MX351226B - Celulas t con memoria central anti tercera parte, metodos para producirlas y uso de las mismas en transplante y tratamiento de enfermedades. - Google Patents

Celulas t con memoria central anti tercera parte, metodos para producirlas y uso de las mismas en transplante y tratamiento de enfermedades.

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Publication number
MX351226B
MX351226B MX2014002771A MX2014002771A MX351226B MX 351226 B MX351226 B MX 351226B MX 2014002771 A MX2014002771 A MX 2014002771A MX 2014002771 A MX2014002771 A MX 2014002771A MX 351226 B MX351226 B MX 351226B
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Mexico
Prior art keywords
cells
same
central memory
transplantation
methods
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MX2014002771A
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English (en)
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MX2014002771A (es
Inventor
Reisner Yair
Eidelstein Yaki
Ophir Eran
Lask Assaf
Afik Ran
Or-Geva Noga
Bachar-Lustig Esther
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Yeda Res & Dev
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Publication of MX2014002771A publication Critical patent/MX2014002771A/es
Publication of MX351226B publication Critical patent/MX351226B/es

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    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/461—Cellular immunotherapy characterised by the cell type used
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    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2321—Interleukin-21 (IL-21)
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1121—Dendritic cells

Abstract

La presente invención se refiere a un método para generar una población aislada de células que comprenden células anti-tercera parte no inductoras de enfermedad de injerto contra hospedero ( GVHD) que tienen un fenotipo de linfocito T de memoria central (Tcm), dichas células son células inductoras de tolerancia y/o dotadas con actividad anti-enfermedad, y capaces de albergarse a los ganglios linfáticos después del trasplante, el método está caracterizado porque comprende: (a) tratar células mononucleares de sangre periférica (PBMC) con un agente de agotar células CD4+ y/o CD56+ para obtener células T CD8+; (b) poner en contacto las células CD8+ con un antígeno o antígenos de tercera parte en la presencia de IL-21 durante 12 horas a 5 días para permitir el enriquecimiento de células reactivas con antígeno; y (c) cultivar las células que resultan de la etapa (b) en presencia de IL-21, IL-15, e IL-7 en un ambiente libre de antígeno durante 5-20 días para permitir la proliferación de células que comprenden el fenotipo de linfocito T de memoria central (Tcm), para de esta manera generar la población aislada de células.
MX2014002771A 2011-09-08 2012-09-06 Celulas t con memoria central anti tercera parte, metodos para producirlas y uso de las mismas en transplante y tratamiento de enfermedades. MX351226B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161532172P 2011-09-08 2011-09-08
PCT/IL2012/050354 WO2013035099A1 (en) 2011-09-08 2012-09-06 Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment

Publications (2)

Publication Number Publication Date
MX2014002771A MX2014002771A (es) 2015-02-04
MX351226B true MX351226B (es) 2017-10-05

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MX2014002771A MX351226B (es) 2011-09-08 2012-09-06 Celulas t con memoria central anti tercera parte, metodos para producirlas y uso de las mismas en transplante y tratamiento de enfermedades.

Country Status (15)

Country Link
US (3) US20140212398A1 (es)
EP (1) EP2753351B1 (es)
JP (1) JP6196620B2 (es)
KR (1) KR102073901B1 (es)
CN (1) CN103930130B (es)
AU (1) AU2012305931B2 (es)
BR (1) BR112014005355B1 (es)
CA (1) CA2848121C (es)
ES (1) ES2640813T3 (es)
HK (1) HK1200099A1 (es)
MX (1) MX351226B (es)
RU (1) RU2636503C2 (es)
SG (1) SG11201400513PA (es)
WO (1) WO2013035099A1 (es)
ZA (1) ZA201401993B (es)

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HK1200099A1 (en) 2015-07-31
US20230024587A1 (en) 2023-01-26
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