ATE548643T1 - System und verfahren zur verstärkung von fluoreszenzsignalen - Google Patents

System und verfahren zur verstärkung von fluoreszenzsignalen

Info

Publication number
ATE548643T1
ATE548643T1 AT08742395T AT08742395T ATE548643T1 AT E548643 T1 ATE548643 T1 AT E548643T1 AT 08742395 T AT08742395 T AT 08742395T AT 08742395 T AT08742395 T AT 08742395T AT E548643 T1 ATE548643 T1 AT E548643T1
Authority
AT
Austria
Prior art keywords
fluorescent signals
illumination light
metal particle
amplifying fluorescent
reflectance
Prior art date
Application number
AT08742395T
Other languages
English (en)
Inventor
Jonas Korlach
Kevan Samiee
Stephen Turner
Jake Freudenthal
Original Assignee
Pacific Biosciences California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Biosciences California filed Critical Pacific Biosciences California
Application granted granted Critical
Publication of ATE548643T1 publication Critical patent/ATE548643T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT08742395T 2007-03-30 2008-03-27 System und verfahren zur verstärkung von fluoreszenzsignalen ATE548643T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92116707P 2007-03-30 2007-03-30
PCT/US2008/004148 WO2008121374A2 (en) 2007-03-30 2008-03-27 Systems and methods for enhancing fluorescent signals

Publications (1)

Publication Number Publication Date
ATE548643T1 true ATE548643T1 (de) 2012-03-15

Family

ID=39795079

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08742395T ATE548643T1 (de) 2007-03-30 2008-03-27 System und verfahren zur verstärkung von fluoreszenzsignalen

Country Status (4)

Country Link
US (1) US20080241866A1 (de)
EP (1) EP2134871B1 (de)
AT (1) ATE548643T1 (de)
WO (1) WO2008121374A2 (de)

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CA2790393C (en) 2010-02-19 2019-03-12 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
WO2011139344A2 (en) 2010-04-28 2011-11-10 Pacific Biosciences Of California, Inc Nanoscale apertures having islands of functionality
EP2567218A4 (de) 2010-05-03 2017-11-08 The Regents of The University of California Linsenlose fluoreszierende weitfeld-abbildung auf einem chip
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US9422154B2 (en) 2010-11-02 2016-08-23 International Business Machines Corporation Feedback control of dimensions in nanopore and nanofluidic devices
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US8735175B2 (en) 2011-03-18 2014-05-27 Chris D. Geddes Multicolor microwave-accelerated metal-enhanced fluorescence (M-MAMEF)
US8817259B2 (en) * 2011-03-25 2014-08-26 Parker-Hannifin Corporation Optical sensors for monitoring biopharmaceutical solutions in single-use containers
US10149922B1 (en) 2012-10-24 2018-12-11 The Board Of Trustees Of The Leland Stanford Junior University Engineered collagen matrices for myocardial therapy
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WO2014144883A1 (en) * 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
EP3974814A1 (de) 2013-11-17 2022-03-30 Quantum-si Incorporated Integrierte vorrichtung mit externer lichtquelle zur sondierung, detektion und analyse von molekülen
MX2021007934A (es) 2014-08-08 2023-01-17 Quantum Si Inc Dispositivo integrado para el depósito temporal de fotones recibidos.
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CN109791108A (zh) * 2016-08-10 2019-05-21 阿提拉生物系统公司 用于检测样品发出的荧光信号的装置
CN118099177A (zh) 2016-12-22 2024-05-28 宽腾矽公司 具有直接合并像素的整合式光电侦测器
KR20210022688A (ko) 2018-06-22 2021-03-03 퀀텀-에스아이 인코포레이티드 가변 검출 시간의 전하 저장 빈을 갖는 집적 광검출기
CN110066723A (zh) * 2019-05-05 2019-07-30 京东方科技集团股份有限公司 基因测序芯片、设备、制造方法

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Also Published As

Publication number Publication date
WO2008121374A2 (en) 2008-10-09
EP2134871A2 (de) 2009-12-23
EP2134871B1 (de) 2012-03-07
US20080241866A1 (en) 2008-10-02
EP2134871A4 (de) 2010-05-26
WO2008121374A3 (en) 2008-12-04
WO2008121374A4 (en) 2009-01-15

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