EA038176B9 - Производные пирроло-[1,2,5]бензотиадиазепина и их применение для лечения заболевания, вызванного вирусом гепатита в - Google Patents

Производные пирроло-[1,2,5]бензотиадиазепина и их применение для лечения заболевания, вызванного вирусом гепатита в

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Publication number
EA038176B9
EA038176B9 EA201991910A EA201991910A EA038176B9 EA 038176 B9 EA038176 B9 EA 038176B9 EA 201991910 A EA201991910 A EA 201991910A EA 201991910 A EA201991910 A EA 201991910A EA 038176 B9 EA038176 B9 EA 038176B9
Authority
EA
Eurasian Patent Office
Prior art keywords
treating
pyrrolo
hepatitis
virus
disease caused
Prior art date
Application number
EA201991910A
Other languages
English (en)
Other versions
EA201991910A1 (ru
EA038176B1 (ru
Inventor
Хайин Хэ
Цзин ВАН
Чжигань ЦЗЯН
Ясюнь Ян
Пэн Шао
Чэнь ЧЖАН
Цзянь Ли
Шухуэй Чэнь
Original Assignee
Фуцзянь Косантер Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фуцзянь Косантер Фармасьютикал Ко., Лтд. filed Critical Фуцзянь Косантер Фармасьютикал Ко., Лтд.
Priority claimed from PCT/CN2018/075995 external-priority patent/WO2018153285A1/zh
Publication of EA201991910A1 publication Critical patent/EA201991910A1/ru
Publication of EA038176B1 publication Critical patent/EA038176B1/ru
Publication of EA038176B9 publication Critical patent/EA038176B9/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

В изобретении раскрыты соединение, представленное формулой (I), его таутомер или фармацевтически приемлемая соль и пути их применения в получении лекарственных средств, предназначенных для лечения связанных с HBV заболеваний.
EA201991910A 2018-01-04 2018-02-09 Производные пирроло-[1,2,5]бензотиадиазепина и их применение для лечения заболевания, вызванного вирусом гепатита в EA038176B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810008592 2018-01-04
PCT/CN2018/075995 WO2018153285A1 (zh) 2017-02-23 2018-02-09 三并环类化合物及其应用

Publications (3)

Publication Number Publication Date
EA201991910A1 EA201991910A1 (ru) 2020-01-23
EA038176B1 EA038176B1 (ru) 2021-07-19
EA038176B9 true EA038176B9 (ru) 2021-09-07

Family

ID=69374475

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991910A EA038176B9 (ru) 2018-01-04 2018-02-09 Производные пирроло-[1,2,5]бензотиадиазепина и их применение для лечения заболевания, вызванного вирусом гепатита в

Country Status (1)

Country Link
EA (1) EA038176B9 (ru)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102060786A (zh) * 2011-01-20 2011-05-18 天津大学 4-(取代-1,3-二炔基)-4-(三氟甲基)-3,4-二氢取代喹唑啉-2-酮类化合物及其制备方法和应用
CN105102451A (zh) * 2013-04-03 2015-11-25 爱尔兰詹森科学公司 N-苯基-氨甲酰衍生物及其作为药物用于治疗乙型肝炎的用途
CN106255684A (zh) * 2013-11-14 2016-12-21 诺维拉治疗公司 氮杂环庚烷衍生物和治疗乙型肝炎感染的方法
CN106459032A (zh) * 2014-05-13 2017-02-22 豪夫迈·罗氏有限公司 治疗和预防乙型肝炎病毒感染的新的二氢喹嗪酮类

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102060786A (zh) * 2011-01-20 2011-05-18 天津大学 4-(取代-1,3-二炔基)-4-(三氟甲基)-3,4-二氢取代喹唑啉-2-酮类化合物及其制备方法和应用
CN105102451A (zh) * 2013-04-03 2015-11-25 爱尔兰詹森科学公司 N-苯基-氨甲酰衍生物及其作为药物用于治疗乙型肝炎的用途
CN106255684A (zh) * 2013-11-14 2016-12-21 诺维拉治疗公司 氮杂环庚烷衍生物和治疗乙型肝炎感染的方法
CN106459032A (zh) * 2014-05-13 2017-02-22 豪夫迈·罗氏有限公司 治疗和预防乙型肝炎病毒感染的新的二氢喹嗪酮类

Also Published As

Publication number Publication date
EA201991910A1 (ru) 2020-01-23
EA038176B1 (ru) 2021-07-19

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TH4A Publication of the corrected specification to eurasian patent