JP6681327B2 - 抗pd−1抗体およびその応用 - Google Patents
抗pd−1抗体およびその応用 Download PDFInfo
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- JP6681327B2 JP6681327B2 JP2016522196A JP2016522196A JP6681327B2 JP 6681327 B2 JP6681327 B2 JP 6681327B2 JP 2016522196 A JP2016522196 A JP 2016522196A JP 2016522196 A JP2016522196 A JP 2016522196A JP 6681327 B2 JP6681327 B2 JP 6681327B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C—CHEMISTRY; METALLURGY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Oncology (AREA)
- Communicable Diseases (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
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- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
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- Gastroenterology & Hepatology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310258289.2 | 2013-06-26 | ||
| CN201310258289.2A CN104250302B (zh) | 2013-06-26 | 2013-06-26 | 抗pd‑1抗体及其应用 |
| PCT/CN2014/072574 WO2014206107A1 (zh) | 2013-06-26 | 2014-02-26 | 抗pd-1抗体及其应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016523265A JP2016523265A (ja) | 2016-08-08 |
| JP2016523265A5 JP2016523265A5 (enExample) | 2018-02-08 |
| JP6681327B2 true JP6681327B2 (ja) | 2020-04-15 |
Family
ID=52140971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016522196A Active JP6681327B2 (ja) | 2013-06-26 | 2014-02-26 | 抗pd−1抗体およびその応用 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10066013B2 (enExample) |
| EP (2) | EP3026062B1 (enExample) |
| JP (1) | JP6681327B2 (enExample) |
| CN (1) | CN104250302B (enExample) |
| BR (1) | BR112015031883A2 (enExample) |
| DK (1) | DK3026062T3 (enExample) |
| ES (1) | ES2822927T3 (enExample) |
| HR (1) | HRP20201600T1 (enExample) |
| HU (1) | HUE052487T2 (enExample) |
| MY (1) | MY176822A (enExample) |
| PH (1) | PH12015502819A1 (enExample) |
| PL (1) | PL3026062T3 (enExample) |
| PT (1) | PT3026062T (enExample) |
| RU (1) | RU2663795C2 (enExample) |
| SI (1) | SI3026062T1 (enExample) |
| WO (1) | WO2014206107A1 (enExample) |
Families Citing this family (269)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104250302B (zh) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
| HUE046249T2 (hu) | 2013-12-12 | 2020-02-28 | Shanghai hengrui pharmaceutical co ltd | PD-1 antitest, antigén-kötõ fragmense, és gyógyászati alkalmazása |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| ES3040431T3 (en) | 2014-03-12 | 2025-10-31 | Yeda Res & Dev | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
| US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| CA2957258C (en) | 2014-08-05 | 2023-11-07 | MabQuest SA | Immunological reagents |
| US9982052B2 (en) | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
| US11639385B2 (en) | 2014-12-22 | 2023-05-02 | Pd-1 Acquisition Group, Llc | Anti-PD-1 antibodies |
| DK3237446T3 (en) | 2014-12-22 | 2021-07-26 | Pd 1 Acquisition Group Llc | Anti-PD-1-antistoffer |
| CN108112254B (zh) * | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| CA2986765A1 (en) | 2015-05-29 | 2016-12-08 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
| CN105061597B (zh) * | 2015-06-09 | 2016-04-27 | 北京东方百泰生物科技有限公司 | 一种抗pd-1的单克隆抗体及其获得方法 |
| CA2991976A1 (en) | 2015-07-13 | 2017-01-19 | Cytomx Therapeutics, Inc. | Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof |
| CN116059219A (zh) | 2015-07-16 | 2023-05-05 | 比奥克斯塞尔医疗股份有限公司 | 一种使用免疫调节治疗癌症的新颖方法 |
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| PL2342226T3 (pl) * | 2008-09-26 | 2017-01-31 | Dana-Farber Cancer Institute, Inc. | Ludzkie przeciwciała anty-PD-1, PD-L1 i PD-L2 oraz ich zastosowania |
| KR101050829B1 (ko) * | 2008-10-02 | 2011-07-20 | 서울대학교산학협력단 | 항 pd-1 항체 또는 항 pd-l1 항체를 포함하는 항암제 |
| EP3192811A1 (en) * | 2009-02-09 | 2017-07-19 | Université d'Aix-Marseille | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
| TW201134488A (en) | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
| EP2545078A1 (en) * | 2010-03-11 | 2013-01-16 | UCB Pharma, S.A. | Pd-1 antibody |
| CN102298053B (zh) * | 2011-05-20 | 2014-01-29 | 中山大学肿瘤防治中心 | 原发性肝细胞肝癌术后复发风险评估的组合抗体试剂盒 |
| CN104250302B (zh) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
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2013
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- 2014-02-26 EP EP20189272.6A patent/EP3845562A1/en not_active Withdrawn
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Also Published As
| Publication number | Publication date |
|---|---|
| US10815302B2 (en) | 2020-10-27 |
| SI3026062T1 (sl) | 2020-12-31 |
| HUE052487T2 (hu) | 2021-05-28 |
| JP2016523265A (ja) | 2016-08-08 |
| EP3026062A4 (en) | 2017-08-16 |
| RU2663795C2 (ru) | 2018-08-09 |
| ES2822927T3 (es) | 2021-05-05 |
| BR112015031883A2 (pt) | 2018-02-14 |
| WO2014206107A1 (zh) | 2014-12-31 |
| US20190023782A1 (en) | 2019-01-24 |
| RU2016102176A (ru) | 2017-07-31 |
| EP3026062A1 (en) | 2016-06-01 |
| CN104250302B (zh) | 2017-11-14 |
| EP3845562A1 (en) | 2021-07-07 |
| DK3026062T3 (da) | 2020-10-12 |
| MY176822A (en) | 2020-08-24 |
| US10066013B2 (en) | 2018-09-04 |
| PH12015502819A1 (en) | 2016-03-21 |
| EP3026062B1 (en) | 2020-08-05 |
| HRP20201600T1 (hr) | 2021-03-05 |
| US20160272708A1 (en) | 2016-09-22 |
| PL3026062T3 (pl) | 2021-01-11 |
| CN104250302A (zh) | 2014-12-31 |
| PT3026062T (pt) | 2020-10-13 |
| US20210009688A1 (en) | 2021-01-14 |
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