JP7049394B2 - 近接センサ付き薬物送達装置 - Google Patents
近接センサ付き薬物送達装置 Download PDFInfo
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Description
Claims (27)
- 装着型注射器であって、
第1端部(106)および第2端部(108)を有するボアを含むリザーバと、前記第1端部(106)と前記第2端部(108)との間の前記ボア内で移動可能なプランジャを含むプランジャアセンブリと、
前記リザーバ内に配置された一定量の製剤であって、製剤がヒトプロタンパク質転換酵素サブチリシン/ケキシン9型(PCSK9)と結合するモノクローナル抗体(IgG)を含む、一定量の製剤と、
動作状態では、前記リザーバと流体連通して接続されるカニューレと、
前記製剤を前記リザーバから前記カニューレを通って移動させるために、前記プランジャを前記第1端部(106)と前記第2端部(108)との間で移動させるように前記プランジャアセンブリに連結される駆動部と、
前記リザーバ、前記カニューレおよび前記駆動部がハウジング内に少なくとも部分的に配置されたハウジングと、
前記ハウジングに対して移動するように動作可能に連結された近接センサと、を含み、
前記近接センサは、前記近接センサが前記ハウジングから延びる第1センサ状態と、前記近接センサが前記第1センサ状態に対して前記ハウジング側に後退する第2センサ状態とを有する、装着型注射器。 - 前記近接センサが前記第1センサ状態にある場合、前記リザーバの前記第1端部(106)と前記第2端部(108)との間の前記プランジャの移動を制限するように構成された係止部をさらに含む、請求項1に記載の装着型注射器。
- 前記近接センサが前記第1センサ状態にある場合、前記係止部が、動作線に沿って移動し、かつ、前記プランジャアセンブリおよび前記駆動部のいずれかに動作可能に連結されるプレートの壁を含む、請求項2に記載の装着型注射器。
- 前記プレートが、前記係止部の壁を形成する第1端部(160)と、前記近接センサを形成する第2端部(162)とを有する、請求項3に記載の装着型注射器。
- 前記近接センサが前記第1センサ状態にある場合、前記係止部が、枢軸を中心に移動し、かつ、前記プランジャアセンブリおよび前記駆動部のいずれかに動作可能に連結されるレバーの壁を含む、請求項1に記載の装着型注射器。
- 前記レバーが、前記ハウジング内に配置可能で、かつ前記係止部の壁を形成する第1端部(192)と、前記ハウジングの外側に配置可能で、かつ前記近接センサを形成する第2端部(194)とを有する、請求項5に記載の装着型注射器。
- 前記駆動部がばねを含む、請求項1に記載の装着型注射器。
- 前記近接センサが前記第1センサ状態にある場合、前記係止部が前記プランジャおよび前記ばねのいずれかに選択的に連結される、請求項7に記載の装着型注射器。
- 前記プランジャアセンブリが、
前記プランジャに取り付けられたプランジャアームと、
前記係止部が前記プランジャアセンブリに連結される場合に前記プランジャの移動を制限するように前記プランジャアームに当接する前記係止部の壁と、を含み、
前記近接センサが前記壁に連結され、前記近接センサが前記第1センサ状態にある場合、前記壁は前記プランジャアームに当接し、前記近接センサが前記第2センサ状態にある場合、前記壁は前記プランジャアームから離間される、請求項3に記載の装着型注射器。 - 前記プランジャアームが自身に形成される少なくとも1つの肩部を有し、
前記係止部が前記プランジャアセンブリに連結された場合、前記係止部の壁が、前記プランジャの移動を制限するように前記プランジャアームの少なくとも1つの前記肩部に当接する、請求項9に記載の装着型注射器。 - 前記係止部が前記プランジャアセンブリに連結された場合、前記係止部の壁が前記プランジャの移動を制限するように前記ばねに当接し、
前記近接センサが前記壁に取り付けられ、前記近接センサが前記第1センサ状態にある場合、前記壁は前記ばねに当接し、前記近接センサが前記第2センサ状態にある場合、前記壁は前記ばねから離間される、請求項8に記載の装着型注射器。 - 前記駆動部がガス源を含み、前記近接センサが前記第1センサ状態にある場合、前記係止部が、前記ガス源からの正圧を排出するように前記ガス源に動作可能に連結される通気口を含む、請求項1に記載の装着型注射器。
- 前記ガス源と前記リザーバとの間に配置されかつ前記ガス源と前記リザーバとを接続するチャンバをさらに含み、前記通気口は、前記チャンバの壁に配置される、請求項12に記載の装着型注射器。
- 前記通気口が封止部と通気カニューレとを含み、前記近接センサが前記第1センサ状態にある場合、前記通気カニューレが前記封止部を穿孔する、請求項12に記載の装着型注射器。
- 前記近接センサの移動が通気レバーを介して前記通気カニューレに伝達されるように、前記通気カニューレに接続された第1端部(260)と前記近接センサに接続された第2端部(264)とを有する通気レバーをさらに含む、請求項13に記載の装着型注射器。
- 前記係止部が前記リザーバと前記カニューレとの間に配置された弁を含み、前記弁は開放状態と閉鎖状態との間で移動可能であり、前記近接センサが前記第1センサ状態にある場合に閉鎖状態を占める、請求項1に記載の装着型注射器。
- 前記近接センサが前記第1センサ状態にある場合に前記弁を閉鎖状態に位置決めするための、前記近接センサおよび前記弁に連結されたコントローラをさらに含む、請求項16に記載の装着型注射器。
- 前記リザーバと前記カニューレとの間に配置されて前記リザーバと前記カニューレとを接続する流体ラインをさらに含み、前記弁が前記流体ライン上に配置される、請求項16に記載の装着型注射器。
- 前記リザーバと前記カニューレとの間に配置された可撓性のある流体ラインをさらに含む、請求項1に記載の装着型注射器。
- 前記リザーバと前記カニューレとの間に配置された可撓性のある流体ラインをさらに含む、請求項3に記載の装着型注射器。
- 可動プレートが、可撓性のある前記流体ラインが貫通配置される開口部を含む、請求項20に記載の装着型注射器。
- 前記係止部が壁を含み、前記近接センサが前記第1センサ状態にある場合、前記カニューレの第1端部(616)が前記壁内に存在して前記リザーバと流体連通しない、請求項2に記載の装着型注射器。
- 前記壁内に存在するように前記カニューレの前記第1端部(616)を付勢する付勢部材をさらに含む、請求項22に記載の装着型注射器。
- 前記カニューレの前記第1端部(616)が、前記近接センサが前記第2センサ状態にある場合、前記壁を貫通して前記リザーバと流体連通する、請求項22に記載の装着型注射器。
- 前記近接センサが前記第2センサ状態にある場合に前記プランジャアセンブリに選択的に連結され、前記近接センサが前記第1センサ状態にある場合に前記プランジャアセンブリから選択的に分離されるインジケータをさらに含む、請求項1に記載の装着型注射器。
- 前記近接センサが前記第2センサ状態にある場合に、前記インジケータが前記プランジャアセンブリに機械的に連結される、請求項25に記載の装着型注射器。
- 前記プランジャアセンブリが前記プランジャに取り付けられたプランジャアームを含み、前記インジケータが、係合および脱係合するように移動可能な少なくとも1つのギヤを有するギヤ列を介して前記プランジャアームに機械的に連結され、前記近接センサが、少なくとも1つの前記ギヤを脱係合するように移動させ、かつ前記近接センサが前記第1センサ状態にある場合に前記インジケータを前記プランジャアームから分離させるように、少なくとも1つの前記ギヤに連結される、請求項26に記載の装着型注射器。
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