物中的用途 |
US20150064715A1 (en) * | 2013-08-28 | 2015-03-05 | Musc Foundation For Research Development | Urinary biomarkers of renal and mitochondrial dysfunction |
TW201509425A (zh) * | 2013-09-13 | 2015-03-16 | Taichung Hospital Ministry Of Health And Welfare | 以血液製備修復傷口用醫藥組合物之方法 |
TWI672147B (zh) * | 2014-09-10 | 2019-09-21 | 台灣粒線體應用技術股份有限公司 | 以外源性粒線體爲有效成份之組合物、其用途及修復細胞之方法 |
CN105520891B (zh) * | 2014-09-30 | 2019-05-21 | 台湾粒线体应用技术股份有限公司 | 以外源性线粒体为有效成份的组合物、其用途及修复细胞的方法 |
US10420798B2 (en) * | 2014-12-31 | 2019-09-24 | Taiwan Mitochondrion Applied Technology Co., Ltd | Method for treating lung injury and/or diseases related to lung injury |
CN106029102A (zh) * | 2015-01-15 | 2016-10-12 | 小威廉·K·博斯 | 使用富血小板血浆进行组织的修复和复壮 |
CN104546915B (zh) * | 2015-02-16 | 2018-12-11 | 天晴干细胞股份有限公司 | 一种治疗骨性关节炎的组合物的制备方法 |
IL254071B2 (en) * | 2015-02-26 | 2024-01-01 | Minovia Therapeutics Ltd | Mammalian cells are enriched in active mitochondria |
CN105030647B (zh) * | 2015-09-14 | 2018-04-24 | 广州赛莱拉干细胞科技股份有限公司 | 一种减少皱纹的制剂及其制备方法 |
WO2017076782A1 (en) * | 2015-11-02 | 2017-05-11 | Novahep Ab | Compositions and methods for healing wounds |
CN105477018A (zh) * | 2015-12-07 | 2016-04-13 | 深圳爱生再生医学科技有限公司 | 修复皮肤溃疡的干细胞制剂及其制备方法 |
US20170224764A1 (en) * | 2016-02-10 | 2017-08-10 | Cornell University | Therapeutic targeting of mitochondria to prevent osteoarthritis |
TWI637748B (zh) * | 2016-07-12 | 2018-10-11 | 中山醫學大學 | 蓮蓬萃取物用於治療及/或預防腎臟病變之用途 |
CN106190963A (zh) * | 2016-07-13 | 2016-12-07 | 浙江大学 | 一种采用线粒体移植促进损伤神经元存活的方法 |
WO2018101708A1 (ko) * | 2016-11-30 | 2018-06-07 | 차의과학대학교 산학협력단 | 미토콘드리아를 포함하는 약학 조성물 |
CN106822183B (zh) * | 2016-12-26 | 2020-04-14 | 中山光禾医疗科技有限公司 | 一种光敏富血小板血浆凝胶及其制备方法和用途 |
US20200023005A1 (en) * | 2017-03-26 | 2020-01-23 | Minovia Therapeutics Ltd. | Mitochondrial compositions and methods for treatment of skin and hair |
WO2018212758A1 (en) * | 2017-05-15 | 2018-11-22 | Miron Richard J | Liquid platelet-rich fibrin as a carrier system for biomaterials and biomolecules |
WO2018222906A1 (en) * | 2017-06-01 | 2018-12-06 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Formation of stable cartilage |
US20190008896A1 (en) * | 2017-07-07 | 2019-01-10 | Richard Postrel | Methods and Systems for the Prevention, Treatment and Management of Disease and Effects of Aging Via Cell-to-Cell Restoration Therapy Using Subcellular Transactions |
CN107625969A (zh) * | 2017-10-18 | 2018-01-26 | 南京市儿童医院 | MiR‑214拮抗剂在制备用于减轻蛋白尿引起的肾小管损伤相关病症的药物中的用途 |
WO2019083201A2 (ko) * | 2017-10-24 | 2019-05-02 | 주식회사 엑소코바이오 | 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 신장 기능 개선 용도 |
KR20190052266A (ko) * | 2017-11-08 | 2019-05-16 | 원광대학교산학협력단 | 우르솔산을 유효성분으로 포함하는 신장 기능의 개선 또는 치료용 조성물 |
EP3747449A4 (en) * | 2018-02-02 | 2021-10-20 | Paean Biotechnology Inc. | PHARMACEUTICAL COMPOSITION CONSISTING OF ISOLATED MITOCHONDRIA FOR THE PREVENTION OR TREATMENT OF RHEUMATOID ARTHRITIS |
SG11202008839WA (en) * | 2018-03-13 | 2020-10-29 | Univ Leland Stanford Junior | Transient cellular reprogramming for reversal of cell aging |
WO2019183042A1 (en) * | 2018-03-20 | 2019-09-26 | Unity Biotechnology, Inc. | Autologous mitochondrial extraction and expansion |
CA3106188A1 (en) * | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy with stem cells enriched with functional mitochondria |
US20210275587A1 (en) * | 2018-07-22 | 2021-09-09 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of renal diseases |
EP3851112A4 (en) * | 2018-09-14 | 2022-07-27 | Luca Science Inc. | TRANSPLANTATION OF MITOCHONDRIA IN A LYMPHOID ORGAN AND ASSOCIATED COMPOSITION |
KR102128003B1 (ko) * | 2018-10-31 | 2020-06-29 | 차의과학대학교 산학협력단 | 분리된 미토콘드리아를 포함하는 건병증 예방 또는 치료용 약학 조성물 |
CN110055216A (zh) * | 2019-05-09 | 2019-07-26 | 张秀明 | 一种改善间质干细胞生物学功能的方法 |
CN110638833A (zh) * | 2019-11-15 | 2020-01-03 | 西安圣德生物科技有限公司 | 促进毛发生长的组合物及其使用方法 |
CN110812480B (zh) * | 2019-11-28 | 2021-04-02 | 中国科学院昆明动物研究所 | 一种抗菌肽和线粒体dna复合物及其多克隆抗体和应用 |
TWI789723B (zh) * | 2020-03-20 | 2023-01-11 | 台灣粒線體應用技術股份有限公司 | 粒線體用於治療或/及預防腎臟損傷相關疾病之用途 |
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019507729A (ja) * | 2016-01-15 | 2019-03-22 | ザ チルドレンズ メディカル センター コーポレーション | ミトコンドリアおよび組み合わされたミトコンドリア剤の治療的使用 |
Non-Patent Citations (3)
Title |
---|
HANIEH JABBARI ET AL.: ""Mitochondrial transplantation ameliorates ischemia/reperfusion-induced kidney injury in rat"", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - MOLECULAR BASIS OF DISEASE, vol. 1866, no. 8, JPN6023039555, 28 April 2020 (2020-04-28), pages 165809, ISSN: 0005159706 * |
ILIAS P. DOULAMIS ET AL.: ""Mitochondrial transplantation by intra-arterial injection for acute kidney injury"", AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, vol. 319, no. 3, JPN6023039556, July 2020 (2020-07-01), pages 403 - 413, ISSN: 0005159705 * |
KI WUNG CHUNG ET AL.: ""Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis"", CELL METABOLISM, vol. 30, no. 4, JPN6023039554, October 2019 (2019-10-01), pages 784 - 799, ISSN: 0005159707 * |
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