MX2021005625A - Metodos para aislar, cultivar y dise?ar geneticamente poblaciones de celulas inmunes para terapia adoptiva. - Google Patents

Metodos para aislar, cultivar y dise?ar geneticamente poblaciones de celulas inmunes para terapia adoptiva.

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Publication number
MX2021005625A
MX2021005625A MX2021005625A MX2021005625A MX2021005625A MX 2021005625 A MX2021005625 A MX 2021005625A MX 2021005625 A MX2021005625 A MX 2021005625A MX 2021005625 A MX2021005625 A MX 2021005625A MX 2021005625 A MX2021005625 A MX 2021005625A
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Mexico
Prior art keywords
methods
cells
cell populations
culturing
isolating
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MX2021005625A
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English (en)
Inventor
Chris Ramsborg
Mark L Bonyhadi
Calvin Chan
Pascal Beauchesne
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Juno Therapeutics Inc
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Publication of MX2021005625A publication Critical patent/MX2021005625A/es

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
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    • C12N2510/00—Genetically modified cells
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70514—CD4
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70517—CD8
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
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    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Abstract

La presente descripción se relaciona en algunos aspectos a métodos, células y composiciones para preparar células y composiciones para ingeniería genética y terapia celular. En algunas modalidades se proporcionan métodos de preparación de células optimizados, por ejemplo, para aislamiento, procesamiento, incubación e ingeniería genética de células y poblaciones de células. También se proporcionan células y composiciones producidas por los métodos y métodos de su uso. Las células pueden incluir células inmunes, tales como células T, y generalmente incluyen una pluralidad de poblaciones o tipos de células T aisladas. En algunos aspectos, los métodos son capaces de la preparación de una pluralidad de diferentes poblaciones de células para terapia adoptiva usando menos etapas y/o recursos y/o manejo reducido comparados con otros métodos.
MX2021005625A 2014-04-23 2016-10-19 Metodos para aislar, cultivar y dise?ar geneticamente poblaciones de celulas inmunes para terapia adoptiva. MX2021005625A (es)

Applications Claiming Priority (1)

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US201461983415P 2014-04-23 2014-04-23

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MX2016013747A MX2016013747A (es) 2014-04-23 2015-04-23 Métodos para aislar, cultivar y diseñar genéticamente poblaciones de células inmunes para terapia adoptiva.
MX2021005625A MX2021005625A (es) 2014-04-23 2016-10-19 Metodos para aislar, cultivar y dise?ar geneticamente poblaciones de celulas inmunes para terapia adoptiva.

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Country Status (17)

Country Link
US (3) US11400115B2 (es)
EP (3) EP3647412A1 (es)
JP (3) JP6759187B2 (es)
KR (2) KR102447958B1 (es)
CN (3) CN113046321A (es)
AU (2) AU2015249554B2 (es)
BR (1) BR112016024579A2 (es)
CA (1) CA2946312A1 (es)
ES (1) ES2759260T3 (es)
IL (4) IL292038A (es)
MA (2) MA51794A (es)
MX (2) MX2016013747A (es)
PH (1) PH12016502112A1 (es)
RU (1) RU2763795C2 (es)
SA (1) SA516380118B1 (es)
SG (1) SG11201608862SA (es)
WO (1) WO2015164675A1 (es)

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