BR112018007864A2 - métodos para preparar células t para terapia de células t - Google Patents

métodos para preparar células t para terapia de células t

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Publication number
BR112018007864A2
BR112018007864A2 BR112018007864A BR112018007864A BR112018007864A2 BR 112018007864 A2 BR112018007864 A2 BR 112018007864A2 BR 112018007864 A BR112018007864 A BR 112018007864A BR 112018007864 A BR112018007864 A BR 112018007864A BR 112018007864 A2 BR112018007864 A2 BR 112018007864A2
Authority
BR
Brazil
Prior art keywords
cells
cell therapy
methods
preparing
cell
Prior art date
Application number
BR112018007864A
Other languages
English (en)
Inventor
Perez Arianne
Sabatino Marianna
P Restifo Nicholas
A Rosenberg Steven
Original Assignee
Kite Pharma Inc
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kite Pharma Inc, Us Health filed Critical Kite Pharma Inc
Priority to BR122024000148-9A priority Critical patent/BR122024000148A2/pt
Publication of BR112018007864A2 publication Critical patent/BR112018007864A2/pt

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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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Abstract

a presente invenção refere-se a métodos para retardar ou inibir a maturação ou diferenciação de células t in vitro para uma terapia de células t, compreendendo colocar em contato uma ou mais células t de um indivíduo com necessidade de uma terapia de células t com um inibidor de akt e pelo menos uma interleucina-7 (il-7) exógena e interleucina-15 (il-15) exógena, em que as células t resultantes exibem maturação ou diferenciação atrasada. em algumas modalidades, o método compreende ainda a administração de uma ou mais células t a um indivíduo em necessidade de uma terapia de células t.
BR112018007864A 2015-10-20 2016-10-20 métodos para preparar células t para terapia de células t BR112018007864A2 (pt)

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PCT/US2016/057983 WO2017070395A1 (en) 2015-10-20 2016-10-20 Methods of preparing t cells for t cell therapy

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