MX2007012222A - Metodo para tratamiento de trastornos inmunes asociados con trasplante de injerto con moleculas mutantes ctla4 solubles. - Google Patents
Metodo para tratamiento de trastornos inmunes asociados con trasplante de injerto con moleculas mutantes ctla4 solubles.Info
- Publication number
- MX2007012222A MX2007012222A MX2007012222A MX2007012222A MX2007012222A MX 2007012222 A MX2007012222 A MX 2007012222A MX 2007012222 A MX2007012222 A MX 2007012222A MX 2007012222 A MX2007012222 A MX 2007012222A MX 2007012222 A MX2007012222 A MX 2007012222A
- Authority
- MX
- Mexico
- Prior art keywords
- disorders associated
- immune disorders
- methods
- mutant molecules
- soluble ctla4
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
La presente invencion proporciona el uso de moleculas mutantes de CTLA4 solubles que se aglutinan con mayor afinidad hacia el antigeno de CD80 y/o CD86 que el CTLA4 del tipo silvestre o el CTLA4Ig no mutado en el tratamiento de trastornos inmunes asociados con el trasplante de injerto.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66877405P | 2005-04-06 | 2005-04-06 | |
PCT/US2006/012648 WO2006108035A1 (en) | 2005-04-06 | 2006-04-05 | Methods for treating immune disorders associated with graft transplantation with soluble ctla4 mutant molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007012222A true MX2007012222A (es) | 2007-12-06 |
Family
ID=36694299
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007012222A MX2007012222A (es) | 2005-04-06 | 2006-04-05 | Metodo para tratamiento de trastornos inmunes asociados con trasplante de injerto con moleculas mutantes ctla4 solubles. |
Country Status (25)
Country | Link |
---|---|
US (2) | US7482327B2 (es) |
EP (1) | EP1868635B1 (es) |
JP (1) | JP2008535841A (es) |
KR (1) | KR101235484B1 (es) |
CN (1) | CN101198347A (es) |
AR (1) | AR055052A1 (es) |
AU (1) | AU2006231622B2 (es) |
BR (1) | BRPI0608144A2 (es) |
CA (1) | CA2603970A1 (es) |
CY (1) | CY1119145T1 (es) |
DK (1) | DK1868635T3 (es) |
EA (1) | EA013122B1 (es) |
ES (1) | ES2634260T3 (es) |
HR (1) | HRP20171121T8 (es) |
IL (1) | IL186189A (es) |
LT (1) | LT1868635T (es) |
ME (1) | ME02930B (es) |
MX (1) | MX2007012222A (es) |
NO (1) | NO342966B1 (es) |
NZ (2) | NZ561655A (es) |
PL (1) | PL1868635T3 (es) |
PT (1) | PT1868635T (es) |
RS (1) | RS56138B1 (es) |
SI (1) | SI1868635T1 (es) |
WO (1) | WO2006108035A1 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7094874B2 (en) * | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
MX2007012222A (es) * | 2005-04-06 | 2007-12-06 | Bristol Myers Squibb Co | Metodo para tratamiento de trastornos inmunes asociados con trasplante de injerto con moleculas mutantes ctla4 solubles. |
US9309316B2 (en) | 2005-12-20 | 2016-04-12 | Bristol-Myers Squibb Company | Stable subcutaneous protein formulations and uses thereof |
US7528111B2 (en) * | 2006-05-12 | 2009-05-05 | Bristol-Myers Squibb Company | Method of vaccinating subjects receiving immune modulating therapy |
WO2008014035A2 (en) * | 2006-07-25 | 2008-01-31 | The Regents Of The University Of California | Modulation of nkg2d and method for treating or preventing solid organ allograft rejection |
EP2612868B1 (en) | 2007-11-01 | 2018-08-15 | Astellas Pharma Inc. | Immunosuppressive polypeptides and nucleic acids |
KR20110074850A (ko) * | 2008-08-25 | 2011-07-04 | 앰플리뮨, 인크. | Pd-1 길항제 및 그의 사용 방법 |
EP2365823B1 (en) * | 2008-10-30 | 2016-11-30 | Yeda Research And Development Company Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
US20100297123A1 (en) * | 2009-05-15 | 2010-11-25 | Garrison Fathman C | Combination therapy to inhibit t cell effector function |
KR20130049775A (ko) | 2010-03-12 | 2013-05-14 | 애브비 바이오테라퓨틱스 인크. | Ctla4 단백질 및 이의 용도 |
CA2810631A1 (en) | 2010-09-08 | 2012-03-15 | Yeda Research And Development Co. Ltd. | An immunosuppressive drug combination for a stable and long term engraftment |
CN103282047B (zh) | 2010-09-08 | 2016-08-24 | 耶达研究及发展有限公司 | 抗第三方中枢记忆性t细胞在抗白血病/淋巴瘤治疗中的用途 |
CN103930130B (zh) | 2011-09-08 | 2016-07-06 | 耶达研究及发展有限公司 | 抗第三方中央型记忆t细胞、其产生方法以及其在移植和疾病治疗中的应用 |
JP6163158B2 (ja) | 2011-10-13 | 2017-07-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Cd40lに拮抗する抗体ポリペプチド |
SG11201506919XA (en) * | 2013-03-28 | 2015-10-29 | Bristol Myers Squibb Co | Methods for identifying patients at risk for costimulation blockade resistant rejection |
CN104673822A (zh) * | 2013-11-27 | 2015-06-03 | 深圳先进技术研究院 | 一种重组载体及其制备方法和应用 |
CN104740608A (zh) * | 2013-12-30 | 2015-07-01 | 上海中信国健药业股份有限公司 | 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途 |
MX2016011102A (es) | 2014-03-19 | 2017-01-26 | Bristol Myers Squibb Co | Metodos para tratar rechazo al trasplante usando un anticuerpo de dominio dirigido contra cd40l. |
KR20240046641A (ko) | 2015-04-17 | 2024-04-09 | 알파인 이뮨 사이언시즈, 인코포레이티드 | 조율가능한 친화성을 갖는 면역조절 단백질 |
CA2991690A1 (en) | 2015-07-16 | 2017-01-19 | Yeda Research And Development Co. Ltd. | Genetically modified anti-third party central memory t cells and use of same in immunotherapy |
US10751368B2 (en) | 2017-01-18 | 2020-08-25 | Yeda Research And Development Co. Ltd. | Methods of transplantation and disease treatment |
CN110392736A (zh) | 2017-01-18 | 2019-10-29 | 耶达研究及发展有限公司 | 遗传修饰的反抑细胞及其在免疫治疗中的用途 |
US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
US10286036B2 (en) | 2017-05-12 | 2019-05-14 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
MA50360A (fr) | 2017-10-10 | 2020-08-19 | Alpine Immune Sciences Inc | Protéines immunomodulatrices de variants de ctla-4 et leurs utilisations |
US11925640B2 (en) | 2018-06-22 | 2024-03-12 | Mayo Foundation For Medical Education And Research | Methods and materials for improving arteriovenous fistula maturation and maintaining arteriovenous fistula functionality |
WO2020010259A1 (en) * | 2018-07-06 | 2020-01-09 | Mayo Foundation For Medical Education And Research | Methods and materials for improving transplant outcomes |
JP7137696B2 (ja) | 2019-05-14 | 2022-09-14 | プロヴェンション・バイオ・インコーポレイテッド | 1型糖尿病を予防するための方法および組成物 |
CN115089718A (zh) * | 2021-11-30 | 2022-09-23 | 杭州瑞普晨创科技有限公司 | 用于异种移植的免疫抑制剂组合和免疫抑制方法 |
Family Cites Families (17)
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US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US5851795A (en) | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
US6090914A (en) | 1991-06-27 | 2000-07-18 | Bristol-Myers Squibb Company | CTLA4/CD28Ig hybrid fusion proteins and uses thereof |
US5844095A (en) | 1991-06-27 | 1998-12-01 | Bristol-Myers Squibb Company | CTLA4 Ig fusion proteins |
DE122007000078I2 (de) | 1991-06-27 | 2011-01-13 | Bristol Myers Squibb Co | CTL4A-Rezeptor, ihn enthaltenden Fusionsproteine und deren Verwendung |
US5773253A (en) | 1993-01-22 | 1998-06-30 | Bristol-Myers Squibb Company | MYPPPY variants of CTL A4 and uses thereof |
US6750334B1 (en) | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
US6051228A (en) | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
AU2002243905B2 (en) * | 2001-01-26 | 2007-11-08 | Emory University | Methods of inducing organ transplant tolerance and correcting hemoglobinopathies |
PL204899B1 (pl) * | 2001-05-23 | 2010-02-26 | Bristol Myers Squibb Co | Zastosowanie rozpuszczalnej zmutowanej cząsteczki CTLA4 |
WO2003088991A1 (en) * | 2002-04-19 | 2003-10-30 | Bristol-Myers Squibb Company | Methods for treating an autoimmune disease using a soluble ctla4 molecule and a dmard or nsaid |
ES2354610T5 (es) | 2002-12-23 | 2020-09-14 | Bristol Myers Squibb Co | Mejora de la calidad del producto en procedimientos de cultivo de células de mamífero para la producción de proteína |
WO2004058800A2 (en) | 2002-12-23 | 2004-07-15 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
MX2007012222A (es) * | 2005-04-06 | 2007-12-06 | Bristol Myers Squibb Co | Metodo para tratamiento de trastornos inmunes asociados con trasplante de injerto con moleculas mutantes ctla4 solubles. |
-
2006
- 2006-04-05 MX MX2007012222A patent/MX2007012222A/es active IP Right Grant
- 2006-04-05 NZ NZ561655A patent/NZ561655A/en not_active IP Right Cessation
- 2006-04-05 CA CA002603970A patent/CA2603970A1/en not_active Abandoned
- 2006-04-05 BR BRPI0608144-4A patent/BRPI0608144A2/pt not_active Application Discontinuation
- 2006-04-05 SI SI200632175A patent/SI1868635T1/sl unknown
- 2006-04-05 AU AU2006231622A patent/AU2006231622B2/en active Active
- 2006-04-05 LT LTEP06749324.7T patent/LT1868635T/lt unknown
- 2006-04-05 KR KR1020077025644A patent/KR101235484B1/ko active IP Right Grant
- 2006-04-05 ES ES06749324.7T patent/ES2634260T3/es active Active
- 2006-04-05 DK DK06749324.7T patent/DK1868635T3/en active
- 2006-04-05 EP EP06749324.7A patent/EP1868635B1/en active Active
- 2006-04-05 EA EA200702180A patent/EA013122B1/ru active IP Right Revival
- 2006-04-05 CN CNA2006800198976A patent/CN101198347A/zh active Pending
- 2006-04-05 PT PT67493247T patent/PT1868635T/pt unknown
- 2006-04-05 PL PL06749324T patent/PL1868635T3/pl unknown
- 2006-04-05 ME MEP-2017-162A patent/ME02930B/me unknown
- 2006-04-05 RS RS20170794A patent/RS56138B1/sr unknown
- 2006-04-05 JP JP2008505489A patent/JP2008535841A/ja active Pending
- 2006-04-05 WO PCT/US2006/012648 patent/WO2006108035A1/en active Application Filing
- 2006-04-06 US US11/399,666 patent/US7482327B2/en active Active
- 2006-04-06 AR ARP060101377A patent/AR055052A1/es unknown
-
2007
- 2007-09-23 IL IL186189A patent/IL186189A/en active IP Right Grant
- 2007-10-09 NO NO20075078A patent/NO342966B1/no unknown
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2008
- 2008-11-19 US US12/313,342 patent/US20100041602A1/en not_active Abandoned
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2009
- 2009-04-21 NZ NZ576434A patent/NZ576434A/en not_active IP Right Cessation
-
2017
- 2017-07-21 HR HRP20171121TT patent/HRP20171121T8/hr unknown
- 2017-07-28 CY CY20171100812T patent/CY1119145T1/el unknown
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