JP7114457B2 - キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 - Google Patents
キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 Download PDFInfo
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- A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
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- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021155858A JP7597688B2 (ja) | 2015-04-17 | 2021-09-24 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
| JP2024206929A JP2025061644A (ja) | 2015-04-17 | 2024-11-28 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562149249P | 2015-04-17 | 2015-04-17 | |
| US62/149,249 | 2015-04-17 | ||
| PCT/US2016/027751 WO2016168595A1 (en) | 2015-04-17 | 2016-04-15 | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021155858A Division JP7597688B2 (ja) | 2015-04-17 | 2021-09-24 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516592A JP2018516592A (ja) | 2018-06-28 |
| JP2018516592A5 JP2018516592A5 (cg-RX-API-DMAC7.html) | 2019-05-30 |
| JP7114457B2 true JP7114457B2 (ja) | 2022-08-08 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018505581A Active JP7114457B2 (ja) | 2015-04-17 | 2016-04-15 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
| JP2021155858A Active JP7597688B2 (ja) | 2015-04-17 | 2021-09-24 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
| JP2024206929A Pending JP2025061644A (ja) | 2015-04-17 | 2024-11-28 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021155858A Active JP7597688B2 (ja) | 2015-04-17 | 2021-09-24 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
| JP2024206929A Pending JP2025061644A (ja) | 2015-04-17 | 2024-11-28 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11896614B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP4234685A3 (cg-RX-API-DMAC7.html) |
| JP (3) | JP7114457B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN108473957B (cg-RX-API-DMAC7.html) |
| AU (3) | AU2016249005B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2982996A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2948133T3 (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201708516YA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016168595A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2958942B1 (en) | 2013-02-20 | 2020-06-03 | Novartis AG | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
| ES2760023T3 (es) | 2013-02-20 | 2020-05-12 | Univ Pennsylvania | Tratamiento del cáncer utilizando receptor de antígeno quimérico anti-EGFRvIII humanizado |
| EP2970426B1 (en) | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| KR101947053B1 (ko) | 2013-10-18 | 2019-02-12 | 도이체스 크렙스포르슝스첸트룸 | 전립선 특이적 막 항원(psma)의 표지된 억제제, 조영제로서의 이의 용도 및 전립선암 치료용 약제 |
| RU2714902C2 (ru) | 2013-12-19 | 2020-02-20 | Новартис Аг | Химерные рецепторы антигена против мезотелина человека и их применение |
| EP3087101B1 (en) | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
| EP4303229A3 (en) | 2014-01-21 | 2024-04-17 | Novartis AG | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
| ES2876263T3 (es) | 2014-04-07 | 2021-11-12 | Novartis Ag | Tratamiento del cáncer usando receptor de antígeno quimérico anti-cd19 |
| SG11201700416TA (en) | 2014-07-21 | 2017-02-27 | Novartis Ag | Treatment of cancer using a cd33 chimeric antigen receptor |
| EP3171882A1 (en) | 2014-07-21 | 2017-05-31 | Novartis AG | Treatment of cancer using a cll-1 chimeric antigen receptor |
| US11542488B2 (en) | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| US10174095B2 (en) | 2014-07-21 | 2019-01-08 | Novartis Ag | Nucleic acid encoding a humanized anti-BCMA chimeric antigen receptor |
| DK3183268T3 (da) | 2014-08-19 | 2020-05-11 | Univ Pennsylvania | Behandling af cancer ved anvendelse af en cd123-kimær antigenreceptor |
| KR20210149228A (ko) | 2014-09-17 | 2021-12-08 | 노파르티스 아게 | 입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화 |
| US10774388B2 (en) | 2014-10-08 | 2020-09-15 | Novartis Ag | Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof |
| RU2751362C2 (ru) | 2014-12-29 | 2021-07-13 | Новартис Аг | Способы получения экспрессирующих химерный антигенный рецептор клеток |
| US11459390B2 (en) | 2015-01-16 | 2022-10-04 | Novartis Ag | Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor |
| WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| HUE059218T2 (hu) | 2015-04-08 | 2022-11-28 | Novartis Ag | CD20-terápiák, CD22-terápiák és kombinációs terápiák CD19 kiméra antigénreceptort (CAR-t) expresszáló sejttel |
| US11896614B2 (en) | 2015-04-17 | 2024-02-13 | Novartis Ag | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| EP3286211A1 (en) | 2015-04-23 | 2018-02-28 | Novartis AG | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
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| WO2016168595A1 (en) | 2016-10-20 |
| CN108473957A (zh) | 2018-08-31 |
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| EP3283619B1 (en) | 2023-04-05 |
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