AU2015320349B2 - Continuous flow carboxylation reaction - Google Patents

Continuous flow carboxylation reaction Download PDF

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Publication number
AU2015320349B2
AU2015320349B2 AU2015320349A AU2015320349A AU2015320349B2 AU 2015320349 B2 AU2015320349 B2 AU 2015320349B2 AU 2015320349 A AU2015320349 A AU 2015320349A AU 2015320349 A AU2015320349 A AU 2015320349A AU 2015320349 B2 AU2015320349 B2 AU 2015320349B2
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AU
Australia
Prior art keywords
compound
formula
continuous flow
reaction
reactor
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Active
Application number
AU2015320349A
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English (en)
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AU2015320349A1 (en
Inventor
Elisabeth BROT
Michael Hamlin
David Lathbury
Shuhong Liu
Mark Mclaws
Mary Newman
John ROSENBERG
Scott TWEEDIE
Sripathy Venkatraman
James ZELLER
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Bausch and Lomb Ireland Ltd
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Bausch and Lomb Ireland Ltd
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Filing date
Publication date
Application filed by Bausch and Lomb Ireland Ltd filed Critical Bausch and Lomb Ireland Ltd
Publication of AU2015320349A1 publication Critical patent/AU2015320349A1/en
Assigned to NOVARTIS AG reassignment NOVARTIS AG Request for Assignment Assignors: SARCODE BIOSCIENCE INC.
Application granted granted Critical
Publication of AU2015320349B2 publication Critical patent/AU2015320349B2/en
Assigned to BAUSCH + LOMB IRELAND LIMITED reassignment BAUSCH + LOMB IRELAND LIMITED Request for Assignment Assignors: NOVARTIS AG
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/242—Tubular reactors in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/243—Tubular reactors spirally, concentrically or zigzag wound
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00099—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor the reactor being immersed in the heat exchange medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/02—Apparatus characterised by their chemically-resistant properties
    • B01J2219/025—Apparatus characterised by their chemically-resistant properties characterised by the construction materials of the reactor vessel proper
    • B01J2219/0277—Metal based
    • B01J2219/0286—Steel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2015320349A 2014-09-25 2015-09-25 Continuous flow carboxylation reaction Active AU2015320349B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462055286P 2014-09-25 2014-09-25
US62/055,286 2014-09-25
PCT/US2015/052320 WO2016049509A1 (en) 2014-09-25 2015-09-25 Continuous flow carboxylation reaction

Publications (2)

Publication Number Publication Date
AU2015320349A1 AU2015320349A1 (en) 2017-03-23
AU2015320349B2 true AU2015320349B2 (en) 2020-03-12

Family

ID=55582084

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015320349A Active AU2015320349B2 (en) 2014-09-25 2015-09-25 Continuous flow carboxylation reaction

Country Status (15)

Country Link
US (3) US9725413B2 (https=)
EP (1) EP3197454B1 (https=)
JP (2) JP6754356B2 (https=)
CN (1) CN106714801B (https=)
AU (1) AU2015320349B2 (https=)
BR (1) BR112017005856A2 (https=)
CA (1) CA2960392A1 (https=)
ES (1) ES2857730T3 (https=)
HU (1) HUE053118T2 (https=)
IL (2) IL250958B (https=)
MX (1) MX365010B (https=)
PL (1) PL3197454T3 (https=)
PT (1) PT3197454T (https=)
SA (1) SA517381158B1 (https=)
WO (1) WO2016049509A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2960392A1 (en) 2014-09-25 2016-03-31 Sarcode Bioscience Inc. Process to prepare 5,7-dichloro-3,4-dihydro-1h-isoquinolin-6-carboxylic acid using a continuous flow carboxylation reaction
TWI681958B (zh) * 2017-06-30 2020-01-11 台灣神隆股份有限公司 製備利非斯特及其中間體的方法
JPWO2019026425A1 (ja) * 2017-07-31 2020-05-28 株式会社カネカ フロー式リアクター
CN111465588B (zh) * 2017-11-14 2023-04-28 雅宝德国有限责任公司 在连续流动条件下的有机锂工艺
CN109384717A (zh) * 2018-10-29 2019-02-26 广安凯特制药有限公司 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酸盐酸盐水合物及其制备方法和用途
CN110724098A (zh) * 2019-11-13 2020-01-24 成都福柯斯医药技术有限公司 一种5,7-二氯-1,2,3,4-四氢异喹啉-6-羧酸盐酸盐的合成方法
CN113845478B (zh) * 2020-12-18 2023-11-21 四川大学 一种中间体及其制备方法和应用
CN113277942B (zh) * 2021-05-25 2024-05-03 都创(上海)医药开发有限公司 一种基于微通道反应技术快速制备5-氯-2-氟-4-(三氟甲基)苯甲酸的方法
CN116239532B (zh) * 2022-12-19 2023-11-07 浙江博崤生物制药有限公司 一种二氯四氢异喹啉羧酸的中间体及其制备方法和应用
CN115872929B (zh) * 2022-12-27 2024-12-03 山东金城柯瑞化学有限公司 芳基类化合物连续羧基化反应制备立他司特中间体的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140031387A1 (en) * 2012-07-25 2014-01-30 Sarcode Bioscience Inc. Lfa-1 inhibitor and methods of preparation and polymorph thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767856B2 (en) * 2007-01-25 2010-08-03 Xerox Corporation System and method for producing arylamine compounds
CN101450300A (zh) * 2007-12-05 2009-06-10 海南大学 连续流微反应器及其制备和应用
US8378105B2 (en) * 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
CA2859073A1 (en) * 2011-12-14 2013-06-20 Commonwealth Scientific And Industrial Research Organisation Raft polymers
CA2960392A1 (en) * 2014-09-25 2016-03-31 Sarcode Bioscience Inc. Process to prepare 5,7-dichloro-3,4-dihydro-1h-isoquinolin-6-carboxylic acid using a continuous flow carboxylation reaction

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140031387A1 (en) * 2012-07-25 2014-01-30 Sarcode Bioscience Inc. Lfa-1 inhibitor and methods of preparation and polymorph thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"(2S)-2-[[2-(1-benzofuran-6-carbonyl)-5,7-dichloro3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(3-methylsulfonylphenyl)propanoic acid", PUBCHEM, (2014-07-07), Database accession no. 187051834, URL: NCBI *
FLINT, S et al., "The growth of Bacillus stearothermophilus on stainless steel.", Journal of Applied Microbiology, vol. 90, (2001), pages 151 - 157, URL: http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2672.2001.01215.x/epdf *

Also Published As

Publication number Publication date
US10899715B2 (en) 2021-01-26
US9725413B2 (en) 2017-08-08
IL250958B (en) 2019-08-29
US10273212B2 (en) 2019-04-30
EP3197454B1 (en) 2021-01-06
PL3197454T3 (pl) 2021-06-14
EP3197454A4 (en) 2018-02-21
IL250958A0 (en) 2017-04-30
EP3197454A1 (en) 2017-08-02
US20180118689A1 (en) 2018-05-03
MX2017003505A (es) 2017-07-28
SA517381158B1 (ar) 2021-05-23
CN106714801A (zh) 2017-05-24
CN106714801B (zh) 2021-04-06
ES2857730T3 (es) 2021-09-29
JP6754356B2 (ja) 2020-09-09
JP2017530125A (ja) 2017-10-12
PT3197454T (pt) 2021-03-04
US20160090361A1 (en) 2016-03-31
HUE053118T2 (hu) 2021-06-28
IL268432B (en) 2020-08-31
IL268432A (en) 2019-09-26
BR112017005856A2 (pt) 2017-12-19
US20190300485A1 (en) 2019-10-03
CA2960392A1 (en) 2016-03-31
WO2016049509A1 (en) 2016-03-31
AU2015320349A1 (en) 2017-03-23
JP2020045341A (ja) 2020-03-26
MX365010B (es) 2019-05-20

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Owner name: NOVARTIS AG

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FGA Letters patent sealed or granted (standard patent)
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Owner name: BAUSCH + LOMB IRELAND LIMITED

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