MX2022015555A - Metodos para preparar celulas t para terapia de celulas t. - Google Patents

Metodos para preparar celulas t para terapia de celulas t.

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Publication number
MX2022015555A
MX2022015555A MX2022015555A MX2022015555A MX2022015555A MX 2022015555 A MX2022015555 A MX 2022015555A MX 2022015555 A MX2022015555 A MX 2022015555A MX 2022015555 A MX2022015555 A MX 2022015555A MX 2022015555 A MX2022015555 A MX 2022015555A
Authority
MX
Mexico
Prior art keywords
cells
cell therapy
methods
preparing
differentiation
Prior art date
Application number
MX2022015555A
Other languages
English (en)
Inventor
Steven A Rosenberg
Nicholas P Restifo
Marianna Sabatino
Arianne Perez
Original Assignee
Kite Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kite Pharma Inc filed Critical Kite Pharma Inc
Publication of MX2022015555A publication Critical patent/MX2022015555A/es

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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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Abstract

En la presente se proporcionan métodos para retrasar o inhibir la maduración o diferenciación in vitro de células T para una terapia de células T, que comprende poner en contacto una o más células T de un sujeto en necesidad de terapia de células T con un inhibidor de AKT y al menos una de interleucina-7 (IL-7) exógena e interleucina-15 (IL-15) exógena, en donde las células T resultantes exhiben maduración o diferenciación retrasada. En algunas modalidades, el método comprende además administrar la una o más células T a un sujeto en necesidad de una terapia de células T.
MX2022015555A 2015-10-20 2018-04-13 Metodos para preparar celulas t para terapia de celulas t. MX2022015555A (es)

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