JP6025570B2 - 組織因子経路インヒビター（ｔｆｐｉ）に対する最適化されたモノクローナル抗体 - Google Patents

組織因子経路インヒビター（ｔｆｐｉ）に対する最適化されたモノクローナル抗体 Download PDF

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JP6025570B2
JP6025570B2 JP2012556192A JP2012556192A JP6025570B2 JP 6025570 B2 JP6025570 B2 JP 6025570B2 JP 2012556192 A JP2012556192 A JP 2012556192A JP 2012556192 A JP2012556192 A JP 2012556192A JP 6025570 B2 JP6025570 B2 JP 6025570B2
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antibody
amino acid
tfpi
acid sequence
human
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JP2013520996A5 (enExample
JP2013520996A (ja
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ワン・ジュオジ
ジュンリアン・パン
ヨアンナ・グルドツィンスカ
クリスチャン・フォツマイアー
ヤン・テベ
イェルク・ビルケンフェルト
ニーナ・ヴォブスト
ジモーネ・ブリュックナー
ズザンネ・シュタイニヒ
ペーター・ショルツ
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Bayer Healthcare LLC
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Bayer Healthcare LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Filtering Materials (AREA)
JP2012556192A 2010-03-01 2011-03-01 組織因子経路インヒビター（ｔｆｐｉ）に対する最適化されたモノクローナル抗体 Expired - Fee Related JP6025570B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30929010P 2010-03-01 2010-03-01
US61/309,290 2010-03-01
PCT/US2011/026766 WO2011109452A1 (en) 2010-03-01 2011-03-01 Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI)

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JP2016199718A Division JP6475679B2 (ja) 2010-03-01 2016-10-11 組織因子経路インヒビター（ｔｆｐｉ）に対する最適化されたモノクローナル抗体

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JP2013520996A JP2013520996A (ja) 2013-06-10
JP2013520996A5 JP2013520996A5 (enExample) 2014-04-17
JP6025570B2 true JP6025570B2 (ja) 2016-11-16

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JP2012556192A Expired - Fee Related JP6025570B2 (ja) 2010-03-01 2011-03-01 組織因子経路インヒビター（ｔｆｐｉ）に対する最適化されたモノクローナル抗体
JP2016199718A Expired - Fee Related JP6475679B2 (ja) 2010-03-01 2016-10-11 組織因子経路インヒビター（ｔｆｐｉ）に対する最適化されたモノクローナル抗体
JP2019016811A Expired - Fee Related JP6684369B2 (ja) 2010-03-01 2019-02-01 組織因子経路インヒビター（ｔｆｐｉ）に対する最適化されたモノクローナル抗体
JP2020057005A Withdrawn JP2020115868A (ja) 2010-03-01 2020-03-27 組織因子経路インヒビター（ｔｆｐｉ）に対する最適化されたモノクローナル抗体

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JP2019016811A Expired - Fee Related JP6684369B2 (ja) 2010-03-01 2019-02-01 組織因子経路インヒビター（ｔｆｐｉ）に対する最適化されたモノクローナル抗体
JP2020057005A Withdrawn JP2020115868A (ja) 2010-03-01 2020-03-27 組織因子経路インヒビター（ｔｆｐｉ）に対する最適化されたモノクローナル抗体

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EP (2) EP2542257B1 (enExample)
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KR (4) KR101807894B1 (enExample)
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AU (1) AU2011223710B2 (enExample)
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CL (2) CL2012002415A1 (enExample)
CO (1) CO6620068A2 (enExample)
CR (1) CR20120453A (enExample)
CU (1) CU23982B1 (enExample)
CY (2) CY1119410T1 (enExample)
DK (2) DK3345615T3 (enExample)
DO (1) DOP2012000239A (enExample)
EA (2) EA201892184A1 (enExample)
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ES (2) ES2765418T3 (enExample)
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HK (2) HK1232232A1 (enExample)
HR (2) HRP20171472T1 (enExample)
HU (2) HUE036655T2 (enExample)
IL (3) IL221551B (enExample)
LT (2) LT3345615T (enExample)
ME (2) ME03578B (enExample)
MX (2) MX2012010198A (enExample)
MY (1) MY174760A (enExample)
NZ (2) NZ602115A (enExample)
PE (1) PE20160538A1 (enExample)
PH (4) PH12012501742A1 (enExample)
PL (2) PL3345615T3 (enExample)
PT (2) PT2542257T (enExample)
RS (2) RS56409B1 (enExample)
SG (3) SG183443A1 (enExample)
SI (2) SI2542257T1 (enExample)
SM (1) SMT201700454T1 (enExample)
WO (1) WO2011109452A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017035100A (ja) * 2010-03-01 2017-02-16 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ 組織因子経路インヒビター（ｔｆｐｉ）に対する最適化されたモノクローナル抗体
KR20200108610A (ko) * 2019-03-11 2020-09-21 현대자동차주식회사 상용 전기차용 모터 마운트

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UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
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CN113788897A (zh) 2013-03-15 2021-12-14 拜尔健康护理有限责任公司 改善药代动力学的具有跨pH范围差异结合的抗TFPI抗体变体
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KR102337683B1 (ko) * 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물
EP3863664A1 (en) * 2018-10-11 2021-08-18 Pfizer Inc. Dosage regimen for tfpi antagonists
CN112442127A (zh) 2019-08-29 2021-03-05 苏州康宁杰瑞生物科技有限公司 针对tfpi的单克隆抗体
MX2023005580A (es) * 2020-11-13 2023-05-29 Hanmi Pharmaceutical Co Ltd Uso de una proteina de fusion enzimatica terapeutica en la prevencion y el tratamiento de enfermedades renales provocadas por o acompa?adas de la enfermedad de fabry.
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