CN118557602A - 线粒体及富含血小板纤维蛋白用于抗发炎及/或增加胶原蛋白含量的用途 - Google Patents
线粒体及富含血小板纤维蛋白用于抗发炎及/或增加胶原蛋白含量的用途 Download PDFInfo
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- CN118557602A CN118557602A CN202410555655.9A CN202410555655A CN118557602A CN 118557602 A CN118557602 A CN 118557602A CN 202410555655 A CN202410555655 A CN 202410555655A CN 118557602 A CN118557602 A CN 118557602A
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062992546P | 2020-03-20 | 2020-03-20 | |
| US62/992,546 | 2020-03-20 | ||
| CN202180014788.XA CN115315265B (zh) | 2020-03-20 | 2021-03-19 | 线粒体用于促进伤口修复及/或伤口愈合的用途 |
| PCT/CN2021/081685 WO2021185340A1 (zh) | 2020-03-20 | 2021-03-19 | 线粒体用于促进伤口修复及/或伤口愈合的用途 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180014788.XA Division CN115315265B (zh) | 2020-03-20 | 2021-03-19 | 线粒体用于促进伤口修复及/或伤口愈合的用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118557602A true CN118557602A (zh) | 2024-08-30 |
Family
ID=77768010
Family Applications (16)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410555655.9A Pending CN118557602A (zh) | 2020-03-20 | 2021-03-19 | 线粒体及富含血小板纤维蛋白用于抗发炎及/或增加胶原蛋白含量的用途 |
| CN202180014670.7A Active CN115135328B (zh) | 2020-03-20 | 2021-03-19 | 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途 |
| CN202180014788.XA Active CN115315265B (zh) | 2020-03-20 | 2021-03-19 | 线粒体用于促进伤口修复及/或伤口愈合的用途 |
| CN202411951276.8A Pending CN119876009A (zh) | 2020-03-20 | 2021-03-19 | 细胞培养组合物及其用途 |
| CN202311570784.7A Pending CN117357559A (zh) | 2020-03-20 | 2021-03-19 | 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途 |
| CN202410329249.0A Pending CN118319950A (zh) | 2020-03-20 | 2021-03-19 | 线粒体用于治疗关节疾病或韧带损伤相关疾病的用途 |
| CN202410555664.8A Pending CN118557604A (zh) | 2020-03-20 | 2021-03-19 | 线粒体用于作为促进组织再生或纤维母细胞迁移的组合物的用途 |
| CN202180022924.XA Pending CN115335065A (zh) | 2020-03-20 | 2021-03-19 | 细胞培养组合物及其用途 |
| CN202410329264.5A Pending CN118319951A (zh) | 2020-03-20 | 2021-03-19 | 修复肌腱损伤的组合物 |
| CN202311621466.9A Pending CN117379458A (zh) | 2020-03-20 | 2021-03-19 | 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途 |
| CN202410555661.4A Pending CN118557603A (zh) | 2020-03-20 | 2021-03-19 | 含有线粒体的组合物 |
| CN202180014777.1A Active CN115103683B (zh) | 2020-03-20 | 2021-03-19 | 线粒体用于治疗及/或预防肌腱受损或其相关疾病的用途 |
| CN202180022422.7A Active CN115297872B (zh) | 2020-03-20 | 2021-03-22 | 含有线粒体的组合物及其修复软骨损伤或改善退化性关节炎的用途 |
| CN202180022370.3A Pending CN115315248A (zh) | 2020-03-20 | 2021-03-22 | 促进毛发再生的组合物、富线粒体血浆、其制造方法及其用途 |
| CN202410414725.9A Pending CN118236473A (zh) | 2020-03-20 | 2021-03-22 | 用于修复软骨损伤或改善退化性关节炎的含有线粒体的组合物 |
| CN202410414731.4A Pending CN118252850A (zh) | 2020-03-20 | 2021-03-22 | 含有线粒体的组合物 |
Family Applications After (15)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180014670.7A Active CN115135328B (zh) | 2020-03-20 | 2021-03-19 | 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途 |
| CN202180014788.XA Active CN115315265B (zh) | 2020-03-20 | 2021-03-19 | 线粒体用于促进伤口修复及/或伤口愈合的用途 |
| CN202411951276.8A Pending CN119876009A (zh) | 2020-03-20 | 2021-03-19 | 细胞培养组合物及其用途 |
| CN202311570784.7A Pending CN117357559A (zh) | 2020-03-20 | 2021-03-19 | 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途 |
| CN202410329249.0A Pending CN118319950A (zh) | 2020-03-20 | 2021-03-19 | 线粒体用于治疗关节疾病或韧带损伤相关疾病的用途 |
| CN202410555664.8A Pending CN118557604A (zh) | 2020-03-20 | 2021-03-19 | 线粒体用于作为促进组织再生或纤维母细胞迁移的组合物的用途 |
| CN202180022924.XA Pending CN115335065A (zh) | 2020-03-20 | 2021-03-19 | 细胞培养组合物及其用途 |
| CN202410329264.5A Pending CN118319951A (zh) | 2020-03-20 | 2021-03-19 | 修复肌腱损伤的组合物 |
| CN202311621466.9A Pending CN117379458A (zh) | 2020-03-20 | 2021-03-19 | 线粒体萃取物用于治疗或/及预防肾脏损伤相关疾病的用途 |
| CN202410555661.4A Pending CN118557603A (zh) | 2020-03-20 | 2021-03-19 | 含有线粒体的组合物 |
| CN202180014777.1A Active CN115103683B (zh) | 2020-03-20 | 2021-03-19 | 线粒体用于治疗及/或预防肌腱受损或其相关疾病的用途 |
| CN202180022422.7A Active CN115297872B (zh) | 2020-03-20 | 2021-03-22 | 含有线粒体的组合物及其修复软骨损伤或改善退化性关节炎的用途 |
| CN202180022370.3A Pending CN115315248A (zh) | 2020-03-20 | 2021-03-22 | 促进毛发再生的组合物、富线粒体血浆、其制造方法及其用途 |
| CN202410414725.9A Pending CN118236473A (zh) | 2020-03-20 | 2021-03-22 | 用于修复软骨损伤或改善退化性关节炎的含有线粒体的组合物 |
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Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0202298B1 (en) * | 1984-11-29 | 1992-07-15 | Regents Of The University Of Minnesota | Wound healing agents |
| US6100068A (en) * | 1997-01-21 | 2000-08-08 | Paik-Inje Memorial Institute For Biomedical Science | Method of protein production using mitochondrial translation system |
| US5834418A (en) * | 1996-03-20 | 1998-11-10 | Theratechnologies, Inc. | Process for the preparation of platelet growth factors extract |
| US7005274B1 (en) * | 1999-09-15 | 2006-02-28 | Migenix Corp. | Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass |
| BRPI0507349A (pt) * | 2004-02-02 | 2007-04-17 | Nestec Sa | genes associados á osteoartrite canina e processos e composições relacionados |
| TW200817019A (en) * | 2006-07-10 | 2008-04-16 | Univ Columbia | De novo formation and regeneration of vascularized tissue from tissue progenitor cells and vascular progenitor cells |
| WO2009002811A2 (en) * | 2007-06-22 | 2008-12-31 | Children's Medical Center Corporation | Therapeutic platelet compositions and methods |
| US8734854B2 (en) * | 2009-07-09 | 2014-05-27 | Orogen Biosciences Inc. | Process for removing growth factors from platelets |
| US20130022666A1 (en) * | 2011-07-20 | 2013-01-24 | Anna Brzezinska | Methods and compositions for transfer of mitochondria into mammalian cells |
| EP2741757B1 (en) * | 2011-09-11 | 2018-05-16 | Minovia Therapeutics Ltd. | Compositions of functional mitochondria and uses thereof |
| EP2591812A1 (en) * | 2011-11-14 | 2013-05-15 | University of Twente, Institute for Biomedical Technology and Technical Medicine (MIRA) | A dextran-based tissuelette containing platelet-rich plasma lysate for cartilage repair |
| US20140024677A1 (en) * | 2012-04-09 | 2014-01-23 | Musc Foundation For Research Development | Methods for inducing mitochondrial biogenesis |
| US10702556B2 (en) * | 2012-05-16 | 2020-07-07 | Minovia Therpautices Ltd. | Compositions and methods for inducing angiogenesis |
| AU2013326861A1 (en) * | 2012-10-04 | 2015-04-23 | Genesys Research Institute | Platelet compositions and uses thereof |
| CN105163750B (zh) * | 2013-02-07 | 2022-07-15 | 李震义 | 长效人重组可溶性肿瘤坏死因子α受体在制备预防和治疗慢性肝病重症肝损伤药物中的用途 |
| US20140271589A1 (en) * | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| ES2883580T3 (es) * | 2013-03-21 | 2021-12-09 | Collplant Ltd | Composiciones que comprenden colágeno y PRP para la regeneración de tejidos y su método de producción |
| US20150064715A1 (en) * | 2013-08-28 | 2015-03-05 | Musc Foundation For Research Development | Urinary biomarkers of renal and mitochondrial dysfunction |
| TW201509425A (zh) * | 2013-09-13 | 2015-03-16 | Taichung Hospital Ministry Of Health And Welfare | 以血液製備修復傷口用醫藥組合物之方法 |
| TWI672147B (zh) * | 2014-09-10 | 2019-09-21 | 台灣粒線體應用技術股份有限公司 | 以外源性粒線體爲有效成份之組合物、其用途及修復細胞之方法 |
| JP6441472B2 (ja) * | 2014-09-30 | 2018-12-19 | 台灣粒線體應用技術股▲扮▼有限公司Taiwan Mitochondrion Applied Technology Co.,Ltd. | 活性成分として外因性ミトコンドリアを含む組成物、ならびにその使用およびそのための細胞修復法 |
| CN105520891B (zh) * | 2014-09-30 | 2019-05-21 | 台湾粒线体应用技术股份有限公司 | 以外源性线粒体为有效成份的组合物、其用途及修复细胞的方法 |
| CN107249600A (zh) * | 2014-12-31 | 2017-10-13 | 台湾粒线体应用技术股份有限公司 | 新颖医药组合物及其用于治疗肺损伤的用途 |
| WO2016114781A1 (en) * | 2015-01-15 | 2016-07-21 | Boss William K Jr | Repair and rejuvenation of tissues using platelet-rich plasma |
| CN104546915B (zh) * | 2015-02-16 | 2018-12-11 | 天晴干细胞股份有限公司 | 一种治疗骨性关节炎的组合物的制备方法 |
| IL299482B2 (en) * | 2015-02-26 | 2025-02-01 | Minovia Therapeutics Ltd | Mammalian cells are enriched with active mitochondria |
| CA2987271A1 (en) * | 2015-05-22 | 2016-12-01 | President And Fellows Of Harvard College | Methods, systems, and compositions for determining blood clot formation, and uses thereof |
| CN105030647B (zh) * | 2015-09-14 | 2018-04-24 | 广州赛莱拉干细胞科技股份有限公司 | 一种减少皱纹的制剂及其制备方法 |
| US20180303970A1 (en) * | 2015-11-02 | 2018-10-25 | VeriGraft AB | Compositions and methods for healing wounds |
| US11903974B2 (en) * | 2015-11-30 | 2024-02-20 | Flagship Pioneering Innovations V, Inc. | Methods and compositions relating to chondrisomes from cultured cells |
| CN105477018A (zh) * | 2015-12-07 | 2016-04-13 | 深圳爱生再生医学科技有限公司 | 修复皮肤溃疡的干细胞制剂及其制备方法 |
| SI4272834T1 (sl) * | 2016-01-15 | 2026-03-31 | Beth Israel Deaconess Medical Center, Inc. | Terapevtska uporaba mitohondrijev in kombiniranih mitohondrijskih sredstev |
| US20170224764A1 (en) * | 2016-02-10 | 2017-08-10 | Cornell University | Therapeutic targeting of mitochondria to prevent osteoarthritis |
| TWI637748B (zh) * | 2016-07-12 | 2018-10-11 | 中山醫學大學 | 蓮蓬萃取物用於治療及/或預防腎臟病變之用途 |
| CN106190963A (zh) * | 2016-07-13 | 2016-12-07 | 浙江大学 | 一种采用线粒体移植促进损伤神经元存活的方法 |
| EP3549589A4 (en) * | 2016-11-30 | 2020-07-15 | Paean Biotechnology Inc. | PHARMACEUTICAL COMPOSITION CONTAINING MITOCHONDRIA |
| CN106822183B (zh) * | 2016-12-26 | 2020-04-14 | 中山光禾医疗科技有限公司 | 一种光敏富血小板血浆凝胶及其制备方法和用途 |
| US20200023005A1 (en) * | 2017-03-26 | 2020-01-23 | Minovia Therapeutics Ltd. | Mitochondrial compositions and methods for treatment of skin and hair |
| US20200268940A1 (en) * | 2017-05-15 | 2020-08-27 | Richard J. Miron | Liquid platelet-rich fibrin as a carrier system for biomaterials and biomolecules |
| EP3630134B8 (en) * | 2017-06-01 | 2022-01-19 | The United States of America as represented by The Secretary Department of Health and Human Services | Formation of stable cartilage |
| US20190008896A1 (en) * | 2017-07-07 | 2019-01-10 | Richard Postrel | Methods and Systems for the Prevention, Treatment and Management of Disease and Effects of Aging Via Cell-to-Cell Restoration Therapy Using Subcellular Transactions |
| CN107625969A (zh) * | 2017-10-18 | 2018-01-26 | 南京市儿童医院 | MiR‑214拮抗剂在制备用于减轻蛋白尿引起的肾小管损伤相关病症的药物中的用途 |
| WO2019083201A2 (ko) * | 2017-10-24 | 2019-05-02 | 주식회사 엑소코바이오 | 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 신장 기능 개선 용도 |
| KR20190052266A (ko) * | 2017-11-08 | 2019-05-16 | 원광대학교산학협력단 | 우르솔산을 유효성분으로 포함하는 신장 기능의 개선 또는 치료용 조성물 |
| KR102275822B1 (ko) * | 2018-02-02 | 2021-07-12 | 주식회사 파이안바이오테크놀로지 | 분리된 미토콘드리아를 포함하는 류마티스 관절염 예방 또는 치료용 약학 조성물 |
| CN112154210A (zh) * | 2018-03-13 | 2020-12-29 | 利兰斯坦福初级大学董事会 | 用于逆转细胞老化的瞬时细胞重编程 |
| WO2019183042A1 (en) * | 2018-03-20 | 2019-09-26 | Unity Biotechnology, Inc. | Autologous mitochondrial extraction and expansion |
| US12329781B2 (en) * | 2018-07-22 | 2025-06-17 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of renal diseases |
| CN112601532A (zh) * | 2018-07-22 | 2021-04-02 | 米诺维亚疗法有限公司 | 使用富集有功能性线粒体的干细胞的线粒体增强疗法 |
| US12268714B2 (en) * | 2018-09-14 | 2025-04-08 | Luca Science Inc. | Transplantation of mitochondria into lymphoid organ and composition therefor |
| KR102128003B1 (ko) * | 2018-10-31 | 2020-06-29 | 차의과학대학교 산학협력단 | 분리된 미토콘드리아를 포함하는 건병증 예방 또는 치료용 약학 조성물 |
| CN110055216A (zh) * | 2019-05-09 | 2019-07-26 | 张秀明 | 一种改善间质干细胞生物学功能的方法 |
| CN110638833A (zh) * | 2019-11-15 | 2020-01-03 | 西安圣德生物科技有限公司 | 促进毛发生长的组合物及其使用方法 |
| CN110812480B (zh) * | 2019-11-28 | 2021-04-02 | 中国科学院昆明动物研究所 | 一种抗菌肽和线粒体dna复合物及其多克隆抗体和应用 |
| TWI789724B (zh) * | 2020-03-20 | 2023-01-11 | 台灣粒線體應用技術股份有限公司 | 粒線體用於治療及/或預防肌腱受損或其相關疾病之用途 |
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