MX2020003129A - Composiciones celulares que comprenden linfocitos t específicos para antígenos para una terapia adoptiva. - Google Patents

Composiciones celulares que comprenden linfocitos t específicos para antígenos para una terapia adoptiva.

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Publication number
MX2020003129A
MX2020003129A MX2020003129A MX2020003129A MX2020003129A MX 2020003129 A MX2020003129 A MX 2020003129A MX 2020003129 A MX2020003129 A MX 2020003129A MX 2020003129 A MX2020003129 A MX 2020003129A MX 2020003129 A MX2020003129 A MX 2020003129A
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Mexico
Prior art keywords
cells
cell compositions
composition
specific
antigen
Prior art date
Application number
MX2020003129A
Other languages
English (en)
Inventor
Mathias Oelke
Sojung Kim
Kristi Jones
Lauren Suarez
Ken Carter
Scott Carmer
Dan Bednarik
Original Assignee
Neximmune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neximmune Inc filed Critical Neximmune Inc
Publication of MX2020003129A publication Critical patent/MX2020003129A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00119—Melanoma antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4238—Regulators of development
    • A61K40/424—Apoptosis related proteins, e.g. survivin or livin
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4242—Transcription factors, e.g. SOX or c-MYC
    • A61K40/4243—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/427—PRAME
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A61K40/4272—Melan-A/MART
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
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  • Mycology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención proporciona una composición celular aislada adecuada para la inmunoterapia adoptiva, así como métodos de fabricación de las composiciones celulares y métodos de tratamiento con las composiciones celulares. La composición comprende, en un portador farmacéuticamente aceptable, al menos alrededor de 106 linfocitos T CD8+ específicos para el o los antígenos peptídicos diana. En diversas modalidades, la composición está conformada predominantemente por linfocitos T CD8+, y al menos alrededor del 20 % de los linfocitos T en la composición presentan un fenotipo de memoria central o efectora, lo cual proporciona una terapia adoptiva potente y duradera a partir de un repertorio de linfocitos T naturales sometido a selección natural.
MX2020003129A 2017-09-20 2018-09-20 Composiciones celulares que comprenden linfocitos t específicos para antígenos para una terapia adoptiva. MX2020003129A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762561044P 2017-09-20 2017-09-20
US201862656679P 2018-04-12 2018-04-12
PCT/US2018/051971 WO2019060558A1 (en) 2017-09-20 2018-09-20 CELLULAR COMPOSITIONS COMPRISING ANTIGEN-SPECIFIC T CELLS FOR ADOPTIVE THERAPY

Publications (1)

Publication Number Publication Date
MX2020003129A true MX2020003129A (es) 2020-10-12

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MX2020003129A MX2020003129A (es) 2017-09-20 2018-09-20 Composiciones celulares que comprenden linfocitos t específicos para antígenos para una terapia adoptiva.

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US (2) US20190119639A1 (es)
EP (1) EP3684402A4 (es)
JP (1) JP7475684B2 (es)
KR (1) KR102850471B1 (es)
CN (1) CN111629748A (es)
AU (1) AU2018337960B2 (es)
BR (1) BR112020005552A2 (es)
CA (1) CA3076490A1 (es)
IL (1) IL273452B2 (es)
MX (1) MX2020003129A (es)
RU (1) RU2020113627A (es)
SG (1) SG11202002523YA (es)
WO (1) WO2019060558A1 (es)

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JP7475684B2 (ja) 2024-04-30
WO2019060558A1 (en) 2019-03-28
RU2020113627A (ru) 2021-10-20
KR102850471B1 (ko) 2025-08-27
US20230399613A1 (en) 2023-12-14
AU2018337960A1 (en) 2020-04-30
IL273452B2 (en) 2025-02-01
SG11202002523YA (en) 2020-04-29
CA3076490A1 (en) 2019-03-28
RU2020113627A3 (es) 2021-11-30
EP3684402A4 (en) 2021-05-26
JP2020534313A (ja) 2020-11-26
AU2018337960B2 (en) 2025-08-14
KR20200104283A (ko) 2020-09-03
BR112020005552A2 (pt) 2020-10-27
IL273452B1 (en) 2024-10-01
IL273452A (en) 2020-05-31
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CN111629748A (zh) 2020-09-04
US20190119639A1 (en) 2019-04-25

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