JP6568106B2 - Ｂ型肝炎ウイルス感染症の治療及び予防のための新規ジヒドロキノリジノン類 - Google Patents

Ｂ型肝炎ウイルス感染症の治療及び予防のための新規ジヒドロキノリジノン類 Download PDF

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JP6568106B2
JP6568106B2 JP2016567506A JP2016567506A JP6568106B2 JP 6568106 B2 JP6568106 B2 JP 6568106B2 JP 2016567506 A JP2016567506 A JP 2016567506A JP 2016567506 A JP2016567506 A JP 2016567506A JP 6568106 B2 JP6568106 B2 JP 6568106B2
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methoxy
ethyl
dihydrobenzo
oxo
methoxypropoxy
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JP2017515844A (ja
JP2017515844A5 (enExample
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ハン，シーンチュン
ワーン，ジャングオ
ヤーン，ソーン
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2016567506A 2014-05-13 2015-05-11 Ｂ型肝炎ウイルス感染症の治療及び予防のための新規ジヒドロキノリジノン類 Active JP6568106B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2014077354 2014-05-13
CNPCT/CN2014/077354 2014-05-13
CN2015074462 2015-03-18
CNPCT/CN2015/074462 2015-03-18
PCT/EP2015/060284 WO2015173164A1 (en) 2014-05-13 2015-05-11 Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection

Publications (3)

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JP2017515844A JP2017515844A (ja) 2017-06-15
JP2017515844A5 JP2017515844A5 (enExample) 2018-06-21
JP6568106B2 true JP6568106B2 (ja) 2019-08-28

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US (1) US9920049B2 (enExample)
EP (1) EP3143020B1 (enExample)
JP (1) JP6568106B2 (enExample)
KR (1) KR20160148715A (enExample)
CN (1) CN106459032B (enExample)
CA (1) CA2948080A1 (enExample)
MX (1) MX2016014728A (enExample)
RU (1) RU2016146365A (enExample)
WO (1) WO2015173164A1 (enExample)

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