SA517381158B1 - تفاعل إضافة مجموعة الكربوكسيل بتدفق مستمر - Google Patents
تفاعل إضافة مجموعة الكربوكسيل بتدفق مستمرInfo
- Publication number
- SA517381158B1 SA517381158B1 SA517381158A SA517381158A SA517381158B1 SA 517381158 B1 SA517381158 B1 SA 517381158B1 SA 517381158 A SA517381158 A SA 517381158A SA 517381158 A SA517381158 A SA 517381158A SA 517381158 B1 SA517381158 B1 SA 517381158B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- continuous flow
- carboxylation reaction
- reaction
- flow carboxylation
- aryl group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2415—Tubular reactors
- B01J19/242—Tubular reactors in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2415—Tubular reactors
- B01J19/243—Tubular reactors spirally, concentrically or zigzag wound
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
- B01J2219/00099—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor the reactor being immersed in the heat exchange medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/02—Apparatus characterised by their chemically-resistant properties
- B01J2219/025—Apparatus characterised by their chemically-resistant properties characterised by the construction materials of the reactor vessel proper
- B01J2219/0277—Metal based
- B01J2219/0286—Steel
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/24—Stationary reactors without moving elements inside
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
يتعلق الاختراع الحالي بتفاعل إدخال مجموعة كربوكسيل carboxylation reaction من خطوتين بمجموعة أريل aryl باستخدام ظروف تفاعل التدفق المستمر. وتسمح هذه العملية بتخليق على نطاق واسع لمنتجات التفاعل المفيدة بناتج كبير. شكل 1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462055286P | 2014-09-25 | 2014-09-25 | |
PCT/US2015/052320 WO2016049509A1 (en) | 2014-09-25 | 2015-09-25 | Continuous flow carboxylation reaction |
Publications (1)
Publication Number | Publication Date |
---|---|
SA517381158B1 true SA517381158B1 (ar) | 2021-05-23 |
Family
ID=55582084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA517381158A SA517381158B1 (ar) | 2014-09-25 | 2017-03-22 | تفاعل إضافة مجموعة الكربوكسيل بتدفق مستمر |
Country Status (15)
Country | Link |
---|---|
US (3) | US9725413B2 (ar) |
EP (1) | EP3197454B1 (ar) |
JP (2) | JP6754356B2 (ar) |
CN (1) | CN106714801B (ar) |
AU (1) | AU2015320349B2 (ar) |
BR (1) | BR112017005856A2 (ar) |
CA (1) | CA2960392A1 (ar) |
ES (1) | ES2857730T3 (ar) |
HU (1) | HUE053118T2 (ar) |
IL (2) | IL250958B (ar) |
MX (1) | MX365010B (ar) |
PL (1) | PL3197454T3 (ar) |
PT (1) | PT3197454T (ar) |
SA (1) | SA517381158B1 (ar) |
WO (1) | WO2016049509A1 (ar) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2857730T3 (es) * | 2014-09-25 | 2021-09-29 | Novartis Ag | Reacción de carboxilación de flujo continuo |
WO2019004936A1 (en) * | 2017-06-30 | 2019-01-03 | Scinopharm Taiwan, Ltd. | PROCESS FOR THE PREPARATION OF LIFITEGRAST AND INTERMEDIATES THEREOF |
EP3662994A4 (en) * | 2017-07-31 | 2021-03-17 | Kaneka Corporation | FLOW REACTOR |
CN111465588B (zh) * | 2017-11-14 | 2023-04-28 | 雅宝德国有限责任公司 | 在连续流动条件下的有机锂工艺 |
CN109384717A (zh) * | 2018-10-29 | 2019-02-26 | 广安凯特制药有限公司 | 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酸盐酸盐水合物及其制备方法和用途 |
CN110724098A (zh) * | 2019-11-13 | 2020-01-24 | 成都福柯斯医药技术有限公司 | 一种5,7-二氯-1,2,3,4-四氢异喹啉-6-羧酸盐酸盐的合成方法 |
CN113845478B (zh) * | 2020-12-18 | 2023-11-21 | 四川大学 | 一种中间体及其制备方法和应用 |
CN113277942B (zh) * | 2021-05-25 | 2024-05-03 | 都创(上海)医药开发有限公司 | 一种基于微通道反应技术快速制备5-氯-2-氟-4-(三氟甲基)苯甲酸的方法 |
CN116239532B (zh) * | 2022-12-19 | 2023-11-07 | 浙江博崤生物制药有限公司 | 一种二氯四氢异喹啉羧酸的中间体及其制备方法和应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7767856B2 (en) * | 2007-01-25 | 2010-08-03 | Xerox Corporation | System and method for producing arylamine compounds |
CN101450300A (zh) * | 2007-12-05 | 2009-06-10 | 海南大学 | 连续流微反应器及其制备和应用 |
US8378105B2 (en) * | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
CN104105718B (zh) * | 2011-12-14 | 2017-05-10 | 联邦科学和工业研究组织 | Raft聚合物 |
JP6607780B2 (ja) | 2012-07-25 | 2019-11-20 | サルコード・バイオサイエンス・インコーポレイテッド | Lfa−1阻害剤およびその多形 |
ES2857730T3 (es) | 2014-09-25 | 2021-09-29 | Novartis Ag | Reacción de carboxilación de flujo continuo |
-
2015
- 2015-09-25 ES ES15844846T patent/ES2857730T3/es active Active
- 2015-09-25 HU HUE15844846A patent/HUE053118T2/hu unknown
- 2015-09-25 PT PT158448464T patent/PT3197454T/pt unknown
- 2015-09-25 CN CN201580050837.XA patent/CN106714801B/zh active Active
- 2015-09-25 BR BR112017005856A patent/BR112017005856A2/pt not_active Application Discontinuation
- 2015-09-25 AU AU2015320349A patent/AU2015320349B2/en active Active
- 2015-09-25 MX MX2017003505A patent/MX365010B/es active IP Right Grant
- 2015-09-25 US US14/866,085 patent/US9725413B2/en active Active
- 2015-09-25 EP EP15844846.4A patent/EP3197454B1/en active Active
- 2015-09-25 WO PCT/US2015/052320 patent/WO2016049509A1/en active Application Filing
- 2015-09-25 PL PL15844846T patent/PL3197454T3/pl unknown
- 2015-09-25 JP JP2017516101A patent/JP6754356B2/ja active Active
- 2015-09-25 CA CA2960392A patent/CA2960392A1/en not_active Abandoned
-
2017
- 2017-03-06 IL IL250958A patent/IL250958B/en active IP Right Grant
- 2017-03-22 SA SA517381158A patent/SA517381158B1/ar unknown
- 2017-06-28 US US15/635,632 patent/US10273212B2/en active Active
-
2019
- 2019-04-09 US US16/378,868 patent/US10899715B2/en active Active
- 2019-08-01 IL IL268432A patent/IL268432B/en active IP Right Grant
- 2019-10-16 JP JP2019189312A patent/JP2020045341A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2017530125A (ja) | 2017-10-12 |
JP6754356B2 (ja) | 2020-09-09 |
IL250958B (en) | 2019-08-29 |
US10273212B2 (en) | 2019-04-30 |
HUE053118T2 (hu) | 2021-06-28 |
EP3197454A1 (en) | 2017-08-02 |
US20160090361A1 (en) | 2016-03-31 |
EP3197454A4 (en) | 2018-02-21 |
IL250958A0 (en) | 2017-04-30 |
ES2857730T3 (es) | 2021-09-29 |
IL268432A (en) | 2019-09-26 |
WO2016049509A1 (en) | 2016-03-31 |
AU2015320349A1 (en) | 2017-03-23 |
US20190300485A1 (en) | 2019-10-03 |
US20180118689A1 (en) | 2018-05-03 |
JP2020045341A (ja) | 2020-03-26 |
AU2015320349B2 (en) | 2020-03-12 |
CN106714801A (zh) | 2017-05-24 |
US10899715B2 (en) | 2021-01-26 |
IL268432B (en) | 2020-08-31 |
CN106714801B (zh) | 2021-04-06 |
PL3197454T3 (pl) | 2021-06-14 |
US9725413B2 (en) | 2017-08-08 |
PT3197454T (pt) | 2021-03-04 |
CA2960392A1 (en) | 2016-03-31 |
EP3197454B1 (en) | 2021-01-06 |
MX365010B (es) | 2019-05-20 |
MX2017003505A (es) | 2017-07-28 |
BR112017005856A2 (pt) | 2017-12-19 |
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