MX2014002771A - Celulas t con memoria central anti tercera parte, metodos para producirlas y uso de las mismas en transplante y tratamiento de enfermedades. - Google Patents

Celulas t con memoria central anti tercera parte, metodos para producirlas y uso de las mismas en transplante y tratamiento de enfermedades.

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Publication number
MX2014002771A
MX2014002771A MX2014002771A MX2014002771A MX2014002771A MX 2014002771 A MX2014002771 A MX 2014002771A MX 2014002771 A MX2014002771 A MX 2014002771A MX 2014002771 A MX2014002771 A MX 2014002771A MX 2014002771 A MX2014002771 A MX 2014002771A
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Mexico
Prior art keywords
cells
same
central memory
transplantation
methods
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MX2014002771A
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English (en)
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MX351226B (es
Inventor
Yair Reisner
Yaki Eidelstein
Eran Ophir
Assaf Lask
Ran Afik
Noga Or-Geva
Esther Bachar-Lustig
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Yeda Res & Dev
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Publication of MX2014002771A publication Critical patent/MX2014002771A/es
Publication of MX351226B publication Critical patent/MX351226B/es

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    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/46—Cellular immunotherapy
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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)

Abstract

Se describe un método para generar una población aislada de células que comprenden células anti-tercera parte que tienen un fenotipo de linfocito T (Tcm) de memoria central, las células que son células inductoras de tolerancia y/o dotadas con actividad anti-enfermedad, y capaces de albergarse a los ganglios linfáticos después del trasplante. El método que comprende: (a) poner en contacto células mononucleares de sangre periférica (PBMC) con un antígeno o antígenos de tercera parte en la presencia de IL-21 para permitir el enriquecimiento de células reactivas con antígeno; (b) cultivar las células que resultan de la etapa (a) en la presencia de IL-21, IL-15 e IL-7 en un ambiente libre de antígeno para permitir la proliferación de células que comprenden el fenotipo de linfocito T (Tcm) de memoria central.
MX2014002771A 2011-09-08 2012-09-06 Celulas t con memoria central anti tercera parte, metodos para producirlas y uso de las mismas en transplante y tratamiento de enfermedades. MX351226B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161532172P 2011-09-08 2011-09-08
PCT/IL2012/050354 WO2013035099A1 (en) 2011-09-08 2012-09-06 Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment

Publications (2)

Publication Number Publication Date
MX2014002771A true MX2014002771A (es) 2015-02-04
MX351226B MX351226B (es) 2017-10-05

Family

ID=47003163

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014002771A MX351226B (es) 2011-09-08 2012-09-06 Celulas t con memoria central anti tercera parte, metodos para producirlas y uso de las mismas en transplante y tratamiento de enfermedades.

Country Status (15)

Country Link
US (3) US20140212398A1 (es)
EP (1) EP2753351B1 (es)
JP (1) JP6196620B2 (es)
KR (1) KR102073901B1 (es)
CN (1) CN103930130B (es)
AU (1) AU2012305931B2 (es)
BR (1) BR112014005355B1 (es)
CA (1) CA2848121C (es)
ES (1) ES2640813T3 (es)
HK (1) HK1200099A1 (es)
MX (1) MX351226B (es)
RU (1) RU2636503C2 (es)
SG (1) SG11201400513PA (es)
WO (1) WO2013035099A1 (es)
ZA (1) ZA201401993B (es)

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MX351226B (es) 2017-10-05
US20230024587A1 (en) 2023-01-26
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US20140212398A1 (en) 2014-07-31
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