JP7066728B2 - Ｃ型肝炎ウイルスの治療のためのヌクレオチドヘミ硫酸塩 - Google Patents

Ｃ型肝炎ウイルスの治療のためのヌクレオチドヘミ硫酸塩 Download PDF

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JP7066728B2
JP7066728B2 JP2019541346A JP2019541346A JP7066728B2 JP 7066728 B2 JP7066728 B2 JP 7066728B2 JP 2019541346 A JP2019541346 A JP 2019541346A JP 2019541346 A JP2019541346 A JP 2019541346A JP 7066728 B2 JP7066728 B2 JP 7066728B2
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JP2020505423A (ja
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アデル ムサ
ジャン－ピエール ソマドッシ
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アテア ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
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  • Genetics & Genomics (AREA)
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  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Storage Device Security (AREA)
JP2019541346A 2017-02-01 2018-01-31 Ｃ型肝炎ウイルスの治療のためのヌクレオチドヘミ硫酸塩 Active JP7066728B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022034074A JP2022078216A (ja) 2017-02-01 2022-03-07 Ｃ型肝炎ウイルスの治療のためのヌクレオチドヘミ硫酸塩
JP2024075425A JP2024102245A (ja) 2017-02-01 2024-05-07 Ｃ型肝炎ウイルスの治療のためのヌクレオチドヘミ硫酸塩

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762453437P 2017-02-01 2017-02-01
US62/453,437 2017-02-01
US201762469912P 2017-03-10 2017-03-10
US62/469,912 2017-03-10
US201762488366P 2017-04-21 2017-04-21
US62/488,366 2017-04-21
US201762575248P 2017-10-20 2017-10-20
US62/575,248 2017-10-20
PCT/US2018/016301 WO2018144640A1 (en) 2017-02-01 2018-01-31 Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus

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JP2022034074A Division JP2022078216A (ja) 2017-02-01 2022-03-07 Ｃ型肝炎ウイルスの治療のためのヌクレオチドヘミ硫酸塩

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JP2020505423A JP2020505423A (ja) 2020-02-20
JP2020505423A5 JP2020505423A5 (enExample) 2021-03-18
JP7066728B2 true JP7066728B2 (ja) 2022-05-13

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JP2019541346A Active JP7066728B2 (ja) 2017-02-01 2018-01-31 Ｃ型肝炎ウイルスの治療のためのヌクレオチドヘミ硫酸塩
JP2022034074A Pending JP2022078216A (ja) 2017-02-01 2022-03-07 Ｃ型肝炎ウイルスの治療のためのヌクレオチドヘミ硫酸塩
JP2024075425A Pending JP2024102245A (ja) 2017-02-01 2024-05-07 Ｃ型肝炎ウイルスの治療のためのヌクレオチドヘミ硫酸塩

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JP2022034074A Pending JP2022078216A (ja) 2017-02-01 2022-03-07 Ｃ型肝炎ウイルスの治療のためのヌクレオチドヘミ硫酸塩
JP2024075425A Pending JP2024102245A (ja) 2017-02-01 2024-05-07 Ｃ型肝炎ウイルスの治療のためのヌクレオチドヘミ硫酸塩

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US (6) US10519186B2 (enExample)
EP (2) EP4450129A3 (enExample)
JP (3) JP7066728B2 (enExample)
KR (3) KR102693011B1 (enExample)
CN (2) CN110248951B (enExample)
AU (3) AU2018215203B2 (enExample)
CA (2) CA3048033C (enExample)
CO (1) CO2019009215A2 (enExample)
DK (1) DK3577124T3 (enExample)
ES (1) ES3009733T3 (enExample)
FI (1) FI3577124T3 (enExample)
GE (1) GEP20237457B (enExample)
HR (1) HRP20250266T1 (enExample)
HU (1) HUE070331T2 (enExample)
IL (3) IL295609B2 (enExample)
LT (1) LT3577124T (enExample)
MX (2) MX394394B (enExample)
MY (1) MY201105A (enExample)
PH (1) PH12019550113A1 (enExample)
PL (1) PL3577124T3 (enExample)
PT (1) PT3577124T (enExample)
RS (1) RS66554B1 (enExample)
SG (2) SG10202012214WA (enExample)
SI (1) SI3577124T1 (enExample)
SM (1) SMT202500048T1 (enExample)
TW (2) TWI808072B (enExample)
UA (1) UA127407C2 (enExample)
WO (1) WO2018144640A1 (enExample)
ZA (3) ZA201904336B (enExample)

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KR20200140865A (ko) 2018-04-10 2020-12-16 아테아 파마슈티컬즈, 인크. 간경변증을 갖는 hcv 감염 환자의 치료
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JP2022510014A (ja) * 2018-12-05 2022-01-25 アテア ファーマシューティカルズ， インコーポレイテッド Ｃ型肝炎ウイルスの治療のための高活性な合剤
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US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
WO2021216722A1 (en) * 2020-04-23 2021-10-28 Atea Pharmaceuticals, Inc. Stereoselective process of manufacture of purine phosphoramidates
CN112782311B (zh) * 2020-12-30 2022-12-27 南京百泽医药科技有限公司 一种富马酸丙酚替诺福韦中l-丙氨酸异丙酯的hplc测定方法
JP2024504392A (ja) * 2021-01-26 2024-01-31 アテア ファーマシューティカルズ， インコーポレイテッド Ａｔ－５２７ヘミ硫酸塩の有利な形態
CN112940053B (zh) * 2021-02-26 2022-08-12 江苏阿尔法药业股份有限公司 一种抗hcv药物的制备方法
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