AU2017337121B2 - C7 substituted oxysterols and methods as NMDA modulators - Google Patents

C7 substituted oxysterols and methods as NMDA modulators Download PDF

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AU2017337121B2
AU2017337121B2 AU2017337121A AU2017337121A AU2017337121B2 AU 2017337121 B2 AU2017337121 B2 AU 2017337121B2 AU 2017337121 A AU2017337121 A AU 2017337121A AU 2017337121 A AU2017337121 A AU 2017337121A AU 2017337121 B2 AU2017337121 B2 AU 2017337121B2
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compound
substituted
alkyl
disorder
formula
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AU2017337121A1 (en
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Andrew Griffin
Boyd L. Harrison
Daniel La
Gabriel Martinez Botella
Albert J. Robichaud
Francesco G. Salituro
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Sage Therapeutics Inc
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    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
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    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16

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AU2017337121A 2016-09-30 2017-09-30 C7 substituted oxysterols and methods as NMDA modulators Active AU2017337121B2 (en)

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Application Number Priority Date Filing Date Title
US201662402797P 2016-09-30 2016-09-30
US201662402789P 2016-09-30 2016-09-30
US62/402,797 2016-09-30
US62/402,789 2016-09-30
PCT/US2017/054657 WO2018064649A1 (en) 2016-09-30 2017-09-30 C7 substituted oxysterols and methods as nmda modulators

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AU2017337121A1 AU2017337121A1 (en) 2019-04-18
AU2017337121B2 true AU2017337121B2 (en) 2022-01-27

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US (4) US11149056B2 (https=)
EP (1) EP3519422B1 (https=)
JP (3) JP7149266B2 (https=)
CN (3) CN115850361B (https=)
AU (1) AU2017337121B2 (https=)
CA (1) CA3038900A1 (https=)
ES (1) ES2935057T3 (https=)
MA (1) MA46351A (https=)
MX (1) MX392270B (https=)
PT (1) PT3519422T (https=)
WO (1) WO2018064649A1 (https=)

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SMT201800657T1 (it) 2013-03-13 2019-01-11 Sage Therapeutics Inc Steroidi neuroattivi e loro metodi di utilizzo
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PL3319611T3 (pl) 2015-07-06 2021-07-12 Sage Therapeutics, Inc. Oksysterole i sposoby ich stosowania
MX382122B (es) 2015-07-06 2025-03-13 Sage Therapeutics Inc Oxiesteroles y metodos de uso de los mismos.
EP3436022B1 (en) 2016-04-01 2022-03-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
WO2018009867A1 (en) 2016-07-07 2018-01-11 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
PT3519422T (pt) 2016-09-30 2022-12-05 Sage Therapeutics Inc Oxisteróis substituídos em c7 e métodos como moduladores nmda
CA3041088C (en) 2016-10-18 2024-05-21 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
DK4105223T3 (da) 2016-10-18 2025-07-07 Sage Therapeutics Inc Oxysteroler og fremgangsmåder til anvendelse deraf
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