MX365010B - Reaccion de carboxilacion con flujo continuo. - Google Patents

Reaccion de carboxilacion con flujo continuo.

Info

Publication number
MX365010B
MX365010B MX2017003505A MX2017003505A MX365010B MX 365010 B MX365010 B MX 365010B MX 2017003505 A MX2017003505 A MX 2017003505A MX 2017003505 A MX2017003505 A MX 2017003505A MX 365010 B MX365010 B MX 365010B
Authority
MX
Mexico
Prior art keywords
continuous flow
carboxylation reaction
reaction
flow carboxylation
aryl group
Prior art date
Application number
MX2017003505A
Other languages
English (en)
Other versions
MX2017003505A (es
Inventor
Tweedie Scott
Venkatraman Sripathy
Liu Shuhong
Zeller James
BROT Elisabeth
Hamlin Michael
Newman Mary
MCLAWS Marck
ROSENBERG John
Lathbury David
Original Assignee
Sarcode Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarcode Bioscience Inc filed Critical Sarcode Bioscience Inc
Publication of MX2017003505A publication Critical patent/MX2017003505A/es
Publication of MX365010B publication Critical patent/MX365010B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/242—Tubular reactors in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/243—Tubular reactors spirally, concentrically or zigzag wound
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00099—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor the reactor being immersed in the heat exchange medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/02—Apparatus characterised by their chemically-resistant properties
    • B01J2219/025—Apparatus characterised by their chemically-resistant properties characterised by the construction materials of the reactor vessel proper
    • B01J2219/0277—Metal based
    • B01J2219/0286—Steel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención se refiere a una reacción de carboxilación en dos etapas de un grupo arilo usando condiciones de la reacción de flujo continuo. Este proceso permite la síntesis a gran escala de los productos de reacción útiles con alto rendimiento.
MX2017003505A 2014-09-25 2015-09-25 Reaccion de carboxilacion con flujo continuo. MX365010B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462055286P 2014-09-25 2014-09-25
PCT/US2015/052320 WO2016049509A1 (en) 2014-09-25 2015-09-25 Continuous flow carboxylation reaction

Publications (2)

Publication Number Publication Date
MX2017003505A MX2017003505A (es) 2017-07-28
MX365010B true MX365010B (es) 2019-05-20

Family

ID=55582084

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017003505A MX365010B (es) 2014-09-25 2015-09-25 Reaccion de carboxilacion con flujo continuo.

Country Status (15)

Country Link
US (3) US9725413B2 (es)
EP (1) EP3197454B1 (es)
JP (2) JP6754356B2 (es)
CN (1) CN106714801B (es)
AU (1) AU2015320349B2 (es)
BR (1) BR112017005856A2 (es)
CA (1) CA2960392A1 (es)
ES (1) ES2857730T3 (es)
HU (1) HUE053118T2 (es)
IL (2) IL250958B (es)
MX (1) MX365010B (es)
PL (1) PL3197454T3 (es)
PT (1) PT3197454T (es)
SA (1) SA517381158B1 (es)
WO (1) WO2016049509A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2857730T3 (es) * 2014-09-25 2021-09-29 Novartis Ag Reacción de carboxilación de flujo continuo
WO2019004936A1 (en) * 2017-06-30 2019-01-03 Scinopharm Taiwan, Ltd. PROCESS FOR THE PREPARATION OF LIFITEGRAST AND INTERMEDIATES THEREOF
EP3662994A4 (en) * 2017-07-31 2021-03-17 Kaneka Corporation FLOW REACTOR
CN111465588B (zh) * 2017-11-14 2023-04-28 雅宝德国有限责任公司 在连续流动条件下的有机锂工艺
CN109384717A (zh) * 2018-10-29 2019-02-26 广安凯特制药有限公司 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酸盐酸盐水合物及其制备方法和用途
CN110724098A (zh) * 2019-11-13 2020-01-24 成都福柯斯医药技术有限公司 一种5,7-二氯-1,2,3,4-四氢异喹啉-6-羧酸盐酸盐的合成方法
CN113845478B (zh) * 2020-12-18 2023-11-21 四川大学 一种中间体及其制备方法和应用
CN113277942B (zh) * 2021-05-25 2024-05-03 都创(上海)医药开发有限公司 一种基于微通道反应技术快速制备5-氯-2-氟-4-(三氟甲基)苯甲酸的方法
CN116239532B (zh) * 2022-12-19 2023-11-07 浙江博崤生物制药有限公司 一种二氯四氢异喹啉羧酸的中间体及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767856B2 (en) * 2007-01-25 2010-08-03 Xerox Corporation System and method for producing arylamine compounds
CN101450300A (zh) * 2007-12-05 2009-06-10 海南大学 连续流微反应器及其制备和应用
US8378105B2 (en) * 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
CN104105718B (zh) * 2011-12-14 2017-05-10 联邦科学和工业研究组织 Raft聚合物
JP6607780B2 (ja) 2012-07-25 2019-11-20 サルコード・バイオサイエンス・インコーポレイテッド Ｌｆａ−１阻害剤およびその多形
ES2857730T3 (es) 2014-09-25 2021-09-29 Novartis Ag Reacción de carboxilación de flujo continuo

Also Published As

Publication number Publication date
JP2017530125A (ja) 2017-10-12
JP6754356B2 (ja) 2020-09-09
IL250958B (en) 2019-08-29
US10273212B2 (en) 2019-04-30
HUE053118T2 (hu) 2021-06-28
EP3197454A1 (en) 2017-08-02
US20160090361A1 (en) 2016-03-31
EP3197454A4 (en) 2018-02-21
IL250958A0 (en) 2017-04-30
ES2857730T3 (es) 2021-09-29
IL268432A (en) 2019-09-26
WO2016049509A1 (en) 2016-03-31
AU2015320349A1 (en) 2017-03-23
US20190300485A1 (en) 2019-10-03
US20180118689A1 (en) 2018-05-03
SA517381158B1 (ar) 2021-05-23
JP2020045341A (ja) 2020-03-26
AU2015320349B2 (en) 2020-03-12
CN106714801A (zh) 2017-05-24
US10899715B2 (en) 2021-01-26
IL268432B (en) 2020-08-31
CN106714801B (zh) 2021-04-06
PL3197454T3 (pl) 2021-06-14
US9725413B2 (en) 2017-08-08
PT3197454T (pt) 2021-03-04
CA2960392A1 (en) 2016-03-31
EP3197454B1 (en) 2021-01-06
MX2017003505A (es) 2017-07-28
BR112017005856A2 (pt) 2017-12-19

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