SG10201806787VA - Modulators of complement factor b - Google Patents
Modulators of complement factor bInfo
- Publication number
- SG10201806787VA SG10201806787VA SG10201806787VA SG10201806787VA SG10201806787VA SG 10201806787V A SG10201806787V A SG 10201806787VA SG 10201806787V A SG10201806787V A SG 10201806787VA SG 10201806787V A SG10201806787V A SG 10201806787VA SG 10201806787V A SG10201806787V A SG 10201806787VA
- Authority
- SG
- Singapore
- Prior art keywords
- modulators
- complement factor
- complement
- factor
- cfb
- Prior art date
Links
- 102000003712 Complement factor B Human genes 0.000 title abstract 4
- 108090000056 Complement factor B Proteins 0.000 title abstract 4
- 230000024203 complement activation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21047—Alternative-complement-pathway C3/C5 convertase (3.4.21.47), i.e. properdin factor B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
Abstract
MODULATORS OF COMPLEMENT FACTOR B The embodiments methods, and tions treating, or ameliorating disease with of complement pathway administering a Complement Factor B (CFB) specific inhibitor to a subject. No Figure
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361877624P | 2013-09-13 | 2013-09-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201806787VA true SG10201806787VA (en) | 2018-09-27 |
Family
ID=52666522
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201806787VA SG10201806787VA (en) | 2013-09-13 | 2014-09-12 | Modulators of complement factor b |
SG11201601445XA SG11201601445XA (en) | 2013-09-13 | 2014-09-12 | Modulators of complement factor b |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201601445XA SG11201601445XA (en) | 2013-09-13 | 2014-09-12 | Modulators of complement factor b |
Country Status (33)
Country | Link |
---|---|
US (4) | US20160222389A1 (en) |
EP (2) | EP3603677A1 (en) |
JP (3) | JP6666250B2 (en) |
KR (1) | KR102381790B1 (en) |
CN (2) | CN105744959B (en) |
AU (2) | AU2014318580B2 (en) |
BR (1) | BR112016004671B1 (en) |
CA (1) | CA2921842A1 (en) |
CL (2) | CL2016000606A1 (en) |
CR (1) | CR20160170A (en) |
DK (1) | DK3043827T3 (en) |
DO (1) | DOP2016000063A (en) |
EA (1) | EA035433B1 (en) |
ES (1) | ES2745758T3 (en) |
HK (1) | HK1225638A1 (en) |
HR (1) | HRP20191600T1 (en) |
HU (1) | HUE045109T2 (en) |
IL (1) | IL244095A0 (en) |
LT (1) | LT3043827T (en) |
MA (1) | MA38959A1 (en) |
MX (2) | MX371518B (en) |
MY (1) | MY181251A (en) |
PE (2) | PE20160500A1 (en) |
PH (1) | PH12016500443A1 (en) |
PL (1) | PL3043827T3 (en) |
PT (1) | PT3043827T (en) |
RS (1) | RS59252B1 (en) |
RU (1) | RU2662967C2 (en) |
SG (2) | SG10201806787VA (en) |
SI (1) | SI3043827T1 (en) |
UA (1) | UA119046C2 (en) |
WO (1) | WO2015038939A2 (en) |
ZA (1) | ZA201601236B (en) |
Families Citing this family (20)
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EP3916095A1 (en) | 2006-10-18 | 2021-12-01 | Ionis Pharmaceuticals, Inc. | Antisense compounds |
EP3467109A1 (en) | 2011-02-08 | 2019-04-10 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleotides and uses thereof |
BR112015027321A8 (en) | 2013-05-01 | 2018-01-02 | Isis Pharmaceuticals Inc | COMPOUNDS AND COMPOSITIONS FOR MODULING APOLIPOPROTEIN(A) EXPRESSION AND THEIR USES |
HUE045109T2 (en) * | 2013-09-13 | 2019-12-30 | Ionis Pharmaceuticals Inc | Modulators of complement factor b |
JP6710638B2 (en) * | 2013-12-12 | 2020-06-17 | アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. | Complement component iRNA composition and method of using the same |
ES2745825T3 (en) | 2014-05-01 | 2020-03-03 | Ionis Pharmaceuticals Inc | Compositions and methods for modulating expression of complement factor B |
WO2017135397A1 (en) * | 2016-02-05 | 2017-08-10 | 協和発酵キリン株式会社 | Antisense oligonucleotide for suppressing expression of complement b factor |
EP3448389B1 (en) | 2016-06-27 | 2021-09-29 | Achillion Pharmaceuticals, Inc. | Quinazoline and indole compounds to treat medical disorders |
US20180193270A1 (en) | 2016-11-29 | 2018-07-12 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
WO2018117253A1 (en) * | 2016-12-23 | 2018-06-28 | 協和発酵キリン株式会社 | Nucleic acid inhibiting expression of complement factor b |
TW201909925A (en) * | 2017-08-02 | 2019-03-16 | 日商協和醱酵麒麟有限公司 | Nucleic acid complex |
SG11202002940QA (en) | 2017-11-01 | 2020-04-29 | Alnylam Pharmaceuticals Inc | Complement component c3 irna compositions and methods of use thereof |
WO2020109343A1 (en) | 2018-11-29 | 2020-06-04 | F. Hoffmann-La Roche Ag | Combination therapy for treatment of macular degeneration |
JP2023523790A (en) * | 2020-04-30 | 2023-06-07 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | COMPLEMENT FACTOR B (CFB) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
BR112023001195A2 (en) | 2020-08-07 | 2023-02-28 | Shanghai Meiyue Biotech Dev Co Ltd | COMPOUND OR RACEMATE, STEREOISOMER, TAUTOMER, ISOTOPICALLY LABELED COMPOUND, SOLVATE, POLYMORPH, PHARMACEUTICALLY ACCEPTABLE SALT OR PRODRUG COMPOUND THEREOF, COMPOUND, METHOD OF PREPARATION FOR COMPOUND OR RACEMATE, STEREOISOMER, TAUTOMER, ISOTOPICALLY LABELED COMPOUND, POLYFOLD, SALTED, SALTED ACCEPTABLE PHARMACEUTICALLY OR PRODRUG COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD FOR TREAT A DISEASE ASSOCIATED WITH ALTERNATIVE COMPLEMENT PATHWAY ACTIVATION, AND, USE OF THE COMPOUND |
CN114057692B (en) | 2020-08-07 | 2023-07-21 | 上海美悦生物科技发展有限公司 | Heterocyclic compound, preparation method and application thereof |
IL310180A (en) * | 2021-07-17 | 2024-03-01 | Sirnaomics Inc | Products and compositions |
CA3230589A1 (en) | 2021-09-02 | 2023-03-09 | Sibylle DAMES | Nucleic acids for inhibiting expression of complement factor b (cfb) in a cell |
TW202333749A (en) * | 2021-10-29 | 2023-09-01 | 美商艾拉倫製藥股份有限公司 | Complement factor b (cfb) irna compositions and methods of use thereof |
WO2023129496A2 (en) * | 2021-12-27 | 2023-07-06 | Apellis Pharmaceuticals, Inc. | Rnas for complement inhibition |
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2014
- 2014-09-12 HU HUE14844168A patent/HUE045109T2/en unknown
- 2014-09-12 KR KR1020167009610A patent/KR102381790B1/en active IP Right Grant
- 2014-09-12 SI SI201431272T patent/SI3043827T1/en unknown
- 2014-09-12 US US15/021,651 patent/US20160222389A1/en not_active Abandoned
- 2014-09-12 EP EP19182415.0A patent/EP3603677A1/en active Pending
- 2014-09-12 DK DK14844168.6T patent/DK3043827T3/en active
- 2014-09-12 AU AU2014318580A patent/AU2014318580B2/en active Active
- 2014-09-12 MY MYPI2016700852A patent/MY181251A/en unknown
- 2014-09-12 SG SG10201806787VA patent/SG10201806787VA/en unknown
- 2014-09-12 EA EA201690582A patent/EA035433B1/en unknown
- 2014-09-12 MX MX2016003263A patent/MX371518B/en active IP Right Grant
- 2014-09-12 MA MA38959A patent/MA38959A1/en unknown
- 2014-09-12 ES ES14844168T patent/ES2745758T3/en active Active
- 2014-09-12 JP JP2016542824A patent/JP6666250B2/en active Active
- 2014-09-12 PE PE2016000376A patent/PE20160500A1/en unknown
- 2014-09-12 CN CN201480056788.6A patent/CN105744959B/en active Active
- 2014-09-12 RU RU2016113763A patent/RU2662967C2/en active
- 2014-09-12 SG SG11201601445XA patent/SG11201601445XA/en unknown
- 2014-09-12 WO PCT/US2014/055458 patent/WO2015038939A2/en active Application Filing
- 2014-09-12 EP EP14844168.6A patent/EP3043827B1/en active Active
- 2014-09-12 RS RSP20191160 patent/RS59252B1/en unknown
- 2014-09-12 PE PE2018003111A patent/PE20190354A1/en unknown
- 2014-09-12 PT PT14844168T patent/PT3043827T/en unknown
- 2014-09-12 LT LTEP14844168.6T patent/LT3043827T/en unknown
- 2014-09-12 PL PL14844168T patent/PL3043827T3/en unknown
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2016
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