JP7560882B2 - 遺伝子修飾免疫細胞の生存及び増加を特異的に刺激するための方法 - Google Patents
遺伝子修飾免疫細胞の生存及び増加を特異的に刺激するための方法 Download PDFInfo
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- JP7560882B2 JP7560882B2 JP2021510199A JP2021510199A JP7560882B2 JP 7560882 B2 JP7560882 B2 JP 7560882B2 JP 2021510199 A JP2021510199 A JP 2021510199A JP 2021510199 A JP2021510199 A JP 2021510199A JP 7560882 B2 JP7560882 B2 JP 7560882B2
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/00—Fusion polypeptide
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862724488P | 2018-08-29 | 2018-08-29 | |
| US62/724,488 | 2018-08-29 | ||
| PCT/IB2019/057217 WO2020044239A1 (en) | 2018-08-29 | 2019-08-27 | A method to specifically stimulate survival and expansion of genetically-modified immune cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021534770A JP2021534770A (ja) | 2021-12-16 |
| JP2021534770A5 JP2021534770A5 (https=) | 2022-09-02 |
| JP7560882B2 true JP7560882B2 (ja) | 2024-10-03 |
Family
ID=69645138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021510199A Active JP7560882B2 (ja) | 2018-08-29 | 2019-08-27 | 遺伝子修飾免疫細胞の生存及び増加を特異的に刺激するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12486514B2 (https=) |
| EP (1) | EP3844186A4 (https=) |
| JP (1) | JP7560882B2 (https=) |
| KR (1) | KR102839381B1 (https=) |
| CN (1) | CN112601758A (https=) |
| AU (1) | AU2019330347B2 (https=) |
| SG (1) | SG11202101242VA (https=) |
| WO (1) | WO2020044239A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3143134T3 (da) | 2014-05-15 | 2021-01-04 | Nat Univ Singapore | Modificerede, naturlige dræberceller og anvendelser deraf |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| CA3056591A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| EP3749685A4 (en) | 2018-02-09 | 2021-12-22 | National University of Singapore | ACTIVATOR CHEMERIC RECEPTORS AND THEIR USES IN NATURAL KILLING CELL IMMUNOTHERAPY |
| JP7334985B2 (ja) | 2018-04-02 | 2023-08-29 | ナショナル ユニヴァーシティー オブ シンガポール | 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和 |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| CA3120563A1 (en) | 2018-11-26 | 2020-06-04 | Nkarta, Inc. | Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY |
| EP4110355A1 (en) * | 2020-02-24 | 2023-01-04 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Nk cells or t cells expressing hematopoietic growth factor receptors and use for treating cancer |
| WO2022216877A1 (en) * | 2021-04-06 | 2022-10-13 | Ensoma, Inc. | Modification of epor-encoding nucleic acids |
| US20240409958A1 (en) * | 2021-10-13 | 2024-12-12 | The Board Of Trustees Of The Leland Stanford Junior University | Differential proliferation of human hematopoietic stem and progenitor cells using truncated erythropoietin receptors |
| CN120981484A (zh) | 2023-01-23 | 2025-11-18 | 汉诺威医学院 | 抗entpd3嵌合抗原受体 |
| EP4403580A1 (en) | 2023-01-23 | 2024-07-24 | Medizinische Hochschule Hannover | Anti-entpd3 chimeric antigen receptor |
| AU2024219048A1 (en) | 2023-02-07 | 2025-08-07 | Quell Therapeutics Limited | Culture method for treg cells |
| EP4420676A1 (en) | 2023-02-24 | 2024-08-28 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| WO2024175805A1 (en) | 2023-02-24 | 2024-08-29 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| WO2024194355A1 (en) | 2023-03-20 | 2024-09-26 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| EP4434539A1 (en) | 2023-03-20 | 2024-09-25 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| WO2026008994A1 (en) | 2024-07-04 | 2026-01-08 | Quell Therapeutics Limited | Expression construct |
| GB202411558D0 (en) | 2024-08-06 | 2024-09-18 | Quell Therapeutics Ltd | Culture method |
Citations (2)
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| US20130266551A1 (en) | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| JP2014530002A (ja) | 2011-09-23 | 2014-11-17 | ブルーバードバイオ, インコーポレイテッド | 改善された遺伝子治療方法 |
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| AU2019330347A1 (en) | 2021-02-25 |
| CN112601758A (zh) | 2021-04-02 |
| EP3844186A1 (en) | 2021-07-07 |
| JP2021534770A (ja) | 2021-12-16 |
| EP3844186A4 (en) | 2022-08-17 |
| US12486514B2 (en) | 2025-12-02 |
| KR20210050540A (ko) | 2021-05-07 |
| WO2020044239A1 (en) | 2020-03-05 |
| AU2019330347B2 (en) | 2025-07-24 |
| US20210324388A1 (en) | 2021-10-21 |
| SG11202101242VA (en) | 2021-03-30 |
| KR102839381B1 (ko) | 2025-07-28 |
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