JP6581604B2 - 予防的または治療的適用のためのリポソーム球状核酸による免疫調節物質の多価送達 - Google Patents
予防的または治療的適用のためのリポソーム球状核酸による免疫調節物質の多価送達 Download PDFInfo
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- JP6581604B2 JP6581604B2 JP2016570952A JP2016570952A JP6581604B2 JP 6581604 B2 JP6581604 B2 JP 6581604B2 JP 2016570952 A JP2016570952 A JP 2016570952A JP 2016570952 A JP2016570952 A JP 2016570952A JP 6581604 B2 JP6581604 B2 JP 6581604B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
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- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A61K39/02—Bacterial antigens
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- A61K2121/00—Preparations for use in therapy
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- Engineering & Computer Science (AREA)
- Mycology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
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- Communicable Diseases (AREA)
- Pulmonology (AREA)
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- Molecular Biology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Genetics & Genomics (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462007528P | 2014-06-04 | 2014-06-04 | |
| US62/007,528 | 2014-06-04 | ||
| PCT/US2015/034226 WO2015187966A1 (en) | 2014-06-04 | 2015-06-04 | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524658A JP2017524658A (ja) | 2017-08-31 |
| JP2017524658A5 JP2017524658A5 (enExample) | 2018-07-12 |
| JP6581604B2 true JP6581604B2 (ja) | 2019-09-25 |
Family
ID=53887176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570952A Active JP6581604B2 (ja) | 2014-06-04 | 2015-06-04 | 予防的または治療的適用のためのリポソーム球状核酸による免疫調節物質の多価送達 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10434064B2 (enExample) |
| EP (2) | EP3164113B1 (enExample) |
| JP (1) | JP6581604B2 (enExample) |
| KR (1) | KR102290205B1 (enExample) |
| CN (1) | CN106535876B (enExample) |
| AU (1) | AU2015269412B2 (enExample) |
| CA (1) | CA2953216C (enExample) |
| ES (1) | ES2725948T3 (enExample) |
| PL (1) | PL3164113T3 (enExample) |
| TR (1) | TR201908550T4 (enExample) |
| WO (1) | WO2015187966A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| WO2015013673A1 (en) | 2013-07-25 | 2015-01-29 | Aurasense Therapeutics, Llc | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| US10568898B2 (en) | 2013-08-13 | 2020-02-25 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| MX389323B (es) | 2013-12-03 | 2025-03-20 | Univ Northwestern | Particulas liposomales, metodos para elaborarlas y sus usos. |
| US10413565B2 (en) | 2014-04-30 | 2019-09-17 | Northwestern University | Nanostructures for modulating intercellular communication and uses thereof |
| US10434064B2 (en) | 2014-06-04 | 2019-10-08 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| JP6741673B2 (ja) | 2014-10-06 | 2020-08-19 | イグジキュア, インコーポレーテッドExicure, Inc. | 抗ｔｎｆ化合物 |
| CA2968531A1 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| WO2016085986A1 (en) | 2014-11-24 | 2016-06-02 | Northwestern University | High density lipoprptein nanoparticles for inflammation |
| EP3247796A4 (en) | 2015-01-14 | 2018-07-11 | Exicure, Inc. | Nucleic acid nanostructures with core motifs |
| WO2016134104A1 (en) * | 2015-02-18 | 2016-08-25 | Exicure, Inc. | Immuno-regulatory lipid containing spherical nucleic acids |
| US10078092B2 (en) | 2015-03-18 | 2018-09-18 | Northwestern University | Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules |
| WO2017136467A1 (en) * | 2016-02-01 | 2017-08-10 | Exicure, Inc. | Surface functionaliztion of liposomes and liposomal spherical nucleic acids (snas) |
| KR102617833B1 (ko) | 2016-05-06 | 2023-12-27 | 엑시큐어 오퍼레이팅 컴퍼니 | 인터류킨 17 수용체 mRNA의 특이적 녹다운을 위한 안티센스 올리고뉴클레오티드 (ASO)를 제시하는 리포좀성 구형 핵산 (SNA) 구축물 |
| CA3023445A1 (en) * | 2016-05-06 | 2017-11-09 | Exicure, Inc. | Spherical nucleic acid tlr9 agonists |
| CA3023449A1 (en) * | 2016-05-06 | 2017-11-09 | Exicure, Inc. | Tlr9-targeted spherical nucleic acids having potent antitumor activity |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| WO2019184991A1 (zh) * | 2018-03-29 | 2019-10-03 | 中国医学科学院基础医学研究所 | 化合物或中药提取物在制备核酸递送试剂中的应用及其相关产品 |
| MA49023A (fr) * | 2017-03-29 | 2020-02-05 | Inst Basic Medical Sciences Cams | Application d'un composé ou d'un extrait de médecine chinoise traditionnelle dans la préparation d'un agent d'administration d'acide nucléique et produits apparentés correspondants |
| CN116082391A (zh) * | 2017-03-29 | 2023-05-09 | 中国医学科学院基础医学研究所 | 化合物或中药提取物在制备核酸递送试剂中的应用及其相关产品 |
| US20200248183A1 (en) * | 2017-04-03 | 2020-08-06 | Subbarao Nallagatla | Tlr9-targeted spherical nucleic acids having potent antitumor activity |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| WO2018209270A1 (en) * | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| KR20200028997A (ko) | 2017-07-13 | 2020-03-17 | 노오쓰웨스턴 유니버시티 | 올리고뉴클레오타이드-작용화된 금속-유기 프레임워크 나노입자를 제조하는 일반적이고 직접적인 방법 |
| RU2020117611A (ru) * | 2017-11-02 | 2021-12-02 | Янссен Байофарма, Инк. | Олигонуклеотидные конструкты и их применение |
| US20200384104A1 (en) * | 2017-12-15 | 2020-12-10 | Northwestern University | Structure-Function Relationships in the Development of Immunotherapeutic Agents |
| SG11202010910QA (en) | 2018-05-07 | 2020-12-30 | Alnylam Pharmaceuticals Inc | Extrahepatic delivery |
| US20230330219A1 (en) * | 2019-01-24 | 2023-10-19 | Massachusetts Institute Of Technology | Nucleic acid nanostructure platform for programming immune stimulation |
| US20220088059A1 (en) * | 2019-02-12 | 2022-03-24 | Exicure Operating Company | Combined spherical nucleic acid and checkpoint inhibitor for antitumor therapy |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| CN110559263B (zh) * | 2019-10-10 | 2021-05-14 | 中国海洋大学 | 一种△5-胆甾硫酸基类化合物脂质体及其制备方法 |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
| US20210220454A1 (en) * | 2020-01-22 | 2021-07-22 | Northwestern University | Design of immunostimulatory protein-core spherical nucleic acids |
| AU2021254270A1 (en) * | 2020-04-10 | 2022-11-24 | Northwestern University | Oxidized tumor cell lysates encapsulated in liposomal spherical nucleic acids as potent cancer immunotherapeutics |
| WO2022192038A1 (en) * | 2021-03-12 | 2022-09-15 | Northwestern University | Antiviral vaccines using spherical nucleic acids |
| CN118903116B (zh) * | 2023-05-08 | 2025-08-12 | 中山大学 | 溶血磷脂酸抑制剂在制备抑制prrsv复制药物中的应用 |
| WO2025089649A1 (ko) * | 2023-10-26 | 2025-05-01 | 주식회사 차백신연구소 | 양이온성 리포좀을 포함하는 핵산 전달용 조성물 및 그의 용도 |
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| JPS5927900A (ja) | 1982-08-09 | 1984-02-14 | Wakunaga Seiyaku Kk | 固定化オリゴヌクレオチド |
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| KR20170005499A (ko) | 2017-01-13 |
| WO2015187966A1 (en) | 2015-12-10 |
| CA2953216C (en) | 2020-12-22 |
| JP2017524658A (ja) | 2017-08-31 |
| CN106535876A (zh) | 2017-03-22 |
| US10434064B2 (en) | 2019-10-08 |
| EP3164113A1 (en) | 2017-05-10 |
| EP3508198A1 (en) | 2019-07-10 |
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