JP7460555B2 - 様々な検出時間の電荷貯蔵ビンを有する集積光検出器 - Google Patents

様々な検出時間の電荷貯蔵ビンを有する集積光検出器 Download PDF

Info

Publication number
JP7460555B2
JP7460555B2 JP2020571379A JP2020571379A JP7460555B2 JP 7460555 B2 JP7460555 B2 JP 7460555B2 JP 2020571379 A JP2020571379 A JP 2020571379A JP 2020571379 A JP2020571379 A JP 2020571379A JP 7460555 B2 JP7460555 B2 JP 7460555B2
Authority
JP
Japan
Prior art keywords
charge
storage region
charge carrier
region
carrier storage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020571379A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2019246328A5 (enExample
JP2021528905A (ja
Inventor
サーストン、トム
チプリアニー、ベンジャミン
ディ. クラーク、ジョセフ
リアリック、トッド
ジー. ファイフ、キース
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quantum Si Inc
Original Assignee
Quantum Si Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Si Inc filed Critical Quantum Si Inc
Publication of JP2021528905A publication Critical patent/JP2021528905A/ja
Publication of JPWO2019246328A5 publication Critical patent/JPWO2019246328A5/ja
Priority to JP2024044749A priority Critical patent/JP2024071462A/ja
Application granted granted Critical
Publication of JP7460555B2 publication Critical patent/JP7460555B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04NPICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N25/00Circuitry of solid-state image sensors [SSIS]; Control thereof
    • H04N25/70SSIS architectures; Circuits associated therewith
    • H04N25/76Addressed sensors, e.g. MOS or CMOS sensors
    • H04N25/77Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6408Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00Photometry, e.g. photographic exposure meter
    • G01J1/42Photometry, e.g. photographic exposure meter using electric radiation detectors
    • G01J1/44Electric circuits
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00Photometry, e.g. photographic exposure meter
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00Photometry, e.g. photographic exposure meter
    • G01J1/02Details
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00Photometry, e.g. photographic exposure meter
    • G01J1/02Details
    • G01J1/0204Compact construction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00Photometry, e.g. photographic exposure meter
    • G01J1/42Photometry, e.g. photographic exposure meter using electric radiation detectors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N21/643Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" non-biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01SRADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S17/00Systems using the reflection or reradiation of electromagnetic waves other than radio waves, e.g. lidar systems
    • G01S17/88Lidar systems specially adapted for specific applications
    • G01S17/89Lidar systems specially adapted for specific applications for mapping or imaging
    • G01S17/8943D imaging with simultaneous measurement of time-of-flight at a 2D array of receiver pixels, e.g. time-of-flight cameras or flash lidar
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01SRADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/48Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S17/00
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01SRADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/48Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S17/00
    • G01S7/483Details of pulse systems
    • G01S7/486Receivers
    • G01S7/4865Time delay measurement, e.g. time-of-flight measurement, time of arrival measurement or determining the exact position of a peak
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04NPICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N25/00Circuitry of solid-state image sensors [SSIS]; Control thereof
    • H04N25/70SSIS architectures; Circuits associated therewith
    • H04N25/703SSIS architectures incorporating pixels for producing signals other than image signals
    • H04N25/706Pixels for exposure or ambient light measuring
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04NPICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N25/00Circuitry of solid-state image sensors [SSIS]; Control thereof
    • H04N25/70SSIS architectures; Circuits associated therewith
    • H04N25/76Addressed sensors, e.g. MOS or CMOS sensors
    • H04N25/77Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
    • H04N25/771Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components comprising storage means other than floating diffusion
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04NPICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N25/00Circuitry of solid-state image sensors [SSIS]; Control thereof
    • H04N25/70SSIS architectures; Circuits associated therewith
    • H04N25/76Addressed sensors, e.g. MOS or CMOS sensors
    • H04N25/77Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
    • H04N25/772Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components comprising A/D, V/T, V/F, I/T or I/F converters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00Photometry, e.g. photographic exposure meter
    • G01J1/42Photometry, e.g. photographic exposure meter using electric radiation detectors
    • G01J1/44Electric circuits
    • G01J2001/4446Type of detector
    • G01J2001/446Photodiode
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00Photometry, e.g. photographic exposure meter
    • G01J1/42Photometry, e.g. photographic exposure meter using electric radiation detectors
    • G01J1/44Electric circuits
    • G01J2001/4446Type of detector
    • G01J2001/448Array [CCD]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10028Range image; Depth image; 3D point clouds
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10064Fluorescence image
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30204Marker
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04NPICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N25/00Circuitry of solid-state image sensors [SSIS]; Control thereof
    • H04N25/70SSIS architectures; Circuits associated therewith
    • H04N25/76Addressed sensors, e.g. MOS or CMOS sensors

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Signal Processing (AREA)
  • Multimedia (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Remote Sensing (AREA)
  • Radar, Positioning & Navigation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Theoretical Computer Science (AREA)
  • Electromagnetism (AREA)
  • Molecular Biology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Transforming Light Signals Into Electric Signals (AREA)
  • Optical Radar Systems And Details Thereof (AREA)
  • Light Receiving Elements (AREA)
  • Solid State Image Pick-Up Elements (AREA)
JP2020571379A 2018-06-22 2019-06-20 様々な検出時間の電荷貯蔵ビンを有する集積光検出器 Active JP7460555B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024044749A JP2024071462A (ja) 2018-06-22 2024-03-21 様々な検出時間の電荷貯蔵ビンを有する集積光検出器

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862688669P 2018-06-22 2018-06-22
US62/688,669 2018-06-22
PCT/US2019/038105 WO2019246328A1 (en) 2018-06-22 2019-06-20 Integrated photodetector with charge storage bin of varied detection time

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024044749A Division JP2024071462A (ja) 2018-06-22 2024-03-21 様々な検出時間の電荷貯蔵ビンを有する集積光検出器

Publications (3)

Publication Number Publication Date
JP2021528905A JP2021528905A (ja) 2021-10-21
JPWO2019246328A5 JPWO2019246328A5 (enExample) 2022-06-28
JP7460555B2 true JP7460555B2 (ja) 2024-04-02

Family

ID=67211895

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020571379A Active JP7460555B2 (ja) 2018-06-22 2019-06-20 様々な検出時間の電荷貯蔵ビンを有する集積光検出器
JP2024044749A Pending JP2024071462A (ja) 2018-06-22 2024-03-21 様々な検出時間の電荷貯蔵ビンを有する集積光検出器

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024044749A Pending JP2024071462A (ja) 2018-06-22 2024-03-21 様々な検出時間の電荷貯蔵ビンを有する集積光検出器

Country Status (11)

Country Link
US (3) US11391626B2 (enExample)
EP (1) EP3811610A1 (enExample)
JP (2) JP7460555B2 (enExample)
KR (1) KR102835268B1 (enExample)
CN (2) CN119364214A (enExample)
AU (1) AU2019288394B2 (enExample)
BR (1) BR112020024790A2 (enExample)
CA (1) CA3108295A1 (enExample)
MX (1) MX2020013788A (enExample)
TW (1) TWI851582B (enExample)
WO (1) WO2019246328A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3194935B1 (en) 2014-08-08 2018-10-31 Quantum-si Incorporated Integrated device for temporal binning of received photons
US10441174B2 (en) 2016-02-17 2019-10-15 Tesseract Health, Inc. Sensor and device for lifetime imaging and detection applications
TWI836905B (zh) 2016-12-22 2024-03-21 美商寬騰矽公司 具有直接合併像素之整合式光電偵測器
CA3108295A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
CA3144668A1 (en) 2019-06-28 2020-12-30 Quantum-Si Incorporated Optical and electrical secondary path rejection
TW202137577A (zh) 2019-10-31 2021-10-01 美商寬騰矽公司 具有增強汲極之像素
TW202143465A (zh) 2020-01-14 2021-11-16 美商寬騰矽公司 用於壽命特性分析之整合感應器
US11885744B2 (en) 2020-01-14 2024-01-30 Quantum-Si Incorporated Sensor for lifetime plus spectral characterization
JP2023515682A (ja) 2020-03-02 2023-04-13 クアンタム-エスアイ インコーポレイテッド 多次元信号解析用集積センサ
EP4133524A2 (en) 2020-04-08 2023-02-15 Quantum-si Incorporated Integrated sensor with reduced skew
US20240035971A1 (en) * 2020-09-18 2024-02-01 Board Of Regents, The University Of Texas System System and method for fluorescence lifetime imaging
EP4217711A4 (en) 2020-10-22 2024-07-03 Quantum-si Incorporated Integrated circuit with sequentially-coupled charge storage and associated techniques
TWM621936U (zh) 2020-12-04 2022-01-01 神盾股份有限公司 飛時測距裝置
KR20230116930A (ko) 2020-12-11 2023-08-04 퀀텀-에스아이 인코포레이티드 개선된 전하 전송 효율을 갖는 집적 회로 및 연관된기술들
IL307484A (en) 2021-04-08 2023-12-01 Quantum Si Inc Integrated circuit having mirrored pixel configuration
US12433482B2 (en) 2022-01-03 2025-10-07 Ronen Einat Multi-modal diagnostic device and database service for ophthalmology and neurology
WO2024039853A1 (en) 2022-08-19 2024-02-22 Quantum-Si Incorporated Backside illuminated structures with parallel charge transfer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008103647A (ja) 2006-10-20 2008-05-01 National Univ Corp Shizuoka Univ 半導体素子及び固体撮像装置
WO2010074252A1 (ja) 2008-12-25 2010-07-01 国立大学法人静岡大学 半導体素子及び固体撮像装置
JP2017531356A (ja) 2014-08-08 2017-10-19 クアンタム−エスアイ インコーポレイテッドQuantum−Si Incorporated 受け取られた光子の時間ビニングのための集積デバイス

Family Cites Families (208)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3890500A (en) 1974-02-11 1975-06-17 Gen Electric Apparatus for sensing radiation and providing electrical readout
US5198543A (en) 1989-03-24 1993-03-30 Consejo Superior Investigaciones Cientificas PHI29 DNA polymerase
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
CA2044616A1 (en) 1989-10-26 1991-04-27 Roger Y. Tsien Dna sequencing
US5355165A (en) 1992-08-06 1994-10-11 Princeton Scientific Instruments, Inc. Very high frame rate CCD imager
CA2155186A1 (en) 1993-02-01 1994-08-18 Kevin M. Ulmer Methods and apparatus for dna sequencing
US5471515A (en) 1994-01-28 1995-11-28 California Institute Of Technology Active pixel sensor with intra-pixel charge transfer
DE69505370T2 (de) 1994-05-27 1999-04-01 Novartis Ag, Basel Verfahren und sensor zum nachweis abklingend angeregter lumineszenz
US5912155A (en) 1994-09-30 1999-06-15 Life Technologies, Inc. Cloned DNA polymerases from Thermotoga neapolitana
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US6261797B1 (en) 1996-01-29 2001-07-17 Stratagene Primer-mediated polynucleotide synthesis and manipulation techniques
WO1998022799A2 (de) 1996-11-18 1998-05-28 Novartis Ag Messvorrichtung und deren verwendung
CN1251609A (zh) 1997-02-12 2000-04-26 尤金·Y·查恩 分析聚合物的方法和产品
IT1290553B1 (it) 1997-02-27 1998-12-10 Ist Nazionale Fisica Nucleare Rivelatore dell'energia e della posizione di incidenza di radiazioni elettromagnetiche o di particelle ionizzanti a deriva controllata
AU743025B2 (en) 1997-03-12 2002-01-17 Applera Corporation DNA polymerases having improved labeled nucleotide incorporation properties
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
DE19748211A1 (de) 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
EP0921196A1 (en) 1997-12-02 1999-06-09 Roche Diagnostics GmbH Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction
DE19810879A1 (de) 1998-03-13 1999-09-16 Roche Diagnostics Gmbh Polymerasenchimären
US6232103B1 (en) 1998-03-23 2001-05-15 Invitrogen Corporation Methods useful for nucleic acid sequencing using modified nucleotides comprising phenylboronic acid
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
GB9810350D0 (en) 1998-05-14 1998-07-15 Ciba Geigy Ag Organic compounds
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6716394B2 (en) 1998-08-11 2004-04-06 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6210896B1 (en) 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6280939B1 (en) 1998-09-01 2001-08-28 Veeco Instruments, Inc. Method and apparatus for DNA sequencing using a local sensitive force detector
JP4326050B2 (ja) 1998-09-22 2009-09-02 ハイスペック合資会社 高速撮像素子
EP1141409B2 (en) 1998-12-14 2009-05-27 Pacific Biosciences of California, Inc. A kit and methods for nucleic acid sequencing of single molecules by polymerase synthesis
US6445491B2 (en) 1999-01-29 2002-09-03 Irma America, Inc. Method and apparatus for optical sectioning and imaging using time-gated parametric image amplification
EP1159453B1 (en) 1999-03-10 2008-05-28 ASM Scientific, Inc. A method for direct nucleic acid sequencing
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
EP1681357A3 (en) 1999-05-19 2006-07-26 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6137117A (en) 1999-06-21 2000-10-24 The United States Of America As Represented By The Secretary Of The Navy Integrating multi-waveguide sensor
CN2433618Y (zh) 1999-10-29 2001-06-06 中国科学院上海原子核研究所 基因芯片检测装置
US6399335B1 (en) 1999-11-16 2002-06-04 Advanced Research And Technology Institute, Inc. γ-phosphoester nucleoside triphosphates
JP4433347B2 (ja) 2000-01-17 2010-03-17 富士フイルム株式会社 蛍光撮像装置
US20020090650A1 (en) 2000-04-06 2002-07-11 Quantum Dot Corporation Two-dimensional spectral imaging system
EP1285290A1 (en) 2000-04-28 2003-02-26 Edgelight Biosciences, Inc. Micro-array evanescent wave fluorescence detection device
US6917726B2 (en) 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
US6975898B2 (en) 2000-06-19 2005-12-13 University Of Washington Medical imaging, diagnosis, and therapy using a scanning single optical fiber system
US7158224B2 (en) 2000-06-25 2007-01-02 Affymetrix, Inc. Optically active substrates
FR2813121A1 (fr) 2000-08-21 2002-02-22 Claude Weisbuch Dispositif perfectionne de support d'elements chromophores
AU2001286963A1 (en) 2000-08-30 2002-03-13 University Of Rochester Method of performing reverse transcription reaction using reverse transcriptase encoded by non-ltr retrotransposable element
AU2001284681A1 (en) 2000-09-11 2002-03-26 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Fluidics system
EP1207387A1 (en) 2000-11-20 2002-05-22 Institut Curie Multi-photon imaging installation.
US7668697B2 (en) 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
US7033762B2 (en) 2001-08-29 2006-04-25 Amersham Biosciences Corp Single nucleotide amplification and detection by polymerase
WO2003025132A2 (en) 2001-09-14 2003-03-27 Invitrogen Corporation Dna polymerases and mutants thereof
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB2382648B (en) 2001-12-11 2003-11-12 Amersham Pharm Biotech Uk Ltd System and method for time correlated multi-photon counting measurements
CN1138862C (zh) 2002-01-28 2004-02-18 国前 一种核酸分析用收集装置及其应用方法
US7179654B2 (en) 2002-03-18 2007-02-20 Agilent Technologies, Inc. Biochemical assay with programmable array detection
US6924887B2 (en) 2002-03-27 2005-08-02 Sarnoff Corporation Method and apparatus for generating charge from a light pulse
US6657706B2 (en) 2002-03-27 2003-12-02 Sarnoff Corporation Method and apparatus for resolving relative times-of-arrival of light pulses
US8238993B2 (en) 2002-04-04 2012-08-07 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence lifetime
US20040144927A1 (en) 2003-01-28 2004-07-29 Auner Gregory W. Microsystems arrays for digital radiation imaging and signal processing and method for making microsystem arrays
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US20040106163A1 (en) 2002-11-12 2004-06-03 Workman Jerome James Non-invasive measurement of analytes
AU2003294365A1 (en) 2002-11-19 2004-06-15 Safetzone Technologies Corporation Guest communication system and method
US7393640B2 (en) 2003-02-05 2008-07-01 Ge Healthcare Bio-Sciences Corp. Terminal-phosphate-labeled nucleotides with new linkers
US7745116B2 (en) 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
FR2857158B1 (fr) 2003-07-01 2006-04-28 St Microelectronics Sa Procede de commande d'un photocopieur de type mos
US7078670B2 (en) 2003-09-15 2006-07-18 Imagerlabs, Inc. Low noise charge gain circuit and CCD using same
WO2005073407A1 (en) 2003-10-07 2005-08-11 Ut-Battelle, Llc Advanced integrated circuit biochip
JP2007509317A (ja) 2003-10-18 2007-04-12 バイエル・ヘルスケア・アクチェンゲゼルシャフト 生物学的試験システムにおける、蛍光寿命の測定による分子修飾の直接的観察
DE10348949A1 (de) 2003-10-18 2005-05-19 Bayer Healthcare Ag Direkte Beobachtung molekularer Veränderungen ind biologischen Testsystemen mittels Messungen der Fluoreszenz-Lebensdauer
US20070281288A1 (en) 2004-01-27 2007-12-06 Shimshon Belkin Method and System for Detecting Analytes
JP4332628B2 (ja) * 2004-02-13 2009-09-16 国立大学法人 奈良先端科学技術大学院大学 生体組織測定用イメージセンサ及び該センサを用いた生体組織測定方法
EP1716254B1 (en) 2004-02-19 2010-04-07 Helicos Biosciences Corporation Methods for analyzing polynucleotide sequences
EP1583150A1 (en) 2004-03-31 2005-10-05 CSEM Centre Suisse d'Electronique et de Microtechnique SA Image sensor with large-area, high-sensitivity and high-speed pixels
US20060019265A1 (en) 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
EP1622200A1 (en) 2004-07-26 2006-02-01 CSEM Centre Suisse d'Electronique et de Microtechnique SA Solid-state photodetector pixel and photodetecting method
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US7345764B2 (en) 2005-02-07 2008-03-18 Vladimir Bulovic Apparatus and method for a slim format spectrometer
US20060223067A1 (en) 2005-03-31 2006-10-05 Paolo Vatta Mutant DNA polymerases and methods of use
US7365299B2 (en) 2005-05-09 2008-04-29 Sensors Unlimited, Inc. Method and apparatus for providing flexible photodetector binning
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
JP2008546424A (ja) 2005-06-28 2008-12-25 アジェンコート パーソナル ジェノミクス コーポレイション 修飾ポリヌクレオチドを作製する方法および配列決定する方法
WO2007015168A2 (en) 2005-07-01 2007-02-08 Dako Denmark A/S Monomeric and polymeric linkers useful for conjugating biological molecules and other substances
US7426322B2 (en) 2005-07-20 2008-09-16 Searete Llc. Plasmon photocatalysis
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
JP2009519041A (ja) 2005-12-12 2009-05-14 アメリカ合衆国 核酸配列決定のためのプローブおよび使用方法
CA2633524A1 (en) 2005-12-22 2007-07-05 Pacific Biosciences Of California, Inc. Polymerases for nucleotide analogue incorporation
ATE518010T1 (de) 2005-12-22 2011-08-15 Pacific Biosciences California Aktive oberflächengekoppelte polymerasen
WO2007083704A1 (ja) * 2006-01-18 2007-07-26 National University Corporation Shizuoka University 固体撮像装置及びその画素信号の読みだし方法
US7715001B2 (en) 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US20080050747A1 (en) 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
DE102006030541B4 (de) 2006-06-23 2010-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optische Anordnung
US7696545B2 (en) * 2006-08-29 2010-04-13 Micron Technology, Inc. Skimmed charge capture and charge packet removal for increased effective pixel photosensor full well capacity
EP3936857B1 (en) 2006-09-01 2023-06-21 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
AU2007309504B2 (en) 2006-10-23 2012-09-13 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
FR2908888B1 (fr) 2006-11-21 2012-08-03 Centre Nat Rech Scient Dispositif pour la detection exaltee de l'emission d'une particule cible
KR101030263B1 (ko) * 2006-11-30 2011-04-22 고쿠리츠 다이가꾸 호우진 시즈오까 다이가꾸 반도체 거리 측정 소자 및 고체 촬상 장치
JP5270835B2 (ja) 2006-12-29 2013-08-21 パナソニック株式会社 光検出素子、空間情報の検出装置
ATE509265T1 (de) 2007-03-22 2011-05-15 Univ Strasbourg Etablissement Public A Caractere Scient Culturel Et Professionel Gerät zur sortierung und konzentration elektromagnetischer energie und vorrichtung mit mindestens einem derartigen gerät
ATE548643T1 (de) 2007-03-30 2012-03-15 Pacific Biosciences California System und verfahren zur verstärkung von fluoreszenzsignalen
US7873085B2 (en) 2007-10-23 2011-01-18 Andrei Babushkin Method and device for controlling optical output of laser diode
WO2009082706A1 (en) 2007-12-21 2009-07-02 The Trustees Of Columbia University In The City Of New York Active cmos sensor array for electrochemical biomolecular detection
US20110165652A1 (en) 2008-01-14 2011-07-07 Life Technologies Corporation Compositions, methods and systems for single molecule sequencing
CA2714630A1 (en) 2008-02-07 2009-08-13 Pacific Biosciences Of California, Inc. Cis reactive oxygen quenchers integrated into linkers
AU2009223702B2 (en) 2008-03-13 2013-08-22 Pacific Biosciences Of California, Inc. Labeled reactants and their uses
US7973146B2 (en) 2008-03-26 2011-07-05 Pacific Biosciences Of California, Inc. Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing
WO2009120372A2 (en) 2008-03-28 2009-10-01 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
AU2009251881B2 (en) 2008-03-31 2015-03-26 Pacific Biosciences Of California, Inc Single molecule loading methods and compositions
US9127259B2 (en) 2008-03-31 2015-09-08 Pacific Biosciences Of California, Inc. Enzymes resistant to photodamage
EP2274446B1 (en) 2008-03-31 2015-09-09 Pacific Biosciences of California, Inc. Two slow-step polymerase enzyme systems and methods
WO2010044932A2 (en) 2008-07-11 2010-04-22 Cornell University Nanofluidic channels with integrated charge sensors and methods based thereon
JP5283216B2 (ja) 2008-07-31 2013-09-04 国立大学法人静岡大学 高速電荷転送フォトダイオード、ロックインピクセル及び固体撮像装置
WO2010025331A1 (en) 2008-08-28 2010-03-04 Mesa Imaging Ag Demodulation pixel with daisy chain charge storage sites and method of operation therefor
US20100148221A1 (en) 2008-11-13 2010-06-17 Zena Technologies, Inc. Vertical photogate (vpg) pixel structure with nanowires
CA3063032A1 (en) 2008-09-16 2010-03-25 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
US8481264B2 (en) 2008-09-19 2013-07-09 Pacific Biosciences Of California, Inc. Immobilized nucleic acid complexes for sequence analysis
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8247216B2 (en) 2008-09-30 2012-08-21 Pacific Biosciences Of California, Inc. Ultra-high multiplex analytical systems and methods
EP2182523B1 (en) 2008-10-31 2013-01-09 CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement Charge sampling device and method based on a MOS-transmission line
WO2010057185A1 (en) 2008-11-17 2010-05-20 Pacific Biosciences Of California, Inc. Phospholink nucleotides for sequencing applications
US8519340B2 (en) 2008-12-22 2013-08-27 Koninklijke Philips N.V. High dynamic range light sensor
CA2750874A1 (en) 2009-01-30 2010-08-05 Oxford Nanopore Technologies Limited Hybridization linkers
JP5519711B2 (ja) 2009-03-12 2014-06-11 アールエスピー システムズ アクティーゼルスカブ 光信号を生体内測定するための光学プローブ
US20100255487A1 (en) 2009-03-27 2010-10-07 Life Technologies Corporation Methods and apparatus for single molecule sequencing using energy transfer detection
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
JP5415805B2 (ja) 2009-03-31 2014-02-12 オリンパスメディカルシステムズ株式会社 診断支援装置
RU2525706C2 (ru) 2009-04-15 2014-08-20 Конинклейке Филипс Электроникс Н.В. Устройство для регулируемого по времени определения флуоресценции
JP4798254B2 (ja) 2009-05-13 2011-10-19 株式会社デンソー 受光デバイス及びその制御方法
US20120224053A1 (en) 2009-06-17 2012-09-06 Board Of Regents, The University Of Texas System Method and apparatus for quantitative microimaging
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
JP2011023469A (ja) 2009-07-14 2011-02-03 Murata Mfg Co Ltd 回路モジュール
DE102009037596B4 (de) 2009-08-14 2014-07-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Pixelstruktur, System und Verfahren zur optischen Abstandsmessung sowie Steuerschaltung für die Pixelstruktur
JP5648922B2 (ja) 2009-10-05 2015-01-07 国立大学法人静岡大学 半導体素子及び固体撮像装置
US8278728B2 (en) 2009-10-17 2012-10-02 Florida Institute Of Technology Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels
US9579402B2 (en) 2009-12-04 2017-02-28 Biotium, Inc. Heterocycle-substituted xanthene dyes
JP6017107B2 (ja) 2009-12-28 2016-10-26 ソニー株式会社 イメージセンサ及びその製造方法、並びにセンサデバイス
WO2011090745A1 (en) 2009-12-29 2011-07-28 Life Technologies Corporation Single molecule detection and sequencing using fluorescence lifetime imaging
EP2362207A1 (de) 2010-01-28 2011-08-31 F. Hoffmann-La Roche AG Messsystem und Messverfahren insbesondere zur Blutzuckerbestimmung
CA2789932A1 (en) 2010-02-19 2011-08-25 Glysure Ltd Intravascular glucose sensor
US9410891B2 (en) 2010-02-19 2016-08-09 Pacific Biosciences Of California, Inc. Optics collection and detection system and method
US20130005047A1 (en) 2010-03-25 2013-01-03 Mocon, Inc. Luminescence lifetime based analyte sensing instruments and calibration technique
WO2011150431A1 (en) 2010-05-28 2011-12-01 The Regents Of The University Of Colorado, A Body Corporate Multi-photon tissue imaging
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
JP2012132741A (ja) 2010-12-21 2012-07-12 Fujifilm Corp 時間分解蛍光測定装置、及び方法
JP2012134827A (ja) 2010-12-22 2012-07-12 Toshiba Corp 放射線画像検出器
US8946845B1 (en) 2011-02-02 2015-02-03 Aptina Imaging Corporation Stacked pixels for high resolution CMOS image sensors with BCMD charge detectors
CN103404124A (zh) 2011-03-01 2013-11-20 松下电器产业株式会社 固体摄像装置
WO2012129242A2 (en) 2011-03-23 2012-09-27 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
US20170161557A9 (en) 2011-07-13 2017-06-08 Sionyx, Inc. Biometric Imaging Devices and Associated Methods
WO2013040058A1 (en) 2011-09-12 2013-03-21 Jian Guo Imaging fluorescence or luminescence lifetime
US20130090537A1 (en) 2011-10-07 2013-04-11 2M Engineering Limited Blood glucose sensor
WO2013063382A2 (en) 2011-10-28 2013-05-02 Illumina, Inc. Microarray fabrication system and method
WO2013066959A1 (en) 2011-10-31 2013-05-10 The Trustees Of Columbia University In The City Of New York Systems and methods for imaging using single photon avalanche diodes
US8804021B2 (en) 2011-11-03 2014-08-12 Omnivision Technologies, Inc. Method, apparatus and system for providing improved full well capacity in an image sensor pixel
US9606060B2 (en) 2012-01-13 2017-03-28 California Institute Of Technology Filterless time-domain detection of one or more fluorophores
US8906660B2 (en) 2012-02-01 2014-12-09 Pacific Biosciences Of California, Inc. Recombinant polymerases with increased phototolerance
EP2814953B1 (en) 2012-02-15 2017-06-07 Pacific Biosciences Of California, Inc. Polymerase enzyme substrates with protein shield
DE102012206089B4 (de) 2012-03-15 2017-02-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Halbleiterstruktur, verfahren zum betreiben derselben und herstellungsverfahren
US20130256822A1 (en) 2012-03-28 2013-10-03 Omnivision Technologies, Inc. Method and device with enhanced ion doping
CN102914525B (zh) 2012-04-10 2016-06-01 广东工业大学 基于光学加法外差调制的新型荧光寿命显微成像装置及方法
WO2013171197A1 (en) 2012-05-15 2013-11-21 Ait Austrian Institute Of Technology Gmbh Compact plasmon-enhanced fluorescence biosensor
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
CA3040684C (en) 2012-08-20 2023-02-07 Hod Finkelstein Method and system for fluorescence lifetime based sequencing
JP6281771B2 (ja) 2012-10-30 2018-02-21 パナソニックIpマネジメント株式会社 蛍光検出装置
EP2936222B1 (en) 2012-12-18 2019-07-03 Pacific Biosciences Of California, Inc. An optical analytical device
KR20250133999A (ko) 2012-12-28 2025-09-09 가부시키가이샤 한도오따이 에네루기 켄큐쇼 반도체 장치
GB201302664D0 (en) * 2013-02-15 2013-04-03 Cmosis Nv A pixel structure
US10206561B2 (en) 2013-02-28 2019-02-19 DePuy Synthes Products, Inc. Videostroboscopy of vocal cords with CMOS sensors
US9741754B2 (en) 2013-03-06 2017-08-22 Apple Inc. Charge transfer circuit with storage nodes in image sensors
WO2015006345A2 (en) 2013-07-09 2015-01-15 Nd Industries, Inc. Multi-row magnetic dial for the conveyance of workpieces and related method
US20150042954A1 (en) 2013-08-08 2015-02-12 University Of Rochester System and Method for Fluorescence Lifetime Imaging Aided by Adaptive Optics
JP6211898B2 (ja) 2013-11-05 2017-10-11 浜松ホトニクス株式会社 リニアイメージセンサ
JP6673843B2 (ja) 2013-11-17 2020-03-25 クアンタム−エスアイ インコーポレイテッドQuantum−Si Incorporated 分子をプローブし、検出し、分析するための光学システム及びアッセイ・チップ
JP2016001712A (ja) 2013-11-29 2016-01-07 株式会社半導体エネルギー研究所 半導体装置の作製方法
WO2015084991A1 (en) 2013-12-04 2015-06-11 Rambus Inc. High dynamic-range image sensor
CN103728446B (zh) 2013-12-11 2016-02-24 天津大学 光子计数型多通道时间分辨荧光免疫分析系统及计数方法
US9736388B2 (en) 2013-12-13 2017-08-15 Bio-Rad Laboratories, Inc. Non-destructive read operations with dynamically growing images
JP6247530B2 (ja) * 2013-12-27 2017-12-13 キヤノン株式会社 撮像装置
US10524707B2 (en) 2014-01-31 2020-01-07 The General Hospital Corporation System and method for photoluminescence detection
TWI665778B (zh) 2014-02-05 2019-07-11 日商半導體能源研究所股份有限公司 半導體裝置、模組及電子裝置
US9765395B2 (en) 2014-04-28 2017-09-19 Nanomedical Diagnostics, Inc. System and method for DNA sequencing and blood chemistry analysis
KR20150134543A (ko) 2014-05-22 2015-12-02 삼성전자주식회사 소자 제조용 기판 및 반도체 소자
WO2016016761A1 (en) 2014-07-31 2016-02-04 Semiconductor Energy Laboratory Co., Ltd. Method of manufacturing semiconductor device
CA2957546A1 (en) 2014-08-08 2016-02-11 Quantum-Si Incorporated Integrated device with external light source for probing, detecting, and analyzing molecules
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
MX383892B (es) 2014-08-08 2025-03-14 Quantum Si Inc Sistema optico y circuito integrado de valoración para sondear, detectar y analizar moleculas.
JP2018505565A (ja) 2014-12-19 2018-02-22 ジーレイ スイッツァーランド エスアー モノリシックcmos集積ピクセル検出器ならびに様々な用途を含む粒子検出および撮像のためのシステムおよび方法
US9871065B2 (en) 2014-12-22 2018-01-16 Google Inc. RGBZ pixel unit cell with first and second Z transfer gates
US9666748B2 (en) 2015-01-14 2017-05-30 International Business Machines Corporation Integrated on chip detector and zero waveguide module structure for use in DNA sequencing
CN107003410B (zh) 2015-02-09 2018-08-24 埃斯普罗光电股份公司 Tof距离传感器
CN113064236B (zh) 2015-03-16 2022-11-01 加利福尼亚太平洋生物科学股份有限公司 用于自由空间光耦合的集成装置及系统
TWI569008B (zh) 2015-04-27 2017-02-01 財團法人工業技術研究院 尿素濃度檢測元件以及尿素濃度檢測方法
EP3998471A1 (en) * 2015-05-20 2022-05-18 Quantum-si Incorporated Method of determining the sequence of a nucleic acid using time resolved luminescence
US10246742B2 (en) 2015-05-20 2019-04-02 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US10976257B2 (en) 2015-06-08 2021-04-13 The Regents Of The University Of Michigan Pixel circuit and method for optical sensing
US9578265B2 (en) * 2015-06-11 2017-02-21 Stmicroelectronics (Grenoble 2) Sas Double charge storage area image capture device pixel structure
CN105300949B (zh) 2015-11-26 2019-06-11 浙江大学 一种荧光寿命测量方法及装置
US10441174B2 (en) 2016-02-17 2019-10-15 Tesseract Health, Inc. Sensor and device for lifetime imaging and detection applications
MX2018014856A (es) 2016-06-01 2019-03-07 Quantum Si Inc Llamador de pulso y llamador de base.
US10249656B2 (en) 2016-06-07 2019-04-02 Semiconductor Components Industries, Llc Charge packet signal processing using pinned photodiode devices
TW201817223A (zh) * 2016-10-20 2018-05-01 原相科技股份有限公司 全域快門高動態範圍像素及全域快門高動態範圍影像感測器
EP4250361A3 (en) 2016-12-13 2024-04-17 STMicroelectronics (Research & Development) Limited A charge storage cell and method of manufacturing a charge storage cell
TWI836905B (zh) 2016-12-22 2024-03-21 美商寬騰矽公司 具有直接合併像素之整合式光電偵測器
US11105925B2 (en) 2017-03-01 2021-08-31 Ouster, Inc. Accurate photo detector measurements for LIDAR
CA3108295A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
US20200072752A1 (en) 2018-08-29 2020-03-05 Quantum-Si Incorporated System and methods for detecting lifetime using photon counting photodetectors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008103647A (ja) 2006-10-20 2008-05-01 National Univ Corp Shizuoka Univ 半導体素子及び固体撮像装置
WO2010074252A1 (ja) 2008-12-25 2010-07-01 国立大学法人静岡大学 半導体素子及び固体撮像装置
JP2017531356A (ja) 2014-08-08 2017-10-19 クアンタム−エスアイ インコーポレイテッドQuantum−Si Incorporated 受け取られた光子の時間ビニングのための集積デバイス

Also Published As

Publication number Publication date
JP2024071462A (ja) 2024-05-24
US20190391010A1 (en) 2019-12-26
AU2019288394B2 (en) 2025-01-30
US12123772B2 (en) 2024-10-22
BR112020024790A2 (pt) 2021-03-02
KR20210022688A (ko) 2021-03-03
CN119364214A (zh) 2025-01-24
US20250130103A1 (en) 2025-04-24
EP3811610A1 (en) 2021-04-28
JP2021528905A (ja) 2021-10-21
KR102835268B1 (ko) 2025-07-18
CA3108295A1 (en) 2019-12-26
TW202002259A (zh) 2020-01-01
AU2019288394A1 (en) 2021-01-07
US20230137697A1 (en) 2023-05-04
MX2020013788A (es) 2021-03-02
TWI851582B (zh) 2024-08-11
CN112534803A (zh) 2021-03-19
WO2019246328A1 (en) 2019-12-26
CN112534803B (zh) 2024-10-29
US11391626B2 (en) 2022-07-19

Similar Documents

Publication Publication Date Title
JP7460555B2 (ja) 様々な検出時間の電荷貯蔵ビンを有する集積光検出器
US12111261B2 (en) Integrated photodetector with direct binning pixel
US12203854B2 (en) Integrated device for temporal binning of received photons
JP2023501225A (ja) 改良されたドレインを備えるピクセル
HK40013626A (en) Integrated photodetector with direct binning pixel
HK40013626B (en) Integrated photodetector with direct binning pixel

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220620

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220620

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230629

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230704

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20231004

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240104

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240220

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240321

R150 Certificate of patent or registration of utility model

Ref document number: 7460555

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150