JP6754356B2 - 連続流のカルボキシル化反応 - Google Patents

連続流のカルボキシル化反応 Download PDF

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JP6754356B2
JP6754356B2 JP2017516101A JP2017516101A JP6754356B2 JP 6754356 B2 JP6754356 B2 JP 6754356B2 JP 2017516101 A JP2017516101 A JP 2017516101A JP 2017516101 A JP2017516101 A JP 2017516101A JP 6754356 B2 JP6754356 B2 JP 6754356B2
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compound
formula
reaction
hcl
carbon dioxide
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Japanese (ja)
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JP2017530125A5 (https=
JP2017530125A (ja
Inventor
スコット トゥイーディ，
スコット トゥイーディ，
スリパシー ベンカトラマン，
スリパシー ベンカトラマン，
シューホン リウ，
シューホン リウ，
ジェイムズ ゼラー，
ジェイムズ ゼラー，
エリザベス ブロット，
エリザベス ブロット，
マイケル ハムリン，
マイケル ハムリン，
メアリー ニューマン，
メアリー ニューマン，
マーク マクローズ，
マーク マクローズ，
ジョン ローゼンバーグ，
ジョン ローゼンバーグ，
デイビッド ラスベリー，
デイビッド ラスベリー，
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ノバルティス アーゲー
ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/242—Tubular reactors in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/243—Tubular reactors spirally, concentrically or zigzag wound
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00099—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor the reactor being immersed in the heat exchange medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/02—Apparatus characterised by their chemically-resistant properties
    • B01J2219/025—Apparatus characterised by their chemically-resistant properties characterised by the construction materials of the reactor vessel proper
    • B01J2219/0277—Metal based
    • B01J2219/0286—Steel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2017516101A 2014-09-25 2015-09-25 連続流のカルボキシル化反応 Active JP6754356B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462055286P 2014-09-25 2014-09-25
US62/055,286 2014-09-25
PCT/US2015/052320 WO2016049509A1 (en) 2014-09-25 2015-09-25 Continuous flow carboxylation reaction

Related Child Applications (1)

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JP2019189312A Division JP2020045341A (ja) 2014-09-25 2019-10-16 連続流のカルボキシル化反応

Publications (3)

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JP2017530125A JP2017530125A (ja) 2017-10-12
JP6754356B2 true JP6754356B2 (ja) 2020-09-09
JP2017530125A5 JP2017530125A5 (https=) 2020-09-17

Family

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Family Applications (2)

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JP2017516101A Active JP6754356B2 (ja) 2014-09-25 2015-09-25 連続流のカルボキシル化反応
JP2019189312A Withdrawn JP2020045341A (ja) 2014-09-25 2019-10-16 連続流のカルボキシル化反応

Family Applications After (1)

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JP2019189312A Withdrawn JP2020045341A (ja) 2014-09-25 2019-10-16 連続流のカルボキシル化反応

Country Status (15)

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US (3) US9725413B2 (https=)
EP (1) EP3197454B1 (https=)
JP (2) JP6754356B2 (https=)
CN (1) CN106714801B (https=)
AU (1) AU2015320349B2 (https=)
BR (1) BR112017005856A2 (https=)
CA (1) CA2960392A1 (https=)
ES (1) ES2857730T3 (https=)
HU (1) HUE053118T2 (https=)
IL (2) IL250958B (https=)
MX (1) MX365010B (https=)
PL (1) PL3197454T3 (https=)
PT (1) PT3197454T (https=)
SA (1) SA517381158B1 (https=)
WO (1) WO2016049509A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2960392A1 (en) 2014-09-25 2016-03-31 Sarcode Bioscience Inc. Process to prepare 5,7-dichloro-3,4-dihydro-1h-isoquinolin-6-carboxylic acid using a continuous flow carboxylation reaction
TWI681958B (zh) * 2017-06-30 2020-01-11 台灣神隆股份有限公司 製備利非斯特及其中間體的方法
JPWO2019026425A1 (ja) * 2017-07-31 2020-05-28 株式会社カネカ フロー式リアクター
CN111465588B (zh) * 2017-11-14 2023-04-28 雅宝德国有限责任公司 在连续流动条件下的有机锂工艺
CN109384717A (zh) * 2018-10-29 2019-02-26 广安凯特制药有限公司 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酸盐酸盐水合物及其制备方法和用途
CN110724098A (zh) * 2019-11-13 2020-01-24 成都福柯斯医药技术有限公司 一种5,7-二氯-1,2,3,4-四氢异喹啉-6-羧酸盐酸盐的合成方法
CN113845478B (zh) * 2020-12-18 2023-11-21 四川大学 一种中间体及其制备方法和应用
CN113277942B (zh) * 2021-05-25 2024-05-03 都创(上海)医药开发有限公司 一种基于微通道反应技术快速制备5-氯-2-氟-4-(三氟甲基)苯甲酸的方法
CN116239532B (zh) * 2022-12-19 2023-11-07 浙江博崤生物制药有限公司 一种二氯四氢异喹啉羧酸的中间体及其制备方法和应用
CN115872929B (zh) * 2022-12-27 2024-12-03 山东金城柯瑞化学有限公司 芳基类化合物连续羧基化反应制备立他司特中间体的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767856B2 (en) * 2007-01-25 2010-08-03 Xerox Corporation System and method for producing arylamine compounds
CN101450300A (zh) * 2007-12-05 2009-06-10 海南大学 连续流微反应器及其制备和应用
US8378105B2 (en) * 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
CA2859073A1 (en) * 2011-12-14 2013-06-20 Commonwealth Scientific And Industrial Research Organisation Raft polymers
CA2879982C (en) 2012-07-25 2020-09-01 Sarcode Bioscience Inc. Lfa-1 inhibitor and polymorph thereof
CA2960392A1 (en) * 2014-09-25 2016-03-31 Sarcode Bioscience Inc. Process to prepare 5,7-dichloro-3,4-dihydro-1h-isoquinolin-6-carboxylic acid using a continuous flow carboxylation reaction

Also Published As

Publication number Publication date
US10899715B2 (en) 2021-01-26
US9725413B2 (en) 2017-08-08
IL250958B (en) 2019-08-29
US10273212B2 (en) 2019-04-30
EP3197454B1 (en) 2021-01-06
PL3197454T3 (pl) 2021-06-14
EP3197454A4 (en) 2018-02-21
IL250958A0 (en) 2017-04-30
EP3197454A1 (en) 2017-08-02
US20180118689A1 (en) 2018-05-03
MX2017003505A (es) 2017-07-28
SA517381158B1 (ar) 2021-05-23
CN106714801A (zh) 2017-05-24
CN106714801B (zh) 2021-04-06
ES2857730T3 (es) 2021-09-29
JP2017530125A (ja) 2017-10-12
PT3197454T (pt) 2021-03-04
US20160090361A1 (en) 2016-03-31
HUE053118T2 (hu) 2021-06-28
IL268432B (en) 2020-08-31
IL268432A (en) 2019-09-26
BR112017005856A2 (pt) 2017-12-19
AU2015320349B2 (en) 2020-03-12
US20190300485A1 (en) 2019-10-03
CA2960392A1 (en) 2016-03-31
WO2016049509A1 (en) 2016-03-31
AU2015320349A1 (en) 2017-03-23
JP2020045341A (ja) 2020-03-26
MX365010B (es) 2019-05-20

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