JP6479660B2 - Ｒｏｒ１癌の治療および転移の阻害に使用するための抗体およびワクチン - Google Patents

Ｒｏｒ１癌の治療および転移の阻害に使用するための抗体およびワクチン

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JP6479660B2
JP6479660B2 JP2015528458A JP2015528458A JP6479660B2 JP 6479660 B2 JP6479660 B2 JP 6479660B2 JP 2015528458 A JP2015528458 A JP 2015528458A JP 2015528458 A JP2015528458 A JP 2015528458A JP 6479660 B2 JP6479660 B2 JP 6479660B2
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ror1
antibody
cells
cancer
seq
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JP2015532644A (ja
JP2015532644A5 (cg-RX-API-DMAC7.html
Inventor
トーマス ジェイムズ キップス
トーマス ジェイムズ キップス
チアン ユ
チアン ユ
ビン キュイ
ビン キュイ
リガン チェン
リガン チェン
ジョージ ウィドホップ
ジョージ ウィドホップ
チャールズ プルサク
チャールズ プルサク
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University of California
University of California Berkeley
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University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015528458A 2012-08-24 2013-03-15 Ｒｏｒ１癌の治療および転移の阻害に使用するための抗体およびワクチン Active JP6479660B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261693230P 2012-08-24 2012-08-24
US61/693,230 2012-08-24
US201261709055P 2012-10-02 2012-10-02
US61/709,055 2012-10-02
US201261709803P 2012-10-04 2012-10-04
US61/709,803 2012-10-04
PCT/US2013/032572 WO2014031174A1 (en) 2012-08-24 2013-03-15 Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis

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JP2019019281A Division JP6823094B2 (ja) 2012-08-24 2019-02-06 Ｒｏｒ１癌の治療および転移の阻害に使用するための抗体およびワクチン

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JP2015532644A JP2015532644A (ja) 2015-11-12
JP2015532644A5 JP2015532644A5 (cg-RX-API-DMAC7.html) 2016-06-02
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JP2015528458A Active JP6479660B2 (ja) 2012-08-24 2013-03-15 Ｒｏｒ１癌の治療および転移の阻害に使用するための抗体およびワクチン
JP2019019281A Active JP6823094B2 (ja) 2012-08-24 2019-02-06 Ｒｏｒ１癌の治療および転移の阻害に使用するための抗体およびワクチン
JP2021001318A Active JP7138735B2 (ja) 2012-08-24 2021-01-07 Ｒｏｒ１癌の治療および転移の阻害に使用するための抗体およびワクチン
JP2022141122A Pending JP2022174167A (ja) 2012-08-24 2022-09-06 Ｒｏｒ１癌の治療および転移の阻害に使用するための抗体およびワクチン

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JP2019019281A Active JP6823094B2 (ja) 2012-08-24 2019-02-06 Ｒｏｒ１癌の治療および転移の阻害に使用するための抗体およびワクチン
JP2021001318A Active JP7138735B2 (ja) 2012-08-24 2021-01-07 Ｒｏｒ１癌の治療および転移の阻害に使用するための抗体およびワクチン
JP2022141122A Pending JP2022174167A (ja) 2012-08-24 2022-09-06 Ｒｏｒ１癌の治療および転移の阻害に使用するための抗体およびワクチン

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US (5) US9758591B2 (cg-RX-API-DMAC7.html)
EP (3) EP3489261B1 (cg-RX-API-DMAC7.html)
JP (4) JP6479660B2 (cg-RX-API-DMAC7.html)
KR (3) KR102134088B1 (cg-RX-API-DMAC7.html)
CN (2) CN104662044B (cg-RX-API-DMAC7.html)
AU (3) AU2013306390B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015003757B1 (cg-RX-API-DMAC7.html)
CA (1) CA2881966C (cg-RX-API-DMAC7.html)
CL (1) CL2015000431A1 (cg-RX-API-DMAC7.html)
DK (3) DK3489261T3 (cg-RX-API-DMAC7.html)
ES (3) ES2702315T3 (cg-RX-API-DMAC7.html)
IL (2) IL236962B (cg-RX-API-DMAC7.html)
MX (1) MX362456B (cg-RX-API-DMAC7.html)
MY (1) MY181648A (cg-RX-API-DMAC7.html)
NI (1) NI201500024A (cg-RX-API-DMAC7.html)
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PL (2) PL3489261T3 (cg-RX-API-DMAC7.html)
PT (1) PT2888283T (cg-RX-API-DMAC7.html)
SG (1) SG11201500730XA (cg-RX-API-DMAC7.html)
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