JP7149266B2 - Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法 - Google Patents

Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法 Download PDF

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JP7149266B2
JP7149266B2 JP2019517289A JP2019517289A JP7149266B2 JP 7149266 B2 JP7149266 B2 JP 7149266B2 JP 2019517289 A JP2019517289 A JP 2019517289A JP 2019517289 A JP2019517289 A JP 2019517289A JP 7149266 B2 JP7149266 B2 JP 7149266B2
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substituted
alkyl
compound
disorders
formula
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JP2019529495A (ja
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フランセスコ ジー． サリトゥロ，
アルバート ジェイ． ロビチャウド，
ボテーラ， ガブリエル マルティネス
アンドリュー グリフィン，
ボイド エル． ハリソン，
ダニエル ラ，
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Sage Therapeutics LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
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    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
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    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
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    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
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    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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JP2019517289A 2016-09-30 2017-09-30 Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法 Active JP7149266B2 (ja)

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JP2022003714A JP2022036260A (ja) 2016-09-30 2022-01-13 Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法
JP2024041201A JP2024069502A (ja) 2016-09-30 2024-03-15 Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法

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US201662402797P 2016-09-30 2016-09-30
US201662402789P 2016-09-30 2016-09-30
US62/402,797 2016-09-30
US62/402,789 2016-09-30
PCT/US2017/054657 WO2018064649A1 (en) 2016-09-30 2017-09-30 C7 substituted oxysterols and methods as nmda modulators

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JP2019529495A JP2019529495A (ja) 2019-10-17
JP2019529495A5 JP2019529495A5 (https=) 2020-11-12
JP7149266B2 true JP7149266B2 (ja) 2022-10-06

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JP2022003714A Withdrawn JP2022036260A (ja) 2016-09-30 2022-01-13 Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法
JP2024041201A Pending JP2024069502A (ja) 2016-09-30 2024-03-15 Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法

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JP2024041201A Pending JP2024069502A (ja) 2016-09-30 2024-03-15 Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法

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US (4) US11149056B2 (https=)
EP (1) EP3519422B1 (https=)
JP (3) JP7149266B2 (https=)
CN (3) CN115850361B (https=)
AU (1) AU2017337121B2 (https=)
CA (1) CA3038900A1 (https=)
ES (1) ES2935057T3 (https=)
MA (1) MA46351A (https=)
MX (1) MX392270B (https=)
PT (1) PT3519422T (https=)
WO (1) WO2018064649A1 (https=)

Cited By (1)

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JP2022036260A (ja) * 2016-09-30 2022-03-04 セージ セラピューティクス， インコーポレイテッド Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法

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HRP20230747T1 (hr) 2011-09-08 2024-01-05 Sage Therapeutics, Inc. Neuroaktivni steroidi, pripravci i njihova uporaba
SMT201800657T1 (it) 2013-03-13 2019-01-11 Sage Therapeutics Inc Steroidi neuroattivi e loro metodi di utilizzo
WO2015195967A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
PL3319611T3 (pl) 2015-07-06 2021-07-12 Sage Therapeutics, Inc. Oksysterole i sposoby ich stosowania
MX382122B (es) 2015-07-06 2025-03-13 Sage Therapeutics Inc Oxiesteroles y metodos de uso de los mismos.
EP3436022B1 (en) 2016-04-01 2022-03-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
WO2018009867A1 (en) 2016-07-07 2018-01-11 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
CA3041088C (en) 2016-10-18 2024-05-21 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
DK4105223T3 (da) 2016-10-18 2025-07-07 Sage Therapeutics Inc Oxysteroler og fremgangsmåder til anvendelse deraf
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
IL308273A (en) * 2021-05-04 2024-01-01 Sage Therapeutics Inc Neuroactive steroids for the treatment of mild cognitive impairment associated with Parkinson's disease
EP4405370A1 (en) * 2021-09-22 2024-07-31 Sage Therapeutics, Inc. Deuterated positive nmda-modulating compounds and methods of use thereof
EP4671260A3 (en) * 2024-06-28 2026-03-04 Industriale Chimica S.r.l. Process for the preparation of (3-beta,24s)-25,25,25-trifluoro-3-methyl-26,27-dinorergost-5-ene-3,24-diol

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