BR112017005856A2 - reação de carboxilação de fluxo contínuo - Google Patents

reação de carboxilação de fluxo contínuo

Info

Publication number
BR112017005856A2
BR112017005856A2 BR112017005856A BR112017005856A BR112017005856A2 BR 112017005856 A2 BR112017005856 A2 BR 112017005856A2 BR 112017005856 A BR112017005856 A BR 112017005856A BR 112017005856 A BR112017005856 A BR 112017005856A BR 112017005856 A2 BR112017005856 A2 BR 112017005856A2
Authority
BR
Brazil
Prior art keywords
continuous flow
carboxylation reaction
reaction
flow carboxylation
carboxylation
Prior art date
Application number
BR112017005856A
Other languages
English (en)
Inventor
Lathbury David
BROT Elisabeth
Zeller James
ROSENBERG John
Mclaws Mark
Newman Mary
Hamlin Michael
Tweedie Scott
Liu Shuhong
Venkatraman Sripathy
Original Assignee
Sarcode Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarcode Bioscience Inc filed Critical Sarcode Bioscience Inc
Publication of BR112017005856A2 publication Critical patent/BR112017005856A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/242—Tubular reactors in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/243—Tubular reactors spirally, concentrically or zigzag wound
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00099—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor the reactor being immersed in the heat exchange medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/02—Apparatus characterised by their chemically-resistant properties
    • B01J2219/025—Apparatus characterised by their chemically-resistant properties characterised by the construction materials of the reactor vessel proper
    • B01J2219/0277—Metal based
    • B01J2219/0286—Steel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside

Abstract

resumo ?reação de carboxilação de fluxo contínuo? a presente invenção está relacionada a uma reação de carboxilação de duas etapas de um grupo arila usando condições de reação de fluxo contínuo. este processo permite a síntese em larga escala de produtos de reação úteis em alto rendimento.
BR112017005856A 2014-09-25 2015-09-25 reação de carboxilação de fluxo contínuo BR112017005856A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462055286P 2014-09-25 2014-09-25
PCT/US2015/052320 WO2016049509A1 (en) 2014-09-25 2015-09-25 Continuous flow carboxylation reaction

Publications (1)

Publication Number Publication Date
BR112017005856A2 true BR112017005856A2 (pt) 2017-12-19

Family

ID=55582084

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017005856A BR112017005856A2 (pt) 2014-09-25 2015-09-25 reação de carboxilação de fluxo contínuo

Country Status (15)

Country Link
US (3) US9725413B2 (pt)
EP (1) EP3197454B1 (pt)
JP (2) JP6754356B2 (pt)
CN (1) CN106714801B (pt)
AU (1) AU2015320349B2 (pt)
BR (1) BR112017005856A2 (pt)
CA (1) CA2960392A1 (pt)
ES (1) ES2857730T3 (pt)
HU (1) HUE053118T2 (pt)
IL (2) IL250958B (pt)
MX (1) MX365010B (pt)
PL (1) PL3197454T3 (pt)
PT (1) PT3197454T (pt)
SA (1) SA517381158B1 (pt)
WO (1) WO2016049509A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3197454B1 (en) 2014-09-25 2021-01-06 Novartis AG Continuous flow carboxylation reaction
WO2019004936A1 (en) 2017-06-30 2019-01-03 Scinopharm Taiwan, Ltd. PROCESS FOR THE PREPARATION OF LIFITEGRAST AND INTERMEDIATES THEREOF
EP3662994A4 (en) * 2017-07-31 2021-03-17 Kaneka Corporation FLOW REACTOR
JP2021502985A (ja) * 2017-11-14 2021-02-04 アルベマール・ジャーマニー・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 連続フロー条件下での有機リチウムプロセス
CN109384717A (zh) * 2018-10-29 2019-02-26 广安凯特制药有限公司 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酸盐酸盐水合物及其制备方法和用途
CN110724098A (zh) * 2019-11-13 2020-01-24 成都福柯斯医药技术有限公司 一种5,7-二氯-1,2,3,4-四氢异喹啉-6-羧酸盐酸盐的合成方法
CN113845478B (zh) * 2020-12-18 2023-11-21 四川大学 一种中间体及其制备方法和应用
CN113277942B (zh) * 2021-05-25 2024-05-03 都创(上海)医药开发有限公司 一种基于微通道反应技术快速制备5-氯-2-氟-4-(三氟甲基)苯甲酸的方法
CN116239532B (zh) * 2022-12-19 2023-11-07 浙江博崤生物制药有限公司 一种二氯四氢异喹啉羧酸的中间体及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767856B2 (en) * 2007-01-25 2010-08-03 Xerox Corporation System and method for producing arylamine compounds
CN101450300A (zh) * 2007-12-05 2009-06-10 海南大学 连续流微反应器及其制备和应用
WO2011050175A1 (en) * 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
CA2859073A1 (en) * 2011-12-14 2013-06-20 Commonwealth Scientific And Industrial Research Organisation Raft polymers
CN110922393A (zh) 2012-07-25 2020-03-27 诺华股份有限公司 Lfa-1抑制剂及其多晶型物
EP3197454B1 (en) * 2014-09-25 2021-01-06 Novartis AG Continuous flow carboxylation reaction

Also Published As

Publication number Publication date
AU2015320349B2 (en) 2020-03-12
US10273212B2 (en) 2019-04-30
PL3197454T3 (pl) 2021-06-14
WO2016049509A1 (en) 2016-03-31
HUE053118T2 (hu) 2021-06-28
MX365010B (es) 2019-05-20
AU2015320349A1 (en) 2017-03-23
EP3197454A1 (en) 2017-08-02
EP3197454A4 (en) 2018-02-21
IL250958A0 (en) 2017-04-30
CN106714801B (zh) 2021-04-06
EP3197454B1 (en) 2021-01-06
JP2020045341A (ja) 2020-03-26
JP6754356B2 (ja) 2020-09-09
CA2960392A1 (en) 2016-03-31
US20160090361A1 (en) 2016-03-31
IL250958B (en) 2019-08-29
CN106714801A (zh) 2017-05-24
ES2857730T3 (es) 2021-09-29
US20190300485A1 (en) 2019-10-03
SA517381158B1 (ar) 2021-05-23
US9725413B2 (en) 2017-08-08
PT3197454T (pt) 2021-03-04
MX2017003505A (es) 2017-07-28
JP2017530125A (ja) 2017-10-12
US20180118689A1 (en) 2018-05-03
IL268432B (en) 2020-08-31
US10899715B2 (en) 2021-01-26
IL268432A (en) 2019-09-26

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25A Requested transfer of rights approved

Owner name: NOVARTIS AG (CH)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]