JP7449275B2 - リポソーム薬物製剤の製造方法 - Google Patents

リポソーム薬物製剤の製造方法 Download PDF

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Publication number
JP7449275B2
JP7449275B2 JP2021510282A JP2021510282A JP7449275B2 JP 7449275 B2 JP7449275 B2 JP 7449275B2 JP 2021510282 A JP2021510282 A JP 2021510282A JP 2021510282 A JP2021510282 A JP 2021510282A JP 7449275 B2 JP7449275 B2 JP 7449275B2
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lipid
amikacin
aminoglycoside
amikacin sulfate
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Japanese (ja)
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JP2021523224A (ja
JP2021523224A5 (https=
JPWO2019213398A5 (https=
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ウォーシャム，ロバート
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Insmed Inc
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Insmed Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021510282A 2018-05-02 2019-05-02 リポソーム薬物製剤の製造方法 Active JP7449275B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024031179A JP2024075590A (ja) 2018-05-02 2024-03-01 リポソーム薬物製剤の製造方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862665564P 2018-05-02 2018-05-02
US62/665,564 2018-05-02
PCT/US2019/030404 WO2019213398A1 (en) 2018-05-02 2019-05-02 Methods for the manufacture of liposomal drug formulations

Related Child Applications (1)

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JP2024031179A Division JP2024075590A (ja) 2018-05-02 2024-03-01 リポソーム薬物製剤の製造方法

Publications (4)

Publication Number Publication Date
JP2021523224A JP2021523224A (ja) 2021-09-02
JP2021523224A5 JP2021523224A5 (https=) 2022-05-10
JPWO2019213398A5 JPWO2019213398A5 (https=) 2022-05-10
JP7449275B2 true JP7449275B2 (ja) 2024-03-13

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JP2021510282A Active JP7449275B2 (ja) 2018-05-02 2019-05-02 リポソーム薬物製剤の製造方法
JP2024031179A Pending JP2024075590A (ja) 2018-05-02 2024-03-01 リポソーム薬物製剤の製造方法

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Country Status (8)

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US (3) US20210113467A1 (https=)
EP (1) EP3787602A4 (https=)
JP (2) JP7449275B2 (https=)
KR (1) KR20210024451A (https=)
CN (1) CN112584821A (https=)
AU (1) AU2019262117C1 (https=)
CA (1) CA3098573A1 (https=)
WO (1) WO2019213398A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT202000516T1 (it) 2014-05-15 2020-11-10 Insmed Inc Metodi per trattamento di infezioni micobatteriche polmonati non tubercolari
EP3773505B1 (en) 2018-03-30 2026-04-29 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
WO2019213398A1 (en) * 2018-05-02 2019-11-07 Insmed Incorporated Methods for the manufacture of liposomal drug formulations

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005525375A (ja) 2002-03-05 2005-08-25 トランセイブ， インク． 生物活性物質をリポソーム又は脂質複合体内に封入する方法
JP2009502794A (ja) 2005-07-19 2009-01-29 トランセイブ， インク． 徐放性抗感染剤
JP2009532481A (ja) 2006-04-06 2009-09-10 トランセイブ， インク． コアセルベート化誘導リポソーム被包法及びその調合物
JP2016505545A (ja) 2012-11-29 2016-02-25 インスメッド， インコーポレイテッド 安定化されたバンコマイシン処方物

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